Publications

Featured Publications

A genome-wide investigation into the underlying genetic architecture of personality traits and overlap with psychopathology
Gupta P, Galimberti M, Liu Y, Beck S, Wingo A, Wingo T, Kranzler H, Stein M, Gelernter J, Levey D. A genome-wide investigation into the underlying genetic architecture of personality traits and overlap with psychopathology. Nature Human Behaviour 2024, 8: 2235-2249. PMID: 39134740, PMCID: PMC11576509, DOI: 10.1038/s41562-024-01951-3.
Peer-Reviewed Original Research
Multi-ancestry genome-wide association study of cannabis use disorder yields insight into disease biology and public health implications
Levey D, Galimberti M, Deak J, Wendt F, Bhattacharya A, Harrington K, Quaden R, Johnson E, Gupta P, Biradar M, Lam M, Cooke M, Rajagopal V, Empke S, Zhou H, Nunez Y, Kranzler H, Edenberg H, Agrawal A, Smoller J, Lencz T, Hougaard D, Børglum A, Demontis D, Gaziano J, Gandal M, Polimanti R, Stein M, Gelernter J. Multi-ancestry genome-wide association study of cannabis use disorder yields insight into disease biology and public health implications. Nature Genetics 2023, 55: 2094-2103. PMID: 37985822, PMCID: PMC10703690, DOI: 10.1038/s41588-023-01563-z.
Peer-Reviewed Original Research
MeSH Keywords
Bi-ancestral depression GWAS in the Million Veteran Program and meta-analysis in >1.2 million individuals highlight new therapeutic directions
Levey DF, Stein MB, Wendt FR, Zhou H, Aslan M, Quaden R, Harrington KM, Nuñez YZ, Overstreet C, Radhakrishnan K, Sanacora G, McIntosh AM, Shi J, Shringarpure SS, Concato J, Polimanti R, Gelernter J. Bi-ancestral depression GWAS in the Million Veteran Program and meta-analysis in >1.2 million individuals highlight new therapeutic directions. Nature Neuroscience 2021, 24: 954-963. PMID: 34045744, PMCID: PMC8404304, DOI: 10.1038/s41593-021-00860-2.
Peer-Reviewed Original Research
MeSH Keywords
Reproducible Genetic Risk Loci for Anxiety: Results From ∼200,000 Participants in the Million Veteran Program
Levey DF, Gelernter J, Polimanti R, Zhou H, Cheng Z, Aslan M, Quaden R, Concato J, Radhakrishnan K, Bryois J, Sullivan PF, Program M, Stein M. Reproducible Genetic Risk Loci for Anxiety: Results From ∼200,000 Participants in the Million Veteran Program. American Journal Of Psychiatry 2020, 177: 223-232. PMID: 31906708, PMCID: PMC7869502, DOI: 10.1176/appi.ajp.2019.19030256.
Peer-Reviewed Original Research
MeSH Keywords
Genetic associations with suicide attempt severity and genetic overlap with major depression
Levey DF, Polimanti R, Cheng Z, Zhou H, Nuñez YZ, Jain S, He F, Sun X, Ursano RJ, Kessler RC, Smoller JW, Stein MB, Kranzler HR, Gelernter J. Genetic associations with suicide attempt severity and genetic overlap with major depression. Translational Psychiatry 2019, 9: 22. PMID: 30655502, PMCID: PMC6336846, DOI: 10.1038/s41398-018-0340-2.
Peer-Reviewed Original Research
MeSH Keywords
Towards understanding and predicting suicidality in women: biomarkers and clinical risk assessment
Levey DF, Niculescu EM, Le-Niculescu H, Dainton HL, Phalen PL, Ladd TB, Weber H, Belanger E, Graham DL, Khan FN, Vanipenta NP, Stage EC, Ballew A, Yard M, Gelbart T, Shekhar A, Schork NJ, Kurian SM, Sandusky GE, Salomon DR, Niculescu AB. Towards understanding and predicting suicidality in women: biomarkers and clinical risk assessment. Molecular Psychiatry 2016, 21: 768-785. PMID: 27046645, DOI: 10.1038/mp.2016.31.
