Publications

Phenome-wide analysis of genetically imputed neuroimaging phenotypes reveals associations with psychiatric traits in a multi-ancestry cohort.Chihoub L, Wiers CE, Gelernter J, Zhao B, Davis CN, Kranzler HR. medRxiv. 2025 Dec 17; 2025 Dec 17. PMID: 41445655.
Mapping the genetic landscape across 14 psychiatric disorders.Grotzinger AD, Werme J, Peyrot WJ, Frei O, de Leeuw C, Bicks LK, Guo Q, Margolis MP, Coombes BJ, Batzler A, Pazdernik V, Biernacka JM, Andreassen OA, Anttila V, Børglum AD, Breen G, Cai N, Demontis D, Edenberg HJ, Faraone SV, Franke B, Gandal MJ, Gelernter J, Hatoum AS, Hettema JM, Johnson EC, Jonas KG, Knowles JA, Koenen KC, Maihofer AX, Mallard TT, Mattheisen M, Mitchell KS, Neale BM, Nievergelt CM, Nurnberger JI, O'Connell KS, Peterson RE, Robinson EB, Sanchez-Roige SS, Santangelo SL, Scharf JM, Stefansson H, Stefansson K, Stein MB, Strom NI, Thornton LM, Tucker-Drob EM, Verhulst B, Waldman ID, Walters GB, Wray NR, Yu D, Lee PH, Kendler KS, Smoller JW. Nature. 2025 Dec 10; 2025 Dec 10. PMID: 41372416.
Measures of General Intelligence and Risk for Alcohol Use Disorder.Capusan AJ, Davis CN, Thern E, Rehm J, Gelernter J, Kranzler HR, Heilig M. JAMA Psychiatry. 2025 Dec 1. PMID: 41032335.
Developmental timing of index trauma exposure and accelerated epigenetic aging in United States military veterans.Tamman AJF, Nagamatsu ST, Cabrera-Mendoza B, Averill LA, Dunn EC, Krystal JH, Gelernter J, Montalvo-Ortiz JL, Polimanti R, Pietrzak RH. Psychoneuroendocrinology. 2025 Dec; 2025 Sep 17. PMID: 41016323.
Defining suicidality phenotypes for genetic studies: perspectives of the Psychiatric Genomics Consortium Suicide Working Group.Colbert SMC, Monson ET, Andreassen OA, Ayinde OO, Barr PB, Bejan CA, Ceja Z, Coon H, DiBlasi E, Edenberg HJ, Gelernter J, Hatoum A, Izotova A, Johnson EC, Kaufman EA, Kranzler HR, Koromina M, Lehto K, Myung W, Nurnberger JI Jr, Serretti A, Smoller JW, Stein MB, Zai CC, Erlangsen A, Gaine M, Martorell L, Sud R, Toma C, Bigdeli TB, Kimbrel NA, Ruderfer D, Docherty AR, Mann JJ, Mullins N. Mol Psychiatry. 2025 Dec; 2025 Sep 25. PMID: 40999039.
Multi-ancestry investigation of the genomics of erectile dysfunction.Bright U, Chen Y, Deak JD, Zhou H, Levey DF, Gelernter J. Nat Commun. 2025 Nov 24; 2025 Nov 24. PMID: 41285899.
Genotype-by-sex interaction analyses for alcohol use disorder across biobanks.Zhou H, Wang L, Mao Z, Deans PJM, Kember RL, Chen Q, Zakiniaeiz Y, Kohler R, Peltier MR, Verplaetse TL, Potenza MN, Brennand KJ, Justice AC, Kranzler HR, Gelernter J, McKee SA. Alcohol Clin Exp Res (Hoboken). 2025 Nov; 2025 Sep 29. PMID: 41017299.
Environmental, Psychiatric, and Genetic Predictors of Alcohol Use Disorder Criterion Count: Analyses of African and European Ancestries.Na PJ, Deak JD, Levey DF, Kember RL, Kranzler HR, Pietrzak RH, Gelernter J. Am J Psychiatry. 2025 Nov 1; 2025 Sep 24. PMID: 40988466.
Whole-exome sequencing study of opioid dependence offers novel insights into the contributions of exome variants.Wang L, Nuñez YZ, Martínez-Magaña JJ, Rivera-Hernandez M, Mao Z, Brennand KJ, Montalvo-Ortiz JL, Kranzler HR, Gelernter J, Zhou H. Transl Psychiatry. 2025 Oct 6; 2025 Oct 6. PMID: 41052974.
The genetics of cannabis lifetime use.Bright U, Beck S, Galimberti M, Gupta P, Chen Y, Dao C, Nunez YZ, Kranzler HR, Zhou Y, Zhang Y, Choi KW, Levey DF, Gelernter J. Neuropsychopharmacology. 2025 Oct 3; 2025 Oct 3. PMID: 41044382.
Alcohol use and risk of dementia in diverse populations: evidence from cohort, case-control and Mendelian randomisation approaches.Topiwala A, Levey DF, Zhou H, Deak JD, Adhikari K, Ebmeier KP, Bell S, Burgess S, Nichols TE, Gaziano M, Stein M, Gelernter J. BMJ Evid Based Med. 2025 Sep 23; 2025 Sep 23. PMID: 40987604.
A semi-empirical Bayes approach for calibrating weak instrumental bias in sex-specific Mendelian randomization studies.Huang YJ, Kurniansyah N, Levey DF, Gelernter J, Huffman JE, Cho K, Wilson PWF, Gottlieb DJ, Rice KM, Sofer T. Am J Hum Genet. 2025 Sep 4. PMID: 40912238.
DNA Methylation Signatures of Alcohol Use Disorder - A large-scale Meta-Analysis in the Psychiatric Genomics Consortium.Zillich L, D'Augello S, Avetyan D, Delgado GE, Gizer IR, Jung J, Katrinli S, Kleber ME, Merrill N, Moissl AP, Núñez-Rios DL, Otto JM, Zillich E, Friedel E, Hancock DB, Johnson EO, Martínez-Magaña JJ, Nagamatsu ST, Sosnowski DW, White JD, Aberg KA, Copeland WE, Diazgranados N, Fani N, Gelernter J, Goldman D, Foo JC, Kranzler HR, Levey DF, März W, Penninx BWJH, Polimanti R, Powers A, Smith AK, Spanagel R, van den Oord EJCG, Wilhelmsen KC, Witt SH, Domschke K, Schiele MA, Maher BS, Montalvo Ortiz JL, Clark SL, Lohoff FW. medRxiv. 2025 Sep 2; 2025 Sep 2. PMID: 40950452.
Genetics of SSRI antidepressant use and relationship to psychiatric and medical traits.Levey D, Galimberti M, Deak J, Gupta P, Empke SLL, Adhikari K, Harrington K, Quaden R, Gaziano JJM, Stein MB, Gelernter J. HGG Adv. 2025 Sep 2; 2025 Sep 2. PMID: 40903904.
Predicting treatment-seeking status for alcohol use disorder using polygenic scores and machine learning in a deeply-phenotyped sample.Jinwala Z, Green R, Khan Y, Gelernter J, Kember RL, Hartwell EE. Drug Alcohol Depend. 2025 Sep 1; 2025 Jul 16. PMID: 40695097.
Epigenetic and genetic profiling of comorbidity patterns among substance dependence diagnoses.Pathak GA, Pietrzak RH, Lacobelle A, Overstreet C, Wendt FR, Deak JD, Friligkou E, Nunez YZ, Montalvo-Ortiz JL, Levey DF, Kranzler HR, Gelernter J, Polimanti R. Mol Psychiatry. 2025 Sep; 2025 Apr 17. PMID: 40247127.
Functional Validation of Alcohol Dependence-Associated FYN Variants Using Gene Editing and Stem Cell Study Approaches.Cakir B, Tanaka Y, Choe MS, Chu PY, Xiang Y, Kim KY, Zhong M, Gelernter J, Zhang H, Krystal J, Park IH. Int J Stem Cells. 2025 Aug 30; 2025 Apr 10. PMID: 40205763.
