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Showing 1 - 100 results of 114 publications
Featured Publications
- Multi-ancestry genome-wide association study of cannabis use disorder yields insight into disease biology and public health implicationsLevey D, Galimberti M, Deak J, Wendt F, Bhattacharya A, Koller D, Harrington K, Quaden R, Johnson E, Gupta P, Biradar M, Lam M, Cooke M, Rajagopal V, Empke S, Zhou H, Nunez Y, Kranzler H, Edenberg H, Agrawal A, Smoller J, Lencz T, Hougaard D, Børglum A, Demontis D, Gaziano J, Gandal M, Polimanti R, Stein M, Gelernter J. Multi-ancestry genome-wide association study of cannabis use disorder yields insight into disease biology and public health implications. Nature Genetics 2023, 55: 2094-2103. PMID: 37985822, PMCID: PMC10703690, DOI: 10.1038/s41588-023-01563-z.
- Bi-ancestral depression GWAS in the Million Veteran Program and meta-analysis in >1.2 million individuals highlight new therapeutic directionsLevey DF, Stein MB, Wendt FR, Pathak GA, Zhou H, Aslan M, Quaden R, Harrington KM, Nuñez YZ, Overstreet C, Radhakrishnan K, Sanacora G, McIntosh AM, Shi J, Shringarpure SS, Concato J, Polimanti R, Gelernter J. Bi-ancestral depression GWAS in the Million Veteran Program and meta-analysis in >1.2 million individuals highlight new therapeutic directions. Nature Neuroscience 2021, 24: 954-963. PMID: 34045744, PMCID: PMC8404304, DOI: 10.1038/s41593-021-00860-2.
- Reproducible Genetic Risk Loci for Anxiety: Results From ∼200,000 Participants in the Million Veteran ProgramLevey DF, Gelernter J, Polimanti R, Zhou H, Cheng Z, Aslan M, Quaden R, Concato J, Radhakrishnan K, Bryois J, Sullivan PF, Stein M. Reproducible Genetic Risk Loci for Anxiety: Results From ∼200,000 Participants in the Million Veteran Program. American Journal Of Psychiatry 2020, 177: 223-232. PMID: 31906708, PMCID: PMC7869502, DOI: 10.1176/appi.ajp.2019.19030256.
- Genetic associations with suicide attempt severity and genetic overlap with major depressionLevey DF, Polimanti R, Cheng Z, Zhou H, Nuñez YZ, Jain S, He F, Sun X, Ursano RJ, Kessler RC, Smoller JW, Stein MB, Kranzler HR, Gelernter J. Genetic associations with suicide attempt severity and genetic overlap with major depression. Translational Psychiatry 2019, 9: 22. PMID: 30655502, PMCID: PMC6336846, DOI: 10.1038/s41398-018-0340-2.
- Towards understanding and predicting suicidality in women: biomarkers and clinical risk assessmentLevey DF, Niculescu EM, Le-Niculescu H, Dainton HL, Phalen PL, Ladd TB, Weber H, Belanger E, Graham DL, Khan FN, Vanipenta NP, Stage EC, Ballew A, Yard M, Gelbart T, Shekhar A, Schork NJ, Kurian SM, Sandusky GE, Salomon DR, Niculescu AB. Towards understanding and predicting suicidality in women: biomarkers and clinical risk assessment. Molecular Psychiatry 2016, 21: 768-785. PMID: 27046645, DOI: 10.1038/mp.2016.31.
2025
- Trans-ancestry genome-wide study of depression identifies 697 associations implicating cell types and pharmacotherapies.Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium. Electronic address: andrew.mcintosh@ed.ac.uk, Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium. Trans-ancestry genome-wide study of depression identifies 697 associations implicating cell types and pharmacotherapies. Cell 2025 PMID: 39814019, DOI: 10.1016/j.cell.2024.12.002.
2024
- Genetic vulnerability and adverse mental health outcomes following mild traumatic brain injury: a meta-analysis of CENTER-TBI and TRACK-TBI cohortsKals M, Wilson L, Levey D, Parodi L, Steyerberg E, Richardson S, He F, Sun X, Jain S, Palotie A, Ripatti S, Rosand J, Manley G, Maas A, Stein M, Menon D, Consortium T, Ackerlund C, Adams H, Amrein K, Andelic N, Andreassen L, Anke A, Antoni A, Audibert G, Azouvi P, Azzolini M, Bartels R, Barzó P, Beauvais R, Beer R, Bellander B, Belli A, Benali H, Berardino M, Beretta L, Blaabjerg M, Bragge P, Brazinova A, Brinck V, Brooker J, Brorsson C, Buki A, Bullinger M, Cabeleira M, Caccioppola A, Calappi E, Calvi M, Cameron P, Lozano G, Carbonara M, Castaño-León A, Cavallo S, Chevallard G, Chieregato A, Citerio G, Clusmann H, Coburn M, Coles J, Cooper J, Correia M, Čović A, Curry N, Czeiter E, Czosnyka M, Dahyot-Fizelier C, Dark P, Dawes H, De Keyser V, Degos V, Della Corte F, Boogert H, Depreitere B, Đilvesi Đ, Dixit A, Donoghue E, Dreier J, Dulière G, Ercole A, Esser P, Ezer E, Fabricius M, Feigin V, Foks K, Frisvold S, Furmanov A, Gagliardo P, Galanaud D, Gantner D, Gao G, George P, Ghuysen A, Giga L, Glocker B, Golubović J, Gomez P, Gratz J, Gravesteijn B, Grossi F, Gruen R, Gupta D, Haagsma J, Haitsma I, Helbok R, Helseth E, Horton L, Huijben J, Hutchinson P, Jacobs B, Jankowski S, Jarrett M, Jiang J, Johnson F, Jones K, Karan M, Kolias A, Kompanje E, Kondziella D, Koskinen L, Kovács N, Kowark A, Lagares A, Lanyon L, Laureys S, Lecky F, Ledoux D, Lefering R, Legrand V, Lejeune A, Levi L, Lightfoot R, Lingsma H, Maegele M, Majdan M, Manara A, Maréchal H, Martino C, Mattern J, McFadyen C, McMahon C, Melegh B, Menovsky T, Mikolic A, Misset B, Muraleedharan V, Murray L, Negru A, Nelson D, Newcombe V, Nieboer D, Nyirádi J, Oresic M, Ortolano F, Otesile O, Parizel P, Payen J, Perera N, Perlbarg V, Persona P, Peul W, Piippo-Karjalainen A, Pirinen M, Pisica D, Ples H, Polinder S, Pomposo I, Posti J, Puybasset L, Rădoi A, Ragauskas A, Raj R, Rambadagalla M, Rehorčíková V, Helmrich I, Rhodes J, Richter S, Rocka S, Roe C, Roise O, Rosenfeld J, Rosenlund C, Rosenthal G, Rossaint R, Rossi S, Rueckert D, Rusnák M, Sahuquillo J, Sakowitz O, Sanchez-Porras R, Sandor J, Schäfer N, Schmidt S, Schoechl H, Schoonman G, Schou R, Schwendenwein E, Sewalt C, Singh R, Skandsen T, Smielewski P, Sorinola A, Stamatakis E, Stanworth S, Stevens R, Stewart W, Stocchetti N, Sundström N, Takala R, Tamás V, Tamosuitis T, Taylor M, Ao B, Tenovuo O, Theadom A, Thibaut A, Thomas M, Tibboel D, Timmers M, Tolias C, Trapani T, Tudora C, Unterberg A, Vajkoczy P, Valeinis E, Vallance S, Vámos Z, van der Jagt M, van der Naalt J, Van der Steen G, van Dijck J, van Erp I, van Essen T, Van Hecke W, van Heugten C, Van Praag D, van Veen E, van Wijk R, Vyvere T, Vargiolu A, Vega E, Velt K, Verheyden J, Vespa P, Vik A, Vilcinis R, Volovici V, von Steinbüchel N, Voormolen D, Vulekovic P, Whitehouse D, Wiegers E, Williams G, Wolf S, Yang Z, Ylén P, Younsi A, Zeiler F, Ziverte A, Zoerle T, Adeoye O, Badjatia N, Barber J, Bergin M, Boase K, Bodien Y, Chesnut R, Corrigan J, Crawford K, Diaz-Arrastia R, Dikmen S, Duhaime A, Ellenbogen R, Feeser V, Ferguson A, Foreman B, Gaudette E, Giacino J, Gonzalez L, Gopinath S, Grandhi R, Gullapalli R, Hemphill C, Hotz G, Huie R, Jha R, Keene D, Kitagawa R, Korley F, Kramer J, Kreitzer N, Levin H, Lindsell C, Machamer J, Madden C, Martin A, McAllister T, McCrea M, Merchant R, Mukherjee P, Nelson L, Ngwenya L, Noel F, Nolan A, Okonkwo D, Palacios E, Perl D, Puccio A, Rabinowitz M, Robertson C, Rodgers R, Rosenthal E, Sander A, Sandsmark D, Schneider A, Schnyer D, Seabury S, Sherer M, Sugar G, Temkin N, Toga A, Torres-Espin A, Valadka A, Vassar M, Wang K, Wang V, Yue J, Yuh E, Zafonte R. Genetic vulnerability and adverse mental health outcomes following mild traumatic brain injury: a meta-analysis of CENTER-TBI and TRACK-TBI cohorts. EClinicalMedicine 2024, 78: 102956. PMID: 39720422, PMCID: PMC11667043, DOI: 10.1016/j.eclinm.2024.102956.
