2022
Type I interferon transcriptional network regulates expression of coinhibitory receptors in human T cells
Sumida TS, Dulberg S, Schupp JC, Lincoln MR, Stillwell HA, Axisa PP, Comi M, Unterman A, Kaminski N, Madi A, Kuchroo VK, Hafler DA. Type I interferon transcriptional network regulates expression of coinhibitory receptors in human T cells. Nature Immunology 2022, 23: 632-642. PMID: 35301508, PMCID: PMC8989655, DOI: 10.1038/s41590-022-01152-y.Peer-Reviewed Original ResearchConceptsCoinhibitory receptor expressionHuman T cellsIFN-I responsesCoinhibitory receptorsT cellsTIGIT expressionReceptor expressionAcute SARS-CoV-2 infectionPD-1/TimSARS-CoV-2 infectionEnhancement of immunotherapyType 1 interferonT-cell featuresLAG-3Infectious diseasesDifferent temporal kineticsTranscription factorsCancer therapyReceptorsCell featuresKey transcription factorIFNPresent studyMRNA profilingKey regulator
2010
Characterization of Microrna Expression Profile In Platelets In Sickle Cell Disease
Jain S, Raghavachari N, Woodhouse K, Kaminski N, Gladwin M. Characterization of Microrna Expression Profile In Platelets In Sickle Cell Disease. Blood 2010, 116: 2030. DOI: 10.1182/blood.v116.21.2030.2030.Peer-Reviewed Original ResearchSickle cell diseasePulmonary hypertensionSCD patientsPathological platelet activationPlatelet activationCell diseaseRace-matched healthy controlsSickle cell disease patientsAfrican American control subjectsPittsburgh Medical CenterPlatelet-rich plasma samplesP-valueThromboembolic complicationsStudy enrollmentBlood InstitutePresent studyControl subjectsDisease patientsNational HeartIntravascular hemolysisHealthy controlsSCD groupSCD pathogenesisReal-time PCRIndividual patients