2024
Stability and Reliability of Repeated Plasma Pregnenolone Levels After Oral Pregnenolone Dosing in Individuals with Cocaine Use Disorder: Pilot Findings
Gao H, Magin Z, Fogelman N, Sinha R, Angarita G, Milivojevic V. Stability and Reliability of Repeated Plasma Pregnenolone Levels After Oral Pregnenolone Dosing in Individuals with Cocaine Use Disorder: Pilot Findings. Life 2024, 14: 1483. PMID: 39598281, PMCID: PMC11595496, DOI: 10.3390/life14111483.Peer-Reviewed Original ResearchCocaine use disorderSubstance use disordersUse disorderPregnenolone levelsTreatment of cocaine use disorderReduce alcohol cravingTreatment-seeking individualsAssociated across timeAdministration of pregnenoloneEight-week trialSignificant main effectAlcohol cravingPregnenolone administrationNegative health risksDouble-blind clinical trialMain effectPilot findingsLevels of pregnenoloneChronic dosingStudy medication doseMedication dosesDisordersCocainePilot studyStress biology
2023
Laboratory and Real-World Experimental Approaches to Understanding Alcohol Relapse
Milivojevic V, Sinha R. Laboratory and Real-World Experimental Approaches to Understanding Alcohol Relapse. Current Topics In Behavioral Neurosciences 2023, 1-25. PMID: 37985542, DOI: 10.1007/7854_2023_456.Peer-Reviewed Original ResearchAlcohol use disorderUse disordersHuman laboratory proceduresHuman laboratory modelRelapse riskAlcohol cuesBiobehavioral markersPsychobiological mechanismsStress dysregulationChronic alcohol useAlcohol relapseAlcohol useEffective interventionsNovel interventionsStress biologyReal worldDisordersInterventionCuesSignificant implicationsSignificant treatment challengeHigher relapse riskAUDRisk factorsAdaptation