2022
Sex differences in default mode network connectivity in healthy aging adults
Ficek-Tani B, Horien C, Ju S, Xu W, Li N, Lacadie C, Shen X, Scheinost D, Constable T, Fredericks C. Sex differences in default mode network connectivity in healthy aging adults. Cerebral Cortex 2022, 33: 6139-6151. PMID: 36563018, PMCID: PMC10183749, DOI: 10.1093/cercor/bhac491.Peer-Reviewed Original ResearchConceptsDefault mode networkPreclinical Alzheimer's diseaseAlzheimer's diseaseSex differencesBrain connectivity changesDefault mode network connectivityIntrinsic connectivity distributionSeed-based analysisMode network connectivityMedial prefrontal cortexPosterior DMN nodesHealthy aging adultsImpact of sexLifetime riskDMN connectivityWhole brainPosterior cingulateDMN nodesSignificant sex differencesPrefrontal cortexConnectivity changesAging AdultsHealthy participantsDMN functionMode networkArousal impacts distributed hubs modulating the integration of brain functional connectivity
Lee K, Horien C, O’Connor D, Garand-Sheridan B, Tokoglu F, Scheinost D, Lake EMR, Constable RT. Arousal impacts distributed hubs modulating the integration of brain functional connectivity. NeuroImage 2022, 258: 119364. PMID: 35690257, PMCID: PMC9341222, DOI: 10.1016/j.neuroimage.2022.119364.Peer-Reviewed Original ResearchA cognitive state transformation model for task-general and task-specific subsystems of the brain connectome
Yoo K, Rosenberg MD, Kwon YH, Scheinost D, Constable RT, Chun MM. A cognitive state transformation model for task-general and task-specific subsystems of the brain connectome. NeuroImage 2022, 257: 119279. PMID: 35577026, PMCID: PMC9307138, DOI: 10.1016/j.neuroimage.2022.119279.Peer-Reviewed Original ResearchConceptsDifferent cognitive statesCognitive stateWhole-brain functional connectomeRelevant individual differencesFunctional reorganizationFunctional magnetic resonanceResting-state dataSpecific task goalsTask-induced modulationHuman Connectome ProjectContext-dependent changesIndividual differencesTask goalsContextual demandsBehavioral predictionsCognitive behaviorFunctional connectomeConnectome ProjectBrain connectomeHuman brainBrain functional reorganizationC2C modelConnectomeBrainMemory
2020
Functional brain connectivity in ex utero premature infants compared to in utero fetuses
De Asis-Cruz J, Kapse K, Basu SK, Said M, Scheinost D, Murnick J, Chang T, du Plessis A, Limperopoulos C. Functional brain connectivity in ex utero premature infants compared to in utero fetuses. NeuroImage 2020, 219: 117043. PMID: 32534962, PMCID: PMC7493786, DOI: 10.1016/j.neuroimage.2020.117043.Peer-Reviewed Original ResearchConceptsPremature infantsHealthy fetusesBrain connectivityStructural brain injuryBlood oxygenation level-dependent (BOLD) signalBrain structural changesStress-related areasNormal brain MRIState functional MRIFunctional connectivity strengthFunctional brain connectivityLevel-dependent signalMedial temporal lobeNetwork-based statisticsSeed-based correlation analysisUtero fetusesBasal gangliaBrain injuryTerm ageBrain MRITemporal lobeExposure altersInfantsRegion of interestFunctional MRI
2019
There is no single functional atlas even for a single individual: Functional parcel definitions change with task
Salehi M, Greene AS, Karbasi A, Shen X, Scheinost D, Constable RT. There is no single functional atlas even for a single individual: Functional parcel definitions change with task. NeuroImage 2019, 208: 116366. PMID: 31740342, DOI: 10.1016/j.neuroimage.2019.116366.Peer-Reviewed Original ResearchIndividualized functional networks reconfigure with cognitive state