- Genome-wide meta-analysis of myasthenia gravis uncovers new loci and provides insights into polygenic predictionBraun A, Shekhar S, Levey D, Straub P, Kraft J, Panagiotaropoulou G, Heilbron K, Awasthi S, Meleka Hanna R, Hoffmann S, Stein M, Lehnerer S, Mergenthaler P, Elnahas A, Topaloudi A, Koromina M, Palviainen T, Asbjornsdottir B, Stefansson H, Skuladóttir A, Jónsdóttir I, Stefansson K, Reis K, Esko T, Palotie A, Leypoldt F, Stein M, Fontanillas P, Kaprio J, Gelernter J, Davis L, Paschou P, Tannemaat M, Verschuuren J, Kuhlenbäumer G, Gregersen P, Huijbers M, Stascheit F, Meisel A, Ripke S. Genome-wide meta-analysis of myasthenia gravis uncovers new loci and provides insights into polygenic prediction. Nature Communications 2024, 15: 9839. PMID: 39537604, PMCID: PMC11560923, DOI: 10.1038/s41467-024-53595-6.
- Bipolar disorder among individuals with atopic dermatitis: A case-control study in the All of Us Research ProgramWride A, Chen G, Fan R, Leasure A, Jones S, Levey D, Damsky W, Cohen J. Bipolar disorder among individuals with atopic dermatitis: A case-control study in the All of Us Research Program. Clinical And Experimental Dermatology 2024, llae451. PMID: 39425681, DOI: 10.1093/ced/llae451.
- T4. RELATIONSHIP OF GENETICALLY-INDEXED PHYSICAL ACTIVITY WITH MENTAL DISORDERSGalimberti M, Gupta P, Deak J, Dao C, Nitin R, Zhou H, Harrington K, Na P, Topiwala A, Davis L, Gaziano M, Levey D, Stein M, Gelernter J. T4. RELATIONSHIP OF GENETICALLY-INDEXED PHYSICAL ACTIVITY WITH MENTAL DISORDERS. European Neuropsychopharmacology 2024, 87: 157-158. DOI: 10.1016/j.euroneuro.2024.08.314.
- F96. ALCOHOL USE AND DEMENTIA IN DIVERSE POPULATIONSTopiwala A, Levey D, Zhou H, Deak J, Adhikari K, Ebmeier K, Bell S, Burgess S, Nichols T, Gaziano M, Stein M, Gelernter J. F96. ALCOHOL USE AND DEMENTIA IN DIVERSE POPULATIONS. European Neuropsychopharmacology 2024, 87: 256-257. DOI: 10.1016/j.euroneuro.2024.08.507.
- EXPLORING THE IMMUNOGENETIC BASIS OF POST-TRAUMATIC STRESS DISORDERBraun A, Maihofer A, Katrinli S, Panagiotaropoulou G, Levey D, Ripke S, Gelernter J, Nievergelt C, Group P. EXPLORING THE IMMUNOGENETIC BASIS OF POST-TRAUMATIC STRESS DISORDER. European Neuropsychopharmacology 2024, 87: 4-5. DOI: 10.1016/j.euroneuro.2024.08.017.
- 54712 Bipolar disorder among patients with atopic dermatitis: A case-control study in the All of Us research programWride M, Chen G, Fan R, Leasure A, Levey D, Damsky W, Cohen J. 54712 Bipolar disorder among patients with atopic dermatitis: A case-control study in the All of Us research program. Journal Of The American Academy Of Dermatology 2024, 91: ab147. DOI: 10.1016/j.jaad.2024.07.584.
- A genome-wide investigation into the underlying genetic architecture of personality traits and overlap with psychopathologyGupta P, Galimberti M, Liu Y, Beck S, Wingo A, Wingo T, Adhikari K, Kranzler H, Stein M, Gelernter J, Levey D. A genome-wide investigation into the underlying genetic architecture of personality traits and overlap with psychopathology. Nature Human Behaviour 2024, 8: 2235-2249. PMID: 39134740, PMCID: PMC11576509, DOI: 10.1038/s41562-024-01951-3.
- Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran ProgramVerma A, Huffman J, Rodriguez A, Conery M, Liu M, Ho Y, Kim Y, Heise D, Guare L, Panickan V, Garcon H, Linares F, Costa L, Goethert I, Tipton R, Honerlaw J, Davies L, Whitbourne S, Cohen J, Posner D, Sangar R, Murray M, Wang X, Dochtermann D, Devineni P, Shi Y, Nandi T, Assimes T, Brunette C, Carroll R, Clifford R, Duvall S, Gelernter J, Hung A, Iyengar S, Joseph J, Kember R, Kranzler H, Kripke C, Levey D, Luoh S, Merritt V, Overstreet C, Deak J, Grant S, Polimanti R, Roussos P, Shakt G, Sun Y, Tsao N, Venkatesh S, Voloudakis G, Justice A, Begoli E, Ramoni R, Tourassi G, Pyarajan S, Tsao P, O'Donnell C, Muralidhar S, Moser J, Casas J, Bick A, Zhou W, Cai T, Voight B, Cho K, Gaziano J, Madduri R, Damrauer S, Liao K. Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program. Science 2024, 385: eadj1182. PMID: 39024449, DOI: 10.1126/science.adj1182.
- Shared genetics of ADHD, cannabis use disorder and cannabis use and prediction of cannabis use disorder in ADHDNielsen T, Duan J, Levey D, Walters G, Johnson E, Thorgeirsson T, Werge T, Mortensen P, Stefansson H, Stefansson K, Hougaard D, Agrawal A, Gelernter J, Grove J, Børglum A, Demontis D. Shared genetics of ADHD, cannabis use disorder and cannabis use and prediction of cannabis use disorder in ADHD. Nature Mental Health 2024, 2: 1071-1083. DOI: 10.1038/s44220-024-00277-3.
- Cross-ancestry genetic investigation of schizophrenia, cannabis use disorder, and tobacco smokingJohnson E, Austin-Zimmerman I, Thorpe H, Levey D, Baranger D, Colbert S, Demontis D, Khokhar J, Davis L, Edenberg H, Di Forti M, Sanchez-Roige S, Gelernter J, Agrawal A. Cross-ancestry genetic investigation of schizophrenia, cannabis use disorder, and tobacco smoking. Neuropsychopharmacology 2024, 49: 1655-1665. PMID: 38906991, PMCID: PMC11399264, DOI: 10.1038/s41386-024-01886-3.
- Genome-wide association study of the common retinal disorder epiretinal membrane: Significant risk loci in each of three American populationsGelernter J, Levey D, Galimberti M, Harrington K, Zhou H, Adhikari K, Gupta P, Program V, Gaziano J, Eliott D, Stein M. Genome-wide association study of the common retinal disorder epiretinal membrane: Significant risk loci in each of three American populations. Cell Genomics 2024, 4: 100582. PMID: 38870908, PMCID: PMC11228954, DOI: 10.1016/j.xgen.2024.100582.
- Gene × environment effects and mediation involving adverse childhood events, mood and anxiety disorders, and substance dependenceKranzler H, Davis C, Feinn R, Jinwala Z, Khan Y, Oikonomou A, Silva-Lopez D, Burton I, Dixon M, Milone J, Ramirez S, Shifman N, Levey D, Gelernter J, Hartwell E, Kember R. Gene × environment effects and mediation involving adverse childhood events, mood and anxiety disorders, and substance dependence. Nature Human Behaviour 2024, 8: 1616-1627. PMID: 38834750, DOI: 10.1038/s41562-024-01885-w.
- Association between psoriasis and obsessive-compulsive disorder: a case-control study in the All of Us research programCraver A, Chen G, Fan R, Levey D, Cohen J. Association between psoriasis and obsessive-compulsive disorder: a case-control study in the All of Us research program. Archives Of Dermatological Research 2024, 316: 280. PMID: 38796663, DOI: 10.1007/s00403-024-03112-y.
- Polygenic liability for anxiety in association with comorbid anxiety in multiple sclerosisKowalec K, Harder A, Dolovich C, Fitzgerald K, Salter A, Lu Y, Bernstein C, Bolton J, Cutter G, Fisk J, Gelernter J, Graff L, Hägg S, Hitchon C, Levey D, Lublin F, McKay K, Patten S, Patki A, Stein M, Tiwari H, Wolinsky J, Marrie R. Polygenic liability for anxiety in association with comorbid anxiety in multiple sclerosis. Annals Of Clinical And Translational Neurology 2024, 11: 1393-1404. PMID: 38715244, PMCID: PMC11187942, DOI: 10.1002/acn3.52025.
- Dissecting the Relationships Between Cannabis Use Disorder and Schizophrenia Using Genome-Wide ApproachesJohnson E, Levey D, Baranger D, Colbert S, Gelernter J, Agrawal A. Dissecting the Relationships Between Cannabis Use Disorder and Schizophrenia Using Genome-Wide Approaches. Biological Psychiatry 2024, 95: s28-s29. DOI: 10.1016/j.biopsych.2024.02.075.
