2024
Stability and Reliability of Repeated Plasma Pregnenolone Levels After Oral Pregnenolone Dosing in Individuals with Cocaine Use Disorder: Pilot Findings
Gao H, Magin Z, Fogelman N, Sinha R, Angarita G, Milivojevic V. Stability and Reliability of Repeated Plasma Pregnenolone Levels After Oral Pregnenolone Dosing in Individuals with Cocaine Use Disorder: Pilot Findings. Life 2024, 14: 1483. PMID: 39598281, PMCID: PMC11595496, DOI: 10.3390/life14111483.Peer-Reviewed Original ResearchCocaine use disorderSubstance use disordersUse disorderPregnenolone levelsTreatment of cocaine use disorderReduce alcohol cravingTreatment-seeking individualsAssociated across timeAdministration of pregnenoloneEight-week trialSignificant main effectAlcohol cravingPregnenolone administrationNegative health risksDouble-blind clinical trialMain effectPilot findingsLevels of pregnenoloneChronic dosingStudy medication doseMedication dosesDisordersCocainePilot studyStress biologyMindfulness-based therapy for insomnia in Black women: a pilot randomized controlled trial
Nam S, Jeon S, Ordway M, Mazure C, Sinha R, Yau L, Iennaco J. Mindfulness-based therapy for insomnia in Black women: a pilot randomized controlled trial. Journal Of Behavioral Medicine 2024, 47: 1094-1106. PMID: 39306634, DOI: 10.1007/s10865-024-00521-2.Peer-Reviewed Original ResearchPatient Health Questionnaire-9Spielberger State-Trait Anxiety InventoryInsomnia Severity IndexHealth educationMindfulness-based therapyBlack womenDepressive symptomsEfficacy of mindfulness-based therapyAttention control groupSleep health disparitiesPost-intervention changesState-Trait Anxiety InventoryPittsburgh Sleep Quality IndexInsomnia severity scoresSleep Quality IndexInsomnia Severity Index scoreBehavioral sleep strategiesRandomized controlled trialsClinically significant improvementPhysical activityHealth disparitiesHealthy eatingSleep hygiene practicesImprove anxietyWeekly sessionsNetwork state dynamics underpin basal craving in a transdiagnostic population
Ye J, Garrison K, Lacadie C, Potenza M, Sinha R, Goldfarb E, Scheinost D. Network state dynamics underpin basal craving in a transdiagnostic population. Molecular Psychiatry 2024, 1-10. PMID: 39183336, DOI: 10.1038/s41380-024-02708-0.Peer-Reviewed Original ResearchConnectome-based predictive modelingBrain responsesRegulation of affective statesSample of healthy controlsTransdiagnostic populationTransdiagnostic sampleHigher cravingMotivational stateCravingFMRI methodsAffective statesScan runsExperimental stimuliNetwork engagementBrain dynamicsClinical implicationsHealthy controlsBrainIndividual variationState dynamicsCharacterize individualsReplication datasetPsychopathologyFMRIEngagementStress and substance use disorders: risk, relapse, and treatment outcomes
Sinha R. Stress and substance use disorders: risk, relapse, and treatment outcomes. Journal Of Clinical Investigation 2024, 134: e172883. PMID: 39145454, PMCID: PMC11324296, DOI: 10.1172/jci172883.Peer-Reviewed Original ResearchConceptsSubstance use disordersDrug-related environmentPathophysiology of addictionAdaptive stress responseSUD treatment outcomesAssociated with substance misuseTreatment outcomesStress-related alterationsDrug motivationIncreased cravingNeurobiological disruptionsMaladaptive copingRepeated stressorsTreatment implicationsSubstance misuseStress pathophysiologyStress responseDrug intakeDrug withdrawalRelapse riskDrug misuseIntervention developmentDisordersCravingRelapseDrawbacks to Strengthening Neural Salience Encoding: A Link Between Cortisol and Risky Drinking
