Flavell Lab Publications

• Sclerotic GVHD and scleroderma share dysregulated gene expression that is ameliorated by EREG therapeutic antibody.Newton NM, Agrawal K, Odell AV, Tracy T, Hackett C, Eldrup A, Whitfield M, Martyanov V, Girardi M, Sefik E, Flavell RA, Odell ID. Blood. 2025 Dec 25. PMID: 40961242.
• The history and promise of Treg cells.Benoist C, Vignali DAA, Flavell RA, Mathis D. Immunity. 2025 Dec 9. PMID: 41371212.
• Rroid2 regulates effector-to-memory CD8(+) T cell differentiation during infection in vivo.Erber J, Stecher C, Plajer V, Braun N, Mallard W, Goff LA, Barozzi I, Mohr T, Rinn JL, Flavell RA, Herndler-Brandstetter D. Proc Natl Acad Sci U S A. 2025 Dec 2; 2025 Nov 24. PMID: 41284876.
• The cutaneous response to a mosquito bite is influenced by the diurnal rhythm.Raduwan H, Park J, Marín-López A, Skadow MH, Chen TY, Flavell RA, Shaw AC, Montgomery RR, Fikrig E. iScience. 2025 Nov 21; 2025 Sep 30. PMID: 41146707.
• Self-RNA Rmrp pre-dimerizes TLR3 for immune activation.Han A, Flavell RA. Cell Res. 2025 Nov. PMID: 41016931.
• Linker histone regulates the myeloid versus lymphoid bifurcation of multipotent hematopoietic stem and progenitors.Karatepe K, Mafra de Faria B, Zhang J, Chen X, Pinto H, Fyodorov D, Sefik E, Willcockson MA, Flavell RA, Skoultchi AI, Guo S. Proc Natl Acad Sci U S A. 2025 Oct 28; 2025 Oct 21. PMID: 41118213.
• FABP5 regulates ether lipid metabolism to ameliorate atopic dermatitis.Skadow MH, Mowel WK, Blackburn HN, Madden MZ, Mirza H, Zhang F, York AG, Flavell RA. bioRxiv. 2025 Oct 25; 2025 Oct 25. PMID: 41279180.
• EGFR-STAT1 pathway drives fibrosis initiation in fibroinflammatory skin diseases.Odell AV, Newton NM, Eisenstein A, Micevic G, Flavell RA, Odell ID. Nat Commun. 2025 Oct 9; 2025 Oct 9. PMID: 41068129.
• Targeting eRNA-Producing Super-Enhancers Regulates TNFα Expression and Mitigates Chronic Inflammation in Mice and Patient-Derived Immune Cells.Cho M, Kim SM, Lee J, Kwon OC, Woo W, Lee E, Park HJ, Lee Y, Dho SH, Kim TK, Park MC, Flavell RA, Kim LK. Adv Sci (Weinh). 2025 Oct; 2025 Jul 21. PMID: 40692264.
• Large-Scale Production of Transfusion-Ready Red Blood Cells From Induced Pluripotent Stem Cells.Varga E, Brandsma E, Juarez-Garza BE, Ramlal RPE, Karrich JJ, Laurent A, Chavli A, Paskel R, Fu K, Flavell RA, von Lindern M, Amsen D, Klijn ME, van den Akker E. Adv Sci (Weinh). 2025 Oct; 2025 Jul 12. PMID: 40650659.
• Humanization of CD47 enables development of functional human neutrophils via postirradiation remodeling of the bone marrow.Sefik E, Philbrick W, Zhang F, Agrawal K, Van Lee B, Sam J, Karatepe K, Zheng Y, Liang K, Peng S, Mirza H, Rangavajhula A, Simon P, Arun N, Babu P, Eynon E, Chiorazzi M, Shan L, Halene S, Luo HR, Rongvaux A, Kluger Y, Flavell RA. Proc Natl Acad Sci U S A. 2025 Sep 23; 2025 Sep 16. PMID: 40956886.
