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The Insogna research program has three components: translational, clinical, and analytical clinical research.

Translational Research

Translational research in the Insogna lab is largely wet bench work, centered on cellular and molecular mechanisms of bone remodeling. The lab has had a long-standing interest in the role of cytokines in mediating both the anabolic and catabolic actions of PTH in bone. This work includes studies on the role of Colony Stimulating Factor 1 in mediating PTH-induced resorption. Exploring the effect in bone of the major CSF1 isoforms and clarifying the intracellular mediators of CSF1’s effects on mature osteoclasts are two examples of ongoing projects related to this growth factor. Another area of investigative interest is the role of dietary protein in regulating mineral homeostasis and the mechanisms by which amino acids regulate paracellular calcium transport and iron metabolism.

Two new areas or research in the lab are dysregulated osteoclastogenesis in myeloma and the role of the hypothalamus in regulating bone metabolism.

Karl Insogna directs the Yale Core Center for Musculoskeletal Disorders, a P30 Core Center funded by NIAMS, which supports the development and analysis of animal models of musculoskeletal disorders.

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