Roshan Gunasekara, PhD
Assistant ProfessorDownloadHi-Res Photo
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Neurology
Primary
Contact Info
About
Titles
Assistant Professor
Appointments
Neurology
Assistant ProfessorPrimary
Other Departments & Organizations
- Grutzendler Lab
- Gunasekara Lab
- Janeway Society
- Neurology
Education & Training
- Research Scientist
- Yale University (2020)
- Associate Research Scientist
- Yale University (2019)
- Postdoctoral Associate
- Yale University (2018)
- PhD
- Iowa State University, Organic Chemistry (2016)
- Research Assistant
- Iowa State University (2016)
- Teaching Assistant
- Iowa State University (2015)
- Teaching Assistant
- University of Peradeniya (2011)
- BSc (Hon)
- University of Peradeniya, Chemistry (2010)
Research
Research at a Glance
Yale Co-Authors
Frequent collaborators of Roshan Gunasekara's published research.
Publications Timeline
A big-picture view of Roshan Gunasekara's research output by year.
Frederic Pincet, PhD
Sathish Ramakrishnan, PhD
Themis Kyriakides, PhD
11Publications
284Citations
Publications
2024
Photosensitive Nanoprobes for Rapid High Purity Isolation and Size‐Specific Enrichment of Synthetic and Extracellular Vesicle Subpopulations
Weerakkody J, Tseng T, Topper M, Thoduvayil S, Radhakrishnan A, Pincet F, Kyriakides T, Gunasekara R, Ramakrishnan S. Photosensitive Nanoprobes for Rapid High Purity Isolation and Size‐Specific Enrichment of Synthetic and Extracellular Vesicle Subpopulations. Advanced Functional Materials 2024 DOI: 10.1002/adfm.202400390.Peer-Reviewed Original ResearchCitationsAltmetricConceptsExtracellular vesicle subpopulationsVesicle subpopulationsIsolation of vesiclesPurity extracellular vesiclesRelease of vesiclesAnalysis of nucleic acidsNear-native formLarge-scale isolationLipid nanoprobesDownstream analysisPurity isolationEfficient isolationVesiclesSynthetic vesiclesNucleic acidsExtracellular vesiclesIsolation methodIsolatesBiomarker discoveryExposure to lightSubpopulationsEnrichmentProteinComplex biological mediaCleavage
2019
Recognition and protection of glycosphingolipids by synthetic nanoparticle receptors
Gunasekara RW, Zhao Y. Recognition and protection of glycosphingolipids by synthetic nanoparticle receptors. Chemical Communications 2019, 55: 4773-4776. PMID: 30946397, PMCID: PMC7474536, DOI: 10.1039/c9cc01694e.Peer-Reviewed Original ResearchCitationsAltmetric
2017
Intrinsic Hydrophobicity versus Intraguest Interactions in Hydrophobically Driven Molecular Recognition in Water
Gunasekara RW, Zhao Y. Intrinsic Hydrophobicity versus Intraguest Interactions in Hydrophobically Driven Molecular Recognition in Water. Organic Letters 2017, 19: 4159-4162. PMID: 28753291, DOI: 10.1021/acs.orglett.7b01535.Peer-Reviewed Original ResearchCitationsCorrection to “A General Method for Selective Recognition of Monosaccharides and Oligosaccharides in Water”
Gunasekara R, Zhao Y. Correction to “A General Method for Selective Recognition of Monosaccharides and Oligosaccharides in Water”. Journal Of The American Chemical Society 2017, 139: 2530-2530. PMID: 28145116, DOI: 10.1021/jacs.7b00661.Peer-Reviewed Original ResearchCitationsSequence-Selective Binding of Oligopeptides in Water through Hydrophobic Coding
Awino JK, Gunasekara RW, Zhao Y. Sequence-Selective Binding of Oligopeptides in Water through Hydrophobic Coding. Journal Of The American Chemical Society 2017, 139: 2188-2191. PMID: 28128940, PMCID: PMC5310974, DOI: 10.1021/jacs.6b12949.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsA General Method for Selective Recognition of Monosaccharides and Oligosaccharides in Water
Gunasekara RW, Zhao Y. A General Method for Selective Recognition of Monosaccharides and Oligosaccharides in Water. Journal Of The American Chemical Society 2017, 139: 829-835. PMID: 27983819, PMCID: PMC5243169, DOI: 10.1021/jacs.6b10773.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsCross-linked micellesMonosaccharide building blocksAdditional functional groupsEnhanced hydrophobic interactionCovalent imprintingNanoparticle receptorsFunctional monomerSynthetic receptorsExcellent selectivitySelective recognitionMolecular recognitionImportant hexosesFunctional groupsD-aldohexosesHydrophobic interactionsChain lengthStrong bindingGlycosidic linkagesBuilding blocksDiolBinding affinitiesNanoparticlesOligosaccharidesMicellesCisBinding a Specific Peptide in Those Dimples
Joseph K. Awino, Roshan W. Gunasekara, and Yan Zhao J. Am. Chem. Soc., 2017, 139 (7), 2531–2531Peer-Reviewed Original Research
2016
Selective Recognition of d‑Aldohexoses in Water by Boronic Acid-Functionalized, Molecularly Imprinted Cross-Linked Micelles
Awino JK, Gunasekara RW, Zhao Y. Selective Recognition of d‑Aldohexoses in Water by Boronic Acid-Functionalized, Molecularly Imprinted Cross-Linked Micelles. Journal Of The American Chemical Society 2016, 138: 9759-9762. PMID: 27442012, PMCID: PMC4982515, DOI: 10.1021/jacs.6b04613.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsEnhancing binding affinity and selectivity through preorganization and cooperative enhancement of the receptor
Gunasekara RW, Zhao Y. Enhancing binding affinity and selectivity through preorganization and cooperative enhancement of the receptor. Chemical Communications 2016, 52: 4345-4348. PMID: 26923346, DOI: 10.1039/c5cc10405j.Peer-Reviewed Original ResearchCitations
2015
Conformationally Switchable Water-Soluble Fluorescent Bischolate Foldamers as Membrane-Curvature Sensors
Gunasekara RW, Zhao Y. Conformationally Switchable Water-Soluble Fluorescent Bischolate Foldamers as Membrane-Curvature Sensors. Langmuir 2015, 31: 3919-3925. PMID: 25782344, DOI: 10.1021/acs.langmuir.5b00379.Peer-Reviewed Original ResearchCitationsMeSH Keywords and ConceptsConceptsMembrane curvature sensorMembrane curvatureIonic natureProtein-derived peptidesCellular movementLipid membranesVesicle fusionOnly proteinBiological processesAnionic lipidsΑ-faceSensitive fluorophoreFluorescent labelsFoldamersLipid compositionNBD groupAmount of cholesterolMembraneFluorophoresBuddingProteinSensorsBindingCholateAnalogues
Academic Achievements and Community Involvement
honor Yale Center for Clinical Investigation Award
Yale School of Medicine AwardYale UniversityDetails12/02/2019United Stateshonor The Alpha Chi Sigma Research Award
National AwardIowa State UniversityDetails03/16/2016United Stateshonor Graduate Research Symposium Award
National AwardAmerican Chemical SocietyDetails07/23/2015United Stateshonor Frank J. Moore and Thoreen Beth Moore Fellowship Award
National AwardIowa State UniversityDetails04/15/2015United States
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Locations
Neurology
Academic Office
300 George Street
New Haven, CT 06511