- Genome-wide association analyses identify 95 risk loci and provide insights into the neurobiology of post-traumatic stress disorderNievergelt C, Maihofer A, Atkinson E, Chen C, Choi K, Coleman J, Daskalakis N, Duncan L, Polimanti R, Aaronson C, Amstadter A, Andersen S, Andreassen O, Arbisi P, Ashley-Koch A, Austin S, Avdibegoviç E, Babić D, Bacanu S, Baker D, Batzler A, Beckham J, Belangero S, Benjet C, Bergner C, Bierer L, Biernacka J, Bierut L, Bisson J, Boks M, Bolger E, Brandolino A, Breen G, Bressan R, Bryant R, Bustamante A, Bybjerg-Grauholm J, Bækvad-Hansen M, Børglum A, Børte S, Cahn L, Calabrese J, Caldas-de-Almeida J, Chatzinakos C, Cheema S, Clouston S, Colodro-Conde L, Coombes B, Cruz-Fuentes C, Dale A, Dalvie S, Davis L, Deckert J, Delahanty D, Dennis M, Desarnaud F, DiPietro C, Disner S, Docherty A, Domschke K, Dyb G, Kulenović A, Edenberg H, Evans A, Fabbri C, Fani N, Farrer L, Feder A, Feeny N, Flory J, Forbes D, Franz C, Galea S, Garrett M, Gelaye B, Gelernter J, Geuze E, Gillespie C, Goleva S, Gordon S, Goçi A, Grasser L, Guindalini C, Haas M, Hagenaars S, Hauser M, Heath A, Hemmings S, Hesselbrock V, Hickie I, Hogan K, Hougaard D, Huang H, Huckins L, Hveem K, Jakovljević M, Javanbakht A, Jenkins G, Johnson J, Jones I, Jovanovic T, Karstoft K, Kaufman M, Kennedy J, Kessler R, Khan A, Kimbrel N, King A, Koen N, Kotov R, Kranzler H, Krebs K, Kremen W, Kuan P, Lawford B, Lebois L, Lehto K, Levey D, Lewis C, Liberzon I, Linnstaedt S, Logue M, Lori A, Lu Y, Luft B, Lupton M, Luykx J, Makotkine I, Maples-Keller J, Marchese S, Marmar C, Martin N, Martínez-Levy G, McAloney K, McFarlane A, McLaughlin K, McLean S, Medland S, Mehta D, Meyers J, Michopoulos V, Mikita E, Milani L, Milberg W, Miller M, Morey R, Morris C, Mors O, Mortensen P, Mufford M, Nelson E, Nordentoft M, Norman S, Nugent N, O’Donnell M, Orcutt H, Pan P, Panizzon M, Pathak G, Peters E, Peterson A, Peverill M, Pietrzak R, Polusny M, Porjesz B, Powers A, Qin X, Ratanatharathorn A, Risbrough V, Roberts A, Rothbaum A, Rothbaum B, Roy-Byrne P, Ruggiero K, Rung A, Runz H, Rutten B, de Viteri S, Salum G, Sampson L, Sanchez S, Santoro M, Seah C, Seedat S, Seng J, Shabalin A, Sheerin C, Silove D, Smith A, Smoller J, Sponheim S, Stein D, Stensland S, Stevens J, Sumner J, Teicher M, Thompson W, Tiwari A, Trapido E, Uddin M, Ursano R, Valdimarsdóttir U, Van Hooff M, Vermetten E, Vinkers C, Voisey J, Wang Y, Wang Z, Waszczuk M, Weber H, Wendt F, Werge T, Williams M, Williamson D, Winsvold B, Winternitz S, Wolf C, Wolf E, Xia Y, Xiong Y, Yehuda R, Young K, Young R, Zai C, Zai G, Zervas M, Zhao H, Zoellner L, Zwart J, deRoon-Cassini T, van Rooij S, van den Heuvel L, Stein M, Ressler K, Koenen K. Genome-wide association analyses identify 95 risk loci and provide insights into the neurobiology of post-traumatic stress disorder. Nature Genetics 2024, 56: 792-808. PMID: 38637617, PMCID: PMC11396662, DOI: 10.1038/s41588-024-01707-9.
- Genetic influences and causal pathways shared between cannabis use disorder and other substance use traitsGalimberti M, Levey D, Deak J, Zhou H, Stein M, Gelernter J. Genetic influences and causal pathways shared between cannabis use disorder and other substance use traits. Molecular Psychiatry 2024, 29: 2905-2910. PMID: 38580809, PMCID: PMC11419938, DOI: 10.1038/s41380-024-02548-y.
- Whole-exome sequencing in UK Biobank reveals rare genetic architecture for depressionTian R, Ge T, Kweon H, Rocha D, Lam M, Liu J, Singh K, Levey D, Gelernter J, Stein M, Tsai E, Huang H, Chabris C, Lencz T, Runz H, Chen C. Whole-exome sequencing in UK Biobank reveals rare genetic architecture for depression. Nature Communications 2024, 15: 1755. PMID: 38409228, PMCID: PMC10897433, DOI: 10.1038/s41467-024-45774-2.
- Pleiotropy and genetically inferred causality linking multisite chronic pain to substance use disordersKoller D, Friligkou E, Stiltner B, Pathak G, Løkhammer S, Levey D, Zhou H, Hatoum A, Deak J, Kember R, Treur J, Kranzler H, Johnson E, Stein M, Gelernter J, Polimanti R. Pleiotropy and genetically inferred causality linking multisite chronic pain to substance use disorders. Molecular Psychiatry 2024, 29: 2021-2030. PMID: 38355787, PMCID: PMC11324857, DOI: 10.1038/s41380-024-02446-3.
- Genetic contribution to the comorbidity between attention-deficit/hyperactivity disorder and substance use disordersKoller D, Mitjans M, Kouakou M, Friligkou E, Cabrera-Mendoza B, Deak J, Llonga N, Pathak G, Stiltner B, Løkhammer S, Levey D, Zhou H, Hatoum A, Kember R, Kranzler H, Stein M, Corominas R, Demontis D, Artigas M, Ramos-Quiroga J, Gelernter J, Ribasés M, Cormand B, Polimanti R. Genetic contribution to the comorbidity between attention-deficit/hyperactivity disorder and substance use disorders. Psychiatry Research 2024, 333: 115758. PMID: 38335780, PMCID: PMC11157987, DOI: 10.1016/j.psychres.2024.115758.
- Multi-ancestry genome-wide association study of major depression aids locus discovery, fine mapping, gene prioritization and causal inferenceMeng X, Navoly G, Giannakopoulou O, Levey D, Koller D, Pathak G, Koen N, Lin K, Adams M, Rentería M, Feng Y, Gaziano J, Stein D, Zar H, Campbell M, van Heel D, Trivedi B, Finer S, McQuillin A, Bass N, Chundru V, Martin H, Huang Q, Valkovskaya M, Chu C, Kanjira S, Kuo P, Chen H, Tsai S, Liu Y, Kendler K, Peterson R, Cai N, Fang Y, Sen S, Scott L, Burmeister M, Loos R, Preuss M, Actkins K, Davis L, Uddin M, Wani A, Wildman D, Aiello A, Ursano R, Kessler R, Kanai M, Okada Y, Sakaue S, Rabinowitz J, Maher B, Uhl G, Eaton W, Cruz-Fuentes C, Martinez-Levy G, Campos A, Millwood I, Chen Z, Li L, Wassertheil-Smoller S, Jiang Y, Tian C, Martin N, Mitchell B, Byrne E, Awasthi S, Coleman J, Ripke S, Sofer T, Walters R, McIntosh A, Polimanti R, Dunn E, Stein M, Gelernter J, Lewis C, Kuchenbaecker K. Multi-ancestry genome-wide association study of major depression aids locus discovery, fine mapping, gene prioritization and causal inference. Nature Genetics 2024, 56: 222-233. PMID: 38177345, PMCID: PMC10864182, DOI: 10.1038/s41588-023-01596-4.
- Association between cannabis use and brain structure and function: an observational and Mendelian randomisation studyIshrat S, Levey D, Gelernter J, Ebmeier K, Topiwala A. Association between cannabis use and brain structure and function: an observational and Mendelian randomisation study. BMJ Mental Health 2024, 27: e301065. PMID: 39477366, PMCID: PMC11529520, DOI: 10.1136/bmjment-2024-301065.
2023
- Multi-ancestry study of the genetics of problematic alcohol use in over 1 million individualsZhou H, Kember R, Deak J, Xu H, Toikumo S, Yuan K, Lind P, Farajzadeh L, Wang L, Hatoum A, Johnson J, Lee H, Mallard T, Xu J, Johnston K, Johnson E, Nielsen T, Galimberti M, Dao C, Levey D, Overstreet C, Byrne E, Gillespie N, Gordon S, Hickie I, Whitfield J, Xu K, Zhao H, Huckins L, Davis L, Sanchez-Roige S, Madden P, Heath A, Medland S, Martin N, Ge T, Smoller J, Hougaard D, Børglum A, Demontis D, Krystal J, Gaziano J, Edenberg H, Agrawal A, Justice A, Stein M, Kranzler H, Gelernter J. Multi-ancestry study of the genetics of problematic alcohol use in over 1 million individuals. Nature Medicine 2023, 29: 3184-3192. PMID: 38062264, PMCID: PMC10719093, DOI: 10.1038/s41591-023-02653-5.