• Inflammatory cytokine interleukin-18 prevents murine miscarriage by inducing appropriate inflammation.Horii Y, Ino H, Sasaki F, Ishibashi M, Koike E, Kawamoto Y, Flavell RA, Ohashi R, Suzuki S, Negishi Y, Morita R. Sci Rep. 2025 Aug 21; 2025 Aug 21. PMID: 40841464.
• Integrated molecular and clinical characterization of pulmonary large cell neuroendocrine carcinoma.Nassar AH, Kim C, Adeyelu T, Bou Farhat E, Abushukair H, Rakaee M, Matteson K, Lau SF, Takabe Y, Ocejo A, Ardeshir-Larijani F, Leal T, Ramalingam S, Alam S, Gray JE, Hicks J, Kaldas D, Baena J, Berjaga MZ, Nana FA, Grohe C, Leuders H, Citarella F, Cortellini A, Mingo EC, Pancirer D, Das M, Ellis-Caleo TJ, Cheung JM, Lin JJ, Watson AS, Camidge DR, Sridhar A, Parikh K, Crowley F, Marron TU, Aggarwal V, Ahmed M, Sankar K, Kawtharany H, Zhang J, Owen DH, Li M, Nagasaka M, Pinato DJ, Awosika N, Alhamad K, Puri S, Zaman U, Gupta DM, Lau C, Khan H, Liauw J, Velazquez AI, Brown T, Moliner L, Mosteiro M, Rocha P, Evans M, Vanderwalde A, Elliott A, Nieva J, Lopes G, Ma PC, Borghaei H, Lee M, Young L, Aljumaily R, Mirza H, Kwiatkowski DJ, Herbst RS, Flavell RA, Naqash AR, Chiang AC. Nat Commun. 2025 Aug 19; 2025 Aug 19. PMID: 40830141.
• Engineering Mice to Study Human Immunity.Sefik E, Xiao T, Chiorazzi M, Odell I, Zhang F, Agrawal K, Micevic G, Flavell RA. Annu Rev Immunol. 2025 Apr; 2025 Feb 28. PMID: 40020225.
• Gene trajectory inference for single-cell data by optimal transport metrics.Qu R, Cheng X, Sefik E, Stanley Iii JS, Landa B, Strino F, Platt S, Garritano J, Odell ID, Coifman R, Flavell RA, Myung P, Kluger Y. Nat Biotechnol. 2025 Feb; 2024 Apr 5. PMID: 38580861.
• Human AKR1C3 binds agonists of GPR84 and participates in an expanded polyamine pathway.Dudkina N, Park HB, Song D, Jain A, Khan SA, Flavell RA, Johnson CH, Palm NW, Crawford JM. Cell Chem Biol. 2025 Jan 16; 2024 Aug 19. PMID: 39163853.
• Scaling deep identifiable models enables zero-shot characterization of single-cell biological states.Dong M, Agrawal K, Fan R, Sefik E, Flavell RA, Kluger Y. bioRxiv. 2024 Dec 18; 2024 Dec 18. PMID: 38014345.
• Sensing DNA as danger: The discovery of cGAS.Flavell RA, Sefik E. Immunity. 2024 Oct 8; 2024 Sep 19. PMID: 39303723.
• A metabolic switch orchestrated by IL-18 and the cyclic dinucleotide cGAMP programs intestinal tolerance.Mertens RT, Misra A, Xiao P, Baek S, Rone JM, Mangani D, Sivanathan KN, Arojojoye AS, Awuah SG, Lee I, Shi GP, Petrova B, Brook JR, Anderson AC, Flavell RA, Kanarek N, Hemberg M, Nowarski R. Immunity. 2024 Sep 10; 2024 Jun 20. PMID: 38906145.
• The human CD47 checkpoint is targeted by an immunosuppressive Aedes aegypti salivary factor to enhance arboviral skin infectivity.Marin-Lopez A, Huck JD, Esterly AT, Azcutia V, Rosen C, Garcia-Milian R, Sefik E, Vidal-Pedrola G, Raduwan H, Chen TY, Arora G, Halene S, Shaw AC, Palm NW, Flavell RA, Parkos CA, Thangamani S, Ring AM, Fikrig E. Sci Immunol. 2024 Aug 9; 2024 Aug 9. PMID: 39121194.