Harris B, Sinha R, Goldfarb E. Drawbacks to Strengthening Neural Salience Encoding: A Link Between Cortisol and Risky Drinking. Journal Of Neuroscience 2024, 44: e1027242024. PMID: 39147591, PMCID: PMC11450530, DOI: 10.1523/jneurosci.1027-24.2024.Peer-Reviewed Original ResearchAlcohol motivationInfluence later behaviorEnhance memorySalience responseFemale social drinkersAlcohol drinkingEmotionally salient experiencesResponse to alcoholDouble-blind cross-over designMemory biasSalient memoriesAlcohol-related eventsRisky alcohol drinkingSocial drinkersMotivated behaviorMaladaptive consequencesLateral behaviorCross-over designRisky drinkingMemoryRodent modelsHuman researchSalienceRisky drinkersCortisolSex differences in binge drinking-related higher morning cortisol levels and in prospective association with future alcohol intake
McGowan C, Krah M, Fogelman N, Seo D, Sinha R. Sex differences in binge drinking-related higher morning cortisol levels and in prospective association with future alcohol intake. Alcohol And Alcoholism 2024, 59: agae047. PMID: 39053499, DOI: 10.1093/alcalc/agae047.Peer-Reviewed Original ResearchConceptsMorning cortisol levelsCortisol levelsHigher morning cortisol levelsHypothalamic-pituitary-adrenal (HPA) axisSex differencesReports of alcohol consumptionProblematic drinking behaviorAlcohol consumptionAverage cortisol levelsBasal cortisol levelsAlcohol intakeHeavy alcohol useChronic alcohol consumptionHPA axisDrinking behaviorNeuroimaging scansPeripheral cortisolAlcohol useStress systemBinge drinkingMorning cortisolStress hormonesMorning plasma cortisolBingeNon-significant relationshipS143 Traumatic Events, Chronic Pain, and Multiple Substance Use in Women With Poly-Substance Use Disorder
Fogelman N, Tate M, Wemm S, Vacey E, Bera S, Hermes G, Swain J, Fox H, Sinha R. S143 Traumatic Events, Chronic Pain, and Multiple Substance Use in Women With Poly-Substance Use Disorder. Drug And Alcohol Dependence 2024, 260: 110254. DOI: 10.1016/j.drugalcdep.2023.110254.Peer-Reviewed Original ResearchM68 Individuals With Cannabis Use Disorder Display Altered Parasympathetic HRV During Waking and Sleeping Hours Relative to Light Cannabis Users
Pearlman M, Wemm S, Pearlman M, Liston J, Sinha R. M68 Individuals With Cannabis Use Disorder Display Altered Parasympathetic HRV During Waking and Sleeping Hours Relative to Light Cannabis Users. Drug And Alcohol Dependence 2024, 260: 110348. DOI: 10.1016/j.drugalcdep.2023.110348.Peer-Reviewed Original ResearchM75 Co-Occurrence of Cannabis Use and Cigarette Smoking Accelerates Epigenetic Age
Bradley B, Cheng Y, Liang X, Sinha R, Xu K. M75 Co-Occurrence of Cannabis Use and Cigarette Smoking Accelerates Epigenetic Age. Drug And Alcohol Dependence 2024, 260: 110355. DOI: 10.1016/j.drugalcdep.2023.110355.Peer-Reviewed Original ResearchLow‐calorie diet‐induced weight loss is associated with altered brain connectivity and food desire in obesity
Hoang H, Lacadie C, Hwang J, Lam K, Elshafie A, Rosenberg S, Watt C, Sinha R, Constable R, Savoye M, Seo D, Belfort‐DeAguiar R. Low‐calorie diet‐induced weight loss is associated with altered brain connectivity and food desire in obesity. Obesity 2024, 32: 1362-1372. PMID: 38831482, PMCID: PMC11211061, DOI: 10.1002/oby.24046.Peer-Reviewed Original ResearchFunctional magnetic resonance imagingIntrinsic connectivity distributionDiet-induced weight lossBrain connectivityAssociated with altered brain connectivityLow-calorie dietEating behavior changesShort-term low-calorie dietRight hippocampusTemporal cortexBrain networksWeight lossBrain clustersEffects of diet-induced weight lossGroup differencesFood desireGlucose levelsDiagnosis of type 2 diabetesBehavioral changesMagnetic resonance imagingType 2 diabetesBrainLeptin levelsFood intakeResonance imagingBrain correlates and functional connectivity linking stress, autonomic dysregulation, and alcohol motivation
