2024
Brain age prediction and deviations from normative trajectories in the neonatal connectome
Sun H, Mehta S, Khaitova M, Cheng B, Hao X, Spann M, Scheinost D. Brain age prediction and deviations from normative trajectories in the neonatal connectome. Nature Communications 2024, 15: 10251. PMID: 39592647, PMCID: PMC11599754, DOI: 10.1038/s41467-024-54657-5.Peer-Reviewed Original ResearchConceptsPostmenstrual agePerinatal periodBrain age predictionFunctional connectomeMonths of postnatal lifeMonths of lifePreterm infantsNormative trajectoryConnectome-based predictive modelingThird trimesterPerinatal exposureBrain age gapPostnatal lifeResting-state fMRIInfantsHuman Connectome ProjectNeonatal connectomeDevelopmental trajectoriesBrainBehavioral outcomesNormative dataMonthsConnectome ProjectDTI dataConnectome
2023
Population level multimodal neuroimaging correlates of attention-deficit hyperactivity disorder among children
Lin H, Haider S, Kaltenhauser S, Mozayan A, Malhotra A, Constable R, Scheinost D, Ment L, Konrad K, Payabvash S. Population level multimodal neuroimaging correlates of attention-deficit hyperactivity disorder among children. Frontiers In Neuroscience 2023, 17: 1138670. PMID: 36908780, PMCID: PMC9992191, DOI: 10.3389/fnins.2023.1138670.Peer-Reviewed Original ResearchAttention deficit hyperactivity disorderADHD diagnosisHyperactivity disorderChildhood attention deficit hyperactivity disorderAssociation of ADHDDorsal attention networkFunctional MRI studyDefault mode networkResting-state fMRIADHD childrenAttention functionLimitations of machineAttention networkFrontal regionsNeuroimaging datasetsNeurobiological implicationsParietal lobeFrontal lobe cortexCortical volumeFractional anisotropyFunctional neuroimaging datasetsChildrenWhite matter tractsNeurite densityMicrostructural integrity
2014
Altered functional connectivity in seizure onset zones revealed by fMRI intrinsic connectivity
Lee HW, Arora J, Papademetris X, Tokoglu F, Negishi M, Scheinost D, Farooque P, Blumenfeld H, Spencer DD, Constable RT. Altered functional connectivity in seizure onset zones revealed by fMRI intrinsic connectivity. Neurology 2014, 83: 2269-2277. PMID: 25391304, PMCID: PMC4277677, DOI: 10.1212/wnl.0000000000001068.Peer-Reviewed Original ResearchConceptsSeizure onset zoneIntrinsic connectivity contrastTemporal lobe epilepsyLobe epilepsySurgical outcomesOnset zoneExtratemporal lobe epilepsyIntractable partial epilepsyGood surgical outcomeAltered functional connectivityFunctional connectivity changesResting-state fMRIGlobal network changesEpileptic hemisphereClinical factorsPartial epilepsyEpileptogenic networksEpileptogenic zoneSeizure localizationFocal epilepsyIntracranial EEG recordingsTLE groupIndependent reviewersConnectivity abnormalitiesPatientsResting state functional connectivity predicts neurofeedback response
Scheinost D, Stoica T, Wasylink S, Gruner P, Saksa J, Pittenger C, Hampson M. Resting state functional connectivity predicts neurofeedback response. Frontiers In Behavioral Neuroscience 2014, 8: 338. PMID: 25309375, PMCID: PMC4173810, DOI: 10.3389/fnbeh.2014.00338.Peer-Reviewed Original ResearchObsessive-compulsive disorderOrbitofrontal cortexFunctional connectivityNeurofeedback trainingState functional connectivityWhole-brain connectivityBrain functional connectivityResting-state fMRITarget brain regionsBrodmann area 10Clinical symptomatologyContamination anxietyProminent symptomAnterior prefrontal cortexBrain regionsNeuropsychiatric disordersRs-fMRIBehavioral improvementPrefrontal cortexSame protocolPilot dataBA 10Neurofeedback protocolReliable predictorCortex
2013
Orbitofrontal cortex neurofeedback produces lasting changes in contamination anxiety and resting-state connectivity
Scheinost D, Stoica T, Saksa J, Papademetris X, Constable RT, Pittenger C, Hampson M. Orbitofrontal cortex neurofeedback produces lasting changes in contamination anxiety and resting-state connectivity. Translational Psychiatry 2013, 3: e250-e250. PMID: 23632454, PMCID: PMC3641411, DOI: 10.1038/tp.2013.24.Peer-Reviewed Original ResearchConceptsResting-state connectivityContamination anxietyBrain regionsNF trainingBrain connectivityResting-state functional connectivityFunctional magnetic resonance imaging (fMRI) neurofeedbackPotential of neurofeedbackRelevant brain networksResting-state fMRIDorsolateral prefrontal cortexTarget brain regionsBrain functional architectureUseful therapyLimbic circuitryMatched subjectsOrbitofrontal regionsOrbitofrontal cortexFunctional connectivityPrefrontal cortexHuman emotionsFeedback control tasksSubclinical anxietyAnxiety regulationBrain networks
2012
The intrinsic connectivity distribution: A novel contrast measure reflecting voxel level functional connectivity
Scheinost D, Benjamin J, Lacadie CM, Vohr B, Schneider KC, Ment LR, Papademetris X, Constable RT. The intrinsic connectivity distribution: A novel contrast measure reflecting voxel level functional connectivity. NeuroImage 2012, 62: 1510-1519. PMID: 22659477, PMCID: PMC3538880, DOI: 10.1016/j.neuroimage.2012.05.073.Peer-Reviewed Original ResearchConceptsIntrinsic connectivity distributionTerm control subjectsFunctional connectivity differencesControl subjectsVoxel-level functional connectivityConnectivity differencesResting-state fMRIDisease groupTemporal-parietal areasPsychiatric disordersRs-fMRINeurological disordersClinical toolFunctional connectivityYoung adultsFMRI measuresRelevant differencesDisordersSubjectsLanguage processing areasSurvey studyTissue connectivityPretermDifferences