- Obsessive–compulsive disorder among patients with atopic dermatitis: a case–control study in the All of Us research programChen G, Fan R, Leasure A, Levey D, Damsky W, Cohen J. Obsessive–compulsive disorder among patients with atopic dermatitis: a case–control study in the All of Us research program. Archives Of Dermatological Research 2023, 316: 11. PMID: 38038754, DOI: 10.1007/s00403-023-02767-3.
- Multi-ancestry genome-wide association study of cannabis use disorder yields insight into disease biology and public health implicationsLevey D, Galimberti M, Deak J, Wendt F, Bhattacharya A, Koller D, Harrington K, Quaden R, Johnson E, Gupta P, Biradar M, Lam M, Cooke M, Rajagopal V, Empke S, Zhou H, Nunez Y, Kranzler H, Edenberg H, Agrawal A, Smoller J, Lencz T, Hougaard D, Børglum A, Demontis D, Gaziano J, Gandal M, Polimanti R, Stein M, Gelernter J. Multi-ancestry genome-wide association study of cannabis use disorder yields insight into disease biology and public health implications. Nature Genetics 2023, 55: 2094-2103. PMID: 37985822, PMCID: PMC10703690, DOI: 10.1038/s41588-023-01563-z.
- 8. A CROSS-POPULATION GENOME-WIDE ASSOCIATION STUDY OF SLEEP DURATIONAustin-Zimmerman I, Levey D, Deak J, Galimberti M, Adhikari K, Zhou H, Di Forti M, Polimanti R, Stein M, Gelernter J. 8. A CROSS-POPULATION GENOME-WIDE ASSOCIATION STUDY OF SLEEP DURATION. European Neuropsychopharmacology 2023, 75: s60. DOI: 10.1016/j.euroneuro.2023.08.119.
- 79. A LARGE-SCALE GENOME-WIDE ASSOCIATION STUDY OF COCAINE USE DISORDERDeak J, Zhou H, Levey D, Galimberti M, Farajzadeh L, Hougaard D, Jennings M, Davis L, Sanchez-Roige S, Demontis D, Børglum A, Kranzler H, Gaziano M, Stein M, Gelernter J. 79. A LARGE-SCALE GENOME-WIDE ASSOCIATION STUDY OF COCAINE USE DISORDER. European Neuropsychopharmacology 2023, 75: s99. DOI: 10.1016/j.euroneuro.2023.08.184.
- T1. GENOME-WIDE ASSOCIATION STUDY OF THE FIVE-FACTOR DYSPHORIC AROUSAL MODEL OF POSTTRAUMATIC STRESS DISORDER IN THE MILLION VETERAN PROGRAMOverstreet C, Levey D, Coleman J, Galimberti M, Adhikari K, Zhou H, Quaden R, Harrington K, Gaziano M, Pietrzak R, Stein M, Gelernter J. T1. GENOME-WIDE ASSOCIATION STUDY OF THE FIVE-FACTOR DYSPHORIC AROUSAL MODEL OF POSTTRAUMATIC STRESS DISORDER IN THE MILLION VETERAN PROGRAM. European Neuropsychopharmacology 2023, 75: s162. DOI: 10.1016/j.euroneuro.2023.08.291.
- W101. EPIGENETIC PROFILES OF LATENT CLASSES FOR POLYSUBSTANCE USE DISORDERPathak G, Pietrzak R, Levey D, Montalvo-Ortiz J, Kranzler H, Gelernter J, Polimanti R. W101. EPIGENETIC PROFILES OF LATENT CLASSES FOR POLYSUBSTANCE USE DISORDER. European Neuropsychopharmacology 2023, 75: s158-s159. DOI: 10.1016/j.euroneuro.2023.08.287.
- 17. ANCESTRY-AWARE MIXED MODEL GWAS OF MAJOR DEPRESSION CHARTS A PATH FOR INCLUSIVE AND DIVERSE GENETIC RESEARCHMeng X, Giannakopoulou O, Navoly G, Levey D, Mitchell B, Oliveira A, Martin N, Salum G, Stein M, Gelernter J, Belangero S, Ota V, McIntosh A, Lewis C, Kuchenbaecker K. 17. ANCESTRY-AWARE MIXED MODEL GWAS OF MAJOR DEPRESSION CHARTS A PATH FOR INCLUSIVE AND DIVERSE GENETIC RESEARCH. European Neuropsychopharmacology 2023, 75: s65-s66. DOI: 10.1016/j.euroneuro.2023.08.128.
- Genome-wide association studies and cross-population meta-analyses investigating short and long sleep durationAustin-Zimmerman I, Levey D, Giannakopoulou O, Deak J, Galimberti M, Adhikari K, Zhou H, Denaxas S, Irizar H, Kuchenbaecker K, McQuillin A, Concato J, Buysse D, Gaziano J, Gottlieb D, Polimanti R, Stein M, Bramon E, Gelernter J. Genome-wide association studies and cross-population meta-analyses investigating short and long sleep duration. Nature Communications 2023, 14: 6059. PMID: 37770476, PMCID: PMC10539313, DOI: 10.1038/s41467-023-41249-y.
- Loneliness and depression: bidirectional mendelian randomization analyses using data from three large genome-wide association studiesSbarra D, Ramadan F, Choi K, Treur J, Levey D, Wootton R, Stein M, Gelernter J, Klimentidis Y. Loneliness and depression: bidirectional mendelian randomization analyses using data from three large genome-wide association studies. Molecular Psychiatry 2023, 28: 4594-4601. PMID: 37735503, PMCID: PMC11406447, DOI: 10.1038/s41380-023-02259-w.
- Depression pathophysiology, risk prediction of recurrence and comorbid psychiatric disorders using genome-wide analysesAls T, Kurki M, Grove J, Voloudakis G, Therrien K, Tasanko E, Nielsen T, Naamanka J, Veerapen K, Levey D, Bendl J, Bybjerg-Grauholm J, Zeng B, Demontis D, Rosengren A, Athanasiadis G, Bækved-Hansen M, Qvist P, Bragi Walters G, Thorgeirsson T, Stefánsson H, Musliner K, Rajagopal V, Farajzadeh L, Thirstrup J, Vilhjálmsson B, McGrath J, Mattheisen M, Meier S, Agerbo E, Stefánsson K, Nordentoft M, Werge T, Hougaard D, Mortensen P, Stein M, Gelernter J, Hovatta I, Roussos P, Daly M, Mors O, Palotie A, Børglum A. Depression pathophysiology, risk prediction of recurrence and comorbid psychiatric disorders using genome-wide analyses. Nature Medicine 2023, 29: 1832-1844. PMID: 37464041, PMCID: PMC10839245, DOI: 10.1038/s41591-023-02352-1.
- Modeling the longitudinal changes of ancestry diversity in the Million Veteran ProgramWendt F, Pathak G, Vahey J, Qin X, Koller D, Cabrera-Mendoza B, Haeny A, Harrington K, Rajeevan N, Duong L, Levey D, De Angelis F, De Lillo A, Bigdeli T, Pyarajan S, Gaziano J, Gelernter J, Aslan M, Provenzale D, Helmer D, Hauser E, Polimanti R. Modeling the longitudinal changes of ancestry diversity in the Million Veteran Program. Human Genomics 2023, 17: 46. PMID: 37268996, PMCID: PMC10239111, DOI: 10.1186/s40246-023-00487-3.
- Identifying Brain Proteins Predisposing to PTSDWingo T, Gerasimov E, Liu Y, Duong D, Vattathil S, Lori A, Breen M, Maihofer A, Nievergelt C, Koenen K, Levey D, Gelernter J, Ressler K, Stein M, Bennett D, Levey A, Seyfried N, Wingo A. Identifying Brain Proteins Predisposing to PTSD. Biological Psychiatry 2023, 93: s11. DOI: 10.1016/j.biopsych.2023.02.047.
- 3. Genetic Overlap and Causal Relationship Between Multisite Chronic Pain and Substance Use DisordersKoller D, Pathak G, Stiltner B, Levey D, Zhou H, Hatoum A, Deak J, Kranzler H, Agrawal A, Gelernter J, Polimanti R. 3. Genetic Overlap and Causal Relationship Between Multisite Chronic Pain and Substance Use Disorders. Biological Psychiatry 2023, 93: s94-s95. DOI: 10.1016/j.biopsych.2023.02.243.
- Epidemiologic and Genetic Associations of Endometriosis With Depression, Anxiety, and Eating DisordersKoller D, Pathak G, Wendt F, Tylee D, Levey D, Overstreet C, Gelernter J, Taylor H, Polimanti R. Epidemiologic and Genetic Associations of Endometriosis With Depression, Anxiety, and Eating Disorders. Obstetrical & Gynecological Survey 2023, 78: 282-283. DOI: 10.1097/01.ogx.0000935848.53207.07.
- Genetic Decomposition of the Heritable Component of Reported Childhood MaltreatmentKuile A, Hübel C, Cheesman R, Coleman J, Peel A, Levey D, Stein M, Gelernter J, Rayner C, Eley T, Breen G. Genetic Decomposition of the Heritable Component of Reported Childhood Maltreatment. Biological Psychiatry Global Open Science 2023, 3: 716-724. PMID: 37881567, PMCID: PMC10593925, DOI: 10.1016/j.bpsgos.2023.03.003.