Peer-Reviewed Original Research
MeSH Keywords

2026

Robust inference and correlates from genetic associations with personality
Schwaba T, Clapp Sullivan M, Akingbuwa W, Ilves K, Tanksley P, Williams C, Dragostinov Y, Mallard T, Tubbs J, Liao W, Ackerman L, Fealy J, Hemani G, de la Fuente J, Smith G, Gupta P, Stein M, Gelernter J, Levey D, Võsa U, Ausmees L, Realo A, Vaht M, Allik J, Esko T, Mõttus R, Vainik U, Jonsdottir G, Thorleifsson G, Gunnarsson Á, Bjornsdottir G, Thorgeirsson T, Stefansson H, Stefansson K, Cheesman R, Qin Q, Corfield E, Ask H, Torvik F, Ystrom E, Tesli M, Boomsma D, de Geus E, Hottenga J, Melo D, Snieder H, Hartman C, Xia C, Campbell A, Luciano M, Deary I, Hill W, Jang S, Vrieze S, Abecasis G, Lupton M, Mitchell B, Viher P, Colodro-Conde L, Martin N, Medland S, Derks E, Wormington B, Kaprio J, Silventoinen K, Palviainen T, Musial A, Rimfeld K, Plomin R, Malanchini M, Dick D, Aliev F, Wesseldijk L, Ullén F, Mosing M, Kranzler H, Nunez Y, Beck S, Polimanti R, Edwards T, Giannelis A, Willoughby E, Lee J, McGue M, Terracciano A, Marongiu M, Fiorillo E, Cucca F, Sutin A, van der Most P, Oldehinkel A, Kretschmer T, Shabalin A, Docherty A, Krueger R, Freilich C, Mishra B, Lehtimäki T, Raitakari O, Kähönen M, Saarinen A, Dobewall H, Keltikangas-Järvinen L, Berger K, Herrera-Rivero M, Streit F, Awasthi S, Witt S, Tuhkanen J, Räikkönen K, Eriksson J, Lahti J, Davies G, Redmond P, Taylor A, Corley J, Russ T, Ciullo M, Nutile T, Ding J, Qian Y, Tanaka T, Ferrucci L, Zillich L, Sirignano L, Harden K, Genç E, Gajewski P, Getzmann S, Fraenz C, Schneider Peñate J, Lis S, Hall A, Schmahl C, Herpertz S, Abdellaoui A, Nivard M, Tucker-Drob E. Robust inference and correlates from genetic associations with personality. Nature 2026, 1-11. PMID: 42686911, PMCID: PMC13589609, DOI: 10.1038/s41586-026-10992-9.
Peer-Reviewed Original Research
The genetics of fibromyalgia and its relationships to psychiatric and medical traits
Bright U, Beck S, Levey D, Deak J, Gaziano J, Stein M, Gelernter J. The genetics of fibromyalgia and its relationships to psychiatric and medical traits. Nature Communications 2026, 17: 6248. PMID: 42521668, PMCID: PMC13415558, DOI: 10.1038/s41467-026-75256-6.
Peer-Reviewed Original Research
MeSH Keywords
A large-scale meta-analysis of DNA methylation signatures of alcohol use disorder in the Psychiatric Genomics Consortium
Zillich L, D’Augello S, Avetyan D, Delgado G, Gizer I, Jung J, Katrinli S, Kleber M, Merrill N, Moissl-Blanke A, Núñez-Rios D, Otto J, Zillich E, Friedel E, Hancock D, Johnson E, Martínez-Magaña J, Sosnowski D, White J, Aberg K, Copeland W, Diazgranados N, Fani N, Gelernter J, Goldman D, Foo J, Kranzler H, Levey D, März W, Penninx B, Polimanti R, Powers A, Smith A, Spanagel R, van den Oord E, Wilhelmsen K, Witt S, Domschke K, Schiele M, Maher B, Montalvo Ortiz J, Clark S, Lohoff F. A large-scale meta-analysis of DNA methylation signatures of alcohol use disorder in the Psychiatric Genomics Consortium. Nature Mental Health 2026, 4: 1088-1098. DOI: 10.1038/s44220-026-00666-w.
Peer-Reviewed Original Research
Opioid use disorder and dementia risk: evidence from observational and genetic analyses in diverse ancestry cohorts
Javidnia S, Roe J, Karhunen V, Gill D, Bell S, Deak J, Levey D, Kember R, Kranzler H, Cronjé H, Burgess S, Gelernter J, Ebmeier K, Topiwala A. Opioid use disorder and dementia risk: evidence from observational and genetic analyses in diverse ancestry cohorts. Alzheimer's & Dementia 2026, 22: e71418. PMID: 42170857, PMCID: PMC13240559, DOI: 10.1002/alz.71418.
