2012
Global Methylation Patterns in Idiopathic Pulmonary Fibrosis
Rabinovich EI, Kapetanaki MG, Steinfeld I, Gibson KF, Pandit KV, Yu G, Yakhini Z, Kaminski N. Global Methylation Patterns in Idiopathic Pulmonary Fibrosis. PLOS ONE 2012, 7: e33770. PMID: 22506007, PMCID: PMC3323629, DOI: 10.1371/journal.pone.0033770.Peer-Reviewed Original ResearchConceptsCpG islandsMethylation patternsEpigenetic changesMethylation profilesHuman CpG island microarrayNuclear element-1 (LINE-1 or L1) retrotransposonsCellular biosynthetic processesCpG island microarrayGlobal methylation profilesRegulation of apoptosisGlobal methylation patternsLung phenotypeBRB-Array ToolsElement-1 (LINE-1 or L1) retrotransposonsCancer-specific changesBiosynthetic processesGlobal hypomethylationSpecific changesExtensive remodelingFalse discovery rateExtracellular matrix depositionArray resultsGenesHypomethylationLung cancer samples
2007
Towards Systems Biology of Human Pulmonary Fibrosis
Studer SM, Kaminski N. Towards Systems Biology of Human Pulmonary Fibrosis. Annals Of The American Thoracic Society 2007, 4: 85-91. PMID: 17202296, PMCID: PMC2647618, DOI: 10.1513/pats.200607-139jg.Peer-Reviewed Original ResearchConceptsSystems biology approachBiology approachSystems biologyHigh-throughput genotypingHigh-throughput technologiesMicroarray resultsBiological processesQuantitative phenotypingEnvironmental stimuliFibrosis researchMultiple pathwaysLung phenotypeBiologyGlobal analysisHuman pulmonary fibrosisGenetic polymorphismsIdiopathic pulmonary fibrosisComputational toolsPulmonary fibrosisSystemwide viewHigh-resolution profilesPhenotypePathwayLethal lung diseasePolymorphism