2024
Inducing representational change in the hippocampus through real-time neurofeedback
Peng K, Wammes J, Nguyen A, Iordan C, Norman K, Turk-Browne N. Inducing representational change in the hippocampus through real-time neurofeedback. Philosophical Transactions Of The Royal Society B Biological Sciences 2024, 379: 20230091. PMID: 39428880, PMCID: PMC11491844, DOI: 10.1098/rstb.2023.0091.Peer-Reviewed Original ResearchMeSH KeywordsAdultFemaleHippocampusHumansMagnetic Resonance ImagingMaleMemoryNeurofeedbackVisual CortexYoung AdultConceptsFunctional magnetic resonance imagingReal-time functional magnetic resonance imagingPatterns of fMRI activityCategorical perception taskReal-time neurofeedbackNeurocognitive mechanismsFMRI sessionStimulus similarityFMRI activationTask demandsBehavioral consequencesUntrained objectsNeural representationPerception taskMemory integrationRepresentational changeEndogenous neuromodulatorNeurofeedbackHippocampusCortical representationIncreased coactivationMagnetic resonance imagingVisual cortexMemoryMultiple theoriesInfant neuroscience: how to measure brain activity in the youngest minds
Turk-Browne N, Aslin R. Infant neuroscience: how to measure brain activity in the youngest minds. Trends In Neurosciences 2024, 47: 338-354. PMID: 38570212, DOI: 10.1016/j.tins.2024.02.003.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsMeSH KeywordsBrainBrain MappingElectroencephalographyHumansInfantMagnetic Resonance ImagingMagnetoencephalographyNeurosciencesSpectroscopy, Near-InfraredConceptsFunctional magnetic resonance imagingFunctional near-infrared spectroscopyMeasure brain activityBrain activityApplication of functional magnetic resonance imagingHuman infantsCognitive neuroscienceCognitive tasksInfant brainAwake infantsMagnetic resonance imagingNear-infrared spectroscopyMagnetoencephalographyMindfulnessResonance imagingNon-invasive methodInfantsElectroencephalography
2023
Hippocampal Mechanisms Support Cortisol-Induced Memory Enhancements
Sherman B, Harris B, Turk-Browne N, Sinha R, Goldfarb E. Hippocampal Mechanisms Support Cortisol-Induced Memory Enhancements. Journal Of Neuroscience 2023, 43: 7198-7212. PMID: 37813570, PMCID: PMC10601369, DOI: 10.1523/jneurosci.0916-23.2023.Peer-Reviewed Original ResearchMeSH KeywordsBrainEmotionsFemaleHippocampusHumansHydrocortisoneMagnetic Resonance ImagingMaleMemory, EpisodicConceptsFunctional magnetic resonance imagingMemory enhancementEpisodic memoryAssociative memoryEpisodic memory encodingBrain regionsHigh-resolution functional magnetic resonance imagingHuman hippocampusHigh-resolution fMRIStress-related hormone cortisolHormone cortisolMemory benefitsEmotional memoryMemory encodingEmotional eventsEmotional associationsHippocampal representationsHippocampal signaturesFunctional neuroimagingHippocampal mechanismsStressful eventsFunctional connectivityHippocampal functionMemory formationSalient informationFunctional networks in the infant brain during sleep and wake states
Yates T, Ellis C, Turk-Browne N. Functional networks in the infant brain during sleep and wake states. Cerebral Cortex 2023, 33: 10820-10835. PMID: 37718160, DOI: 10.1093/cercor/bhad327.Peer-Reviewed Original ResearchMeSH KeywordsAdultBrainBrain MappingConsciousnessHumansInfantMagnetic Resonance ImagingNerve NetRestSleepConceptsFunctional connectivityMagnetic resonance imaging (MRI) scansFunctional magnetic resonance imaging (fMRI) scansWhole-brain functional connectivityResonance imaging scansInfant stateFunctional networksImaging scansAdult stateNatural sleepFunctional brain networksInfantsAwake restAwake fMRIInfant brainSleepBrain networksAdultsFrontoparietal control networkWake statesState of consciousnessDevelopmental changesBrainPerception and memory retrieval states are reflected in distributed patterns of background functional connectivity