Salehi M, Karbasi A, Barron DS, Scheinost D, Constable RT. Individualized functional networks reconfigure with cognitive state. NeuroImage 2019, 206: 116233. PMID: 31574322, PMCID: PMC7216521, DOI: 10.1016/j.neuroimage.2019.116233.Peer-Reviewed Original ResearchConceptsCognitive stateFunctional networksMultiple cognitive statesFunctional network organizationFunctional organizationBrain functional networksTask demandsFMRI dataSimilar tasksParcellation approachHuman brainNetwork organizationExtensive evidenceMultiple subjectsBrainNetwork membershipTaskOrganizationSubjectsParcellationSuch reconfigurationMeasuresMembershipFindingsSuch definitionsRegions and Connections: Complementary Approaches to Characterize Brain Organization and Function
Horien C, Greene AS, Constable RT, Scheinost D. Regions and Connections: Complementary Approaches to Characterize Brain Organization and Function. The Neuroscientist 2019, 26: 117-133. PMID: 31304866, PMCID: PMC7079335, DOI: 10.1177/1073858419860115.Peer-Reviewed Original ResearchThe Functional Brain Organization of an Individual Allows Prediction of Measures of Social Abilities Transdiagnostically in Autism and Attention-Deficit/Hyperactivity Disorder
Lake EMR, Finn ES, Noble SM, Vanderwal T, Shen X, Rosenberg MD, Spann MN, Chun MM, Scheinost D, Constable RT. The Functional Brain Organization of an Individual Allows Prediction of Measures of Social Abilities Transdiagnostically in Autism and Attention-Deficit/Hyperactivity Disorder. Biological Psychiatry 2019, 86: 315-326. PMID: 31010580, PMCID: PMC7311928, DOI: 10.1016/j.biopsych.2019.02.019.Peer-Reviewed Original ResearchConceptsAttention-deficit/hyperactivity disorderAutism spectrum disorderSpectrum disorderFunctional connectivity profilesHyperactivity disorderBrain organizationAutism Brain Imaging Data ExchangeConnectome-based predictive modelingAutism Diagnostic Observation ScheduleAutism spectrum disorder traitsAutism spectrum disorder severitySocial Responsiveness Scale scoresADHD Rating Scale scoresFunctional magnetic resonance imagingBrain-behavior associationsSocial Responsiveness ScaleResting-state functional magnetic resonanceFunctional brain organizationFunctional magnetic resonanceADHD traitsNeurofunctional basisADHD symptomsSplit-half analysisResponsiveness ScaleSocial abilitiesThe individual functional connectome is unique and stable over months to years
Horien C, Shen X, Scheinost D, Constable RT. The individual functional connectome is unique and stable over months to years. NeuroImage 2019, 189: 676-687. PMID: 30721751, PMCID: PMC6422733, DOI: 10.1016/j.neuroimage.2019.02.002.Peer-Reviewed Original ResearchConceptsHigh ID ratesIndividual differencesFunctional connectomeIndividual functional connectomesStable individual differencesID rateResting-state fMRI datasetsFrontoparietal networkFunctional connectivityParietal cortexFMRI datasetsIdiosyncratic aspectsConnectomeHead motionEntire brainFMRIBrainCortexSpecific datasetDifferencesConnectivity
2018
Task-induced brain state manipulation improves prediction of individual traits
Greene AS, Gao S, Scheinost D, Constable RT. Task-induced brain state manipulation improves prediction of individual traits. Nature Communications 2018, 9: 2807. PMID: 30022026, PMCID: PMC6052101, DOI: 10.1038/s41467-018-04920-3.Peer-Reviewed Original ResearchConceptsBrain statesIndividual differencesBrain-behavior relationshipsFluid intelligence scoresTask-based functional connectivity analysisResting-state fMRI dataBrain functional organizationFunctional connectivity analysisCognitive tasksFluid intelligenceIntelligence scoresFunctional connectivityFMRI dataConnectivity analysisHuman behaviorIndividual traitsTaskCertain tasksFunctional organizationOutperform modelsSuch relationshipsCognitionState manipulationIntelligenceVarianceData-Driven Analysis of Functional Connectivity Reveals a Potential Auditory Verbal Hallucination Network