Multi-ancestry Genome-wide Association Study of Inpatient Opioid Dosing Following Knee or Hip Arthroplasty.Jinwala Z, Davis CN, SooHoo JF, Gelernter J, Kember RL, Vickers-Smith R, Kranzler HR. Res Sq. 2025 Aug 21; 2025 Aug 21. PMID: 40894051.
Multi-ancestral genome-wide association study of clinically defined nicotine dependence reveals strong genetic correlations with other substance use disorders and health-related traits.Johnson EC, Lai D, Balbona JV, Miller AP, Hatoum AS, Deak JD, Jennings M, Baranger DAA, Galimberti M, Sanichwankul K, Thorgeirsson T, Colbert SMC, Adhikari K, Docherty AR, Degenhardt L, Edwards T, Fox L, Giannelis A, Jeffries PW, Korhonen T, Morrison CL, Nunez YZ, Palviainen T, Su MH, Romero Villela PN, Wetherill L, Willoughby EA, Zellers SM, Bierut LJ, Buchwald J, Copeland WE, Corley RP, Friedman NP, Foroud TM, Gillespie NA, Gizer IR, Heath AC, Hickie IB, Kaprio J, Keller MC, Lee JJ, Lind P, Madden PA, Maes HHM, Martin NG, McGue M, Medland SE, Nelson EC, Pearson J, Porjesz B, Stallings MC, Vrieze S, Wilhelmson KC, Kranzler HR, Walters RK, Polimanti R, Malison R, Zhou H, Stefansson K, Sanchez-Roige S, Potenza M, Mutirangura A, Shotelersuk V, Kalayasiri R, Edenberg HJ, Gelernter J, Agrawal A. Psychol Med. 2025 Aug 20; 2025 Aug 20. PMID: 40831304.
A contextual genomic perspective on physical activity and its relationship to health, well being and illness.Galimberti M, Levey DF, Deak JD, Adhikari K, Overstreet C, Gupta P, Nitin R, Zhou H, Lake NJ, Harrington KM, Djousse L, Davis LK, Gaziano JM, Stein MB, Gelernter J. Nat Genet. 2025 Aug; 2025 Jul 21. PMID: 40691405.
The Psychiatric Genomics Consortium: discoveries and directions.Agrawal A, Bulik CM, Abebe DS, Andreassen OA, Atkinson EG, Choi KW, Corvin A, Davies HL, Davis LK, Docherty AR, Edenberg HJ, Franke B, Gelernter J, Giusti-Rodríguez P, Hettema JM, Hjerling-Leffler J, Huang H, Johnson EC, Lewis CM, Lu Y, Lynall ME, Martin J, McIntosh AM, Montalvo-Ortiz JL, Mullins N, Nievergelt CM, O'Connell KS, O'Donovan MC, Okewole A, Peterson RE, Posthuma D, Sebat J, Smoller JW, Sud R, Viswanath B, Walters JTR, Won H, Wray NR, Sullivan PF. Lancet Psychiatry. 2025 Aug; 2025 Jun 26. PMID: 40582370.
Polygenic risk and childhood adversity as moderators of drug and alcohol withdrawal symptoms.Han A, Davis CN, Jinwala Z, SooHoo J, Gelernter J, Feinn R, Kranzler HR. Drug Alcohol Depend. 2025 Aug 1; 2025 May 14. PMID: 40449208.
Multi-ancestry genome-wide association meta-analysis of buprenorphine treatment response.Davis CN, Khan Y, Crist RC, Vickers-Smith R, Hartwell EE, Gelernter J, Kampman K, Kember RL, Le Moigne A, Laffont CM, Kranzler HR. Neuropsychopharmacology. 2025 Aug; 2025 May 6. PMID: 40328918.
Cell-type-specific and inflammatory DNA methylation patterns associated with PTSD.Smith AK, Katrinli S, Maihofer AX, Aiello AE, Baker DG, Boks MP, Brick LA, Chen CY, Dalvie S, Fani N, Fortier CB, Gelernter J, Geuze E, Gillespie CF, Hayes JP, Hong S, Kessler RC, King AP, Koen N, Koenen KC, Liberzon I, Linnstaedt SD, McLean SA, Michopoulos V, Milberg WP, Miller MW, Mufford MS, Nugent NR, Orcutt HK, Powers A, Rauch SAM, Ressler KJ, Risbrough VB, Rutten BPF, Smoller JW, Stein DJ, Stein MB, Ursano RJ, Verfaellie MH, Vermetten E, Vinkers CH, Wani AH, WareVinkers EB, Wildman DE, Wolf EJ, Zhao Y, Logue MW, Nievergelt CM, Uddin M, Zannas AS. Brain Behav Immun. 2025 Aug; 2025 Apr 24. PMID: 40286993.
Differences and similarities between the genetic architecture of lifetime substance use across different substances.Bright U, Overstreet C, Levey DF, Gelernter J. Psychol Med. 2025 Jul 30; 2025 Jul 30. PMID: 40736093.
Multi-ancestry Genome-wide Association Study of Inpatient Opioid Dosing Following Knee or Hip Arthroplasty.Jinwala Z, Davis CN, SooHoo JF, Gelernter J, Kember RL, Vickers-Smith R, Kranzler HR. medRxiv. 2025 Jul 24; 2025 Jul 24. PMID: 40778174.
Shared genetic architecture of posttraumatic stress disorder with cardiovascular imaging, risk, and diagnoses.Shen J, Valentim W, Friligkou E, Overstreet C, Choi KW, Koller D, O'Donnell CJ, Stein MB, Gelernter J, Lv H, Sun L, Falcone GJ, Polimanti R, Pathak GA. Nat Commun. 2025 Jul 1; 2025 Jul 1. PMID: 40595462.
Single-cell transcriptomic and chromatin dynamics of the human brain in PTSD.Hwang A, Skarica M, Xu S, Coudriet J, Lee CY, Lin L, Terwilliger R, Sliby AN, Wang J, Nguyen T, Li H, Wu M, Dai Y, Duan Z, Srinivasan SS, Zhang X, Lin Y, Cruz D, Deans PJM, Huber BR, Levey D, Glausier JR, Lewis DA, Gelernter J, Holtzheimer PE, Friedman MJ, Gerstein M, Sestan N, Brennand KJ, Xu K, Zhao H, Krystal JH, Young KA, Williamson DE, Che A, Zhang J, Girgenti MJ. Nature. 2025 Jul; 2025 Jun 18. PMID: 40533550.
Investigating the Contribution of Coding Variants in Alcohol Use Disorder Using Whole-Exome Sequencing Across Ancestries.Wang L, Kranzler HR, Gelernter J, Zhou H. Biol Psychiatry. 2025 Jul 1; 2025 Jan 30. PMID: 39892688.
Basal forebrain volume is associated with cortical amyloid burden in cognitively unimpaired older adults at varying genetic risk for Alzheimer's disease.Cho G, Kelly K, Toyonaga T, Carson RE, Miner B, Gelernter J, Varma P, van Dyck CH, Mecca AP, O'Dell R. bioRxiv. 2025 Jun 30; 2025 Jun 30. PMID: 40501985.
Psychometric properties and socio-demographic correlates of the Connor-Davidson Resilience Scale in three large population-based cohorts including Danish and Icelandic adults.Didriksen M, Daníelsdottir H, Bjarnadóttir MD, Overstreet C, Choi KW, Christoffersen LAN, Mikkelsen C, Aspelund T, Hauksdóttir A, Thordardottir EB, Jakobsdóttir J, Tómasson G, Erikstrup C, Aagaard B, Bruun MT, Ullum H, Sørensen E, Fischer IC, Pietrzak RH, Gelernter J, Campbell-Sills L, Stein MB, Werge T, Pedersen OB, Valdimarsdóttir U, Ostrowski SR, Schork AJ. J Mood Anxiety Disord. 2025 Jun; 2025 Feb 17. PMID: 40657597.
