Recent Publications

• Ataxin-2 polyglutamine expansions aberrantly sequester TDP-43 ribonucleoprotein condensates disrupting mRNA transport and local translation in neurons.Wijegunawardana D, Nayak A, Vishal SS, Venkatesh N, Gopal PP. Dev Cell. 2025 Jan 20; 2024 Oct 16. PMID: 39419034.
• Single-cell transcriptomic and proteomic analysis of Parkinson's disease brains.Zhu B, Park JM, Coffey SR, Russo A, Hsu IU, Wang J, Su C, Chang R, Lam TT, Gopal PP, Ginsberg SD, Zhao H, Hafler DA, Chandra SS, Zhang L. Sci Transl Med. 2024 Oct 30; 2024 Oct 30. PMID: 39475571.
• Rational Design of TDP-43 Derived α-Helical Peptide Inhibitors: An In Silico Strategy to Prevent TDP-43 Aggregation in Neurodegenerative Disorders.Salaikumaran MR, Gopal PP. ACS Chem Neurosci. 2024 Mar 20; 2024 Mar 11. PMID: 38466778.
• Rational Design of TDP-43 Derived α-Helical Peptide Inhibitors: an In-Silico Strategy to Prevent TDP-43 Aggregation in Neurodegenerative Disorders.Salaikumaran MR, Gopal PP. bioRxiv. 2023 Oct 31; 2023 Oct 31. PMID: 37961353.
• Phase separation and pathologic transitions of RNP condensates in neurons: implications for amyotrophic lateral sclerosis, frontotemporal dementia and other neurodegenerative disorders.Naskar A, Nayak A, Salaikumaran MR, Vishal SS, Gopal PP. Front Mol Neurosci. 2023; 2023 Sep 1. PMID: 37720552.
• Clinical utility of whole-genome DNA methylation profiling as a primary molecular diagnostic assay for central nervous system tumors-A prospective study and guidelines for clinical testing.Galbraith K, Vasudevaraja V, Serrano J, Shen G, Tran I, Abdallat N, Wen M, Patel S, Movahed-Ezazi M, Faustin A, Spino-Keeton M, Roberts LG, Maloku E, Drexler SA, Liechty BL, Pisapia D, Krasnozhen-Ratush O, Rosenblum M, Shroff S, Boué DR, Davidson C, Mao Q, Suchi M, North P, Hopp A, Segura A, Jarzembowski JA, Parsons L, Johnson MD, Mobley B, Samore W, McGuone D, Gopal PP, Canoll PD, Horbinski C, Fullmer JM, Farooqui MS, Gokden M, Wadhwani NR, Richardson TE, Umphlett M, Tsankova NM, DeWitt JC, Sen C, Placantonakis DG, Pacione D, Wisoff JH, Teresa Hidalgo E, Harter D, William CM, Cordova C, Kurz SC, Barbaro M, Orringer DA, Karajannis MA, Sulman EP, Gardner SL, Zagzag D, Tsirigos A, Allen JC, Golfinos JG, Snuderl M. Neurooncol Adv. 2023 Jan-Dec; 2023 Jun 26. PMID: 37476329.
• Single-cell transcriptomic atlas of Alzheimer's disease middle temporal gyrus reveals region, cell type and sex specificity of gene expression with novel genetic risk for MERTK in female.Zhang L, He CH, Coffey S, Yin D, Hsu IU, Su C, Ye Y, Zhang C, Spurrier J, Nicholson L, Rothlin CV, Ghosh S, Gopal PP, Hafler DA, Zhao H, Strittmatter SM. medRxiv. 2023 Feb 23; 2023 Feb 23. PMID: 36865305.
• Ataxin-2 polyglutamine expansions aberrantly sequester TDP-43, drive ribonucleoprotein condensate transport dysfunction and suppress local translation.Wijegunawardana D, Vishal SS, Venkatesh N, Gopal PP. bioRxiv. 2023 Feb 15; 2023 Feb 15. PMID: 36778347.
• Epstein-Barr virus-associated primary intracranial leiomyosarcoma in an immunocompetent patient: illustrative case.Tabor JK, Lei H, Morales-Valero SF, O'Brien J, Gopal PP, Erson-Omay EZ, Fulbright RK, Moliterno J. J Neurosurg Case Lessons. 2023 Jan 23; 2023 Jan 23. PMID: 36692065.
