Lab Members

  • Jaime Grutzendler

    Dr. Harry M. Zimmerman and Dr. Nicholas and Viola Spinelli Professor of Neurology and Neuroscience; Director, Center for Experimental Neuroimaging

    Dr. Grutzendler obtained his MD at Universidad Javeriana in Bogota, Colombia where he was born and raised. He completed a medical internship in Internal Medicine and a residency in Neurology at Washington University/Barnes-Jewish Hospital in St. Louis. This was followed by a combined clinical and research fellowship in the Alzheimer Disease Research Center and the Department of Neurobiology at Washington University and further neurobiology research training at the Skirball Institute of New York University. Dr. Grutzendler's clinical interests focus on neurodegenerative disorders with special emphasis in dementias such as Alzheimer's disease. He also leads a research laboratory focused on understanding brain function and the cellular basis of neurological diseases. His lab uses advanced microscopy to visualize neurons, endothelium, astrocytes, pericytes, microglia and oligodendrocytes in living animals with the goal of exploring their dynamic behavior and learning how cell-cell interactions develop. He aims to understand how these interactions are disrupted in disease states such as in Alzheimer's disease, stroke and demyelination with the ultimate goal of designing new therapies for these conditions.

  • Alice Ma Li

    MD/PhD student

    Publications

    • Li AM, Martins J, Tovmasyan A, Valentine JS, Batinic-Haberle I, Spasojevic I, Gralla EB. Differential localization and potency of manganese porphyrin superoxide dismutase-mimicking compounds in Saccharomyces cerevisiae. Redox Biology. (3):1-6.
    • Reyes-Lamothe R, Tran T, Meas D, Lee L, Li AM, Sherratt DJ, Tolmasky ME. High-copy bacterial plasmids diffuse in the nucleoid-free space, replicate stochastically and are randomly partitioned at cell division. Nucleic Acids Res. 2014 Jan;42(2):1042-51.
    • Mineur YS, Obayemi A, Wigestrand MB, Fote GM, Calarco CA, Li AM, Picciotto MR. Cholinergic signaling in the hippocampus regulates social stress resilience and anxiety- and depression-like behavior. Proc Natl Acad Sci U S A. 2013 Feb 26;110(9):3573-8.
    • Rajic Z, Tovmasyan A, Spasojevic I, Sheng H, Lu M, Li AM, Gralla EB, Warner DS, Benov L, Batinic-Haberle I. A new SOD mimic, Mn(III) ortho N-butoxyethylpyridylporphyrin, combines superb potency and lipophilicity with low toxicity. Free Radic Biol Med. 2012 May 1;52(9):1828-34.