Scheinost D, Tokoglu F, Hampson M, Hoffman R, Constable RT. Data-Driven Analysis of Functional Connectivity Reveals a Potential Auditory Verbal Hallucination Network. Schizophrenia Bulletin 2018, 45: 415-424. PMID: 29660081, PMCID: PMC6403094, DOI: 10.1093/schbul/sby039.Peer-Reviewed Original ResearchConceptsAuditory Hallucination Rating ScaleIntrinsic connectivity distributionAuditory verbal hallucinationsHealthy controlsFunctional connectivityLateralized connectivitySevere global health problemSeed connectivity analysesBest treatment strategyGlobal health problemWhole-brain connectivityMedial prefrontal cortexPosterior cingulate cortexDefault mode networkSuch patientsPatient groupLeft putamenTreatment strategiesPatientsActionable targetsSchizoaffective disorderCingulate cortexHealth problemsVoxel-based measurePrefrontal cortexMaternal Immune Activation During the Third Trimester Is Associated with Neonatal Functional Connectivity of the Salience Network and Fetal to Toddler Behavior
Spann MN, Monk C, Scheinost D, Peterson BS. Maternal Immune Activation During the Third Trimester Is Associated with Neonatal Functional Connectivity of the Salience Network and Fetal to Toddler Behavior. Journal Of Neuroscience 2018, 38: 2877-2886. PMID: 29487127, PMCID: PMC5852665, DOI: 10.1523/jneurosci.2272-17.2018.Peer-Reviewed Original ResearchConceptsMaternal immune activationC-reactive proteinFetal heart rate variabilityNeonatal functional connectivityInterleukin-6Postmenstrual ageImmune activationSalience networkFunctional connectivityPsychiatric disordersCRP levelsEpidemiological studiesMaternal C-reactive proteinResting-state imaging dataC-reactive protein levelsMaternal CRP levelsMaternal IL-6Months postmenstrual agePrenatal maternal immune activationSame psychiatric disordersWeeks postmenstrual ageIL-6 levelsAlters functional connectivityAltered brain developmentSame gestational age
2017
An exemplar-based approach to individualized parcellation reveals the need for sex specific functional networks
Salehi M, Karbasi A, Shen X, Scheinost D, Constable RT. An exemplar-based approach to individualized parcellation reveals the need for sex specific functional networks. NeuroImage 2017, 170: 54-67. PMID: 28882628, PMCID: PMC5905726, DOI: 10.1016/j.neuroimage.2017.08.068.Peer-Reviewed Original ResearchConceptsIndividualized parcellationParcellation techniqueFunctional networksCross-validated predictive modelSpecific functional networksCerebral cortexPatient subgroupsFunctional connectivity dataFunctional organizationBrainParcellation schemesClinical applicationParcellation approachParcellationSexSubgroupsConnectivity dataIndividualized studyNetwork organizationIndividualsAmple evidencePatientsCortexCan brain state be manipulated to emphasize individual differences in functional connectivity?
Finn ES, Scheinost D, Finn DM, Shen X, Papademetris X, Constable RT. Can brain state be manipulated to emphasize individual differences in functional connectivity? NeuroImage 2017, 160: 140-151. PMID: 28373122, PMCID: PMC8808247, DOI: 10.1016/j.neuroimage.2017.03.064.Peer-Reviewed Original ResearchConceptsIndividual differencesFunctional connectivityBrain statesIndividual differences researchBrain functional organizationHuman Connectome ProjectDifferences researchBrain activityConnectome ProjectSubject variabilityNetworks of interestBehavioral phenotypesCertain tasksFunctional organizationDefault stateNeutral backdropOutline questionsFuture studiesConnectivityTaskCharacterizing Attention with Predictive Network Models