Seo D, Martins J, Sinha R. Brain correlates and functional connectivity linking stress, autonomic dysregulation, and alcohol motivation. Neurobiology Of Stress 2024, 31: 100645. PMID: 38933283, PMCID: PMC11201348, DOI: 10.1016/j.ynstr.2024.100645.Peer-Reviewed Original ResearchAutonomic nervous system disruptionAlcohol use disorderFunctional magnetic resonance imagingHigh-risk drinkingSocial drinkersFunctional connectivityLow-risk drinkingAlcohol motivationAutonomic arousalDevelopment of alcohol use disordersNeural correlates of stressNon-dependent social drinkersWhole-brain correlation analysesResponse to stress exposureAlcohol taste testFrontal-striatal regionsStress-induced cravingVentromedial prefrontal cortexBehaviors associated with stressAnterior cingulate cortexDecreased functional connectivityExposure to stressAutonomic nervous systemAlcohol intakeHazardous alcohol useChildhood adversity, accelerated GrimAge, and associated health consequences
Harvanek Z, Kudinova A, Wong S, Xu K, Brick L, Daniels T, Marsit C, Burt A, Sinha R, Tyrka A. Childhood adversity, accelerated GrimAge, and associated health consequences. Journal Of Behavioral Medicine 2024, 47: 913-926. PMID: 38762606, PMCID: PMC11365810, DOI: 10.1007/s10865-024-00496-0.Peer-Reviewed Original ResearchBody mass indexChildhood Trauma QuestionnaireGrimAge accelerationEarly life stressChildhood adversityAssociated with higher body mass indexCross-sectional cohort of adultsMetabolic healthEffect of body mass indexHigher body mass indexPhysical health problemsLife stressCohort of adultsAssociated health consequencesEffects of early life stressMetabolic health effectsModerating effect of body mass indexChildhood Trauma Questionnaire subscalesCross-sectional cohortCardiometabolic healthAccelerated GrimAgeCardiometabolic diseasesMedical illnessHealth consequencesMass indexGreater Stress and Trauma Mediate Race-Related Differences in Epigenetic Age Between Black and White Young Adults in a Community Sample
Holloway T, Harvanek Z, Xu K, Gordon D, Sinha R. Greater Stress and Trauma Mediate Race-Related Differences in Epigenetic Age Between Black and White Young Adults in a Community Sample. Biological Psychiatry 2024, 95: s41. DOI: 10.1016/j.biopsych.2024.02.104.Peer-Reviewed Original Research353. Methylation of CRHR1 and CRHR2 is Associated With Lifetime Adversity, HPA-Axis Signaling Changes, and Obesity
Harvanek Z, Zhang X, Xu K, Sinha R. 353. Methylation of CRHR1 and CRHR2 is Associated With Lifetime Adversity, HPA-Axis Signaling Changes, and Obesity. Biological Psychiatry 2024, 95: s244. DOI: 10.1016/j.biopsych.2024.02.852.Peer-Reviewed Original ResearchEvidence that personalized racial stress procedures elicit a stress response and increases alcohol craving among Black adults with alcohol use disorder: A laboratory pilot study
Haeny A, Schick M, McKenley C, Chowdhary A, Bellamy C, O'Malley S, Sinha R. Evidence that personalized racial stress procedures elicit a stress response and increases alcohol craving among Black adults with alcohol use disorder: A laboratory pilot study. Drug And Alcohol Dependence 2024, 260: 111312. PMID: 38749311, DOI: 10.1016/j.drugalcdep.2024.111312.Peer-Reviewed Original ResearchAlcohol use disorderAlcohol cravingIncreased alcohol cravingUse disorderRacial stressEmotional responsesImpact of racial stressBlack adultsExposure to stressStress scriptsImagery procedureExposure sessionsCravingPersonal eventsStress procedureNegative emotionsNeutral conditionsPositive emotionsIdentity explorationStress responseExploratory analysisPhysiological responsesSessionsEmotionsAlcoholParent Stress and Observed Parenting in a Parent-Child Interaction Task in a Predominantly Minority and Low-Income Sample.