• Sequence Determinants of TDP-43 Ribonucleoprotein Condensate Formation and Axonal Transport in Neurons.Vishal SS, Wijegunawardana D, Salaikumaran MR, Gopal PP. Front Cell Dev Biol. 2022; 2022 May 12. PMID: 35646935.
• Comprehensive Genomic Characterization of A Case of Granular Cell Tumor of the Posterior Pituitary Gland: A Case Report.Hong CS, Elsamadicy AA, Fisayo A, Inzucchi SE, Gopal PP, Vining EM, Erson-Omay EZ, Bulent Omay S. Front Endocrinol (Lausanne). 2021; 2021 Dec 1. PMID: 34925233.
• RNA-binding proteins in neurological development and disease.Prashad S, Gopal PP. RNA Biol. 2021 Jul; 2020 Aug 30. PMID: 32865115.
• Genetic characterization of an aggressive optic nerve pilocytic glioma.Hong CS, Fliney G, Fisayo A, An Y, Gopal PP, Omuro A, Pointdujour-Lim R, Erson-Omay EZ, Omay SB. Brain Tumor Pathol. 2021 Jan; 2020 Oct 24. PMID: 33098465.
• Novel EWSR1-VGLL1 fusion in a pediatric neuroepithelial neoplasm.Kundishora AJ, Reeves BC, Nelson-Williams C, Hong CS, Gopal PP, Snuderl M, Kahle KT, Erson-Omay EZ. Clin Genet. 2020 May; 2020 Jan 16. PMID: 31925773.
• Expression of WIPI2B counteracts age-related decline in autophagosome biogenesis in neurons.Stavoe AK, Gopal PP, Gubas A, Tooze SA, Holzbaur EL. Elife. 2019 Jul 16; 2019 Jul 16. PMID: 31309927.
• Dural Arteriovenous Fistula Associated With a Vestibular Tumor: An Unusual Case and Review of the Literature.Kritikos ME, Oselkin M, Sharma N, Gopal PP, Bigelow DC, Grady S, Hurst RW, Pukenas BA, Choudhri O, Kung D. Cureus. 2018 Jun 27; 2018 Jun 27. PMID: 30159216.
• Commentary: Pitfalls in the Neuroimaging of Glioblastoma in the Era of Antiangiogenic and Immuno/Targeted Therapy.Skolnik AD, Wang S, Gopal PP, Mohan S. Front Neurol. 2018; 2018 Feb 5. PMID: 29459848.
• Amyotrophic lateral sclerosis-linked mutations increase the viscosity of liquid-like TDP-43 RNP granules in neurons.Gopal PP, Nirschl JJ, Klinman E, Holzbaur EL. Proc Natl Acad Sci U S A. 2017 Mar 21; 2017 Mar 6. PMID: 28265061.
• MicroRNA-124 expression counteracts pro-survival stress responses in glioblastoma.Mucaj V, Lee SS, Skuli N, Giannoukos DN, Qiu B, Eisinger-Mathason TS, Nakazawa MS, Shay JE, Gopal PP, Venneti S, Lal P, Minn AJ, Simon MC, Mathew LK. Oncogene. 2015 Apr 23; 2014 Jun 23. PMID: 24954504.
• Systemic inflammatory pseudotumor and myasthenia gravis.Levin MH, Gopal PP, Galetta SL. JAMA Ophthalmol. 2014 Mar. PMID: 24626829.
• Advanced neuroimaging findings of pseudotumoral hemicerebellitis in an elderly male requiring surgical decompression.Gupta R, Maralani PJ, Chawla S, Gopal PP, Mohan S. J Neurosurg. 2014 Feb; 2013 Dec 13. PMID: 24329022.
• The variable presentations of anaplastic spindle cell squamous carcinoma associated with tall cell variant of papillary thyroid carcinoma.Gopal PP, Montone KT, Baloch Z, Tuluc M, LiVolsi V. Thyroid. 2011 May; 2011 Feb 10. PMID: 21309723.
• Leading process branch instability in Lis1+/- nonradially migrating interneurons.Gopal PP, Simonet JC, Shapiro W, Golden JA. Cereb Cortex. 2010 Jun; 2009 Oct 27. PMID: 19861636.
• Pax6-/- mice have a cell nonautonomous defect in nonradial interneuron migration.Gopal PP, Golden JA. Cereb Cortex. 2008 Apr; 2007 Jul 18. PMID: 17634386.
• Axon mediated interneuron migration.McManus MF, Nasrallah IM, Gopal PP, Baek WS, Golden JA. J Neuropathol Exp Neurol. 2004 Sep. PMID: 15453092.