Featured Publications
Introducing the PLOS ONE Collection on the neuroscience of reward and decision making
Groman SM, Ikemoto S, Rushworth M, Taylor JR, Whelan R. Introducing the PLOS ONE Collection on the neuroscience of reward and decision making. PLOS ONE 2020, 15: e0240505. PMID: 33031482, PMCID: PMC7544023, DOI: 10.1371/journal.pone.0240505.Peer-Reviewed Original ResearchConceptsAction-outcome associationsDecision-making deficitsPast experienceDecision makingNeuroscience techniquesNeurobiological mechanismsBehavioral approachNovel inferencesAdaptive decisionDecision-making functionsMechanistic linkParticular actionNeuroscienceAlternative outcomesBiological mechanismsOrganismsComputational functionsRewardNew insightsParticular outcomeNew environmentRecent advancesPredatorsMakingBiology
2024
Lesions to the mediodorsal thalamus, but not orbitofrontal cortex, enhance volatility beliefs linked to paranoia
Suthaharan P, Thompson S, Rossi-Goldthorpe R, Rudebeck P, Walton M, Chakraborty S, Noonan M, Costa V, Murray E, Mathys C, Groman S, Mitchell A, Taylor J, Corlett P, Chang S. Lesions to the mediodorsal thalamus, but not orbitofrontal cortex, enhance volatility beliefs linked to paranoia. Cell Reports 2024, 43: 114355. PMID: 38870010, PMCID: PMC11231991, DOI: 10.1016/j.celrep.2024.114355.Peer-Reviewed Original ResearchOrbitofrontal cortexMediodorsal thalamusReward learning rateAssociated with paranoiaExcitotoxic lesionsBrain regionsUnoperated monkeysAction selectionAdaptive behaviorParanoiaBelief updatingMDmcMeaningful changeCortexThalamusBeliefsLearning rateRobust to variabilityCompare performanceRewardBehaviorBrainMonkeysAction policiesPerception