2023
Patients with AUD exhibit dampened heart rate variability during sleep as compared to social drinkers
Wemm S, Golden M, Martins J, Fogelman N, Sinha R. Patients with AUD exhibit dampened heart rate variability during sleep as compared to social drinkers. Alcohol And Alcoholism 2023, 58: 653-661. PMID: 37756494, PMCID: PMC10642609, DOI: 10.1093/alcalc/agad061.Peer-Reviewed Original ResearchConceptsAlcohol use disorderHeart rate variabilitySocial drinkersAUD groupChronic heavy alcohol useRate variabilityLife-threatening cardiovascular diseaseHRV measuresPatient-related symptomsPatient-reported symptomsHF/LF ratioSevere alcohol use disorderNervous system processesHeavy alcohol useParasympathetic dysfunctionCardiovascular diseaseHeart rate monitoringObservational studySleep difficultiesHeart rateParasympathetic activationUse disordersRSA amplitudeCardiovascular systemDays of monitoring
2022
Daily Stress Predicts Later Drinking Initiation via Craving in Heavier Social Drinkers: A Prospective In-Field Daily Diary Study
Wemm SE, Tennen H, Sinha R, Seo D. Daily Stress Predicts Later Drinking Initiation via Craving in Heavier Social Drinkers: A Prospective In-Field Daily Diary Study. Journal Of Psychopathology And Clinical Science 2022, 131: 780-792. PMID: 36048091, PMCID: PMC9561019, DOI: 10.1037/abn0000771.Peer-Reviewed Original Research
2021
Alcohol craving and withdrawal at treatment entry prospectively predict alcohol use outcomes during outpatient treatment
Martins JS, Fogelman N, Wemm S, Hwang S, Sinha R. Alcohol craving and withdrawal at treatment entry prospectively predict alcohol use outcomes during outpatient treatment. Drug And Alcohol Dependence 2021, 231: 109253. PMID: 34998258, PMCID: PMC8818273, DOI: 10.1016/j.drugalcdep.2021.109253.Peer-Reviewed Original ResearchConceptsAlcohol use outcomesAlcohol cravingTreatment entryDays/weekSleep difficultiesOutpatient treatmentAbstinence symptomsUse outcomesPre-treatment alcohol useEffects of cravingTreatment-seeking adultsAlcohol useAlcohol use disorder treatmentRelapse prevention counselingDrinking-related outcomesHeavy drinkingDrinking days/weekOutpatient AUD treatmentGreater alcoholChronic alcohol useDistress symptomsUse disorder treatmentAUD treatmentAverage drinksCravingAlcohol withdrawal symptoms predict corticostriatal dysfunction that is reversed by prazosin treatment in alcohol use disorder
Sinha R, Fogelman N, Wemm S, Angarita G, Seo D, Hermes G. Alcohol withdrawal symptoms predict corticostriatal dysfunction that is reversed by prazosin treatment in alcohol use disorder. Addiction Biology 2021, 27: e13116. PMID: 34856641, PMCID: PMC9872962, DOI: 10.1111/adb.13116.Peer-Reviewed Original ResearchConceptsMedial prefrontal cortexFunctional magnetic resonance imagingAlcohol use disorderAlcohol cuesHeavy drinking daysStudy 2Alcohol withdrawal symptomsNeutral visual imagesDrinking daysStudy 1 resultsUse disordersCortico-striatal dysfunctionAlcohol treatment outcomesAlcohol intakeFMRI sessionsResilient copingStriatal responsesPrefrontal cortexStudy 1Chronic alcohol useCorticostriatal dysfunctionStriatal functioningAUD patientsVisual imagesPlacebo treatment
2019
Fluctuations in progesterone moderate the relationship between daily mood and alcohol use in young adult women
Holzhauer CG, Wemm SE, Wulfert E, Cao ZT. Fluctuations in progesterone moderate the relationship between daily mood and alcohol use in young adult women. Addictive Behaviors 2019, 101: 106146. PMID: 31639640, PMCID: PMC6876695, DOI: 10.1016/j.addbeh.2019.106146.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAffectAlcohol DrinkingFemaleHumansMenstrual CycleProgesteroneSalivaStudentsSurveys and QuestionnairesYoung AdultConceptsLevels of progesteroneYoung adult womenAlcohol useMenstrual cycleProgesterone levelsAdult womenDaily ratingsMenstrual cycle phaseDaily moodWomen's alcohol useOdds of drinkingProtective effectHormonal fluctuationsSalivary samplesPremenstrual phaseProgesteroneLow moodMood changesWomenLinear mixed modelsStandard deviation increaseTwo-week periodWeeksDaily logsMoodA day-by-day prospective analysis of stress, craving and risk of next day alcohol intake during alcohol use disorder treatment
Wemm SE, Larkin C, Hermes G, Tennen H, Sinha R. A day-by-day prospective analysis of stress, craving and risk of next day alcohol intake during alcohol use disorder treatment. Drug And Alcohol Dependence 2019, 204: 107569. PMID: 31574406, PMCID: PMC6916671, DOI: 10.1016/j.drugalcdep.2019.107569.Peer-Reviewed Original ResearchConceptsAlcohol use disorderAlcohol intakeEarly treatmentAlcohol use disorder treatmentStressful eventsNovel treatment approachesAlcohol relapse riskUse disorder treatmentNext dayWeeks of outpatientStress-induced cravingAlcohol use outcomesRelapse riskProspective analysisUse disordersAUD patientsTreatment approachesDisorder treatmentHigher cravingDaily diariesUse outcomesIntakeAUD individualsCravingDrinking amount
2017
Distress Tolerance and Physiological Reactivity to Stress Predict Women’s Problematic Alcohol Use
Holzhauer CG, Wemm S, Wulfert E. Distress Tolerance and Physiological Reactivity to Stress Predict Women’s Problematic Alcohol Use. Experimental And Clinical Psychopharmacology 2017, 25: 156-165. PMID: 28437123, DOI: 10.1037/pha0000116.Peer-Reviewed Original ResearchConceptsBehavioral distress toleranceDistress tolerancePhysiological reactivityStress reactivityAlcohol misuseNegative alcohol-related consequencesPhysiological stress reactivityAlcohol-related consequencesLow stress reactivityDrinking-related negative consequencesLower physiological reactivityWomen's alcohol misuseGreater urgeNonclinical sampleStressful taskYoung adult womenMeasures of reactivityCollege womenSubjective levelPrior findingsInteractive associationsAlcohol useNegative consequencesCurrent studyAdult women
2013
Problematic drinking and physiological responses among female college students
Wemm S, Fanean A, Baker A, Blough ER, Mewaldt S, Bardi M. Problematic drinking and physiological responses among female college students. Alcohol 2013, 47: 149-157. PMID: 23333036, DOI: 10.1016/j.alcohol.2012.12.006.Peer-Reviewed Original ResearchConceptsProblematic drinkingLow DHEAS levelsImpaired physiological responseExcessive alcohol useCollege studentsHigher cortisol levelsHigh basal levelsMajority of participantsDHEAS levelsSalivary levelsBinge drinkingAdrenal activityCardiovascular measurementsAlcohol-related consequencesCortisol levelsBehavioral stress responsesAlcohol dependenceSelf-reported consequencesSelf-reported drinkingSaliva samplesAlcohol useBasal levelsFemale college studentsDistress tolerancePhysiological responses