Moderation of treatment outcomes by polygenic risk for alcohol-related traits in placebo-controlled trials of topiramate.Kranzler HR, Jinwala Z, Davis CN, Xu H, Biernacka JM, Zhou H, Kember RL, Gelernter J, Feinn R. Alcohol Clin Exp Res (Hoboken). 2025 Jun; 2025 May 30. PMID: 40445294.
Genome-wide analyses identify 30 loci associated with obsessive-compulsive disorder.Strom NI, Gerring ZF, Galimberti M, Yu D, Halvorsen MW, Abdellaoui A, Rodriguez-Fontenla C, Sealock JM, Bigdeli T, Coleman JR, Mahjani B, Thorp JG, Bey K, Burton CL, Luykx JJ, Zai G, Alemany S, Andre C, Askland KD, Bäckman J, Banaj N, Barlassina C, Nissen JB, Bienvenu OJ, Black D, Bloch MH, Børte S, Bosch R, Breen M, Brennan BP, Brentani H, Buxbaum JD, Bybjerg-Grauholm J, Byrne EM, Cabana-Dominguez J, Camarena B, Camarena A, Cappi C, Carracedo A, Casas M, Cavallini MC, Ciullo V, Cook EH, Crosby J, Cullen BA, De Schipper EJ, Delorme R, Djurovic S, Elias JA, Estivill X, Falkenstein MJ, Fundin BT, Garner L, Gironda C, Goes FS, Grados MA, Grove J, Guo W, Haavik J, Hagen K, Harrington K, Havdahl A, Höffler KD, Hounie AG, Hucks D, Hultman C, Janecka M, Jenike E, Karlsson EK, Kelley K, Klawohn J, Krasnow JE, Krebs K, Lange C, Lanzagorta N, Levey D, Lindblad-Toh K, Macciardi F, Maher B, Mathes B, McArthur E, McGregor N, McLaughlin NC, Meier S, Miguel EC, Mulhern M, Nestadt PS, Nurmi EL, O'Connell KS, Osiecki L, Ousdal OT, Palviainen T, Pedersen NL, Piras F, Piras F, Potluri S, Rabionet R, Ramirez A, Rauch S, Reichenberg A, Riddle MA, Ripke S, Rosário MC, Sampaio AS, Schiele MA, Skogholt AH, Sloofman LG, Smit J, Artigas MS, Thomas LF, Tifft E, Vallada H, van Kirk N, Veenstra-VanderWeele J, Vulink NN, Walker CP, Wang Y, Wendland JR, Winsvold BS, Yao Y, Zhou H, Agrawal A, Alonso P, Berberich G, Bucholz KK, Bulik CM, Cath D, Denys D, Eapen V, Edenberg H, Falkai P, Fernandez TV, Fyer AJ, Gaziano JM, Geller DA, Grabe HJ, Greenberg BD, Hanna GL, Hickie IB, Hougaard DM, Kathmann N, Kennedy J, Lai D, Landén M, Hellard SL, Leboyer M, Lochner C, McCracken JT, Medland SE, Mortensen PB, Neale BM, Nicolini H, Nordentoft M, Pato M, Pato C, Pauls DL, Piacentini J, Pittenger C, Posthuma D, Ramos-Quiroga JA, Rasmussen SA, Richter MA, Rosenberg DR, Ruhrmann S, Samuels JF, Sandin S, Sandor P, Spalletta G, Stein DJ, Stewart SE, Storch EA, Stranger BE, Turiel M, Werge T, Andreassen OA, Børglum AD, Walitza S, Hveem K, Hansen BK, Rück C, Martin NG, Milani L, Mors O, Reichborn-Kjennerud T, Ribasés M, Kvale G, Mataix-Cols D, Domschke K, Grünblatt E, Wagner M, Zwart JA, Breen G, Nestadt G, Kaprio J, Arnold PD, Grice DE, Knowles JA, Ask H, Verweij KJ, Davis LK, Smit DJ, Crowley JJ, Scharf JM, Stein MB, Gelernter J, Mathews CA, Derks EM, Mattheisen M. Nat Genet. 2025 Jun; 2025 May 13. PMID: 40360802.
Optimism moderates the relationship between inflammatory polygenic risk and major depressive disorder in U.S. Military veterans.Fischer IC, Overstreet C, Cabrera-Mendoza B, Qiu D, Krystal JH, Polimanti R, Gelernter J, Pietrzak RH. World J Biol Psychiatry. 2025 Jun; 2025 May 9. PMID: 40343713.
A contextual genomic perspective on physical activity and its relationship to health, well-being and illness.Galimberti M, Levey DF, Deak JD, Adhikari K, Overstreet C, Gupta P, Nitin R, Zhou H, Lake NJ, Harrington KM, Djousse L, Davis LK, Gaziano JM, Stein MB, Gelernter J. medRxiv. 2025 May 28; 2025 May 28. PMID: 40321252.
Associations of Childhood Adversity and Polygenic Scores with Substance Use Initiation and Disorder Severity - ERRATUM.SooHoo JF, Davis CN, Han A, Jinwala Z, Gelernter J, Feinn R, Kranzler HR. Psychol Med. 2025 May 22; 2025 May 22. PMID: 40400391.
Multi-ancestry genetic architecture of sleep duration and its relationship to other sleep and psychiatric phenotypes.Austin-Zimmerman I, Levey DF, Deak JD, Galimberti M, Adhikari K, Coleman JRI, Buysse DJ, Wilson PWF, Sofer T, Gaziano JM, Gottlieb DJ, Stein MB, Forti MD, Gelernter J. medRxiv. 2025 May 21; 2025 May 21. PMID: 40475156.
Robust inference and widespread genetic correlates from a large-scale genetic association study of human personality.Schwaba T, Clapp Sullivan ML, Akingbuwa WA, Ilves K, Tanksley PT, Williams CM, Dragostinov Y, Liao W, Ackerman LS, Fealy JCM, Hemani G, de la Fuente J, Gupta P, Stein MB, Gelernter J, Levey DF, Võsa U, Ausmees L, Realo A, Vaht M, Allik J, Esko T, Mõttus R, Vainik U, Jonsdottir GA, Thorleifsson G, Gunnarsson ÁF, Bjornsdottir G, Thorgeirsson TE, Stefansson H, Stefansson K, Cheesman R, Qin Q, Corfield EC, Ask H, Torvik FA, Ystrom E, Tesli M, Boomsma DI, de Geus EJC, Hottenga JJ, Melo DC, Snieder H, Hartman CA, Xia C, Campbell A, Luciano M, Deary IJ, Hill WD, Jang SK, Vrieze SI, Abecasis G, Lupton MK, Mitchell BL, Viher PV, Colodro-Conde L, Martin NG, Medland SE, Derks EM, Wormington B, Kaprio J, Silventoinen K, Palviainen T, Gidziela A, Rimfeld K, Plomin R, Malanchini M, Dick DM, Aliev F, Wesseldijk LW, Ullén F, Mosing MA, Kranzler HR, Nunez Y, Beck S, Polimanti R, Edwards T, Giannelis A, Willoughby EA, Lee JJ, McGue M, Terracciano A, Marongiu M, Fiorillo E, Cucca F, Sutin AR, van der Most PJ, Oldehinkel AJ, Kretschmer T, Shabalin AA, Docherty AR, Krueger RF, Freilich CD, Mishra BH, Lehtimäki T, Raitakari OT, Kähönen M, Saarinen A, Dobewall H, Keltikangas-Järvinen L, Berger K, Herrera-Rivero M, Streit F, Awasthi S, Witt SH, Tuhkanen J, Räikkönen K, Eriksson JG, Lahti J, Davies G, Redmond P, Taylor A, Corley J, Russ TC, Ciullo M, Nutile T, Ding J, Qian Y, Tanaka T, Ferrucci L, Zillich L, Sirignano L, Harden KP, Genç E, Gajewski PD, Getzmann S, Fraenz C, Schneider Peñate JE, Lis S, Hall ASM, Schmahl C, Herpertz SC, Abdellaoui A, Nivard MG, Tucker-Drob EM. bioRxiv. 2025 May 19; 2025 May 19. PMID: 40475535.
