Small Animal Imaging Center
The Small Animal Imaging Center
The ability to quantify hard tissue content and determine body composition are critical to experimental studies in small animals. Yale’s Small Animal Imaging Center is located in The Anlyan Center (TAC), under the direction and management of the Insogna Lab.
Two imaging instruments are available to investigators:
- A Scanco 35 microCT instrument for ex vivo studies can resolve structures down to 3.5 microns.
- The Faxitron UltraFocus DXA can be used for serial in vivo whole-body composition and total and regional BMD measurement, as well as serial in vivo whole-body radiographs or ex vivo high-resolution radiographs.
- microCT Facility
- UltraFocus DXA Facility
The Yale microCT Facility
About the Yale microCT Facility
The machine features extremely high resolution, with the capacity to resolve structures down to 3.5 microns and provide fine structural images at the level of individual trabeculae. A variety of sized holders can be placed in the machine, and we are able to analyze both soft and hard tissues, including rat and mouse bones and segments of larger bones.
The majority of scientists access the machine to examine either rat or mouse bones, so we have devised template reports to reflect that, anticipating that the majority of users are interesting in analyzing either vertebral bones or femurs. In the femur, we analyze distal femur for trabecular and cortical bone. Our general report includes images at 7 microns that display a cross section of the whole bone to allow investigators to get some sense of the size and shape of their bones and the relative amount of cortex and trabecular bone present. An abstracted summary of the critical parameters, both cortical and trabecular, are included in the report, as well as a graphic summary of those changes that were most significantly different. A third tab on the report form includes all of the parameters acquired by the instrument.
All specimens should be submitted using the MicroCT Submission Form. Samples can be sent to:
Ben-Hua Sun, MD
Internal Medicine Endocrinology
One Gilbert Street, Room TAC S-130
New Haven, CT 06519
Dr. Insogna is available on a consultative basis to help interpret your data, if needed.
Micro CT Scans of one bone (femur or L3) = $70
Micro CT scan of one whole calvaria = $142
Micro CT scan of one C-spine = $158
Micro CT scan of one spine = $292
External, for-profit, customers:
Micro CT Scans of one bone (femur or L3) = $105
Micro CT scan of one whole calvaria = $210
Micro CT scan of one C-spine = $237
Micro CT scan of one spine = $368
External, non-profit, customers:
Micro CT Scans of one bone (femur or L3) = $79
Micro CT scan of one whole calvaria = $158
Micro CT scan of one C-spine = $179
Micro CT scan of one spine = $315