Li Y, Wang Y, Turk-Browne N, Kuhl B, Hutchinson J. Perception and memory retrieval states are reflected in distributed patterns of background functional connectivity. NeuroImage 2023, 276: 120221. PMID: 37290674, PMCID: PMC10484747, DOI: 10.1016/j.neuroimage.2023.120221.Peer-Reviewed Original ResearchMeSH KeywordsBrainBrain MappingHumansMagnetic Resonance ImagingMemoryMemory, EpisodicNeural PathwaysNeuroimagingPerceptionConceptsDefault mode networkMemory retrievalCognitive stateRetrieval statesRetrosplenial cortexFunctional connectivityDistinct neural statesTarget of perceptionLarge-scale brain networksControl networkHuman neuroimaging studiesSame visual inputPerception statesCognitive processingBackground connectivityHuman fMRIVisual stimuliNeuroimaging studiesBrain networksMode networkNeural statesVisual inputNeural activityPatterns of connectivityPerceptionAutomated and manual segmentation of the hippocampus in human infants
Fel J, Ellis C, Turk-Browne N. Automated and manual segmentation of the hippocampus in human infants. Developmental Cognitive Neuroscience 2023, 60: 101203. PMID: 36791555, PMCID: PMC9957787, DOI: 10.1016/j.dcn.2023.101203.Peer-Reviewed Original ResearchMeSH KeywordsAdultHippocampusHumansImage Processing, Computer-AssistedInfantMagnetic Resonance ImagingReproducibility of ResultsConceptsManual segmentationHippocampal segmentationInter-rater reliabilityAutomated SegmentationSegmentation methodSegmentationAnatomical MRI scansEarly hippocampal developmentHead motionFreeSurfer softwareSoftwareHippocampal developmentMRI scansHippocampal structureAwake infantsInfantsHippocampusFMRI protocolAnatomical scansGold standardAdult templateHuman infantsScan qualityScansProtocol
2022
Face processing in the infant brain after pandemic lockdown
Yates T, Ellis C, Turk‐Browne N. Face processing in the infant brain after pandemic lockdown. Developmental Psychobiology 2022, 65: e22346. PMID: 36567649, PMCID: PMC9877889, DOI: 10.1002/dev.22346.Peer-Reviewed Original ResearchMeSH KeywordsAdultBrainBrain MappingCommunicable Disease ControlCOVID-19Facial RecognitionHumansInfantMagnetic Resonance ImagingPandemicsPattern Recognition, VisualPhotic StimulationConceptsFusiform face areaVisual experienceInfant brainDifferent face identitiesGreater neural activityPost-lockdown groupFace processingRepetition enhancementFace identityRepetition suppressionSuppression taskFace areaNeural activitySame identityDifferent identitiesSerendipitous studyFFA responseFacePandemic lockdownCOVID-19 pandemicFMRIQuantity/qualityInfantsExperienceIdentityNeural event segmentation of continuous experience in human infants
Yates T, Skalaban L, Ellis C, Bracher A, Baldassano C, Turk-Browne N. Neural event segmentation of continuous experience in human infants. Proceedings Of The National Academy Of Sciences Of The United States Of America 2022, 119: e2200257119. PMID: 36252007, PMCID: PMC9618143, DOI: 10.1073/pnas.2200257119.Peer-Reviewed Original ResearchConceptsEarly visual regionsEvent segmentationVisual regionsAdults' brain activityContinuous sensory inputFunctional MRI dataEvent cognitionNaturalistic perceptionBehavioral judgmentsInfants' segmentationEvent boundariesNeural patternsBrain activitySensory regionsContinuous experienceSimplified taskInfant brainHuman infantsAssociative regionsSensory inputTemporal integrationAwake infantsBrain regionsAdult experienceTemporal precisionRT-Cloud: A cloud-based software framework to simplify and standardize real-time fMRI
