2013
Divergent neural substrates of inhibitory control in binge eating disorder relative to other manifestations of obesity
Balodis IM, Molina ND, Kober H, Worhunsky PD, White MA, Sinha R, Grilo CM, Potenza MN. Divergent neural substrates of inhibitory control in binge eating disorder relative to other manifestations of obesity. Obesity 2013, 21: 367-377. PMID: 23404820, PMCID: PMC3610836, DOI: 10.1002/oby.20068.Peer-Reviewed Original ResearchConceptsInferior frontal gyrusCognitive controlBED groupNeural correlatesStroop color-word interference taskColor-word interference taskRight inferior frontal gyrusVentromedial prefrontal cortexDivergent neural substratesFunctional magnetic resonanceInterference taskStroop performanceVmPFC activationDietary restraint scoresInhibitory processingDiminished abilityNeural substratesComparison participantsFrontal gyrusInhibitory controlBiobehavioral processesPrefrontal cortexDietary restraintBehavioral controlRelative hypoactivity
2011
Circulating glucose levels modulate neural control of desire for high-calorie foods in humans
Page KA, Seo D, Belfort-DeAguiar R, Lacadie C, Dzuira J, Naik S, Amarnath S, Constable RT, Sherwin RS, Sinha R. Circulating glucose levels modulate neural control of desire for high-calorie foods in humans. Journal Of Clinical Investigation 2011, 121: 4161-4169. PMID: 21926468, PMCID: PMC3195474, DOI: 10.1172/jci57873.Peer-Reviewed Original ResearchConceptsHigh-calorie foodsGlucose levelsHyperinsulinemic euglycemic-hypoglycemic clampsBrain regionsFunctional MRIMedial prefrontal cortexMedial prefrontal cortex activationRisk of overeatingLevels of glucosePostprandial reductionPrefrontal cortex activationObese subjectsNonobese individualsMild hypoglycemiaWorldwide epidemicCortex activationPrefrontal cortexFood cuesFood motivationFood stimuliNeural controlObesityInhibitory controlBehavioral measuresVisual cues
2007
Inhibitory control and emotional stress regulation: Neuroimaging evidence for frontal–limbic dysfunction in psycho-stimulant addiction
Li CS, Sinha R. Inhibitory control and emotional stress regulation: Neuroimaging evidence for frontal–limbic dysfunction in psycho-stimulant addiction. Neuroscience & Biobehavioral Reviews 2007, 32: 581-597. PMID: 18164058, PMCID: PMC2263143, DOI: 10.1016/j.neubiorev.2007.10.003.Peer-Reviewed Original ResearchConceptsInhibitory controlPrefrontal activityDrug seekingHabitual drug seekingCognitive inhibitory controlCompulsive drug seekingVentromedial prefrontal regionsFrontal-limbic dysfunctionStress-related cravingAnterior cingulate cortexStress regulationPsychological processesNeural underpinningsSalient stimuliStress processingPrefrontal regionsComponent processesStriatal responsesDrug use behaviorsCingulate cortexNeural systemsPsychostimulant dependenceUse behaviorsNeural pathwaysAddiction
2006
Imaging Response Inhibition in a Stop-Signal Task: Neural Correlates Independent of Signal Monitoring and Post-Response Processing
Li CS, Huang C, Constable RT, Sinha R. Imaging Response Inhibition in a Stop-Signal Task: Neural Correlates Independent of Signal Monitoring and Post-Response Processing. Journal Of Neuroscience 2006, 26: 186-192. PMID: 16399686, PMCID: PMC6674298, DOI: 10.1523/jneurosci.3741-05.2006.Peer-Reviewed Original ResearchConceptsStop-signal reaction timeStop-signal taskResponse inhibitionPre-potent response tendenciesReaction timeShorter stop-signal reaction timesEfficient response inhibitionFunctional magnetic resonanceLonger stop-signal reaction timesGroups of subjectsHigher cortical functionsError monitoringNeural correlatesTask demandsHabitual responsesBrain activationNeural substrataResponse tendenciesGreater activationInhibitory controlAffective functionsMotor areaBrain regionsFrontal cortexCortical function