• UBXN3B is crucial for B lymphopoiesis.Geng T, Yang D, Lin T, Harrison AG, Wang B, Cao Z, Torrance B, Fan Z, Wang K, Wang Y, Yang L, Haynes L, Cheng G, Vella AT, Flavell RA, Pereira JP, Fikrig E, Wang P. EBioMedicine. 2024 Aug; 2024 Jul 16. PMID: 39018756.
• Deleting the mitochondrial respiration negative regulator MCJ enhances the efficacy of CD8(+) T cell adoptive therapies in pre-clinical studies.Wu MH, Valenca-Pereira F, Cendali F, Giddings EL, Pham-Danis C, Yarnell MC, Novak AJ, Brunetti TM, Thompson SB, Henao-Mejia J, Flavell RA, D'Alessandro A, Kohler ME, Rincon M. Nat Commun. 2024 May 24; 2024 May 24. PMID: 38789421.
• DHX9 maintains epithelial homeostasis by restraining R-loop-mediated genomic instability in intestinal stem cells.Ren X, Liu Q, Zhou P, Zhou T, Wang D, Mei Q, Flavell RA, Liu Z, Li M, Pan W, Zhu S. Nat Commun. 2024 Apr 9; 2024 Apr 9. PMID: 38594251.
• IL-10 dampens antitumor immunity and promotes liver metastasis via PD-L1 induction.Shiri AM, Zhang T, Bedke T, Zazara DE, Zhao L, Lücke J, Sabihi M, Fazio A, Zhang S, Tauriello DVF, Batlle E, Steglich B, Kempski J, Agalioti T, Nawrocki M, Xu Y, Riecken K, Liebold I, Brockmann L, Konczalla L, Bosurgi L, Mercanoglu B, Seeger P, Küsters N, Lykoudis PM, Heumann A, Arck PC, Fehse B, Busch P, Grotelüschen R, Mann O, Izbicki JR, Hackert T, Flavell RA, Gagliani N, Giannou AD, Huber S. J Hepatol. 2024 Apr; 2023 Dec 30. PMID: 38160941.
• IL-10 constrains sphingolipid metabolism to limit inflammation.York AG, Skadow MH, Oh J, Qu R, Zhou QD, Hsieh WY, Mowel WK, Brewer JR, Kaffe E, Williams KJ, Kluger Y, Smale ST, Crawford JM, Bensinger SJ, Flavell RA. Nature. 2024 Mar; 2024 Feb 21. PMID: 38383790.
• Circulating NK cells establish tissue residency upon acute infection of skin and mediate accelerated effector responses to secondary infection.Torcellan T, Friedrich C, Doucet-Ladevèze R, Ossner T, Solé VV, Riedmann S, Ugur M, Imdahl F, Rosshart SP, Arnold SJ, Gomez de Agüero M, Gagliani N, Flavell RA, Backes S, Kastenmüller W, Gasteiger G. Immunity. 2024 Jan 9; 2023 Dec 28. PMID: 38157853.
• Bioactive signalling lipids as drivers of chronic liver diseases.Kaffe E, Tisi A, Magkrioti C, Aidinis V, Mehal WZ, Flavell RA, Maccarrone M. J Hepatol. 2024 Jan; 2023 Sep 21. PMID: 37741346.
• ALKBH5 modulates hematopoietic stem and progenitor cell energy metabolism through m(6)A modification-mediated RNA stability control.Gao Y, Zimmer JT, Vasic R, Liu C, Gbyli R, Zheng SJ, Patel A, Liu W, Qi Z, Li Y, Nelakanti R, Song Y, Biancon G, Xiao AZ, Slavoff S, Kibbey RG, Flavell RA, Simon MD, Tebaldi T, Li HB, Halene S. Cell Rep. 2023 Oct 31; 2023 Sep 23. PMID: 37742191.
• New insights into programmed cell death protein 1 blockade-associated cutaneous immune-related adverse events.Micevic G, Daniels A, Flavell RA. Br J Dermatol. 2023 Sep 15. PMID: 37471669.
