2024
S143 Traumatic Events, Chronic Pain, and Multiple Substance Use in Women With Poly-Substance Use Disorder
Fogelman N, Tate M, Wemm S, Vacey E, Bera S, Hermes G, Swain J, Fox H, Sinha R. S143 Traumatic Events, Chronic Pain, and Multiple Substance Use in Women With Poly-Substance Use Disorder. Drug And Alcohol Dependence 2024, 260: 110254. DOI: 10.1016/j.drugalcdep.2023.110254.Peer-Reviewed Original ResearchSubstance use patterns, quantities, and associated risk factors in women with polysubstance misuse
Fogelman N, Tate M, Wemm S, Sullivan L, Hart R, Vacey E, Fox H, Sinha R. Substance use patterns, quantities, and associated risk factors in women with polysubstance misuse. Addiction Biology 2024, 29: 10.1111/adb.13390. PMID: 38619491, PMCID: PMC11017971, DOI: 10.1111/adb.13390.Peer-Reviewed Original ResearchConceptsPolysubstance useDepressive symptomsSubstance use patternsDrug cravingRisk factorsPatterns of polysubstance useSingle substance useAssociated with polysubstance usePlacebo-controlled studyHigher cravingGuanfacine treatmentCross-sectional observational studyPolysubstance use patternsCraving managementLife eventsCravingPolysubstance misuseSubstance useOpioid amountsPain ratingsStress/traumaObservational studyAnxietyPainPolysubstance
2023
Chronic pain, chronic stress and substance use: overlapping mechanisms and implications
Schaffer J, Fogelman N, Seo D, Sinha R. Chronic pain, chronic stress and substance use: overlapping mechanisms and implications. Frontiers In Pain Research 2023, 4: 1145934. PMID: 37415830, PMCID: PMC10320206, DOI: 10.3389/fpain.2023.1145934.Peer-Reviewed Original ResearchChronic painChronic stressSubstance useSubstance misuseCommon reasons adultsCommon pathophysiologic processChronic pain pathologiesMedial prefrontal circuitsPrefrontal cortex dysfunctionPrescription opioidsPain pathologiesPathophysiologic processesPainBrain areasBiologic underpinningsMedical careReasons adultsEnormous burdenNeural circuitryPrefrontal circuitsVentromedial prefrontal cortex dysfunctionPsychobiological processesIndividual wellnessWellnessRiskRegular cannabis use is associated with history of childhood and lifetime trauma in a non-clinical community sample
Bassir Nia A, Weleff J, Fogelman N, Nourbakhsh S, Sinha R. Regular cannabis use is associated with history of childhood and lifetime trauma in a non-clinical community sample. Journal Of Psychiatric Research 2023, 159: 159-164. PMID: 36736285, PMCID: PMC10024801, DOI: 10.1016/j.jpsychires.2023.01.036.Peer-Reviewed Original ResearchConceptsMajor life eventsChildhood traumaLife eventsChildhood Trauma QuestionnaireLifetime traumaCannabis useNon-clinical community sampleChronic stressNeurobiology of stressRegular cannabis useGender differencesRegular useSelf-report questionnairesRecent life eventsPotential gender differencesCross-sectional studyUrine drug testingLife traumaLogistic regression analysisAdversity indexCommunity sampleCannabis usersTrauma QuestionnaireHigh rateSubstance use
2018
7 Stress System Sensitivity and Emotion Regulation in Early Abstinence from Substance Use Disorders—Targets for Medications Development
Fox H, Milivojevic V, Blaine S, Sinha R. 7 Stress System Sensitivity and Emotion Regulation in Early Abstinence from Substance Use Disorders—Targets for Medications Development. 2018, 120-141. DOI: 10.1016/b978-0-12-813693-5.00007-1.Peer-Reviewed Original ResearchMedication developmentDrug useAlpha-2 adrenergic agonistsStress system dysregulationStress-induced cravingPreclinical dataSystem dysregulationAdrenergic agonistsDrug AdministrationEarly abstinenceBiobehavioral mechanismsBiobehavioral adaptationsDysphoric statesNovel targetSubstance useRelapseAbstinenceNew foodsSeries of studiesUrgent needMedicationsGuanfacineAgonistsHuman paradigm
2008
Chronic Stress, Drug Use, and Vulnerability to Addiction
Sinha R. Chronic Stress, Drug Use, and Vulnerability to Addiction. Annals Of The New York Academy Of Sciences 2008, 1141: 105-130. PMID: 18991954, PMCID: PMC2732004, DOI: 10.1196/annals.1441.030.Peer-Reviewed Original ResearchMeSH KeywordsArousalChronic DiseaseCorticotropin-Releasing HormoneDisease SusceptibilityEmotionsFemaleHumansHypothalamo-Hypophyseal SystemIllicit DrugsLimbic SystemMaleNeurotransmitter AgentsPituitary-Adrenal SystemRewardSelf MedicationStress, PhysiologicalStress, PsychologicalSubstance Withdrawal SyndromeSubstance-Related DisordersSympathetic Nervous SystemConceptsCompulsive drug seekingStress-related riskDevelopment of addictionChronic drug useEarly life stressMotivational systemsIndividual-level variablesRelapse susceptibilityRelapse vulnerabilityDrug seekingAutonomic arousalDrug useLife stressDrug-experienced animalsSpecific stressorsChild maltreatmentSubstance useMesolimbic dopamineStress exposureStress regulationAddictionChronic stressCentral noradrenergic systemNoradrenergic systemButyric acid pathway