Karam Lab

Our lab is dedicated to improving the care of critically ill patients who require extracorporeal life support (ECLS)—life-saving interventions such as extracorporeal membrane oxygenation (ECMO) and ventricular assist devices (VADs). These technologies temporarily support the heart and lungs when conventional treatments have failed. Because blood is circulated outside the body through plastic tubing before being reinfused, patients require anticoagulation and transfusions to prevent life-threatening complications like bleeding and clotting.

Our mission is to develop evidence-based strategies to optimize platelet transfusions, anticoagulation monitoring, and novel anticoagulation therapies, improving outcomes for these critically ill patients.

Beyond the medical challenges, ECMO is often a devastating experience for families, with significant emotional and psychological impacts. Our lab is also committed to supporting parents and families, identifying innovative ways to help them navigate and cope with the immense stress and uncertainty that come with these critical interventions.

Through cutting-edge research, we strive to transform care—enhancing survival, reducing complications, and improving the well-being of both patients and their families.