• IL-6 trans-signaling in a humanized mouse model of scleroderma.Odell ID, Agrawal K, Sefik E, Odell AV, Caves E, Kirkiles-Smith NC, Horsley V, Hinchcliff M, Pober JS, Kluger Y, Flavell RA. Proc Natl Acad Sci U S A. 2023 Sep 12; 2023 Sep 5. PMID: 37669366.
• Humanized mouse liver reveals endothelial control of essential hepatic metabolic functions.Kaffe E, Roulis M, Zhao J, Qu R, Sefik E, Mirza H, Zhou J, Zheng Y, Charkoftaki G, Vasiliou V, Vatner DF, Mehal WZ, Yuval Kluger, Flavell RA. Cell. 2023 Aug 31; 2023 Aug 9. PMID: 37562401.
• IL-7R licenses a population of epigenetically poised memory CD8(+) T cells with superior antitumor efficacy that are critical for melanoma memory.Micevic G, Daniels A, Flem-Karlsen K, Park K, Talty R, McGeary M, Mirza H, Blackburn HN, Sefik E, Cheung JF, Hornick NI, Aizenbud L, Joshi NS, Kluger H, Iwasaki A, Bosenberg MW, Flavell RA. Proc Natl Acad Sci U S A. 2023 Jul 25; 2023 Jul 17. PMID: 37459511.
• METTL3-mediated m6A methylation orchestrates mRNA stability and dsRNA contents to equilibrate γδ T1 and γδ T17 cells.Xiao Z, Wang S, Tian Y, Lv W, Sheng H, Zhan M, Huang Q, Zhang Z, Zhu L, Zhu C, Zhong H, Wen Q, Liu Z, Tan J, Xu Y, Yang M, Liu Y, Flavell RA, Yang Q, Cao G, Yin Z. Cell Rep. 2023 Jul 25; 2023 Jun 23. PMID: 37355989.
• Gasdermin D licenses MHCII induction to maintain food tolerance in small intestine.He K, Wan T, Wang D, Hu J, Zhou T, Tao W, Wei Z, Lu Q, Zhou R, Tian Z, Flavell RA, Zhu S. Cell. 2023 Jul 6; 2023 Jun 15. PMID: 37327784.
• Autologous humanized PDX modeling for immuno-oncology recapitulates features of the human tumor microenvironment.Chiorazzi M, Martinek J, Krasnick B, Zheng Y, Robbins KJ, Qu R, Kaufmann G, Skidmore Z, Juric M, Henze LA, Brösecke F, Adonyi A, Zhao J, Shan L, Sefik E, Mudd J, Bi Y, Goedegebuure SP, Griffith M, Griffith O, Oyedeji A, Fertuzinhos S, Garcia-Milian R, Boffa D, Detterbeck F, Dhanasopon A, Blasberg J, Judson B, Gettinger S, Politi K, Kluger Y, Palucka K, Fields RC, Flavell RA. J Immunother Cancer. 2023 Jul. PMID: 37487666.
• A T(reg)-specific long noncoding RNA maintains immune-metabolic homeostasis in aging liver.Ding C, Yu Z, Sefik E, Zhou J, Kaffe E, Wang G, Li B, Flavell RA, Hu W, Ye Y, Li HB. Nat Aging. 2023 Jul; 2023 Jun 5. PMID: 37277640.
• Interferon-induced IL-10 drives systemic T-cell dysfunction during chronic liver injury.Hackstein CP, Spitzer J, Symeonidis K, Horvatic H, Bedke T, Steglich B, Klein S, Assmus LM, Odainic A, Szlapa J, Kessler N, Beyer M, Schmithausen R, Latz E, Flavell RA, Garbi N, Kurts C, Kümmerer BM, Trebicka J, Roers A, Huber S, Schmidt SV, Knolle PA, Abdullah Z. J Hepatol. 2023 Jul; 2023 Mar 2. PMID: 36870611.