Peer-Reviewed Original Research
MeSH Keywords
Genetic Pathways Point to the Biology Underlying the Association Between Cannabis Use Disorder and Psychosis
Austin-Zimmerman I, Li Q, Johnson E, Trotta G, Spinazzola E, Coleman J, Li Z, Bond B, Quattrone D, Levey D, Gelernter J, Jauhar S, Murray R, Sham P, Vassos E, Di Forti M. Genetic Pathways Point to the Biology Underlying the Association Between Cannabis Use Disorder and Psychosis. Biological Psychiatry Global Open Science 2026, 6: 100711. PMID: 42181294, PMCID: PMC13196363, DOI: 10.1016/j.bpsgos.2026.100711.
Peer-Reviewed Original Research
Genomic Study of Resilience to Posttraumatic Stress Disorder in the Million Veteran Program
Overstreet C, Levey D, Galimberti M, Pietrzak R, Zhou H, Løkhammer S, Polimanti R, Harrington K, Quaden R, Amstadter A, Gaziano J, Stein M, Gelernter J, Overstreet C, Levey D, Galimberti M, Pathak G, Pietrzak R, Zhou H, Polimanti R, Harrington K, Quaden R, Gaziano J, Stein M, Gelernter J. Genomic Study of Resilience to Posttraumatic Stress Disorder in the Million Veteran Program. Biological Psychiatry 2026, 100: 699-709. PMID: 41763442, DOI: 10.1016/j.biopsych.2026.01.022.
Peer-Reviewed Original Research
Cannabis use, cognitive function and dementia risk in older adults: observational and genetic analyses
Ishrat S, Levey D, Gelernter J, Ebmeier K, Topiwala A. Cannabis use, cognitive function and dementia risk in older adults: observational and genetic analyses. BMJ Mental Health 2026, 29: e302290. PMID: 41741130, PMCID: PMC12958891, DOI: 10.1136/bmjment-2025-302290.
Peer-Reviewed Original Research
Genome-wide association study of major anxiety disorders in 122,341 European-ancestry cases identifies 58 loci and highlights GABAergic signaling
Strom N, Verhulst B, Bacanu S, Cheesman R, Purves K, Gedik H, Mitchell B, Kwong A, Faucon A, Singh K, Medland S, Colodro-Conde L, Krebs K, Hoffmann P, Herms S, Gehlen J, Ripke S, Awasthi S, Palviainen T, Tasanko E, Peterson R, Adkins D, Shabalin A, Adams M, Iveson M, Campbell A, Thomas L, Winsvold B, Drange O, Børte S, ter Kuile A, Naamanka J, Nguyen T, Meier S, Corfield E, Hannigan L, Levey D, Czamara D, Weber H, Choi K, Pistis G, Couvy-Duchesne B, Van der Auwera S, Teumer A, Karlsson R, Garcia-Argibay M, Lee D, Wang R, Bjerkeset O, Stordal E, Bäckman J, Salum G, Zai C, Kennedy J, Zai G, Tiwari A, Heilmann-Heimbach S, Schmidt B, Kaprio J, Kennedy M, Boden J, Havdahl A, Middeldorp C, Lopes F, Akula N, McMahon F, Binder E, Fehm L, Ströhle A, Castelao E, Tiemeier H, Stein D, Whiteman D, Olsen C, Fuller Z, Wang X, Wray N, Byrne E, Lewis G, Timpson N, Davis L, Hickie I, Gillespie N, Milani L, Schumacher J, Woldbye D, Forstner A, Nöthen M, Hovatta I, Horwood J, Copeland W, Maes H, McIntosh A, Andreassen O, Zwart J, Mors O, Børglum A, Mortensen P, Ask H, Reichborn-Kjennerud T, Najman J, Stein M, Gelernter J, Milaneschi Y, Penninx B, Boomsma D, Maron E, Erhardt-Lehmann A, Rück C, Kircher T, Melzig C, Alpers G, Arolt V, Domschke K, Smoller J, Preisig M, Martin N, Lupton M, Luik A, Reif A, Grabe H, Larsson H, Magnusson P, Oldehinkel A, Hartman C, Breen G, Docherty A, Coon H, Conrad R, Lehto K, Deckert J, Eley T, Mattheisen M, Hettema J. Genome-wide association study of major anxiety disorders in 122,341 European-ancestry cases identifies 58 loci and highlights GABAergic signaling. Nature Genetics 2026, 58: 275-288. PMID: 41634414, PMCID: PMC12900644, DOI: 10.1038/s41588-025-02485-8.
Peer-Reviewed Original Research
MeSH Keywords

2025

Multi-ancestry investigation of the genomics of erectile dysfunction
Bright U, Chen Y, Deak J, Zhou H, Levey D, Gelernter J. Multi-ancestry investigation of the genomics of erectile dysfunction. Nature Communications 2025, 16: 11602. PMID: 41285899, PMCID: PMC12749275, DOI: 10.1038/s41467-025-66723-7.
