Taylor Intihar, MS
Research Assistant 1, HSSCards
About
Research
Publications
2024
Early goal enteral nutrition associated with decreased in-hospital death in mechanically ventilated critically ill adults: a retrospective cohort study
Powierza C, Doyle M, Wasden K, Intihar T, Korwin A, Honiden S, Knauert M. Early goal enteral nutrition associated with decreased in-hospital death in mechanically ventilated critically ill adults: a retrospective cohort study. BMJ Open Respiratory Research 2024, 11: e001962. PMID: 38749534, PMCID: PMC11097881, DOI: 10.1136/bmjresp-2023-001962.Peer-Reviewed Original ResearchConceptsEarly enteral nutritionIn-Hospital DeathCritically Ill AdultsRetrospective cohort studyDays of intubationEnteral nutritionIll adultsAdult patientsCohort studyAssociated with decreased in-hospital deathsMechanically ventilated critically ill adultsGoal enteral nutritionIncreased hospital dischargeInitiation of ENCritically ill adult patientsMechanically ventilated adult patientsIncidence of in-hospital deathMedical intensive care unitAssociated with significant improvementsIll adult patientsDose of ENIntensive care unitClinical outcomesImprove mortalityPrimary outcome
2023
Tumor suppressor p53 regulates heat shock factor 1 protein degradation in Huntington’s disease
Mansky R, Greguske E, Yu D, Zarate N, Intihar T, Tsai W, Brown T, Thayer M, Kumar K, Gomez-Pastor R. Tumor suppressor p53 regulates heat shock factor 1 protein degradation in Huntington’s disease. Cell Reports 2023, 42: 112198. PMID: 36867535, PMCID: PMC10128052, DOI: 10.1016/j.celrep.2023.112198.Peer-Reviewed Original ResearchConceptsMajor transcription factorTumor suppressor p53Huntington's diseaseHtt aggregationTranscription factorsE3 ligase MDM2Protein degradationSuppressor p53Reciprocal regulationMutant HttP53 stabilizationMolecular differencesCell proliferationHSF1Neurodegenerative diseasesP53Most cancersNeurodegenerationP53 deletionTranscriptionDegradationDeletionAbundanceHTT
2021
Heat Shock Factor 1 Directly Regulates Postsynaptic Scaffolding PSD-95 in Aging and Huntington’s Disease and Influences Striatal Synaptic Density
Zarate N, Intihar T, Yu D, Sawyer J, Tsai W, Syed M, Carlson L, Gomez-Pastor R. Heat Shock Factor 1 Directly Regulates Postsynaptic Scaffolding PSD-95 in Aging and Huntington’s Disease and Influences Striatal Synaptic Density. International Journal Of Molecular Sciences 2021, 22: 13113. PMID: 34884918, PMCID: PMC8657899, DOI: 10.3390/ijms222313113.Peer-Reviewed Original ResearchConceptsHeat shock transcription factor 1PSD-95 levelsPSD-95 expressionPSD-95Huntington's diseaseShock transcription factor 1Synaptic protein levelsFactor 1Heat shock factor 1Direct regulatory relationshipIonotropic glutamate receptorsAge-dependent mannerShock factor 1Protein homeostasisWT miceAcute reductionSynaptic dysfunctionGene regulationTranscription factor 1Synaptic densityProtein essentialSynaptic punctaGlutamate receptorsBehavioral deficitsExcitatory synapses
2019
Mitochondrial Dysfunction in Huntington’s Disease; Interplay Between HSF1, p53 and PGC-1α Transcription Factors
Intihar TA, Martinez EA, Gomez-Pastor R. Mitochondrial Dysfunction in Huntington’s Disease; Interplay Between HSF1, p53 and PGC-1α Transcription Factors. Frontiers In Cellular Neuroscience 2019, 13: 103. PMID: 30941017, PMCID: PMC6433789, DOI: 10.3389/fncel.2019.00103.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsMutant HttTranscription factorsMitochondrial dysfunctionPGC-1αMitochondrial functionCo-activator PGC-1αTranscription factor HSF1Main transcription factorHuntington's diseaseProtein homeostasisHSF1Medium spiny neuronsP53 levelsUnifying mechanismHuntingtin geneNeurodegenerative diseasesP53ProteinPotential roleStriatal medium spiny neuronsCAG repeatsThird mechanismMisfoldHD progressionGenes