Unraveling the genetics of gulf war illness in diverse participants enrolled in the million veteran program.Pathak GA, Koller D, Cabrera-Mendoza B, Nono Djotsa ABS, Wendt FR, De Lillo A, Friligkou E, He J, Kouakou MR, Duong LM, Vahey J, Steele L, Quaden R, Harrington KM, Ahmed ST, Gaziano JM, Concato J, Zhao H, Radhakrishnan K, Gelernter J, Gifford E, Aslan M, Helmer DA, Hauser ER, Polimanti R. Hum Mol Genet. 2025 May 14; 2025 May 14. PMID: 40366759.
PTSD and epigenetic aging: a longitudinal meta-analysis.Zhao X, Katrinli S, McCormick BM, Miller MW, Nugent NR, Wani AH, Zannas AS, Aiello AE, Baker DG, Boks MP, Chen CY, Fortier CB, Gelernter J, Geuze E, Koenen KC, Linnstaedt SD, Luykx JJ, Maihofer AX, McLean SA, Milberg WP, Ratanatharathorn A, Ressler KJ, Risbrough VB, Rutten BPF, Smoller JW, Stein MB, Ursano RJ, Vermetten E, Vinkers CH, Ware EB, Wildman DE, Zhao Y, Logue MW, Nievergelt CM, Smith AK, Uddin M, Wolf EJ. Psychol Med. 2025 May 14; 2025 May 14. PMID: 40366073.
Integrating HiTOP and RDoC frameworks part II: shared and distinct biological mechanisms of externalizing and internalizing psychopathology.Davis CN, Khan Y, Toikumo S, Jinwala Z, Boomsma DI, Levey DF, Gelernter J, Kember RL, Kranzler HR. Psychol Med. 2025 May 9; 2025 May 9. PMID: 40340892.
Integrating HiTOP and RDoC frameworks Part I: Genetic architecture of externalizing and internalizing psychopathology.Davis CN, Khan Y, Toikumo S, Jinwala Z, Boomsma DI, Levey DF, Gelernter J, Kember RL, Kranzler HR. Psychol Med. 2025 May 8; 2025 May 8. PMID: 40336358.
Associations of childhood adversity and substance use disorder polygenic scores with disorder severity and diagnostic criteria.SooHoo JF, Davis CN, Han A, Jinwala Z, Gelernter J, Feinn R, Kranzler HR. Psychol Med. 2025 May 2; 2025 May 2. PMID: 40314172.
Psychiatric genetics in the diverse landscape of Latin American populations.Bruxel EM, Rovaris DL, Belangero SI, Chavarría-Soley G, Cuellar-Barboza AB, Martínez-Magaña JJ, Nagamatsu ST, Nievergelt CM, Núñez-Ríos DL, Ota VK, Peterson RE, Sloofman LG, Adams AM, Albino E, Alvarado AT, Andrade-Brito D, Arguello-Pascualli PY, Bandeira CE, Bau CHD, Bulik CM, Buxbaum JD, Cappi C, Corral-Frias NS, Corrales A, Corsi-Zuelli F, Crowley JJ, Cupertino RB, da Silva BS, De Almeida SS, De la Hoz JF, Forero DA, Fries GR, Gelernter J, González-Giraldo Y, Grevet EH, Grice DE, Hernández-Garayua A, Hettema JM, Ibáñez A, Ionita-Laza I, Lattig MC, Lima YC, Lin YS, López-León S, Loureiro CM, Martínez-Cerdeño V, Martínez-Levy GA, Melin K, Moreno-De-Luca D, Muniz Carvalho C, Olivares AM, Oliveira VF, Ormond R, Palmer AA, Panzenhagen AC, Passos-Bueno MR, Peng Q, Pérez-Palma E, Prieto ML, Roussos P, Sanchez-Roige S, Santamaría-García H, Shansis FM, Sharp RR, Storch EA, Tavares MEA, Tietz GE, Torres-Hernández BA, Tovo-Rodrigues L, Trelles P, Trujillo-ChiVacuan EM, Velásquez MM, Vera-Urbina F, Voloudakis G, Wegman-Ostrosky T, Zhen-Duan J, Zhou H, Santoro ML, Nicolini H, Atkinson EG, Giusti-Rodríguez P, Montalvo-Ortiz JL. Nat Genet. 2025 May; 2025 Apr 2. PMID: 40175716.
Alcohol use disorder and body mass index show genetic pleiotropy and shared neural associations.Malone SG, Davis CN, Piserchia Z, Setzer MR, Toikumo S, Zhou H, Winterlind EL, Gelernter J, Justice A, Leggio L, Rentsch CT, Kranzler HR, Gray JC. Nat Hum Behav. 2025 May; 2025 Mar 31. PMID: 40164914.
Genome-wide analyses identify 30 loci associated with obsessive-compulsive disorder.Strom NI, Gerring ZF, Galimberti M, Yu D, Halvorsen MW, Abdellaoui A, Rodriguez-Fontenla C, Sealock JM, Bigdeli T, Coleman JR, Mahjani B, Thorp JG, Bey K, Burton CL, Luykx JJ, Zai G, Alemany S, Andre C, Askland KD, Bäckmann J, Banaj N, Barlassina C, Nissen JB, Bienvenu OJ, Black D, Bloch MH, Børte S, Bosch R, Breen M, Brennan BP, Brentani H, Buxbaum JD, Bybjerg-Grauholm J, Byrne EM, Cabana-Dominguez J, Camarena B, Camarena A, Cappi C, Carracedo A, Casas M, Cavallini MC, Ciullo V, Cook EH, Crosby J, Cullen BA, De Schipper EJ, Delorme R, Djurovic S, Elias JA, Estivill X, Falkenstein MJ, Fundin BT, Garner L, Gironda C, Goes FS, Grados MA, Grove J, Guo W, Haavik J, Hagen K, Harrington K, Havdahl A, Höffler KD, Hounie AG, Hucks D, Hultman C, Janecka M, Jenike E, Karlsson EK, Kelley K, Klawohn J, Krasnow JE, Krebs K, Lange C, Lanzagorta N, Levey D, Lindblad-Toh K, Macciardi F, Maher B, Mathes B, McArthur E, McGregor N, McLaughlin NC, Meier S, Miguel EC, Mulhern M, Nestadt PS, Nurmi EL, O'Connell KS, Osiecki L, Ousdal OT, Palviainen T, Pedersen NL, Piras F, Piras F, Potluri S, Rabionet R, Ramirez A, Rauch S, Reichenberg A, Riddle MA, Ripke S, Rosário MC, Sampaio AS, Schiele MA, Skogholt AH, Sloofman LG, Smit J, Soler Artigas M, Thomas LF, Tifft E, Vallada H, van Kirk N, Veenstra-VanderWeele J, Vulink NN, Walker CP, Wang Y, Wendland JR, Winsvold BS, Yao Y, Zhou H, Agrawal A, Alonso P, Berberich G, Bucholz KK, Bulik CM, Cath D, Denys D, Eapen V, Edenberg H, Falkai P, Fernandez TV, Fyer AJ, Gaziano JM, Geller DA, Grabe HJ, Greenberg BD, Hanna GL, Hickie IB, Hougaard DM, Kathmann N, Kennedy J, Lai D, Landén M, Le Hellard S, Leboyer M, Lochner C, McCracken JT, Medland SE, Mortensen PB, Neale BM, Nicolini H, Nordentoft M, Pato M, Pato C, Pauls DL, Piacentini J, Pittenger C, Posthuma D, Ramos-Quiroga JA, Rasmussen SA, Richter MA, Rosenberg DR, Ruhrmann S, Samuels JF, Sandin S, Sandor P, Spalletta G, Stein DJ, Stewart SE, Storch EA, Stranger BE, Turiel M, Werge T, Andreassen OA, Børglum AD, Walitza S, Hveem K, Hansen BK, Rück C, Martin NG, Milani L, Mors O, Reichborn-Kjennerud T, Ribasés M, Kvale G, Mataix-Cols D, Domschke K, Grünblatt E, Wagner M, Zwart JA, Breen G, Nestadt G, Kaprio J, Arnold PD, Grice DE, Knowles JA, Ask H, Verweij KJ, Davis LK, Smit DJ, Crowley JJ, Scharf JM, Stein MB, Gelernter J, Mathews CA, Derks EM, Mattheisen M. medRxiv. 2025 Apr 8; 2025 Apr 8. PMID: 38712091.
