2013
Disrupted Ventromedial Prefrontal Function, Alcohol Craving, and Subsequent Relapse Risk
Seo D, Lacadie CM, Tuit K, Hong KI, Constable RT, Sinha R. Disrupted Ventromedial Prefrontal Function, Alcohol Craving, and Subsequent Relapse Risk. JAMA Psychiatry 2013, 70: 727-739. PMID: 23636842, PMCID: PMC3788824, DOI: 10.1001/jamapsychiatry.2013.762.Peer-Reviewed Original ResearchConceptsHealthy control subjectsAD patientsControl subjectsInpatient treatmentAlcohol cravingAlcohol cuesBrain responsesRelapse riskAlcohol relapseHospital-based research unitAnterior cingulate cortex activationAlcohol-related cuesCommunity mental health centerVentromedial prefrontal functionChronic relapsing illnessVentromedial prefrontal cortexStress-induced cravingAbstinent alcohol-dependent patientsFunctional magnetic resonanceMental health centersAlcohol-dependent patientsSubsequent relapse riskNeural correlatesNeutral trialsHazard ratio
2011
Modeling Relapse Situations in the Human Laboratory
Sinha R. Modeling Relapse Situations in the Human Laboratory. Current Topics In Behavioral Neurosciences 2011, 13: 379-402. DOI: 10.1007/978-3-642-28720-6_150.Peer-Reviewed Original ResearchHuman laboratoryAlcohol relapse riskStress-related dysregulationBrain imaging studiesNovel treatment interventionsHuman laboratory proceduresAlcohol-dependent individualsChronic relapsing illnessAlcohol seekingRelapse situationsStress processRelapse outcomesRelapse riskAlcohol relapseAlcohol useTreatment interventionsReciprocal relationshipEmpirical findingsAlcoholism riskCentral stressImaging studiesSuch dysregulationAlcohol consumptionSeekingAlcoholism