2024
Survodutide for treatment of obesity: rationale and design of two randomized phase 3 clinical trials (SYNCHRONIZE™‐1 and ‐2)
Wharton S, le Roux C, Kosiborod M, Platz E, Brueckmann M, Jastreboff A, Hussain S, Pedersen S, Borowska L, Unseld A, Kloer I, Kaplan L, committees and investigators T. Survodutide for treatment of obesity: rationale and design of two randomized phase 3 clinical trials (SYNCHRONIZE™‐1 and ‐2). Obesity 2024 PMID: 39495965, DOI: 10.1002/oby.24184.Peer-Reviewed Original ResearchTreatment of obesityBaseline BMIRandomized phase 3 clinical trialOnce-weekly subcutaneous injectionsPhase 3 clinical trialsBaseline to weekDouble-blind trialObesity-related complicationsBody weight reductionAbsence of T2DSystolic blood pressureLiver fat contentType 2 diabetesMagnetic resonance imagingMeasures of glycemiaSecondary endpointsDosing flexibilityProportion of participantsLifestyle modificationInvestigated glucagonSubcutaneous injectionBlood pressureBody compositionResonance imagingObesity
2019
Clinical Considerations Regarding the Use of Obesity Pharmacotherapy in Adolescents with Obesity
Srivastava G, Fox CK, Kelly AS, Jastreboff AM, Browne AF, Browne NT, Pratt JSA, Bolling C, Michalsky MP, Cook S, Lenders CM, Apovian CM. Clinical Considerations Regarding the Use of Obesity Pharmacotherapy in Adolescents with Obesity. Obesity 2019, 27: 190-204. PMID: 30677262, PMCID: PMC6449849, DOI: 10.1002/oby.22385.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsIntensive lifestyle interventionObesity pharmacotherapyLifestyle interventionSevere obesityPrediabetes/type 2 diabetesObesity-related comorbid diseasesNonalcoholic fatty liver diseasePediatric primary care providersIntensive lifestyle modificationFatty liver diseaseMore effective treatment strategiesObstructive sleep apneaEffective treatment optionPrimary care providersType 2 diabetesEffective treatment strategiesLifestyle modificationPharmacotherapy optionsBariatric surgeryComorbid diseasesLiver diseaseSleep apneaTreatment algorithmExcess adiposityInformed consent regulations
2012
The Diagnosis and Management of Cerebrovascular Disease in Diabetes
Phipps MS, Jastreboff AM, Furie K, Kernan WN. The Diagnosis and Management of Cerebrovascular Disease in Diabetes. Current Diabetes Reports 2012, 12: 314-323. PMID: 22492061, DOI: 10.1007/s11892-012-0271-x.BooksConceptsDiabetic patientsCerebrovascular diseaseNondiabetic patientsDiabetic stroke patientsWorse functional outcomeManagement of strokeCause of deathLifestyle modificationSecondary preventionGlycemic controlStroke patientsFunctional outcomeLeading causePatientsResearch cohortEarly onsetStrokeDiabetesDiseaseDiagnosisPreventionCauseSpecific considerationsMorbidityRisk assessment