Rosenberg MD, Finn ES, Scheinost D, Constable RT, Chun MM. Characterizing Attention with Predictive Network Models. Trends In Cognitive Sciences 2017, 21: 290-302. PMID: 28238605, PMCID: PMC5366090, DOI: 10.1016/j.tics.2017.01.011.Peer-Reviewed Original ResearchConceptsAttention deficit hyperactivity disorderAttentional abilitiesLarge-scale brain networksLaboratory-based tasksDeficit hyperactivity disorderExplicit taskCognitive abilitiesHyperactivity disorderBrain networksBrain computationCognitive functionFunctional connectivityFunctional architectureTaskClinical dysfunctionEmpirical evidenceAttentionPredictive network modelsNeuromarkersNetwork modelAbilityRecent workNetwork propertiesDisordersPeopleUsing connectome-based predictive modeling to predict individual behavior from brain connectivity
Shen X, Finn ES, Scheinost D, Rosenberg MD, Chun MM, Papademetris X, Constable RT. Using connectome-based predictive modeling to predict individual behavior from brain connectivity. Nature Protocols 2017, 12: 506-518. PMID: 28182017, PMCID: PMC5526681, DOI: 10.1038/nprot.2016.178.Peer-Reviewed Original ResearchMulti-modal analysis of functional connectivity and cerebral blood flow reveals shared and unique effects of propofol in large-scale brain networks
Qiu M, Scheinost D, Ramani R, Constable RT. Multi-modal analysis of functional connectivity and cerebral blood flow reveals shared and unique effects of propofol in large-scale brain networks. NeuroImage 2017, 148: 130-140. PMID: 28069540, PMCID: PMC5410383, DOI: 10.1016/j.neuroimage.2016.12.080.Peer-Reviewed Original ResearchConceptsCerebral blood flowIntrinsic connectivity distributionLarge-scale brain networksFunctional connectivityReduced consciousnessBlood flowBrain networksSedation conditionsWhole-brain connectivityAltered connectivityMotor networkCBF dataRs-fMRIPharmacological alterationsConnectivity differencesPropofolMultiple large-scale brain networksUnique neural correlatesBlow flowFrontoparietal networkAnesthesiaKey markersDefault modeNeural correlatesSame subjects
2016
Does prenatal stress alter the developing connectome?
Scheinost D, Sinha R, Cross SN, Kwon SH, Sze G, Constable RT, Ment LR. Does prenatal stress alter the developing connectome? Pediatric Research 2016, 81: 214-226. PMID: 27673421, PMCID: PMC5313513, DOI: 10.1038/pr.2016.197.Peer-Reviewed Original ResearchConceptsAttention deficit hyperactivity disorderDeficit hyperactivity disorderStress-related symptomsPrenatal exposureRisk factorsMajor depressionFetal brainMaternal stressPrenatal stressNeural elementsNeurobehavioral disordersFunctional connectivityHyperactivity disorderHuman neurodevelopmentDisordersAutism spectrum disorderFunctional networksConnectomeSpectrum disorderHuman connectomePregnancySymptomsNeurodevelopmentSchizophreniaBrainFluctuations in Global Brain Activity Are Associated With Changes in Whole-Brain Connectivity of Functional Networks
Scheinost D, Tokoglu F, Shen X, Finn ES, Noble S, Papademetris X, Constable RT. Fluctuations in Global Brain Activity Are Associated With Changes in Whole-Brain Connectivity of Functional Networks. IEEE Transactions On Biomedical Engineering 2016, 63: 2540-2549. PMID: 27541328, PMCID: PMC5180443, DOI: 10.1109/tbme.2016.2600248.Peer-Reviewed Original ResearchConceptsGlobal brain activityResting-state networksWhole-brain connectivityBrain activityResting-state functional magnetic resonance imagingTime pointsFunctional resting-state networksFunctional magnetic resonance imagingMagnetic resonance imagingResting-state studyBrain statesRSN connectivitySensory functionSubcortical regionsResonance imagingCognitive functionCoactivation patternsUnique brain statesBrain connectivityActivity stateCritical time pointsFunctional networksSignal intensityVoxel-based methodBrain dynamics
2015
A neuromarker of sustained attention from whole-brain functional connectivity
Rosenberg MD, Finn ES, Scheinost D, Papademetris X, Shen X, Constable RT, Chun MM. A neuromarker of sustained attention from whole-brain functional connectivity. Nature Neuroscience 2015, 19: 165-171. PMID: 26595653, PMCID: PMC4696892, DOI: 10.1038/nn.4179.Peer-Reviewed Original Research