- Towards precision medicine for anxiety disorders: objective assessment, risk prediction, pharmacogenomics, and repurposed drugsRoseberry K, Le-Niculescu H, Levey D, Bhagar R, Soe K, Rogers J, Palkowitz S, Pina N, Anastasiadis W, Gill S, Kurian S, Shekhar A, Niculescu A. Towards precision medicine for anxiety disorders: objective assessment, risk prediction, pharmacogenomics, and repurposed drugs. Molecular Psychiatry 2023, 28: 2894-2912. PMID: 36878964, PMCID: PMC10615756, DOI: 10.1038/s41380-023-01998-0.
- Epidemiologic and Genetic Associations of Endometriosis With Depression, Anxiety, and Eating DisordersKoller D, Pathak G, Wendt F, Tylee D, Levey D, Overstreet C, Gelernter J, Taylor H, Polimanti R. Epidemiologic and Genetic Associations of Endometriosis With Depression, Anxiety, and Eating Disorders. JAMA Network Open 2023, 6: e2251214. PMID: 36652249, PMCID: PMC9856929, DOI: 10.1001/jamanetworkopen.2022.51214.
- Genetic overlap and causal relationship between multisite chronic pain and substance use disordersKoller D, Friligkou E, Pathak G, Stiltner B, Levey D, Zhou H, Hatoum A, Deak J, Kranzler H, Agrawal A, Gelernter J, Polimanti R. Genetic overlap and causal relationship between multisite chronic pain and substance use disorders. Neuroscience Applied 2023, 2: 102822. DOI: 10.1016/j.nsa.2023.102822.
2022
- Exploring the genetic overlap between twelve psychiatric disordersRomero C, Werme J, Jansen P, Gelernter J, Stein M, Levey D, Polimanti R, de Leeuw C, Posthuma D, Nagel M, van der Sluis S. Exploring the genetic overlap between twelve psychiatric disorders. Nature Genetics 2022, 54: 1795-1802. PMID: 36471075, DOI: 10.1038/s41588-022-01245-2.
- Factor structure of the posttraumatic stress disorder checklist (PCL-17) in 279,897 million veteran program participantsOverstreet C, Levey D, Zhou H, Harrington K, Quaden R, Stein M, Gelernter J, Pietrzak R, Program M. Factor structure of the posttraumatic stress disorder checklist (PCL-17) in 279,897 million veteran program participants. Psychiatry Research 2022, 319: 114994. PMID: 36516638, PMCID: PMC10184787, DOI: 10.1016/j.psychres.2022.114994.
- Collective genomic segments with differential pleiotropic patterns between cognitive dimensions and psychopathologyLam M, Chen C, Hill W, Xia C, Tian R, Levey D, Gelernter J, Stein M, Hatoum A, Huang H, Malhotra A, Runz H, Ge T, Lencz T. Collective genomic segments with differential pleiotropic patterns between cognitive dimensions and psychopathology. Nature Communications 2022, 13: 6868. PMID: 36369282, PMCID: PMC9652380, DOI: 10.1038/s41467-022-34418-y.
- Genetic variants associated with psychiatric disorders are enriched at epigenetically active sites in lymphoid cellsLynall ME, Soskic B, Hayhurst J, Schwartzentruber J, Levey DF, Pathak GA, Polimanti R, Gelernter J, Stein MB, Trynka G, Clatworthy MR, Bullmore E. Genetic variants associated with psychiatric disorders are enriched at epigenetically active sites in lymphoid cells. Nature Communications 2022, 13: 6102. PMID: 36243721, PMCID: PMC9569335, DOI: 10.1038/s41467-022-33885-7.
- Genome-Wide Investigation of Maximum Habitual Alcohol Intake in US Veterans in Relation to Alcohol Consumption Traits and Alcohol Use DisorderDeak JD, Levey DF, Wendt FR, Zhou H, Galimberti M, Kranzler HR, Gaziano JM, Stein MB, Polimanti R, Gelernter J, Muralidhar S, Moser J, Deen J, Gaziano J, Beckham J, Chang K, Tsao P, Luoh S, Casas J, Churby L, Whitbourne S, Brewer J, Brophy M, Selva L, Shayan S, Cho K, Pyarajan S, DuVall S, Connor T, Argyres D, Aslan M, Stephens B, Concato J, Gelernter J, Gleason T, Huang G, Koenen K, Marx C, Radhakrishnan K, Schork N, Stein M, Zhao H, Kaufman J, Nunez Y, Pietrzak R, Beck D, Cissell S, Crutchfield P, Lance W, Cheung K, Li Y, Sun N, Chen Q, Rajeevan N, Sayward F, Gagnon D, Harrington K, Quaden R, O'Leary T, Ramoni R. Genome-Wide Investigation of Maximum Habitual Alcohol Intake in US Veterans in Relation to Alcohol Consumption Traits and Alcohol Use Disorder. JAMA Network Open 2022, 5: e2238880. PMID: 36301540, PMCID: PMC9614582, DOI: 10.1001/jamanetworkopen.2022.38880.
- T119. AN INTERNATIONAL AND MULTI-ANCESTRAL GENOME-WIDE ASSOCIATION STUDY META-ANALYSIS OF CANNABIS USE DISORDERSLevey D, Galimberti M, Johnson E, Cooke M, Rajagopal V, Deak J, Zhou H, Lam M, Nunez Y, Edenberg H, Polimanti R, Lencz T, Demontis D, Stein M, Gelernter J. T119. AN INTERNATIONAL AND MULTI-ANCESTRAL GENOME-WIDE ASSOCIATION STUDY META-ANALYSIS OF CANNABIS USE DISORDERS. European Neuropsychopharmacology 2022, 63: e233. DOI: 10.1016/j.euroneuro.2022.07.415.
- 10. LARGE-SCALE MULTI-ANCESTRY GENOME-WIDE ASSOCIATION META-ANALYSIS OF MAJOR DEPRESSIONMeng X, Giannakopoulou O, Navoly G, Koller D, Levey D, Koen N, Loos R, Davis L, Martin N, MDD T, Walters R, Polimanti R, Stein M, Gelernter J, Kuchenbaecker K. 10. LARGE-SCALE MULTI-ANCESTRY GENOME-WIDE ASSOCIATION META-ANALYSIS OF MAJOR DEPRESSION. European Neuropsychopharmacology 2022, 63: e49. DOI: 10.1016/j.euroneuro.2022.07.101.
- 27. GENOME-WIDE CROSS-DISORDER ANALYSES OF ADHD AND CANNABIS USE DISORDER AND CANNABIS USENielsen T, Levey D, Walters G, Grove J, Johnson E, Thorgeirsson T, Program M, Stein M, Agrawal A, Stefansson H, Stefansson K, Gelernter J, Hougaard D, Børglum A, Demontis D. 27. GENOME-WIDE CROSS-DISORDER ANALYSES OF ADHD AND CANNABIS USE DISORDER AND CANNABIS USE. European Neuropsychopharmacology 2022, 63: e59-e60. DOI: 10.1016/j.euroneuro.2022.07.117.
- 50. GENETIC OVERLAP AND COMORBIDITY AMONG PSYCHIATRIC TRAITS AND ENDOMETRIOSIS, A CHRONIC INFLAMMATORY DISEASEKoller D, Pathak G, Wendt F, Levey D, Gelernter J, Polimanti R. 50. GENETIC OVERLAP AND COMORBIDITY AMONG PSYCHIATRIC TRAITS AND ENDOMETRIOSIS, A CHRONIC INFLAMMATORY DISEASE. European Neuropsychopharmacology 2022, 63: e72. DOI: 10.1016/j.euroneuro.2022.07.138.
- Understanding the comorbidity between posttraumatic stress severity and coronary artery disease using genome-wide information and electronic health recordsPolimanti R, Wendt FR, Pathak GA, Tylee DS, Tcheandjieu C, Hilliard AT, Levey DF, Adhikari K, Gaziano JM, O’Donnell C, Assimes TL, Stein MB, Gelernter J. Understanding the comorbidity between posttraumatic stress severity and coronary artery disease using genome-wide information and electronic health records. Molecular Psychiatry 2022, 27: 3961-3969. PMID: 35986173, PMCID: PMC10986859, DOI: 10.1038/s41380-022-01735-z.
- Alcohol consumption and telomere length: Mendelian randomization clarifies alcohol’s effectsTopiwala A, Taschler B, Ebmeier KP, Smith S, Zhou H, Levey DF, Codd V, Samani NJ, Gelernter J, Nichols TE, Burgess S. Alcohol consumption and telomere length: Mendelian randomization clarifies alcohol’s effects. Molecular Psychiatry 2022, 27: 4001-4008. PMID: 35879401, PMCID: PMC9718662, DOI: 10.1038/s41380-022-01690-9.
- Genome-wide association study in individuals of European and African ancestry and multi-trait analysis of opioid use disorder identifies 19 independent genome-wide significant risk lociDeak JD, Zhou H, Galimberti M, Levey DF, Wendt FR, Sanchez-Roige S, Hatoum AS, Johnson EC, Nunez YZ, Demontis D, Børglum AD, Rajagopal VM, Jennings MV, Kember RL, Justice AC, Edenberg HJ, Agrawal A, Polimanti R, Kranzler HR, Gelernter J. Genome-wide association study in individuals of European and African ancestry and multi-trait analysis of opioid use disorder identifies 19 independent genome-wide significant risk loci. Molecular Psychiatry 2022, 27: 3970-3979. PMID: 35879402, PMCID: PMC9718667, DOI: 10.1038/s41380-022-01709-1.