A multicenter cross-sectional study of gambling disorder among patients with methamphetamine use disorder in drug rehabilitation centers: prevalence, correlates, and network analysis.Peng P, Hao Y, Zhang X, Ma Y, Liu X, Shen D, Shen W, Zhao B, Li D, Beck SE, Nunez YZ, Potenza MN, Gelernter J, Liu T, Yang BZ. Ann Gen Psychiatry. 2025 Mar 3; 2025 Mar 3. PMID: 40033412.
Integrating HiTOP and RDoC Frameworks Part I: Genetic Architecture of Externalizing and Internalizing Psychopathology.Davis CN, Khan Y, Toikumo S, Jinwala Z, Boomsma DI, Levey DF, Gelernter J, Kember RL, Kranzler HR. medRxiv. 2025 Feb 5; 2025 Feb 5. PMID: 38645045.
Multi-ancestral genome-wide association study of clinically defined nicotine dependence reveals strong genetic correlations with other substance use disorders and health-related traits.Johnson EC, Lai D, Miller AP, Hatoum AS, Deak JD, Balbona JV, Baranger DA, Galimberti M, Sanichwankul K, Thorgeirsson T, Colbert SM, Sanchez-Roige S, Adhikari K, Docherty A, Degenhardt L, Edwards T, Fox L, Giannelis A, Jeffries P, Korhonen T, Morrison C, Nunez YZ, Palviainen T, Su MH, Villela PNR, Wetherill L, Willoughby EA, Zellers S, Bierut L, Buchwald J, Copeland W, Corley R, Friedman NP, Foroud TM, Gillespie NA, Gizer IR, Heath AC, Hickie IB, Kaprio JA, Keller MC, Lee JL, Lind PA, Madden PA, Maes HH, Martin NG, McGue M, Medland SE, Nelson EC, Pearson JV, Porjesz B, Stallings M, Vrieze S, Wilhelmsen KC, Walters RK, Polimanti R, Malison RT, Zhou H, Stefansson K, Potenza MN, Mutirangura A, Shotelersuk V, Kalayasiri R, Edenberg HJ, Gelernter J, Agrawal A. medRxiv. 2025 Feb 3; 2025 Feb 3. PMID: 39974067.
Identification of risk variants and cross-disorder pleiotropy through multi-ancestry genome-wide analysis of alcohol use disorder.Icick R, Shadrin A, Holen B, Karadag N, Parker N, O'Connell KS, Frei O, Bahrami S, Høegh MC, Lagerberg TV, Cheng W, Seibert TM, Djurovic S, Dale AM, Zhou H, Edenberg HJ, Gelernter J, Smeland OB, Hindley G, Andreassen OA. Nat Ment Health. 2025 Feb; 2025 Jan 8. PMID: 40322774.
Sex-stratified Genomic Structural Equation Models of Posttraumatic Stress Inform PTSD Etiology: L'utilisation de la modélisation génomique par équations structurelles stratifiée par sexe du stress post-traumatique pour expliquer l'étiologie du TSPT.Moo-Choy A, Stein MB, Gelernter J, Wendt FR. Can J Psychiatry. 2025 Feb; 2024 Dec 9. PMID: 39654303.
Genes in context: path to more precise risk prediction in psychiatry?Na PJ, Pietrzak RH, Gelernter J. Br J Psychiatry. 2025 Feb; 2024 Oct 18. PMID: 39422146.
Concerns about genetic risk testing for opioid use disorder.Hatoum AS, Davis CN, Kember RL, Johnstone M, Oslin DW, Zinkstok JR, Burmeister M, Agrawal A, Kranzler HR, Edenberg HJ, Gelernter J, Docherty AR, Lencz T. Lancet Psychiatry. 2025 Feb; 2024 Oct 13. PMID: 39413801.
The Landscape of Shared and Divergent Genetic Influences across 14 Psychiatric Disorders.Grotzinger AD, Werme J, Peyrot WJ, Frei O, de Leeuw C, Bicks LK, Guo Q, Margolis MP, Coombes BJ, Batzler A, Pazdernik V, Biernacka JM, Andreassen OA, Anttila V, Børglum AD, Cai N, Demontis D, Edenberg HJ, Faraone SV, Franke B, Gandal MJ, Gelernter J, Hettema JM, Jonas KG, Knowles JA, Koenen KC, Maihofer AX, Mallard TT, Mattheisen M, Mitchell KS, Neale BM, Nievergelt CM, Nurnberger JI, O'Connell KS, Robinson EB, Sanchez-Roige SS, Santangelo SL, Stefansson H, Stefansson K, Stein MB, Strom NI, Thornton LM, Tucker-Drob EM, Verhulst B, Waldman ID, Walters GB, Wray NR, Lee PH, Kendler KS, Smoller JW. medRxiv. 2025 Jan 15; 2025 Jan 15. PMID: 40568675.
A semi-empirical Bayes approach for calibrating weak instrumental bias in sex-specific Mendelian randomization studies.Huang YJ, Kurniansyah N, Levey DF, Gelernter J, Huffman JE, Cho K, Wilson PWF, Gottlieb DJ, Rice KM, Sofer T. medRxiv. 2025 Jan 2; 2025 Jan 2. PMID: 39802770.
Utility of Candidate Genes From an Algorithm Designed to Predict Genetic Risk for Opioid Use Disorder.Davis CN, Jinwala Z, Hatoum AS, Toikumo S, Agrawal A, Rentsch CT, Edenberg HJ, Baurley JW, Hartwell EE, Crist RC, Gray JC, Justice AC, Gelernter J, Kember RL, Kranzler HR. JAMA Netw Open. 2025 Jan 2; 2025 Jan 2. PMID: 39786773.
Author Correction: Multivariate analysis of 1.5 million people identifies genetic associations with traits related to self-regulation and addiction.Karlsson Linnér R, Mallard TT, Barr PB, Sanchez-Roige S, Madole JW, Driver MN, Poore HE, de Vlaming R, Grotzinger AD, Tielbeek JJ, Johnson EC, Liu M, Rosenthal SB, Ideker T, Zhou H, Kember RL, Pasman JA, Verweij KJH, Liu DJ, Vrieze S, Kranzler HR, Gelernter J, Harris KM, Tucker-Drob EM, Waldman ID, Palmer AA, Harden KP, Koellinger PD, Dick DM. Nat Neurosci. 2025 Jan. PMID: 39643700.
Opioid use disorder and brain health: observational and genetic associations.Javidnia S, Roe JM, Karhunen V, Gill D, Bell S, Deak J, Levey D, Cronje T, Burgess S, Gelernter J, Ebmeier KP, Topiwala A. medRxiv. 2024 Dec 18; 2024 Dec 18. PMID: 39763526.
Alcohol use disorder and body mass index show genetic pleiotropy and shared neural associations.Malone SG, Davis CN, Piserchia Z, Setzer MR, Toikumo S, Zhou H, Winterlind EL, Gelernter J, Justice A, Leggio L, Rentsch CT, Kranzler HR, Gray JC. medRxiv. 2024 Dec 14; 2024 Dec 14. PMID: 38746260.
Posttraumatic Stress Disorder, Obesity, and Accelerated Epigenetic Aging Among US Military Veterans.Fischer IC, Na PJ, Nagamatsu ST, Jeste DV, Cabrera-Mendoza B, Montalvo-Ortiz JL, Krystal JH, Polimanti R, Gelernter J, Pietrzak RH. JAMA Psychiatry. 2024 Dec 1. PMID: 39476130.
Application of polygenic scores to a deeply phenotyped sample enriched for substance use disorders reveals extensive pleiotropy with psychiatric and somatic traits.Hartwell EE, Jinwala Z, Milone J, Ramirez S, Gelernter J, Kranzler HR, Kember RL. Neuropsychopharmacology. 2024 Dec; 2024 Jul 23. PMID: 39043921.