Barreto S, Wang S, Guarnaccia U, Fogelman N, Sinha R, Chaplin T. Parent Stress and Observed Parenting in a Parent-Child Interaction Task in a Predominantly Minority and Low-Income Sample. Archives Of Pediatrics 2024, 9 PMID: 38939555, PMCID: PMC11209751, DOI: 10.29011/2575-825x.100308.Peer-Reviewed Original ResearchLow-income samplePerceived life stressLife stressParents of young childrenParenting behaviorsParenting stressParent-child interaction taskEffects of life stressYoung childrenInteraction tasksNegative parenting behaviorsParenting Stress InventoryParenting-related stressPositive parenting behaviorsParent-child interactionsPerceived Stress ScaleLife stress scoresPsychopathological riskLow-income parentsNegative affectNegative parentingObserved parentingStress InventoryBlinded ratersStressed parentsNeural Correlates of Stress and Alcohol Cue-Induced Alcohol Craving and of Future Heavy Drinking: Evidence of Sex Differences
Radoman M, Fogelman N, Lacadie C, Seo D, Sinha R. Neural Correlates of Stress and Alcohol Cue-Induced Alcohol Craving and of Future Heavy Drinking: Evidence of Sex Differences. American Journal Of Psychiatry 2024, 181: 412-422. PMID: 38706332, PMCID: PMC11117176, DOI: 10.1176/appi.ajp.20230849.Peer-Reviewed Original ResearchConceptsAlcohol use disorderPercentage of heavy drinking daysNeural correlates of stressCue-induced cravingHeavy drinking daysAlcohol cravingSex differencesCorrelates of stressDrinking daysAlcohol cue-induced cravingCue-induced alcohol cravingBed nucleus of the stria terminalisSubgenual anterior cingulate cortexAssessment of alcohol cravingHeavy drinkingAlcohol cue reactivityAssociated with poor treatment outcomesCue-induced responsesNeutral cue exposureAssociated with hypoactivationTreatment-seeking adultsHeavy drinking outcomesEvidence of sex differencesVoxel-based regression analysisAnterior cingulate cortexSubstance use patterns, quantities, and associated risk factors in women with polysubstance misuse
Fogelman N, Tate M, Wemm S, Sullivan L, Hart R, Vacey E, Fox H, Sinha R. Substance use patterns, quantities, and associated risk factors in women with polysubstance misuse. Addiction Biology 2024, 29: 10.1111/adb.13390. PMID: 38619491, PMCID: PMC11017971, DOI: 10.1111/adb.13390.Peer-Reviewed Original ResearchConceptsPolysubstance useDepressive symptomsSubstance use patternsDrug cravingRisk factorsPatterns of polysubstance useSingle substance useAssociated with polysubstance usePlacebo-controlled studyHigher cravingGuanfacine treatmentCross-sectional observational studyPolysubstance use patternsCraving managementLife eventsCravingPolysubstance misuseSubstance useOpioid amountsPain ratingsStress/traumaObservational studyAnxietyPainPolysubstanceEffects of prazosin treatment on liver enzymes are moderated by alcohol withdrawal symptoms in individuals with alcohol use disorder
Martins B, Fogelman N, Tate M, Hermes G, Sinha R. Effects of prazosin treatment on liver enzymes are moderated by alcohol withdrawal symptoms in individuals with alcohol use disorder. Alcohol Clinical And Experimental Research 2024, 48: 507-515. PMID: 38258493, PMCID: PMC10939766, DOI: 10.1111/acer.15263.Peer-Reviewed Original ResearchAlcohol withdrawal symptomsAlcohol use disorderEffect of prazosin treatmentWithdrawal symptomsPrazosin treatmentLiver enzyme levelsLiver enzymesAlanine transaminasePrazosin groupAlcohol drinking outcomesAspartate transaminaseGamma-glutamyltransferaseSeverity of AWSLiver enzymes alanine transaminaseWithdrawal severityDrinking outcomesElevated liver enzymesAUD treatmentTreatment effectsAmount of alcoholSignificant liver pathologyGamma-glutamyltransferase levelsEnzyme levelsRandomized controlled trialsDisordered background
2023
Cumulative adversity and emotion dysregulation effects on suicidal ideation and attempts in a community sample
Tate M, Sinha R, Wemm S. Cumulative adversity and emotion dysregulation effects on suicidal ideation and attempts in a community sample. Journal Of Psychiatric Research 2023, 170: 277-282. PMID: 38183699, DOI: 10.1016/j.jpsychires.2023.12.029.Peer-Reviewed Original ResearchEmotion dysregulationCumulative adversityCommunity adultsLifetime traumaLife eventsSuicidal ideationNonacceptance of emotionsHigher emotion dysregulationSuicide attemptsHighest cumulative stressMajor life eventsConcurrent suicidal ideationRecent life eventsTraumatic eventsDifficult emotionsEmotional responsesLife traumaCommunity sampleTrauma historyAdversityChronic stressorsNonacceptanceSuicidal thoughtsCumulative stressEmotions