Walter Mowel, PhD
Associate Research ScientistAbout
Research
Publications
2025
Mitochondrial complex IV remodeling in tumor-associated macrophages amplifies interferon signaling and promotes anti-tumor immunity
Clark M, Simeonov K, Mowel W, Michieletto M, Joannas L, Wright J, Erickson I, Johnson L, Krishnan R, de la Fuente-Núñez C, Minn A, Henao-Mejia J. Mitochondrial complex IV remodeling in tumor-associated macrophages amplifies interferon signaling and promotes anti-tumor immunity. Immunity 2025, 58: 1670-1687.e12. PMID: 40592341, PMCID: PMC12259027, DOI: 10.1016/j.immuni.2025.06.006.Peer-Reviewed Original Research
2024
IL-10 constrains sphingolipid metabolism to limit inflammation
Skadow M, Oh J, Qu R, Zhou Q, Hsieh W, Mowel W, Brewer J, Williams K, Kluger Y, Smale S, Crawford J, Bensinger S, Flavell R. IL-10 constrains sphingolipid metabolism to limit inflammation. Nature 2024, 627: 628-635. PMID: 38383790, PMCID: PMC10954550, DOI: 10.1038/s41586-024-07098-5.Peer-Reviewed Original Research
2022
Multiscale 3D genome organization underlies ILC2 ontogenesis and allergic airway inflammation
Michieletto M, Tello-Cajiao J, Mowel W, Chandra A, Yoon S, Joannas L, Clark M, Jimenez M, Wright J, Lundgren P, Williams A, Thaiss C, Vahedi G, Henao-Mejia J. Multiscale 3D genome organization underlies ILC2 ontogenesis and allergic airway inflammation. Nature Immunology 2022, 24: 42-54. PMID: 36050414, PMCID: PMC10134076, DOI: 10.1038/s41590-022-01295-y.Peer-Reviewed Original Research
2019
The gut microbiota regulates white adipose tissue inflammation and obesity via a family of microRNAs
Virtue AT, McCright SJ, Wright JM, Jimenez MT, Mowel WK, Kotzin JJ, Joannas L, Basavappa MG, Spencer SP, Clark ML, Eisennagel SH, Williams A, Levy M, Manne S, Henrickson SE, Wherry EJ, Thaiss CA, Elinav E, Henao-Mejia J. The gut microbiota regulates white adipose tissue inflammation and obesity via a family of microRNAs. Science Translational Medicine 2019, 11: eaav1892. PMID: 31189717, PMCID: PMC7050429, DOI: 10.1126/scitranslmed.aav1892.Peer-Reviewed Original ResearchThe long noncoding RNA Morrbid regulates CD8 T cells in response to viral infection
Kotzin JJ, Iseka F, Wright J, Basavappa MG, Clark ML, Ali MA, Abdel-Hakeem MS, Robertson TF, Mowel WK, Joannas L, Neal VD, Spencer SP, Syrett CM, Anguera MC, Williams A, Wherry EJ, Henao-Mejia J. The long noncoding RNA Morrbid regulates CD8 T cells in response to viral infection. Proceedings Of The National Academy Of Sciences Of The United States Of America 2019, 116: 11916-11925. PMID: 31138702, PMCID: PMC6575676, DOI: 10.1073/pnas.1819457116.Peer-Reviewed Original ResearchAnimalsCD8-Positive T-LymphocytesCell DifferentiationInterferon Type ILymphocyte ActivationLymphocytic ChoriomeningitisLymphocytic choriomeningitis virusMaleMiceMice, Inbred C57BLMice, TransgenicPhosphatidylinositol 3-KinasesProto-Oncogene Proteins c-bcl-2Receptors, Antigen, T-CellRNA, Long NoncodingSignal Transduction
2017
Viruses hijack a host lncRNA to replicate
Kotzin J, Mowel W, Henao-Mejia J. Viruses hijack a host lncRNA to replicate. Science 2017, 358: 993-994. PMID: 29170219, DOI: 10.1126/science.aar2300.Commentaries, Editorials and LettersControl of Immune Cell Homeostasis and Function by lncRNAs
Mowel W, Kotzin J, McCright S, Neal V, Henao-Mejia J. Control of Immune Cell Homeostasis and Function by lncRNAs. Trends In Immunology 2017, 39: 55-69. PMID: 28919048, PMCID: PMC5748345, DOI: 10.1016/j.it.2017.08.009.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsGroup 1 Innate Lymphoid Cell Lineage Identity Is Determined by a cis-Regulatory Element Marked by a Long Non-coding RNA
Mowel WK, McCright SJ, Kotzin JJ, Collet MA, Uyar A, Chen X, DeLaney A, Spencer SP, Virtue AT, Yang E, Villarino A, Kurachi M, Dunagin MC, Pritchard GH, Stein J, Hughes C, Fonseca-Pereira D, Veiga-Fernandes H, Raj A, Kambayashi T, Brodsky IE, O’Shea J, Wherry EJ, Goff LA, Rinn JL, Williams A, Flavell RA, Henao-Mejia J. Group 1 Innate Lymphoid Cell Lineage Identity Is Determined by a cis-Regulatory Element Marked by a Long Non-coding RNA. Immunity 2017, 47: 435-449.e8. PMID: 28930659, PMCID: PMC5761663, DOI: 10.1016/j.immuni.2017.08.012.Peer-Reviewed Original ResearchAnimalsCell DifferentiationCell LineageChromatin Assembly and DisassemblyFemaleGene Expression ProfilingGene Expression RegulationGenetic LociHomeostasisImmunity, InnateInhibitor of Differentiation Protein 2Killer Cells, NaturalLymphocyte SubsetsLymphocytesMaleMicePromoter Regions, GeneticRegulatory Sequences, Nucleic AcidRNA, Long NoncodingSTAT5 Transcription FactorTranscription, Genetic
2016
The long non-coding RNA Morrbid regulates Bim and short-lived myeloid cell lifespan
Kotzin JJ, Spencer SP, McCright SJ, Kumar DBU, Collet MA, Mowel WK, Elliott EN, Uyar A, Makiya MA, Dunagin MC, Harman CCD, Virtue AT, Zhu S, Bailis W, Stein J, Raj A, Wherry EJ, Goff LA, Klion AD, Rinn JL, Williams A, Flavell RA, Henao-Mejia J. The long non-coding RNA Morrbid regulates Bim and short-lived myeloid cell lifespan. Nature 2016, 537: 239-243. PMID: 27525555, PMCID: PMC5161578, DOI: 10.1038/nature19346.Commentaries, Editorials and Letters
2014
Influenza A virus infection in zebrafish recapitulates mammalian infection and sensitivity to anti-influenza drug treatment
Gabor K, Goody M, Mowel W, Breitbach M, Gratacap R, Witten P, Kim C. Influenza A virus infection in zebrafish recapitulates mammalian infection and sensitivity to anti-influenza drug treatment. Disease Models & Mechanisms 2014, 7: 1227-1237. PMID: 25190709, PMCID: PMC4213727, DOI: 10.1242/dmm.014746.Peer-Reviewed Original Research