- Associations between moderate alcohol consumption, brain iron, and cognition in UK Biobank participants: Observational and mendelian randomization analysesTopiwala A, Wang C, Ebmeier KP, Burgess S, Bell S, Levey DF, Zhou H, McCracken C, Roca-Fernández A, Petersen SE, Raman B, Husain M, Gelernter J, Miller KL, Smith SM, Nichols TE. Associations between moderate alcohol consumption, brain iron, and cognition in UK Biobank participants: Observational and mendelian randomization analyses. PLOS Medicine 2022, 19: e1004039. PMID: 35834561, PMCID: PMC9282660, DOI: 10.1371/journal.pmed.1004039.
- Genome-wide meta-analysis of insomnia prioritizes genes associated with metabolic and psychiatric pathwaysWatanabe K, Jansen PR, Savage JE, Nandakumar P, Wang X, Hinds D, Gelernter J, Levey D, Polimanti R, Stein M, Van Someren E, Smit A, Posthuma D. Genome-wide meta-analysis of insomnia prioritizes genes associated with metabolic and psychiatric pathways. Nature Genetics 2022, 54: 1125-1132. PMID: 35835914, DOI: 10.1038/s41588-022-01124-w.
- An Atlas of Genetic Correlations and Genetically Informed Associations Linking Psychiatric and Immune-Related PhenotypesTylee DS, Lee YK, Wendt FR, Pathak GA, Levey DF, De Angelis F, Gelernter J, Polimanti R. An Atlas of Genetic Correlations and Genetically Informed Associations Linking Psychiatric and Immune-Related Phenotypes. JAMA Psychiatry 2022, 79: 667-676. PMID: 35507366, PMCID: PMC9069342, DOI: 10.1001/jamapsychiatry.2022.0914.
- Advanced Genetic Study of Problematic Alcohol Use in > 1 Million Subjects From Multiple PopulationsZhou H, Kember R, Deak J, Dao C, Galimberti M, Levey D, Overstreet C, Xu K, Zhao H, Justice A, Stein M, Kranzler H, Gelernter J. Advanced Genetic Study of Problematic Alcohol Use in > 1 Million Subjects From Multiple Populations. Biological Psychiatry 2022, 91: s68. DOI: 10.1016/j.biopsych.2022.02.189.
- An International and Multi-Ancestral Genome-Wide Association Study Meta-Analysis of Cannabis Use DisordersLevey D, Galimberti M, Johnson E, Cooke M, Rajagopal V, Deak J, Zhou H, Lam M, Nunez Y, Polimanti R, Lencz T, Roussos P, Smoller J, Demontis D, Agrawal A, Gaziano J, Stein M, Gelernter J. An International and Multi-Ancestral Genome-Wide Association Study Meta-Analysis of Cannabis Use Disorders. Biological Psychiatry 2022, 91: s68-s69. DOI: 10.1016/j.biopsych.2022.02.190.
- Characterizing the Genetic Effects Linking Psychiatric and Immune-Related PhenotypesTylee D, Lee Y, Wendt F, Pathak G, Levey D, De Angelis F, Gelernter J, Polimanti R. Characterizing the Genetic Effects Linking Psychiatric and Immune-Related Phenotypes. Biological Psychiatry 2022, 91: s72-s73. DOI: 10.1016/j.biopsych.2022.02.200.
- P14. Genetics Shared by Alcohol Use Disorder and Frequency of SmokingGalimberti M, Johnson E, Levey D, Agrawal A, Gelernter J. P14. Genetics Shared by Alcohol Use Disorder and Frequency of Smoking. Biological Psychiatry 2022, 91: s93. DOI: 10.1016/j.biopsych.2022.02.249.
- Integrating human brain proteomes with genome-wide association data implicates novel proteins in post-traumatic stress disorderWingo TS, Gerasimov ES, Liu Y, Duong DM, Vattathil SM, Lori A, Gockley J, Breen MS, Maihofer AX, Nievergelt CM, Koenen KC, Levey DF, Gelernter J, Stein MB, Ressler KJ, Bennett DA, Levey AI, Seyfried NT, Wingo AP. Integrating human brain proteomes with genome-wide association data implicates novel proteins in post-traumatic stress disorder. Molecular Psychiatry 2022, 27: 3075-3084. PMID: 35449297, PMCID: PMC9233006, DOI: 10.1038/s41380-022-01544-4.
- Genetically regulated multi-omics study for symptom clusters of posttraumatic stress disorder highlights pleiotropy with hematologic and cardio-metabolic traitsPathak GA, Singh K, Wendt FR, Fleming TW, Overstreet C, Koller D, Tylee DS, De Angelis F, Cabrera Mendoza B, Levey DF, Koenen KC, Krystal JH, Pietrzak RH, O’ Donell C, Gaziano JM, Falcone G, Stein MB, Gelernter J, Pasaniuc B, Mancuso N, Davis LK, Polimanti R. Genetically regulated multi-omics study for symptom clusters of posttraumatic stress disorder highlights pleiotropy with hematologic and cardio-metabolic traits. Molecular Psychiatry 2022, 27: 1394-1404. PMID: 35241783, PMCID: PMC9210390, DOI: 10.1038/s41380-022-01488-9.
- Using phenotype risk scores to enhance gene discovery for generalized anxiety disorder and posttraumatic stress disorderWendt FR, Pathak GA, Deak JD, De Angelis F, Koller D, Cabrera-Mendoza B, Lebovitch DS, Levey DF, Stein MB, Kranzler HR, Koenen KC, Gelernter J, Huckins LM, Polimanti R. Using phenotype risk scores to enhance gene discovery for generalized anxiety disorder and posttraumatic stress disorder. Molecular Psychiatry 2022, 27: 2206-2215. PMID: 35181757, PMCID: PMC9133008, DOI: 10.1038/s41380-022-01469-y.
2021
- Psychosocial moderators of polygenic risk for suicidal ideation: Results from a 7-year population-based, prospective cohort study of U.S. veteransNa PJ, De Angelis F, Nichter B, Wendt FR, Krystal JH, Southwick SM, Levey DF, Gelernter J, Polimanti R, Pietrzak RH. Psychosocial moderators of polygenic risk for suicidal ideation: Results from a 7-year population-based, prospective cohort study of U.S. veterans. Molecular Psychiatry 2021, 27: 1068-1074. PMID: 34725455, DOI: 10.1038/s41380-021-01352-2.
- COMORBID-PHENOME PREDICTION AND PHENOTYPE RISK SCORES INCREASE DATA AVAILABILITY FOR ANXIETY AND PTSD GENE DISCOVERYWendt F, Pathak G, Deak J, De Angelis F, Koller D, Cabrera-Mendoza B, Levey D, Stein M, Kranzler H, Koenen K, Gelernter J, Huckins L, Polimanti R. COMORBID-PHENOME PREDICTION AND PHENOTYPE RISK SCORES INCREASE DATA AVAILABILITY FOR ANXIETY AND PTSD GENE DISCOVERY. European Neuropsychopharmacology 2021, 51: e6-e7. DOI: 10.1016/j.euroneuro.2021.07.023.
- 37. GENETICALLY REGULATED MULTI-OMICS INVESTIGATION OF PREFRONTAL CORTEX FOR SYMPTOM CLUSTERS OF POSTTRAUMATIC STRESS DISORDER IN US VETERAN POPULATIONPathak G, Singh K, Wendt F, Levey D, Stein M, Gelernter J, Mancuso N, Davis L, Polimanti R. 37. GENETICALLY REGULATED MULTI-OMICS INVESTIGATION OF PREFRONTAL CORTEX FOR SYMPTOM CLUSTERS OF POSTTRAUMATIC STRESS DISORDER IN US VETERAN POPULATION. European Neuropsychopharmacology 2021, 51: e60-e61. DOI: 10.1016/j.euroneuro.2021.07.129.
- 67. ADVANCED GENETIC STUDY OF PROBLEMATIC ALCOHOL USE IN MULTIPLE POPULATIONS IN > 1 MILLION SUBJECTSZhou H, Kember R, Deak J, Dao C, Galimberti M, Levey D, Overstreet C, Xu K, Zhao H, Justice A, Stein M, Kranzler H, Gelernter J. 67. ADVANCED GENETIC STUDY OF PROBLEMATIC ALCOHOL USE IN MULTIPLE POPULATIONS IN > 1 MILLION SUBJECTS. European Neuropsychopharmacology 2021, 51: e77. DOI: 10.1016/j.euroneuro.2021.07.156.
- 71. GENOME-WIDE INVESTIGATION OF MAXIMUM HABITUAL ALCOHOL INTAKE IN 258,545 MVP EUROPEAN AND AFRICAN ANCESTRY U.S. VETERANSDeak J, Levey D, Wendt F, Zhou H, Kranzler H, Polimanti R, Stein M, Gelernter J. 71. GENOME-WIDE INVESTIGATION OF MAXIMUM HABITUAL ALCOHOL INTAKE IN 258,545 MVP EUROPEAN AND AFRICAN ANCESTRY U.S. VETERANS. European Neuropsychopharmacology 2021, 51: e79-e80. DOI: 10.1016/j.euroneuro.2021.07.160.