Wallace G, Polcyn S, Brooks P, Mennen A, Zhao K, Scotti P, Michelmann S, Li K, Turk-Browne N, Cohen J, Norman K. RT-Cloud: A cloud-based software framework to simplify and standardize real-time fMRI. NeuroImage 2022, 257: 119295. PMID: 35580808, PMCID: PMC9494277, DOI: 10.1016/j.neuroimage.2022.119295.Peer-Reviewed Original ResearchConceptsCloud computingOpen-source Python software packageHigh-performance computingStandardized data formatsBrain Imaging Data Structure (BIDS) standardPython software packageData structure standardsSoftware frameworkOpen standardsData formatLack of standardsHardware requirementsComputingReal timeSoftware packageOpen scienceReal-time fMRIScalabilityTechnical expertiseExecutionDeploymentApplicationsStructure standardsComplexityFormatBrain charts for the human lifespan
Bethlehem RAI, Seidlitz J, White SR, Vogel JW, Anderson KM, Adamson C, Adler S, Alexopoulos GS, Anagnostou E, Areces-Gonzalez A, Astle DE, Auyeung B, Ayub M, Bae J, Ball G, Baron-Cohen S, Beare R, Bedford SA, Benegal V, Beyer F, Blangero J, Blesa Cábez M, Boardman JP, Borzage M, Bosch-Bayard JF, Bourke N, Calhoun VD, Chakravarty MM, Chen C, Chertavian C, Chetelat G, Chong YS, Cole JH, Corvin A, Costantino M, Courchesne E, Crivello F, Cropley VL, Crosbie J, Crossley N, Delarue M, Delorme R, Desrivieres S, Devenyi GA, Di Biase MA, Dolan R, Donald KA, Donohoe G, Dunlop K, Edwards AD, Elison JT, Ellis CT, Elman JA, Eyler L, Fair DA, Feczko E, Fletcher PC, Fonagy P, Franz CE, Galan-Garcia L, Gholipour A, Giedd J, Gilmore JH, Glahn DC, Goodyer IM, Grant PE, Groenewold NA, Gunning FM, Gur RE, Gur RC, Hammill CF, Hansson O, Hedden T, Heinz A, Henson RN, Heuer K, Hoare J, Holla B, Holmes AJ, Holt R, Huang H, Im K, Ipser J, Jack CR, Jackowski AP, Jia T, Johnson KA, Jones PB, Jones DT, Kahn RS, Karlsson H, Karlsson L, Kawashima R, Kelley EA, Kern S, Kim KW, Kitzbichler MG, Kremen WS, Lalonde F, Landeau B, Lee S, Lerch J, Lewis JD, Li J, Liao W, Liston C, Lombardo MV, Lv J, Lynch C, Mallard TT, Marcelis M, Markello RD, Mathias SR, Mazoyer B, McGuire P, Meaney MJ, Mechelli A, Medic N, Misic B, Morgan SE, Mothersill D, Nigg J, Ong MQW, Ortinau C, Ossenkoppele R, Ouyang M, Palaniyappan L, Paly L, Pan PM, Pantelis C, Park MM, Paus T, Pausova Z, Paz-Linares D, Pichet Binette A, Pierce K, Qian X, Qiu J, Qiu A, Raznahan A, Rittman T, Rodrigue A, Rollins CK, Romero-Garcia R, Ronan L, Rosenberg MD, Rowitch DH, Salum GA, Satterthwaite TD, Schaare HL, Schachar RJ, Schultz AP, Schumann G, Schöll M, Sharp D, Shinohara RT, Skoog I, Smyser CD, Sperling RA, Stein DJ, Stolicyn A, Suckling J, Sullivan G, Taki Y, Thyreau B, Toro R, Traut N, Tsvetanov KA, Turk-Browne NB, Tuulari JJ, Tzourio C, Vachon-Presseau É, Valdes-Sosa MJ, Valdes-Sosa PA, Valk SL, van Amelsvoort T, Vandekar SN, Vasung L, Victoria LW, Villeneuve S, Villringer A, Vértes PE, Wagstyl K, Wang YS, Warfield SK, Warrier V, Westman E, Westwater ML, Whalley HC, Witte AV, Yang N, Yeo B, Yun H, Zalesky A, Zar HJ, Zettergren A, Zhou JH, Ziauddeen H, Zugman A, Zuo XN, Bullmore E, Alexander-Bloch A. Brain charts for the human lifespan. Nature 2022, 604: 525-533. PMID: 35388223, PMCID: PMC9021021, DOI: 10.1038/s41586-022-04554-y.Peer-Reviewed Original ResearchIncreasing stimulus similarity drives nonmonotonic representational change in hippocampus
Wammes J, Norman KA, Turk-Browne N. Increasing stimulus similarity drives nonmonotonic representational change in hippocampus. ELife 2022, 11: e68344. PMID: 34989336, PMCID: PMC8735866, DOI: 10.7554/elife.68344.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultBrainBrain MappingFemaleHippocampusHumansLearningMagnetic Resonance ImagingMaleNerve NetYoung AdultConceptsRepresentational changeHigh-level visual regionsShaped functionPairs of stimuliHigh-resolution fMRIStimulus similarityVisual regionsHuman participantsHippocampal learningMemoryPlasticity hypothesisCoactivationFMRIHippocampusGyrusStimuliWide enough rangeContradictory resultsParticipantsImage similarityLearningHypothesisU-shapeSimilar imagesEnough range