Predicting Treatment-seeking Status for Alcohol Use Disorder Using Polygenic Scores and Machine Learning in a Deeply-Phenotyped Sample.Jinwala Z, Green R, Khan Y, Gelernter J, Kember RL, Hartwell EE. medRxiv. 2024 Nov 23; 2024 Nov 23. PMID: 39606347.
Genome-wide meta-analysis of myasthenia gravis uncovers new loci and provides insights into polygenic prediction.Braun A, Shekhar S, Levey DF, Straub P, Kraft J, Panagiotaropoulou GM, Heilbron K, Awasthi S, Meleka Hanna R, Hoffmann S, Stein M, Lehnerer S, Mergenthaler P, Elnahas AG, Topaloudi A, Koromina M, Palviainen T, Asbjornsdottir B, Stefansson H, Skuladóttir AT, Jónsdóttir I, Stefansson K, Reis K, Esko T, Palotie A, Leypoldt F, Stein MB, Fontanillas P, Kaprio J, Gelernter J, Davis LK, Paschou P, Tannemaat MR, Verschuuren JJGM, Kuhlenbäumer G, Gregersen PK, Huijbers MG, Stascheit F, Meisel A, Ripke S. Nat Commun. 2024 Nov 13; 2024 Nov 13. PMID: 39537604.
What Are the Genetic Building Blocks of Alcohol-Related Behaviors?Gelernter J, Deak JD. Am J Psychiatry. 2024 Nov 1. PMID: 39482951.
A genome-wide investigation into the underlying genetic architecture of personality traits and overlap with psychopathology.Gupta P, Galimberti M, Liu Y, Beck S, Wingo A, Wingo T, Adhikari K, Kranzler HR, Stein MB, Gelernter J, Levey DF. Nat Hum Behav. 2024 Nov; 2024 Aug 12. PMID: 39134740.
Association between cannabis use and brain structure and function: an observational and Mendelian randomisation study.Ishrat S, Levey DF, Gelernter J, Ebmeier K, Topiwala A. BMJ Ment Health. 2024 Oct 30; 2024 Oct 30. PMID: 39477366.
Epigenetic and Genetic Profiling of Comorbidity Patterns among Substance Dependence Diagnoses.Pathak GA, Pietrzak RH, Lacobelle A, Overstreet C, Wendt FR, Deak JD, Friligkou E, Nunez Y, Montalvo-Ortiz JL, Levey DF, Kranzler HR, Gelernter J, Polimanti R. medRxiv. 2024 Oct 8; 2024 Oct 8. PMID: 39417130.
Cross-ancestry genetic investigation of schizophrenia, cannabis use disorder, and tobacco smoking.Johnson EC, Austin-Zimmerman I, Thorpe HHA, Levey DF, Baranger DAA, Colbert SMC, Demontis D, Khokhar JY, Davis LK, Edenberg HJ, Di Forti M, Sanchez-Roige S, Gelernter J, Agrawal A. Neuropsychopharmacology. 2024 Oct; 2024 Jun 21. PMID: 38906991.
Whole-exome sequencing study of opioid dependence offers novel insights into the contributions of exome variants.Wang L, Nuñez YZ, Kranzler HR, Zhou H, Gelernter J. medRxiv. 2024 Sep 17; 2024 Sep 17. PMID: 39371181.
Genetic influences and causal pathways shared between cannabis use disorder and other substance use traits.Galimberti M, Levey DF, Deak JD, Zhou H, Stein MB, Gelernter J. Mol Psychiatry. 2024 Sep; 2024 Apr 5. PMID: 38580809.
Association patterns of antisocial personality disorder across substance use disorders.Low A, Stiltner B, Nunez YZ, Adhikari K, Deak JD, Pietrzak RH, Kranzler HR, Gelernter J, Polimanti R. Transl Psychiatry. 2024 Aug 28; 2024 Aug 28. PMID: 39198385.
Genetics of posttraumatic stress disorder and cardiovascular conditions using Life's Essential 8, Electronic Health Records, and Heart Imaging.Shen J, Valentim W, Friligkou E, Overstreet C, Choi K, Koller D, O'Donnell CJ, Stein MB, Gelernter J, Lv H, Sun L, Falcone GJ, Polimanti R, Pathak GA. medRxiv. 2024 Aug 21; 2024 Aug 21. PMID: 39228734.
Human genetics and epigenetics of alcohol use disorder.Zhou H, Gelernter J. J Clin Invest. 2024 Aug 15; 2024 Aug 15. PMID: 39145449.
Gene × environment effects and mediation involving adverse childhood events, mood and anxiety disorders, and substance dependence.Kranzler HR, Davis CN, Feinn R, Jinwala Z, Khan Y, Oikonomou A, Silva-Lopez D, Burton I, Dixon M, Milone J, Ramirez S, Shifman N, Levey D, Gelernter J, Hartwell EE, Kember RL. Nat Hum Behav. 2024 Aug; 2024 Jun 4. PMID: 38834750.
Multivariate, Multi-omic Analysis in 799,429 Individuals Identifies 134 Loci Associated with Somatoform Traits.Davis CN, Toikumo S, Hatoum AS, Khan Y, Pham BK, Pakala SR, Feuer KL, Gelernter J, Sanchez-Roige S, Kember RL, Kranzler HR. medRxiv. 2024 Jul 29; 2024 Jul 29. PMID: 39132487.
Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program.Verma A, Huffman JE, Rodriguez A, Conery M, Liu M, Ho YL, Kim Y, Heise DA, Guare L, Panickan VA, Garcon H, Linares F, Costa L, Goethert I, Tipton R, Honerlaw J, Davies L, Whitbourne S, Cohen J, Posner DC, Sangar R, Murray M, Wang X, Dochtermann DR, Devineni P, Shi Y, Nandi TN, Assimes TL, Brunette CA, Carroll RJ, Clifford R, Duvall S, Gelernter J, Hung A, Iyengar SK, Joseph J, Kember R, Kranzler H, Kripke CM, Levey D, Luoh SW, Merritt VC, Overstreet C, Deak JD, Grant SFA, Polimanti R, Roussos P, Shakt G, Sun YV, Tsao N, Venkatesh S, Voloudakis G, Justice A, Begoli E, Ramoni R, Tourassi G, Pyarajan S, Tsao P, O'Donnell CJ, Muralidhar S, Moser J, Casas JP, Bick AG, Zhou W, Cai T, Voight BF, Cho K, Gaziano JM, Madduri RK, Damrauer S, Liao KP. Science. 2024 Jul 19; 2024 Jul 19. PMID: 39024449.
Genome-wide association study of major anxiety disorders in 122,341 European-ancestry cases identifies 58 loci and highlights GABAergic signaling.Strom NI, Verhulst B, Bacanu SA, Cheesman R, Purves KL, Gedik H, Mitchell BL, Kwong AS, Faucon AB, Singh K, Medland S, Colodro-Conde L, Krebs K, Hoffmann P, Herms S, Gehlen J, Ripke S, Awasthi S, Palviainen T, Tasanko EM, Peterson RE, Adkins DE, Shabalin AA, Adams MJ, Iveson MH, Campbell A, Thomas LF, Winsvold BS, Drange OK, Børte S, Ter Kuile AR, Nguyen TH, Meier SM, Corfield EC, Hannigan L, Levey DF, Czamara D, Weber H, Choi KW, Pistis G, Couvy-Duchesne B, Van der Auwera S, Teumer A, Karlsson R, Garcia-Argibay M, Lee D, Wang R, Bjerkeset O, Stordal E, Bäckmann J, Salum GA, Zai CC, Kennedy JL, Zai G, Tiwari AK, Heilmann-Heimbach S, Schmidt B, Kaprio J, Kennedy MM, Boden J, Havdahl A, Middeldorp CM, Lopes FL, Akula N, McMahon FJ, Binder EB, Fehm L, Ströhle A, Castelao E, Tiemeier H, Stein DJ, Whiteman D, Olsen C, Fuller Z, Wang X, Wray NR, Byrne EM, Lewis G, Timpson NJ, Davis LK, Hickie IB, Gillespie NA, Milani L, Schumacher J, Woldbye DP, Forstner AJ, Nöthen MM, Hovatta I, Horwood J, Copeland WE, Maes HH, McIntosh AM, Andreassen OA, Zwart JA, Mors O, Børglum AD, Mortensen PB, Ask H, Reichborn-Kjennerud T, Najman JM, Stein MB, Gelernter J, Milaneschi Y, Penninx BW, Boomsma DI, Maron E, Erhardt-Lehmann A, Rück C, Kircher TT, Melzig CA, Alpers GW, Arolt V, Domschke K, Smoller JW, Preisig M, Martin NG, Lupton MK, Luik AI, Reif A, Grabe HJ, Larsson H, Magnusson PK, Oldehinkel AJ, Hartman CA, Breen G, Docherty AR, Coon H, Conrad R, Lehto K, Deckert J, Eley TC, Mattheisen M, Hettema JM. medRxiv. 2024 Jul 5; 2024 Jul 5. PMID: 39006447.
