2014
Leptin Is Associated With Exaggerated Brain Reward and Emotion Responses to Food Images in Adolescent Obesity
Jastreboff AM, Lacadie C, Seo D, Kubat J, Van Name MA, Giannini C, Savoye M, Constable RT, Sherwin RS, Caprio S, Sinha R. Leptin Is Associated With Exaggerated Brain Reward and Emotion Responses to Food Images in Adolescent Obesity. Diabetes Care 2014, 37: 3061-3068. PMID: 25139883, PMCID: PMC4207200, DOI: 10.2337/dc14-0525.Peer-Reviewed Original ResearchConceptsLow-calorie foodsBrain responsesFood imagesEmotion processingEmotion responsesAdolescent brainNeural responsesNeural activationHigh-calorie food consumptionFood cravingsNeural alterationsBrain rewardFunctional MRIAdolescent obesityRisk of overconsumptionAdolescentsObesity-related metabolic changesEndogenous leptin levelsFood advertisingMetabolic changesYouthDevelopment of obesityType 2 diabetesLean adolescentsNation's youth
2012
Year in Diabetes 2012: The Diabetes Tsunami
Sherwin R, Jastreboff AM. Year in Diabetes 2012: The Diabetes Tsunami. The Journal Of Clinical Endocrinology & Metabolism 2012, 97: 4293-4301. PMID: 23185035, PMCID: PMC3513534, DOI: 10.1210/jc.2012-3487.BooksConceptsClinical trialsAmerican Diabetes Association/European AssociationNew-onset type 1 diabetesPrevalence of diabetesCurrent treatment optionsLarge clinical trialsRecent clinical trialsBenefits of exerciseDevelopment of obesityNormal glucose metabolismType 1 diabetesStudy of DiabetesΒ-cell functionNovel therapeutic targetCentral nervous systemObese childrenSignificant morbidityTreatment optionsEndocrine SocietyInpatient settingTreatment strategiesIndividualized careOptimal preventionGlucose metabolismOptimization of interventions