Peer-Reviewed Original Research
The genetics of cannabis lifetime use
Bright U, Beck S, Galimberti M, Gupta P, Chen Y, Dao C, Nunez Y, Kranzler H, Zhou Y, Zhang Y, Choi K, Levey D, Gelernter J. The genetics of cannabis lifetime use. Neuropsychopharmacology 2025, 51: 554-564. PMID: 41044382, PMCID: PMC12824155, DOI: 10.1038/s41386-025-02255-4.
Peer-Reviewed Original Research
Environmental, Psychiatric, and Genetic Predictors of Alcohol Use Disorder Criterion Count: Analyses of African and European Ancestries
Na P, Deak J, Levey D, Kember R, Kranzler H, Pietrzak R, Gelernter J. Environmental, Psychiatric, and Genetic Predictors of Alcohol Use Disorder Criterion Count: Analyses of African and European Ancestries. American Journal Of Psychiatry 2025, 182: 1007-1015. PMID: 40988466, PMCID: PMC13059437, DOI: 10.1176/appi.ajp.20240893.
Peer-Reviewed Original Research
MeSH Keywords
Alcohol use and risk of dementia in diverse populations: evidence from cohort, case–control and Mendelian randomisation approaches
Topiwala A, Levey D, Zhou H, Deak J, Ebmeier K, Bell S, Burgess S, Nichols T, Program V, Gaziano J, Stein M, Gelernter J. Alcohol use and risk of dementia in diverse populations: evidence from cohort, case–control and Mendelian randomisation approaches. BMJ Evidence-Based Medicine 2025, 31: 13-22. PMID: 40987604, PMCID: PMC7618643, DOI: 10.1136/bmjebm-2025-113913.
Peer-Reviewed Original Research
Genetics of SSRI antidepressant use and relationship to psychiatric and medical traits
Levey D, Galimberti M, Deak J, Gupta P, Empke S, Adhikari K, Harrington K, Quaden R, Gaziano J, Program V, Stein M, Gelernter J. Genetics of SSRI antidepressant use and relationship to psychiatric and medical traits. Human Genetics And Genomics Advances 2025, 7: 100500. PMID: 40903904, PMCID: PMC12494825, DOI: 10.1016/j.xhgg.2025.100500.
Peer-Reviewed Original Research
A semi-empirical Bayes approach for calibrating weak instrumental bias in sex-specific Mendelian randomization studies
Huang Y, Kurniansyah N, Levey D, Gelernter J, Huffman J, Cho K, Wilson P, Gottlieb D, Rice K, Sofer T. A semi-empirical Bayes approach for calibrating weak instrumental bias in sex-specific Mendelian randomization studies. American Journal Of Human Genetics 2025, 112: 2213-2231. PMID: 40912238, PMCID: PMC12416758, DOI: 10.1016/j.ajhg.2025.07.015.
Peer-Reviewed Original Research
MeSH Keywords
Differences and similarities between the genetic architecture of lifetime substance use across different substances
Bright U, Overstreet C, Levey D, Gelernter J. Differences and similarities between the genetic architecture of lifetime substance use across different substances. Psychological Medicine 2025, 55: e219. PMID: 40736093, PMCID: PMC12341034, DOI: 10.1017/s0033291725101293.
Peer-Reviewed Original Research
MeSH Keywords
A contextual genomic perspective on physical activity and its relationship to health, well being and illness
Galimberti M, Levey D, Deak J, Adhikari K, Overstreet C, Gupta P, Nitin R, Zhou H, Lake N, Harrington K, Djousse L, Davis L, Gaziano J, Stein M, Gelernter J. A contextual genomic perspective on physical activity and its relationship to health, well being and illness. Nature Genetics 2025, 57: 1860-1871. PMID: 40691405, PMCID: PMC12339386, DOI: 10.1038/s41588-025-02260-9.
Peer-Reviewed Original Research
MeSH Keywords
Single-cell transcriptomic and chromatin dynamics of the human brain in PTSD
Hwang A, Skarica M, Xu S, Coudriet J, Lee C, Lin L, Terwilliger R, Sliby A, Wang J, Nguyen T, Li H, Wu M, Dai Y, Duan Z, Srinivasan S, Zhang X, Cruz D, Deans P, Huber B, Levey D, Glausier J, Lewis D, Gelernter J, Holtzheimer P, Friedman M, Gerstein M, Sestan N, Brennand K, Xu K, Zhao H, Krystal J, Young K, Williamson D, Che A, Zhang J, Girgenti M. Single-cell transcriptomic and chromatin dynamics of the human brain in PTSD. Nature 2025, 643: 744-754. PMID: 40533550, PMCID: PMC12267058, DOI: 10.1038/s41586-025-09083-y.
