2023
Laboratory and Real-World Experimental Approaches to Understanding Alcohol Relapse
Milivojevic V, Sinha R. Laboratory and Real-World Experimental Approaches to Understanding Alcohol Relapse. Current Topics In Behavioral Neurosciences 2023, 1-25. PMID: 37985542, DOI: 10.1007/7854_2023_456.Peer-Reviewed Original ResearchAlcohol use disorderUse disordersHuman laboratory proceduresHuman laboratory modelRelapse riskAlcohol cuesBiobehavioral markersPsychobiological mechanismsStress dysregulationChronic alcohol useAlcohol relapseAlcohol useEffective interventionsNovel interventionsStress biologyReal worldDisordersInterventionCuesSignificant implicationsSignificant treatment challengeHigher relapse riskAUDRisk factorsAdaptation
2017
2320
Brewton H, Stangl B, Kwako L, Sinha R, Ramchandani V. 2320. Journal Of Clinical And Translational Science 2017, 1: 35-35. PMCID: PMC6799609, DOI: 10.1017/cts.2017.129.Peer-Reviewed Original ResearchDrug Effects QuestionnaireBinge drinkersAlcohol Urge QuestionnaireACTH levelsACTH peakNonbinge drinkersAlcohol cuesHPA axis measuresSerial blood samplesHPA axis reactivityAdrenal axis markersAlcohol-dependent individualsACTH ratioBinge groupIntravenous alcoholAlcohol relapseBlood samplesAlcohol consumptionEffects QuestionnaireAlcohol cravingACTH changesDistress ScaleDrinkersSignificant predictorsNeutral scripts
2013
Disrupted Ventromedial Prefrontal Function, Alcohol Craving, and Subsequent Relapse Risk
Seo D, Lacadie CM, Tuit K, Hong KI, Constable RT, Sinha R. Disrupted Ventromedial Prefrontal Function, Alcohol Craving, and Subsequent Relapse Risk. JAMA Psychiatry 2013, 70: 727-739. PMID: 23636842, PMCID: PMC3788824, DOI: 10.1001/jamapsychiatry.2013.762.Peer-Reviewed Original ResearchConceptsHealthy control subjectsAD patientsControl subjectsInpatient treatmentAlcohol cravingAlcohol cuesBrain responsesRelapse riskAlcohol relapseHospital-based research unitAnterior cingulate cortex activationAlcohol-related cuesCommunity mental health centerVentromedial prefrontal functionChronic relapsing illnessVentromedial prefrontal cortexStress-induced cravingAbstinent alcohol-dependent patientsFunctional magnetic resonanceMental health centersAlcohol-dependent patientsSubsequent relapse riskNeural correlatesNeutral trialsHazard ratio
2011
Effects of Adrenal Sensitivity, Stress- and Cue-Induced Craving, and Anxiety on Subsequent Alcohol Relapse and Treatment Outcomes
Sinha R, Fox HC, Hong KI, Hansen J, Tuit K, Kreek MJ. Effects of Adrenal Sensitivity, Stress- and Cue-Induced Craving, and Anxiety on Subsequent Alcohol Relapse and Treatment Outcomes. JAMA Psychiatry 2011, 68: 942-952. PMID: 21536969, PMCID: PMC3668981, DOI: 10.1001/archgenpsychiatry.2011.49.Peer-Reviewed Original ResearchConceptsAlcohol-dependent patientsAlcohol relapseCue-induced alcohol cravingTreatment outcomesAdrenal sensitivityAlcohol cravingCommunity mental health centerCue-induced anxietyEarly alcohol recoveryHPA axis dysregulationHPA axis functionHPA axis responseMental health centersCue-induced alcoholAlcohol cuesStress-induced alcoholHospital-based research unitAlcohol-dependent individualsCue-Induced CravingCorticotropin levelsAxis dysregulationAxis functionAdrenal axisRelapse riskHealthy controls