- 86. GENOME-WIDE ASSOCIATION STUDY OF DEPRESSION IN INDIVIDUALS WITH AFRICAN ANCESTRY IDENTIFIES TWO NOVEL GENETIC ASSOCIATIONSMeng X, Feng Y, Levey D, Giannakopoulou O, Moscati A, Ursano R, Fang Y, Actkins K, Stein D, Koen N, Lewis C, Stein M, Gelernter J, Kuchenbaecker K, Collaborators T. 86. GENOME-WIDE ASSOCIATION STUDY OF DEPRESSION IN INDIVIDUALS WITH AFRICAN ANCESTRY IDENTIFIES TWO NOVEL GENETIC ASSOCIATIONS. European Neuropsychopharmacology 2021, 51: e86-e87. DOI: 10.1016/j.euroneuro.2021.07.172.
- 87. WHOLE-EXOME SEQUENCING IN THE UK BIOBANK REVEALS RISK GENE SLC2A1 AND BIOLOGICAL INSIGHTS FOR MAJOR DEPRESSIVE DISORDERTian R, Ge T, Liu J, Lam M, Levey D, Gelernter J, Stein M, Tsai E, Huang H, Lencz T, Runz H, Chen C. 87. WHOLE-EXOME SEQUENCING IN THE UK BIOBANK REVEALS RISK GENE SLC2A1 AND BIOLOGICAL INSIGHTS FOR MAJOR DEPRESSIVE DISORDER. European Neuropsychopharmacology 2021, 51: e87. DOI: 10.1016/j.euroneuro.2021.07.173.
- TU85. POLYGENIC RISK SCORE FOR CANNABIS USE DISORDER PREDICTS ACUTE INTOXICATING EFFECTS AND COGNITIVE DEFICITS INDUCED BY DELTA-9-TETRAHYDROCANNABINOL: A PILOT STUDYGanesh S, Levey D, Ranganathan M, Gelernter J, D'Souza D. TU85. POLYGENIC RISK SCORE FOR CANNABIS USE DISORDER PREDICTS ACUTE INTOXICATING EFFECTS AND COGNITIVE DEFICITS INDUCED BY DELTA-9-TETRAHYDROCANNABINOL: A PILOT STUDY. European Neuropsychopharmacology 2021, 51: e142. DOI: 10.1016/j.euroneuro.2021.08.086.
- Dissecting the Shared Genetic Architecture of Suicide Attempt, Psychiatric Disorders, and Known Risk FactorsMullins N, Kang J, Campos AI, Coleman JRI, Edwards AC, Galfalvy H, Levey DF, Lori A, Shabalin A, Starnawska A, Su MH, Watson HJ, Adams M, Awasthi S, Gandal M, Hafferty JD, Hishimoto A, Kim M, Okazaki S, Otsuka I, Ripke S, Ware EB, Bergen AW, Berrettini WH, Bohus M, Brandt H, Chang X, Chen WJ, Chen HC, Crawford S, Crow S, DiBlasi E, Duriez P, Fernández-Aranda F, Fichter MM, Gallinger S, Glatt SJ, Gorwood P, Guo Y, Hakonarson H, Halmi KA, Hwu HG, Jain S, Jamain S, Jiménez-Murcia S, Johnson C, Kaplan AS, Kaye WH, Keel PK, Kennedy JL, Klump KL, Li D, Liao SC, Lieb K, Lilenfeld L, Liu CM, Magistretti PJ, Marshall CR, Mitchell JE, Monson ET, Myers RM, Pinto D, Powers A, Ramoz N, Roepke S, Rozanov V, Scherer SW, Schmahl C, Sokolowski M, Strober M, Thornton LM, Treasure J, Tsuang MT, Witt SH, Woodside DB, Yilmaz Z, Zillich L, Adolfsson R, Agartz I, Air TM, Alda M, Alfredsson L, 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- Precision medicine for mood disorders: objective assessment, risk prediction, pharmacogenomics, and repurposed drugsLe-Niculescu H, Roseberry K, Gill SS, Levey DF, Phalen PL, Mullen J, Williams A, Bhairo S, Voegtline T, Davis H, Shekhar A, Kurian SM, Niculescu AB. Precision medicine for mood disorders: objective assessment, risk prediction, pharmacogenomics, and repurposed drugs. Molecular Psychiatry 2021, 26: 2776-2804. PMID: 33828235, PMCID: PMC8505261, DOI: 10.1038/s41380-021-01061-w.
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- Sex-stratified gene-by-environment genome-wide interaction study of trauma, posttraumatic-stress, and suicidalityWendt FR, Pathak GA, Levey DF, Nuñez YZ, Overstreet C, Tyrrell C, Adhikari K, De Angelis F, Tylee DS, Goswami A, Krystal JH, Abdallah CG, Stein MB, Kranzler HR, Gelernter J, Polimanti R. Sex-stratified gene-by-environment genome-wide interaction study of trauma, posttraumatic-stress, and suicidality. Neurobiology Of Stress 2021, 14: 100309. PMID: 33665242, PMCID: PMC7905234, DOI: 10.1016/j.ynstr.2021.100309.
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- Genome-wide association analyses of post-traumatic stress disorder and its symptom subdomains in the Million Veteran ProgramStein MB, Levey DF, Cheng Z, Wendt FR, Harrington K, Pathak GA, Cho K, Quaden R, Radhakrishnan K, Girgenti MJ, Ho YA, Posner D, Aslan M, Duman RS, Zhao H, Polimanti R, Concato J, Gelernter J. Genome-wide association analyses of post-traumatic stress disorder and its symptom subdomains in the Million Veteran Program. Nature Genetics 2021, 53: 174-184. PMID: 33510476, PMCID: PMC7972521, DOI: 10.1038/s41588-020-00767-x.
- Multi-environment gene interactions linked to the interplay between polysubstance dependence and suicidalityPolimanti R, Levey DF, Pathak GA, Wendt FR, Nunez YZ, Ursano RJ, Kessler RC, Kranzler HR, Stein MB, Gelernter J. Multi-environment gene interactions linked to the interplay between polysubstance dependence and suicidality. Translational Psychiatry 2021, 11: 34. PMID: 33431810, PMCID: PMC7801457, DOI: 10.1038/s41398-020-01153-1.
2020
- Genome-wide meta-analysis of problematic alcohol use in 435,563 individuals yields insights into biology and relationships with other traitsZhou H, Sealock JM, Sanchez-Roige S, Clarke TK, Levey DF, Cheng Z, Li B, Polimanti R, Kember RL, Smith RV, Thygesen JH, Morgan MY, Atkinson SR, Thursz MR, Nyegaard M, Mattheisen M, Børglum AD, Johnson EC, Justice AC, Palmer AA, McQuillin A, Davis LK, Edenberg HJ, Agrawal A, Kranzler HR, Gelernter J. Genome-wide meta-analysis of problematic alcohol use in 435,563 individuals yields insights into biology and relationships with other traits. Nature Neuroscience 2020, 23: 809-818. PMID: 32451486, PMCID: PMC7485556, DOI: 10.1038/s41593-020-0643-5.
- Horizontal and Vertical Pleiotropy Linking Coronary Artery Disease, Traumatic Experiences, and Posttraumatic Stress in >650,000 IndividualsPolimanti R, Wendt F, Tcheandjieu C, Hilliard A, Levey D, Cheng Z, O’Donnell C, Stein M, Assimes T, Gelernter J. Horizontal and Vertical Pleiotropy Linking Coronary Artery Disease, Traumatic Experiences, and Posttraumatic Stress in >650,000 Individuals. Biological Psychiatry 2020, 87: s52-s53. DOI: 10.1016/j.biopsych.2020.02.158.
- Complex Multi-Environment Gene Interactions at the Basis of the Interplay Between Polysubstance Abuse and Suicide BehaviorsPolimanti R, Levey D, Pathak G, Wendt F, Nunez Y, Kranzler H, Stein M, Gelernter J. Complex Multi-Environment Gene Interactions at the Basis of the Interplay Between Polysubstance Abuse and Suicide Behaviors. Biological Psychiatry 2020, 87: s155. DOI: 10.1016/j.biopsych.2020.02.411.
- Telomeric Tales: Genetic Interplay of Telomere Length, Brain Morphology, and Brain TranscriptomicsPathak G, Wendt F, Levey D, Gelernter J, Polimanti R. Telomeric Tales: Genetic Interplay of Telomere Length, Brain Morphology, and Brain Transcriptomics. Biological Psychiatry 2020, 87: s227. DOI: 10.1016/j.biopsych.2020.02.590.
- Reproducible Genetic Risk Loci for Anxiety: Results From ∼200,000 Participants in the Million Veteran ProgramLevey DF, Gelernter J, Polimanti R, Zhou H, Cheng Z, Aslan M, Quaden R, Concato J, Radhakrishnan K, Bryois J, Sullivan PF, Stein M. Reproducible Genetic Risk Loci for Anxiety: Results From ∼200,000 Participants in the Million Veteran Program. American Journal Of Psychiatry 2020, 177: 223-232. PMID: 31906708, PMCID: PMC7869502, DOI: 10.1176/appi.ajp.2019.19030256.