Identifying neurofunctional domains across substance use disorders.Hartwell EE, Schwandt M, Nunez YZ, Wetherill RR, Kember RL, Wiers CE, Gelernter J, Kranzler HR. Am J Drug Alcohol Abuse. 2024 Jul 3; 2024 Jul 17. PMID: 39018668.
Distinguishing vulnerability and resilience to posttraumatic stress disorder evaluating traumatic experiences, genetic risk and electronic health records.Løkhammer S, Koller D, Wendt FR, Choi KW, He J, Friligkou E, Overstreet C, Gelernter J, Hellard SL, Polimanti R. Psychiatry Res. 2024 Jul; 2024 May 8. PMID: 38744179.
Author Correction: A multi-ancestry genetic study of pain intensity in 598,339 veterans.Toikumo S, Vickers-Smith R, Jinwala Z, Xu H, Saini D, Hartwell EE, Pavicic M, Sullivan KA, Xu K, Jacobson DA, Gelernter J, Rentsch CT, Stahl E, Cheatle M, Zhou H, Waxman SG, Justice AC, Kember RL, Kranzler HR. Nat Med. 2024 Jul. PMID: 38714900.
Pleiotropy and genetically inferred causality linking multisite chronic pain to substance use disorders.Koller D, Friligkou E, Stiltner B, Pathak GA, Løkhammer S, Levey DF, Zhou H, Hatoum AS, Deak JD, Kember RL, Treur JL, Kranzler HR, Johnson EC, Stein MB, Gelernter J, Polimanti R. Mol Psychiatry. 2024 Jul; 2024 Feb 15. PMID: 38355787.
Genome-wide association study of the common retinal disorder epiretinal membrane: Significant risk loci in each of three American populations.Gelernter J, Levey DF, Galimberti M, Harrington K, Zhou H, Adhikari K, Gupta P, Gaziano JM, Eliott D, Stein MB. Cell Genom. 2024 Jun 12. PMID: 38870908.
Polygenic liability for anxiety in association with comorbid anxiety in multiple sclerosis.Kowalec K, Harder A, Dolovich C, Fitzgerald KC, Salter A, Lu Y, Bernstein CN, Bolton JM, Cutter G, Fisk JD, Gelernter J, Graff LA, Hägg S, Hitchon CA, Levey DF, Lublin FD, McKay KA, Patten S, Patki A, Stein MB, Tiwari HK, Wolinsky JS, Marrie RA. Ann Clin Transl Neurol. 2024 Jun; 2024 May 7. PMID: 38715244.
Multi-ancestry meta-analysis of tobacco use disorder identifies 461 potential risk genes and reveals associations with multiple health outcomes.Toikumo S, Jennings MV, Pham BK, Lee H, Mallard TT, Bianchi SB, Meredith JJ, Vilar-Ribó L, Xu H, Hatoum AS, Johnson EC, Pazdernik VK, Jinwala Z, Pakala SR, Leger BS, Niarchou M, Ehinmowo M, Jenkins GD, Batzler A, Pendegraft R, Palmer AA, Zhou H, Biernacka JM, Coombes BJ, Gelernter J, Xu K, Hancock DB, Cox NJ, Smoller JW, Davis LK, Justice AC, Kranzler HR, Kember RL, Sanchez-Roige S. Nat Hum Behav. 2024 Jun; 2024 Apr 17. PMID: 38632388.
Genetic and non-genetic predictors of risk for opioid dependence.Na PJ, Deak JD, Kranzler HR, Pietrzak RH, Gelernter J. Psychol Med. 2024 Jun; 2024 Feb 6. PMID: 38317430.
Candidate Genes from an FDA-Approved Algorithm Fail to Predict Opioid Use Disorder Risk in Over 450,000 Veterans.Davis CN, Jinwala Z, Hatoum AS, Toikumo S, Agrawal A, Rentsch CT, Edenberg HJ, Baurley JW, Hartwell EE, Crist RC, Gray JC, Justice AC, Gelernter J, Kember RL, Kranzler HR. medRxiv. 2024 May 16; 2024 May 16. PMID: 38798430.
Genome-wide association analyses identify 95 risk loci and provide insights into the neurobiology of post-traumatic stress disorder.Nievergelt CM, Maihofer AX, Atkinson EG, Chen CY, Choi KW, Coleman JRI, Daskalakis NP, Duncan LE, Polimanti R, Aaronson C, Amstadter AB, Andersen SB, Andreassen OA, Arbisi PA, Ashley-Koch AE, Austin SB, Avdibegoviç E, Babić D, Bacanu SA, Baker DG, Batzler A, Beckham JC, Belangero S, Benjet C, Bergner C, Bierer LM, Biernacka JM, Bierut LJ, Bisson JI, Boks MP, Bolger EA, Brandolino A, Breen G, Bressan RA, Bryant RA, Bustamante AC, Bybjerg-Grauholm J, Bækvad-Hansen M, Børglum AD, Børte S, Cahn L, Calabrese JR, Caldas-de-Almeida JM, Chatzinakos C, Cheema S, Clouston SAP, Colodro-Conde L, Coombes BJ, Cruz-Fuentes CS, Dale AM, Dalvie S, Davis LK, Deckert J, Delahanty DL, Dennis MF, Desarnaud F, DiPietro CP, Disner SG, Docherty AR, Domschke K, Dyb G, Kulenović AD, Edenberg HJ, Evans A, Fabbri C, Fani N, Farrer LA, Feder A, Feeny NC, Flory JD, Forbes D, Franz CE, Galea S, Garrett ME, Gelaye B, Gelernter J, Geuze E, Gillespie CF, Goleva SB, Gordon SD, Goçi A, Grasser LR, Guindalini C, Haas M, Hagenaars S, Hauser MA, Heath AC, Hemmings SMJ, Hesselbrock V, Hickie IB, Hogan K, Hougaard DM, Huang H, Huckins LM, Hveem K, Jakovljević M, Javanbakht A, Jenkins GD, Johnson J, Jones I, Jovanovic T, Karstoft KI, Kaufman ML, Kennedy JL, Kessler RC, Khan A, Kimbrel NA, King AP, Koen N, Kotov R, Kranzler HR, Krebs K, Kremen WS, Kuan PF, Lawford BR, Lebois LAM, Lehto K, Levey DF, Lewis C, Liberzon I, Linnstaedt SD, Logue MW, Lori A, Lu Y, Luft BJ, Lupton MK, Luykx JJ, Makotkine I, Maples-Keller JL, Marchese S, Marmar C, Martin NG, Martínez-Levy GA, McAloney K, McFarlane A, McLaughlin KA, McLean SA, Medland SE, Mehta D, Meyers J, Michopoulos V, Mikita EA, Milani L, Milberg W, Miller MW, Morey RA, Morris CP, Mors O, Mortensen PB, Mufford MS, Nelson EC, Nordentoft M, Norman SB, Nugent NR, O'Donnell M, Orcutt HK, Pan PM, Panizzon MS, Pathak GA, Peters ES, Peterson AL, Peverill M, Pietrzak RH, Polusny MA, Porjesz B, Powers A, Qin XJ, Ratanatharathorn A, Risbrough VB, Roberts AL, Rothbaum AO, Rothbaum BO, Roy-Byrne P, Ruggiero KJ, Rung A, Runz H, Rutten BPF, de Viteri SS, Salum GA, Sampson L, Sanchez SE, Santoro M, Seah C, Seedat S, Seng JS, Shabalin A, Sheerin CM, Silove D, Smith AK, Smoller JW, Sponheim SR, Stein DJ, Stensland S, Stevens JS, Sumner JA, Teicher MH, Thompson WK, Tiwari AK, Trapido E, Uddin M, Ursano RJ, Valdimarsdóttir U, Van Hooff M, Vermetten E, Vinkers CH, Voisey J, Wang Y, Wang Z, Waszczuk M, Weber H, Wendt FR, Werge T, Williams MA, Williamson DE, Winsvold BS, Winternitz S, Wolf C, Wolf EJ, Xia Y, Xiong Y, Yehuda R, Young KA, Young RM, Zai CC, Zai GC, Zervas M, Zhao H, Zoellner LA, Zwart JA, deRoon-Cassini T, van Rooij SJH, van den Heuvel LL, Stein MB, Ressler KJ, Koenen KC. Nat Genet. 2024 May; 2024 Apr 18. PMID: 38637617.
