2021
Elevated IL-15 concentrations in the sarcoidosis lung are independent of granuloma burden and disease phenotypes
Minasyan M, Sharma L, Pivarnik T, Liu W, Adams T, Bermejo S, Peng X, Liu A, Ishikawa G, Perry C, Kaminski N, Gulati M, Herzog EL, Dela Cruz CS, Ryu C. Elevated IL-15 concentrations in the sarcoidosis lung are independent of granuloma burden and disease phenotypes. American Journal Of Physiology - Lung Cellular And Molecular Physiology 2021, 320: l1137-l1146. PMID: 33851886, PMCID: PMC8285626, DOI: 10.1152/ajplung.00575.2020.Peer-Reviewed Original ResearchConceptsIL-15 concentrationsIL-15Bronchoalveolar lavageDisease pathogenesisSarcoidosis lungClinical manifestationsLineages of miceIL-15 receptor αHuman cohortsInflammation of sarcoidosisIL-15 levelsOngoing inflammatory processSystemic granulomatous diseaseNumber of granulomasDisease phenotypeSarcoidosis cohortTDM administrationGranuloma numberComorbid conditionsClinical progressionInterleukin-15Granulomatous diseaseInflammatory processGranuloma formationHealthy controls
2015
Epigenetics in idiopathic pulmonary fibrosis1
Tzouvelekis A, Kaminski N. Epigenetics in idiopathic pulmonary fibrosis1. Biochemistry And Cell Biology 2015, 93: 159-170. PMID: 25659821, DOI: 10.1139/bcb-2014-0126.Peer-Reviewed Original ResearchConceptsIdiopathic pulmonary fibrosisChronic lung disordersLung disordersDNA sequencesFibroproliferative lung disordersTranslational epigenetic studiesIndividual DNA sequencesEpithelial wound repairVariable disease phenotypesPulmonary fibrosisChronic inflammationLung cancerInjurious stimuliHeritable changesEffective treatmentGene functionEpigenetic modificationsEpigenomic alterationsEpigenetic studiesCurrent experimental evidenceDisease paradigmWound repairDisease phenotypeDisordersEnvironmental changes