2021
Brain kernel: A new spatial covariance function for fMRI data
Wu A, Nastase SA, Baldassano CA, Turk-Browne NB, Norman KA, Engelhardt BE, Pillow JW. Brain kernel: A new spatial covariance function for fMRI data. NeuroImage 2021, 245: 118580. PMID: 34740792, PMCID: PMC11542064, DOI: 10.1016/j.neuroimage.2021.118580.Peer-Reviewed Original ResearchBrain MappingHumansImage Processing, Computer-AssistedImaging, Three-DimensionalMagnetic Resonance ImagingNeuroimagingRetinotopic organization of visual cortex in human infants
Ellis CT, Yates TS, Skalaban LJ, Bejjanki VR, Arcaro MJ, Turk-Browne NB. Retinotopic organization of visual cortex in human infants. Neuron 2021, 109: 2616-2626.e6. PMID: 34228960, DOI: 10.1016/j.neuron.2021.06.004.Peer-Reviewed Original ResearchMeSH KeywordsBrainBrain MappingFemaleHumansInfantMagnetic Resonance ImagingMalePhotic StimulationVisual CortexVisual FieldsVisual PathwaysConceptsVisual cortexFunctional magnetic resonance imagingAdult visual cortexMagnetic resonance imagingVisual areas V1Retinotopic organizationRetinotopic mapResonance imagingHorizontal meridianRetinotopic mappingCortexSubsequent developmental changesArea V1InfantsHuman infantsFunctional maturityFunctional mapsDevelopmental changesLow spatial frequenciesEarly maturationExtrastriateMonthsEvidence of hippocampal learning in human infants
Ellis CT, Skalaban LJ, Yates TS, Bejjanki VR, Córdova NI, Turk-Browne NB. Evidence of hippocampal learning in human infants. Current Biology 2021, 31: 3358-3364.e4. PMID: 34022155, DOI: 10.1016/j.cub.2021.04.072.Peer-Reviewed Original ResearchMeSH KeywordsGeneralization, PsychologicalHippocampusHumansInfantLearningMagnetic Resonance ImagingMemory, EpisodicConceptsStatistical learningHuman infantsTask-based fMRIMedial prefrontal cortexHuman memoryVisual sequencesDurable memoriesMemory capacityMemory integrationAnterior hippocampusHippocampal activityPrefrontal cortexVital abilityTemporal orderHippocampal learningEarly childhoodLearningMemoryMonosynaptic pathwayTrisynaptic pathwayHippocampusInfantsYounger agePosterior divisionFunctional activityBehavioral and Neural Fusion of Expectation with Sensation
Panichello MF, Turk-Browne NB. Behavioral and Neural Fusion of Expectation with Sensation. Journal Of Cognitive Neuroscience 2021, 33: 814-825. PMID: 33544058, PMCID: PMC8367740, DOI: 10.1162/jocn_a_01684.Peer-Reviewed Original ResearchConceptsIntegration of expectationsMale-female continuumAuditory association regionsRange of tonesExpectation cuesComputational accountBehavioral judgmentsAssociative learningStimulus identityDifferent cuesFMRI experimentSensory cuesNeural fusionNeural activitySensory informationCuesSpecific predictionsAssociation regionsPerceptionExpectationsConsequence of fusionBehavioralSuch integrationStimuliJudgmentsAttention recruits frontal cortex in human infants
Ellis CT, Skalaban LJ, Yates TS, Turk-Browne NB. Attention recruits frontal cortex in human infants. Proceedings Of The National Academy Of Sciences Of The United States Of America 2021, 118: e2021474118. PMID: 33727420, PMCID: PMC7999871, DOI: 10.1073/pnas.2021474118.Peer-Reviewed Original ResearchMeSH KeywordsAttentionBrain MappingChild DevelopmentFrontal LobeHumansInfantInfant, NewbornMagnetic Resonance ImagingTemporal LobeConceptsFunctional magnetic resonance imagingEvent-related functional magnetic resonance imagingOrienting of attentionAllocation of attentionInfant attentionInvalid trialsBrief cueUpcoming targetValid trialsFMRI activityInfants' fixationsTrial typesSalient eventsNeural effectsAttention networkFrontal regionsInfant brainHuman infantsParietal lobeBrain regionsFrontal cortexYoung infantsCuesInfant ageAttention
2020