A phenome-wide association and Mendelian randomisation study of alcohol use variants in a diverse cohort comprising over 3 million individuals.Jennings MV, Martínez-Magaña JJ, Courchesne-Krak NS, Cupertino RB, Vilar-Ribó L, Bianchi SB, Hatoum AS, Atkinson EG, Giusti-Rodriguez P, Montalvo-Ortiz JL, Gelernter J, Artigas MS, Elson SL, Edenberg HJ, Fontanillas P, Palmer AA, Sanchez-Roige S. EBioMedicine. 2024 May; 2024 Apr 4. PMID: 38580523.
Polygenic risk for suicide attempt is associated with lifetime suicide attempt in US soldiers independent of parental risk.Stein MB, Jain S, Papini S, Campbell-Sills L, Choi KW, Martis B, Sun X, He F, Ware EB, Naifeh JA, Aliaga PA, Ge T, Smoller JW, Gelernter J, Kessler RC, Ursano RJ. J Affect Disord. 2024 Apr 15; 2024 Feb 1. PMID: 38309480.
A Multivariate Genome-Wide Association Study Reveals Neural Correlates and Common Biological Mechanisms of Psychopathology Spectra.Davis C, Khan Y, Toikumo S, Jinwala Z, Boomsma D, Levey D, Gelernter J, Kember R, Kranzler H. Res Sq. 2024 Apr 8; 2024 Apr 8. PMID: 38659902.
Multi-ancestry Whole-exome Sequencing Study of Alcohol Use Disorder in Two Cohorts.Wang L, Kranzler HR, Gelernter J, Zhou H. medRxiv. 2024 Apr 8; 2024 Apr 8. PMID: 38645055.
A multi-ancestry genetic study of pain intensity in 598,339 veterans.Toikumo S, Vickers-Smith R, Jinwala Z, Xu H, Saini D, Hartwell EE, Pavicic M, Sullivan KA, Xu K, Jacobson DA, Gelernter J, Rentsch CT, Stahl E, Cheatle M, Zhou H, Waxman SG, Justice AC, Kember RL, Kranzler HR. Nat Med. 2024 Apr; 2024 Mar 1. PMID: 38429522.
Genetic contribution to the comorbidity between attention-deficit/hyperactivity disorder and substance use disorders.Koller D, Mitjans M, Kouakou M, Friligkou E, Cabrera-Mendoza B, Deak JD, Llonga N, Pathak GA, Stiltner B, Løkhammer S, Levey DF, Zhou H, Hatoum AS, Kember RL, Kranzler HR, Stein MB, Corominas R, Demontis D, Artigas MS, Ramos-Quiroga JA, Gelernter J, Ribasés M, Cormand B, Polimanti R. Psychiatry Res. 2024 Mar; 2024 Feb 3. PMID: 38335780.
Correction: Psychosocial moderators of polygenic risk scores of inflammatory biomarkers in relation to GrimAge.Tamman AJF, Koller D, Nagamatsu S, Cabrera-Mendoza B, Abdallah C, Krystal JH, Gelernter J, Montalvo-Ortiz JL, Polimanti R, Pietrzak RH. Neuropsychopharmacology. 2024 Mar. PMID: 38182778.
Psychosocial moderators of polygenic risk scores of inflammatory biomarkers in relation to GrimAge.Tamman AJF, Koller D, Nagamatsu S, Cabrera-Mendoza B, Abdallah C, Krystal JH, Gelernter J, Montalvo-Ortiz JL, Polimanti R, Pietrzak RH. Neuropsychopharmacology. 2024 Mar; 2023 Oct 17. PMID: 37848731.
Whole-exome sequencing in UK Biobank reveals rare genetic architecture for depression.Tian R, Ge T, Kweon H, Rocha DB, Lam M, Liu JZ, Singh K, Levey DF, Gelernter J, Stein MB, Tsai EA, Huang H, Chabris CF, Lencz T, Runz H, Chen CY. Nat Commun. 2024 Feb 26; 2024 Feb 26. PMID: 38409228.
Multi-ancestry genome-wide association study of major depression aids locus discovery, fine mapping, gene prioritization and causal inference.Meng X, Navoly G, Giannakopoulou O, Levey DF, Koller D, Pathak GA, Koen N, Lin K, Adams MJ, Rentería ME, Feng Y, Gaziano JM, Stein DJ, Zar HJ, Campbell ML, van Heel DA, Trivedi B, Finer S, McQuillin A, Bass N, Chundru VK, Martin HC, Huang QQ, Valkovskaya M, Chu CY, Kanjira S, Kuo PH, Chen HC, Tsai SJ, Liu YL, Kendler KS, Peterson RE, Cai N, Fang Y, Sen S, Scott LJ, Burmeister M, Loos RJF, Preuss MH, Actkins KV, Davis LK, Uddin M, Wani AH, Wildman DE, Aiello AE, Ursano RJ, Kessler RC, Kanai M, Okada Y, Sakaue S, Rabinowitz JA, Maher BS, Uhl G, Eaton W, Cruz-Fuentes CS, Martinez-Levy GA, Campos AI, Millwood IY, Chen Z, Li L, Wassertheil-Smoller S, Jiang Y, Tian C, Martin NG, Mitchell BL, Byrne EM, Awasthi S, Coleman JRI, Ripke S, Sofer T, Walters RG, McIntosh AM, Polimanti R, Dunn EC, Stein MB, Gelernter J, Lewis CM, Kuchenbaecker K. Nat Genet. 2024 Feb; 2024 Jan 4. PMID: 38177345.
Application of polygenic scores to a deeply phenotyped sample enriched for substance use disorders reveals extensive pleiotropy with psychiatric and medical traits.Hartwell EE, Jinwala Z, Milone J, Ramirez S, Gelernter J, Kranzler HR, Kember RL. medRxiv. 2024 Jan 23; 2024 Jan 23. PMID: 38343859.
Cross-ancestry genetic investigation of schizophrenia, cannabis use disorder, and tobacco smoking.Johnson EC, Austin-Zimmerman I, Thorpe HH, Levey DF, Baranger DA, Colbert SM, Demontis D, Khokhar JY, Davis LK, Edenberg HJ, Forti MD, Sanchez-Roige S, Gelernter J, Agrawal A. medRxiv. 2024 Jan 18; 2024 Jan 18. PMID: 38293235.
A genome-wide investigation into the underlying genetic architecture of personality traits and overlap with psychopathology.Gupta P, Galimberti M, Liu Y, Beck S, Wingo A, Wingo T, Adhikari K, Stein MB, Gelernter J, Levey DF. medRxiv. 2024 Jan 17; 2024 Jan 17. PMID: 38293137.