2019
- International meta-analysis of PTSD genome-wide association studies identifies sex- and ancestry-specific genetic risk lociNievergelt CM, Maihofer AX, Klengel T, Atkinson EG, Chen CY, Choi KW, Coleman JRI, Dalvie S, Duncan LE, Gelernter J, Levey DF, Logue MW, Polimanti R, Provost AC, Ratanatharathorn A, Stein MB, Torres K, Aiello AE, Almli LM, Amstadter AB, Andersen SB, Andreassen OA, Arbisi PA, Ashley-Koch AE, Austin SB, Avdibegovic E, Babić D, Bækvad-Hansen M, Baker DG, Beckham JC, Bierut LJ, Bisson JI, Boks MP, Bolger EA, Børglum AD, Bradley B, Brashear M, Breen G, Bryant RA, Bustamante AC, Bybjerg-Grauholm J, Calabrese JR, Caldas- de- Almeida J, Dale AM, Daly MJ, Daskalakis NP, Deckert J, Delahanty DL, Dennis MF, Disner SG, Domschke K, Dzubur-Kulenovic A, Erbes CR, Evans A, Farrer LA, Feeny NC, Flory JD, Forbes D, Franz CE, Galea S, Garrett ME, Gelaye B, Geuze E, Gillespie C, Uka AG, Gordon SD, Guffanti G, Hammamieh R, Harnal S, Hauser MA, Heath AC, Hemmings SMJ, Hougaard DM, Jakovljevic M, Jett M, Johnson EO, Jones I, Jovanovic T, Qin XJ, Junglen AG, Karstoft KI, Kaufman ML, Kessler RC, Khan A, Kimbrel NA, King AP, Koen N, Kranzler HR, Kremen WS, Lawford BR, Lebois LAM, Lewis CE, Linnstaedt SD, Lori A, Lugonja B, Luykx JJ, Lyons MJ, Maples-Keller J, Marmar C, Martin AR, Martin NG, Maurer D, Mavissakalian MR, McFarlane A, McGlinchey RE, McLaughlin KA, McLean SA, McLeay S, Mehta D, Milberg WP, Miller MW, Morey RA, Morris CP, Mors O, Mortensen PB, Neale BM, Nelson EC, Nordentoft M, Norman SB, O’Donnell M, Orcutt HK, Panizzon MS, Peters ES, Peterson AL, Peverill M, Pietrzak RH, Polusny MA, Rice JP, Ripke S, Risbrough VB, Roberts AL, Rothbaum AO, Rothbaum BO, Roy-Byrne P, Ruggiero K, Rung A, Rutten BPF, Saccone NL, Sanchez SE, Schijven D, Seedat S, Seligowski AV, Seng JS, Sheerin CM, Silove D, Smith AK, Smoller JW, Sponheim SR, Stein DJ, Stevens JS, Sumner JA, Teicher MH, Thompson WK, Trapido E, Uddin M, Ursano RJ, van den Heuvel LL, Van Hooff M, Vermetten E, Vinkers CH, Voisey J, Wang Y, Wang Z, Werge T, Williams MA, Williamson DE, Winternitz S, Wolf C, Wolf EJ, Wolff JD, Yehuda R, Young RM, Young KA, Zhao H, Zoellner LA, Liberzon I, Ressler KJ, Haas M, Koenen KC. International meta-analysis of PTSD genome-wide association studies identifies sex- and ancestry-specific genetic risk loci. Nature Communications 2019, 10: 4558. PMID: 31594949, PMCID: PMC6783435, DOI: 10.1038/s41467-019-12576-w.
- GWAS OF RESILIENCE TO COMBAT-RELATED PTSD IN THE MILLION VETERAN PROGRAMStein M, Levey D, Polimanti R, Cheng Z, Choi K, Gelernter J, Program O. GWAS OF RESILIENCE TO COMBAT-RELATED PTSD IN THE MILLION VETERAN PROGRAM. European Neuropsychopharmacology 2019, 29: s29. DOI: 10.1016/j.euroneuro.2019.07.059.
- GWAS OF A QUANTITATIVE ANXIETY TRAIT IN THE MILLION VETERAN PROGRAM SAMPLEGelernter J, Levey D, Polimanti R, Zhou H, Cheng Z, Aslan M, Quaden R, Concato J, Radhakrishnan K, Bryois J, Sullivan P, Stein M. GWAS OF A QUANTITATIVE ANXIETY TRAIT IN THE MILLION VETERAN PROGRAM SAMPLE. European Neuropsychopharmacology 2019, 29: s33. DOI: 10.1016/j.euroneuro.2019.07.067.
- GENOMIC CHARACTERIZATION OF POSTTRAUMATIC STRESS DISORDER IN A LARGE (N) MULTI-POPULATION U.S. MILITARY VETERAN SAMPLEStein M, Levey D, Polimanti R, Cheng Z, Harrington K, Radhakrishnan K, Aslan M, Concato J, Group M, Gelernter J. GENOMIC CHARACTERIZATION OF POSTTRAUMATIC STRESS DISORDER IN A LARGE (N) MULTI-POPULATION U.S. MILITARY VETERAN SAMPLE. European Neuropsychopharmacology 2019, 29: s43. DOI: 10.1016/j.euroneuro.2019.07.085.
- 54 GENOME-WIDE ASSOCATIONS WITH DEPRESSIVE SYMPTOMS IN THE MILLION VETERANS PROGRAMLevey D, Gelernter J, Polimanti R, Zhou H, Cheng Z, Aslan M, Quaden R, Harrington K, Cho K, Concato J, Radhakrishnan K, Program M, Stein M. 54 GENOME-WIDE ASSOCATIONS WITH DEPRESSIVE SYMPTOMS IN THE MILLION VETERANS PROGRAM. European Neuropsychopharmacology 2019, 29: s89. DOI: 10.1016/j.euroneuro.2019.07.195.
- M7 TOWARDS PRECISION MEDICINE FOR MOOD DISORDERS: OBJECTIVE ASSESSMENT AND TARGETED THERAPEUTICS FOR DEPRESSION AND MANIANiculescu A, Le-Niculescu H, Roseberry K, Levey D, Phalen P, Nurnberger J, Shekhar A, Kurian S. M7 TOWARDS PRECISION MEDICINE FOR MOOD DISORDERS: OBJECTIVE ASSESSMENT AND TARGETED THERAPEUTICS FOR DEPRESSION AND MANIA. European Neuropsychopharmacology 2019, 29: s169-s170. DOI: 10.1016/j.euroneuro.2019.08.107.
- Apolipoprotein E gene polymorphism, posttraumatic stress disorder, and cognitive function in older U.S. veterans: Results from the National Health and Resilience in Veterans StudyAverill LA, Abdallah CG, Levey DF, Han S, Harpaz‐Rotem I, Kranzler HR, Southwick SM, Krystal JH, Gelernter J, Pietrzak RH. Apolipoprotein E gene polymorphism, posttraumatic stress disorder, and cognitive function in older U.S. veterans: Results from the National Health and Resilience in Veterans Study. Depression And Anxiety 2019, 36: 834-845. PMID: 31385647, DOI: 10.1002/da.22912.
- Genome-wide association study of post-traumatic stress disorder reexperiencing symptoms in >165,000 US veteransGelernter J, Sun N, Polimanti R, Pietrzak R, Levey DF, Bryois J, Lu Q, Hu Y, Li B, Radhakrishnan K, Aslan M, Cheung KH, Li Y, Rajeevan N, Sayward F, Harrington K, Chen Q, Cho K, Pyarajan S, Sullivan PF, Quaden R, Shi Y, Hunter-Zinck H, Gaziano JM, Concato J, Zhao H, Stein MB. Genome-wide association study of post-traumatic stress disorder reexperiencing symptoms in >165,000 US veterans. Nature Neuroscience 2019, 22: 1394-1401. PMID: 31358989, PMCID: PMC6953633, DOI: 10.1038/s41593-019-0447-7.
- S78. Towards Precision Medicine for Mood Disorders: New Diagnostics and Therapeutics for Depression and ManiaNiculescu A, Le-Niculescu H, Roseberry K, Levey D, Phalen P, Mullen J, Nurnberger J, Shekhar A, Schork N, Kurian S. S78. Towards Precision Medicine for Mood Disorders: New Diagnostics and Therapeutics for Depression and Mania. Biological Psychiatry 2019, 85: s327. DOI: 10.1016/j.biopsych.2019.03.829.
- Genome-wide Association Study of Maximum Habitual Alcohol Intake in >140,000 U.S. European and African American Veterans Yields Novel Risk LociGelernter J, Sun N, Polimanti R, Pietrzak RH, Levey DF, Lu Q, Hu Y, Li B, Radhakrishnan K, Aslan M, Cheung KH, Li Y, Rajeevan N, Sayward F, Harrington K, Chen Q, Cho K, Honerlaw J, Pyarajan S, Lencz T, Quaden R, Shi Y, Hunter-Zinck H, Gaziano JM, Kranzler HR, Concato J, Zhao H, Stein MB, Program D, Program M. Genome-wide Association Study of Maximum Habitual Alcohol Intake in >140,000 U.S. European and African American Veterans Yields Novel Risk Loci. Biological Psychiatry 2019, 86: 365-376. PMID: 31151762, PMCID: PMC6919570, DOI: 10.1016/j.biopsych.2019.03.984.