Peer-Reviewed Original Research
The genetic relationship between cannabis use disorder, cannabis use and psychiatric disorders
Galimberti M, Overstreet C, Gupta P, Beck S, Dao C, Deak J, Zhou H, Johnson E, Agrawal A, Stein M, Levey D, Gelernter J. The genetic relationship between cannabis use disorder, cannabis use and psychiatric disorders. Nature Mental Health 2025, 3: 700-708. DOI: 10.1038/s44220-025-00440-4.
Peer-Reviewed Original Research
Genome-wide analyses identify 30 loci associated with obsessive–compulsive disorder
Strom N, Gerring Z, Galimberti M, Yu D, Halvorsen M, Abdellaoui A, Rodriguez-Fontenla C, Sealock J, Bigdeli T, Coleman J, Mahjani B, Thorp J, Bey K, Burton C, Luykx J, Zai G, Alemany S, Andre C, Askland K, Bäckman J, Banaj N, Barlassina C, Nissen J, Bienvenu O, Black D, Bloch M, Børte S, Bosch R, Breen M, Brennan B, Brentani H, Buxbaum J, Bybjerg-Grauholm J, Byrne E, Cabana-Dominguez J, Camarena B, Camarena A, Cappi C, Carracedo A, Casas M, Cavallini M, Ciullo V, Cook E, Crosby J, Cullen B, De Schipper E, Delorme R, Djurovic S, Elias J, Estivill X, Falkenstein M, Fundin B, Garner L, Gironda C, Goes F, Grados M, Grove J, Guo W, Haavik J, Hagen K, Harrington K, Havdahl A, Höffler K, Hounie A, Hucks D, Hultman C, Janecka M, Jenike E, Karlsson E, Kelley K, Klawohn J, Krasnow J, Krebs K, Lange C, Lanzagorta N, Levey D, Lindblad-Toh K, Macciardi F, Maher B, Mathes B, McArthur E, McGregor N, McLaughlin N, Meier S, Miguel E, Mulhern M, Nestadt P, Nurmi E, O’Connell K, Osiecki L, Ousdal O, Palviainen T, Pedersen N, Piras F, Piras F, Potluri S, Rabionet R, Ramirez A, Rauch S, Reichenberg A, Riddle M, Ripke S, Rosário M, Sampaio A, Schiele M, Skogholt A, Sloofman L, Smit J, Artigas M, Thomas L, Tifft E, Vallada H, van Kirk N, Veenstra-VanderWeele J, Vulink N, Walker C, Wang Y, Wendland J, Winsvold B, Yao Y, Zhou H, Agrawal A, Alonso P, Berberich G, Bucholz K, Bulik C, Cath D, Denys D, Eapen V, Edenberg H, Falkai P, Fernandez T, Fyer A, Gaziano J, Geller D, Grabe H, Greenberg B, Hanna G, Hickie I, Hougaard D, Kathmann N, Kennedy J, Lai D, Landén M, Hellard S, Leboyer M, Lochner C, McCracken J, Medland S, Mortensen P, Neale B, Nicolini H, Nordentoft M, Pato M, Pato C, Pauls D, Piacentini J, Pittenger C, Posthuma D, Ramos-Quiroga J, Rasmussen S, Richter M, Rosenberg D, Ruhrmann S, Samuels J, Sandin S, Sandor P, Spalletta G, Stein D, Stewart S, Storch E, Stranger B, Turiel M, Werge T, Andreassen O, Børglum A, Walitza S, Hveem K, Hansen B, Rück C, Martin N, Milani L, Mors O, Reichborn-Kjennerud T, Ribasés M, Kvale G, Mataix-Cols D, Domschke K, Grünblatt E, Wagner M, Zwart J, Breen G, Nestadt G, Kaprio J, Arnold P, Grice D, Knowles J, Ask H, Verweij K, Davis L, Smit D, Crowley J, Scharf J, Stein M, Gelernter J, Mathews C, Derks E, Mattheisen M. Genome-wide analyses identify 30 loci associated with obsessive–compulsive disorder. Nature Genetics 2025, 57: 1389-1401. PMID: 40360802, PMCID: PMC12165847, DOI: 10.1038/s41588-025-02189-z.
Peer-Reviewed Original Research
MeSH Keywords

See All Publications