Searching through functional space reveals distributed visual, auditory, and semantic coding in the human brain
Kumar S, Ellis CT, O’Connell T, Chun MM, Turk-Browne NB. Searching through functional space reveals distributed visual, auditory, and semantic coding in the human brain. PLOS Computational Biology 2020, 16: e1008457. PMID: 33270655, PMCID: PMC7738169, DOI: 10.1371/journal.pcbi.1008457.Peer-Reviewed Original ResearchMeSH KeywordsAuditory PathwaysBrainBrain MappingHumansImage Processing, Computer-AssistedMagnetic Resonance ImagingModels, TheoreticalNatural Language ProcessingSemanticsVisual PathwaysConceptsBrain functionHuman brainHuman brain functionLanguage processing modelsNatural language processing modelsSearchlight analysisSearchlight approachSemantic codingObject representationsAuditory featuresBrain activityStrict modularityDecoding accuracyProcessing modelFMRI techniquesFMRI methodsAtlas parcellationCluster correctionComputational modelSemantic featuresDeep neural networksFoundational questionsAnatomical biasLocalized representationSearchlightEmergence and organization of adult brain function throughout child development
Yates TS, Ellis CT, Turk-Browne NB. Emergence and organization of adult brain function throughout child development. NeuroImage 2020, 226: 117606. PMID: 33271266, PMCID: PMC8323508, DOI: 10.1016/j.neuroimage.2020.117606.Peer-Reviewed Original ResearchMeSH KeywordsBrainChildChild DevelopmentChild, PreschoolFemaleHumansMachine LearningMagnetic Resonance ImagingMaleConceptsFMRI activityDevelopmental trajectoriesAdult cognitive neuroscienceInferior frontal gyrusLateral occipital cortexPain-related eventsCognitive neuroscienceFrontal gyrusFunctional neuroanatomyDevelopmental differencesChild developmentAge-related changesCognitive functionDifferent brain regionsSame movieHuman brain developmentNaturalistic approachOccipital cortexBrain regionsAdult brain functionBrain functionChronological ageYoung childrenBrain developmentBrain spaceCloud-Based Functional Magnetic Resonance Imaging Neurofeedback to Reduce the Negative Attentional Bias in Depression: A Proof-of-Concept Study
Mennen AC, Turk-Browne NB, Wallace G, Seok D, Jaganjac A, Stock J, deBettencourt MT, Cohen JD, Norman KA, Sheline YI. Cloud-Based Functional Magnetic Resonance Imaging Neurofeedback to Reduce the Negative Attentional Bias in Depression: A Proof-of-Concept Study. Biological Psychiatry Cognitive Neuroscience And Neuroimaging 2020, 6: 490-497. PMID: 33422469, PMCID: PMC8035170, DOI: 10.1016/j.bpsc.2020.10.006.Peer-Reviewed Original ResearchMeSH KeywordsAttentional BiasCloud ComputingDepressionDepressive Disorder, MajorHumansMagnetic Resonance ImagingNeurofeedbackConceptsMajor depressive disorderDepressive disorderHealthy control participantsFunctional magnetic resonanceControl participantsFuture clinical trialsFunctional magnetic resonance imaging sessionMagnetic resonance imaging sessionConcept studyClinical trialsDepression severityMagnetic resonanceImaging sessionDisordersNeurofeedback trainingVisual stimuliDepressionParticipantsExploratory analysisInternal attentional stateNegative attentional biasRe-imagining fMRI for awake behaving infants
Ellis CT, Skalaban LJ, Yates TS, Bejjanki VR, Córdova NI, Turk-Browne NB. Re-imagining fMRI for awake behaving infants. Nature Communications 2020, 11: 4523. PMID: 32908125, PMCID: PMC7481790, DOI: 10.1038/s41467-020-18286-y.Peer-Reviewed Original ResearchConceptsCognitive tasksFunctional magnetic resonance imaging studyTask-evoked activityMagnetic resonance imaging studyCognitive neuroscienceResonance imaging studyFMRI acquisitionHuman infantsFMRI datasetsHuman brainFMRITaskUnique methodological challengesMethodological challengesImaging studiesNeuroscienceInner workingsInfantsMindImportant insightsAcquisitionBrainDecisions