2024
Photosensitive Nanoprobes for Rapid High Purity Isolation and Size‐Specific Enrichment of Synthetic and Extracellular Vesicle Subpopulations (Adv. Funct. Mater. 34/2024)
Weerakkody J, Tseng T, Topper M, Thoduvayil S, Radhakrishnan A, Pincet F, Kyriakides T, Gunasekara R, Ramakrishnan S. Photosensitive Nanoprobes for Rapid High Purity Isolation and Size‐Specific Enrichment of Synthetic and Extracellular Vesicle Subpopulations (Adv. Funct. Mater. 34/2024). Advanced Functional Materials 2024, 34 DOI: 10.1002/adfm.202470191.Peer-Reviewed Original ResearchVesicle biogenesisExtracellular vesicle subpopulationsLipid nanoprobesVesicle subpopulationsNative extracellular vesiclesVesicle populationsSeparate vesiclesPurity isolationExtracellular vesiclesVesiclesCellular originHydrophobic interactionsBiogenesisSize variabilitySubpopulationsIsolatesExtracellularPhotosensitive Nanoprobes for Rapid High Purity Isolation and Size‐Specific Enrichment of Synthetic and Extracellular Vesicle Subpopulations
Weerakkody J, Tseng T, Topper M, Thoduvayil S, Radhakrishnan A, Pincet F, Kyriakides T, Gunasekara R, Ramakrishnan S. Photosensitive Nanoprobes for Rapid High Purity Isolation and Size‐Specific Enrichment of Synthetic and Extracellular Vesicle Subpopulations. Advanced Functional Materials 2024, 34 PMID: 39372670, PMCID: PMC11452007, DOI: 10.1002/adfm.202400390.Peer-Reviewed Original ResearchExtracellular vesicle subpopulationsVesicle subpopulationsIsolation of vesiclesPurity extracellular vesiclesRelease of vesiclesAnalysis of nucleic acidsNear-native formLarge-scale isolationLipid nanoprobesDownstream analysisPurity isolationEfficient isolationVesiclesSynthetic vesiclesNucleic acidsExtracellular vesiclesIsolation methodIsolatesBiomarker discoveryExposure to lightSubpopulationsEnrichmentProteinComplex biological mediaCleavage
2019
Recognition and protection of glycosphingolipids by synthetic nanoparticle receptors
Gunasekara RW, Zhao Y. Recognition and protection of glycosphingolipids by synthetic nanoparticle receptors. Chemical Communications 2019, 55: 4773-4776. PMID: 30946397, PMCID: PMC7474536, DOI: 10.1039/c9cc01694e.Peer-Reviewed Original Research
2017
Intrinsic Hydrophobicity versus Intraguest Interactions in Hydrophobically Driven Molecular Recognition in Water
Gunasekara RW, Zhao Y. Intrinsic Hydrophobicity versus Intraguest Interactions in Hydrophobically Driven Molecular Recognition in Water. Organic Letters 2017, 19: 4159-4162. PMID: 28753291, DOI: 10.1021/acs.orglett.7b01535.Peer-Reviewed Original ResearchCorrection to “A General Method for Selective Recognition of Monosaccharides and Oligosaccharides in Water”
Gunasekara R, Zhao Y. Correction to “A General Method for Selective Recognition of Monosaccharides and Oligosaccharides in Water”. Journal Of The American Chemical Society 2017, 139: 2530-2530. PMID: 28145116, DOI: 10.1021/jacs.7b00661.Peer-Reviewed Original ResearchSequence-Selective Binding of Oligopeptides in Water through Hydrophobic Coding
Awino JK, Gunasekara RW, Zhao Y. Sequence-Selective Binding of Oligopeptides in Water through Hydrophobic Coding. Journal Of The American Chemical Society 2017, 139: 2188-2191. PMID: 28128940, PMCID: PMC5310974, DOI: 10.1021/jacs.6b12949.Peer-Reviewed Original ResearchA General Method for Selective Recognition of Monosaccharides and Oligosaccharides in Water
Gunasekara RW, Zhao Y. A General Method for Selective Recognition of Monosaccharides and Oligosaccharides in Water. Journal Of The American Chemical Society 2017, 139: 829-835. PMID: 27983819, PMCID: PMC5243169, DOI: 10.1021/jacs.6b10773.Peer-Reviewed Original ResearchConceptsCross-linked micellesMonosaccharide building blocksAdditional functional groupsEnhanced hydrophobic interactionCovalent imprintingNanoparticle receptorsFunctional monomerSynthetic receptorsExcellent selectivitySelective recognitionMolecular recognitionImportant hexosesFunctional groupsD-aldohexosesHydrophobic interactionsChain lengthStrong bindingGlycosidic linkagesBuilding blocksDiolBinding affinitiesNanoparticlesOligosaccharidesMicellesCisBinding a Specific Peptide in Those Dimples
Joseph K. Awino, Roshan W. Gunasekara, and Yan Zhao J. Am. Chem. Soc., 2017, 139 (7), 2531–2531Peer-Reviewed Original Research
2016
Selective Recognition of d‑Aldohexoses in Water by Boronic Acid-Functionalized, Molecularly Imprinted Cross-Linked Micelles
Awino JK, Gunasekara RW, Zhao Y. Selective Recognition of d‑Aldohexoses in Water by Boronic Acid-Functionalized, Molecularly Imprinted Cross-Linked Micelles. Journal Of The American Chemical Society 2016, 138: 9759-9762. PMID: 27442012, PMCID: PMC4982515, DOI: 10.1021/jacs.6b04613.Peer-Reviewed Original ResearchEnhancing binding affinity and selectivity through preorganization and cooperative enhancement of the receptor
Gunasekara RW, Zhao Y. Enhancing binding affinity and selectivity through preorganization and cooperative enhancement of the receptor. Chemical Communications 2016, 52: 4345-4348. PMID: 26923346, DOI: 10.1039/c5cc10405j.Peer-Reviewed Original Research
2015
Conformationally Switchable Water-Soluble Fluorescent Bischolate Foldamers as Membrane-Curvature Sensors
Gunasekara RW, Zhao Y. Conformationally Switchable Water-Soluble Fluorescent Bischolate Foldamers as Membrane-Curvature Sensors. Langmuir 2015, 31: 3919-3925. PMID: 25782344, DOI: 10.1021/acs.langmuir.5b00379.Peer-Reviewed Original ResearchConceptsMembrane curvature sensorMembrane curvatureIonic natureProtein-derived peptidesCellular movementLipid membranesVesicle fusionOnly proteinBiological processesAnionic lipidsΑ-faceSensitive fluorophoreFluorescent labelsFoldamersLipid compositionNBD groupAmount of cholesterolMembraneFluorophoresBuddingProteinSensorsBindingCholateAnaloguesRationally Designed Cooperatively Enhanced Receptors To Magnify Host–Guest Binding in Water
Gunasekara RW, Zhao Y. Rationally Designed Cooperatively Enhanced Receptors To Magnify Host–Guest Binding in Water. Journal Of The American Chemical Society 2015, 137: 843-849. PMID: 25531747, DOI: 10.1021/ja510823h.Peer-Reviewed Original Research