• Cutting Edge: IL-21 and Tissue-Specific Signals Instruct Tbet+CD11c+ B Cell Development following Viral Infection.Song W, Sanchez GM, Mayer DP, Blackburn HN, Chernova I, Flavell RA, Weinstein JS, Craft J. J Immunol. 2023 Jun 15. PMID: 37133336.
• Author Correction: LACC1 bridges NOS2 and polyamine metabolism in inflammatory macrophages.Wei Z, Oh J, Flavell RA, Crawford JM. Nature. 2023 Jun. PMID: 37231312.
• A lncRNA from an inflammatory bowel disease risk locus maintains intestinal host-commensal homeostasis.Ma H, Hu T, Tao W, Tong J, Han Z, Herndler-Brandstetter D, Wei Z, Liu R, Zhou T, Liu Q, Xu X, Zhang K, Zhou R, Cho JH, Li HB, Huang H, Flavell RA, Zhu S. Cell Res. 2023 May; 2023 Apr 13. PMID: 37055591.
• Epithelial Nlrp10 inflammasome mediates protection against intestinal autoinflammation.Zheng D, Mohapatra G, Kern L, He Y, Shmueli MD, Valdés-Mas R, Kolodziejczyk AA, Próchnicki T, Vasconcelos MB, Schorr L, Hertel F, Lee YS, Rufino MC, Ceddaha E, Shimshy S, Hodgetts RJ, Dori-Bachash M, Kleimeyer C, Goldenberg K, Heinemann M, Stettner N, Harmelin A, Shapiro H, Puschhof J, Chen M, Flavell RA, Latz E, Merbl Y, Abdeen SK, Elinav E. Nat Immunol. 2023 Apr; 2023 Mar 20. PMID: 36941399.
• Humanized MISTRG as a preclinical in vivo model to study human neutrophil-mediated immune processes.Martinez-Sanz P, Laurent ARG, Slot E, Hoogenboezem M, Bąbała N, van Bruggen R, Rongvaux A, Flavell RA, Tytgat GAM, Franke K, Matlung HL, Kuijpers TW, Amsen D, Karrich JJ. Front Immunol. 2023; 2023 Mar 8. PMID: 36969261.
• NLRP6 deficiency expands a novel CD103(+) B cell population that confers immune tolerance in NOD mice.Pearson JA, Peng J, Huang J, Yu X, Tai N, Hu Y, Sha S, Flavell RA, Zhao H, Wong FS, Wen L. Front Immunol. 2023; 2023 Feb 23. PMID: 36911699.
• Nucleic DHX9 cooperates with STAT1 to transcribe interferon-stimulated genes.Ren X, Wang D, Zhang G, Zhou T, Wei Z, Yang Y, Zheng Y, Lei X, Tao W, Wang A, Li M, Flavell RA, Zhu S. Sci Adv. 2023 Feb 3; 2023 Feb 3. PMID: 36735791.
• Allobaculum mucilyticum sp. nov. and Allobaculum fili sp. nov., isolated from the human intestinal tract.van Muijlwijk GH, Rice TA, Flavell RA, Palm NW, de Zoete MR. Int J Syst Evol Microbiol. 2023 Feb. PMID: 36748696.
• Cholinergic control of Th17 cell pathogenicity in experimental autoimmune encephalomyelitis.Nechanitzky R, Nechanitzky D, Ramachandran P, Duncan GS, Zheng C, Göbl C, Gill KT, Haight J, Wakeham AC, Snow BE, Bradaschia-Correa V, Ganguly M, Lu Z, Saunders ME, Flavell RA, Mak TW. Cell Death Differ. 2023 Feb; 2022 Dec 17. PMID: 36528755.
• T cell-derived interleukin-22 drives the expression of CD155 by cancer cells to suppress NK cell function and promote metastasis.Briukhovetska D, Suarez-Gosalvez J, Voigt C, Markota A, Giannou AD, Schübel M, Jobst J, Zhang T, Dörr J, Märkl F, Majed L, Müller PJ, May P, Gottschlich A, Tokarew N, Lücke J, Oner A, Schwerdtfeger M, Andreu-Sanz D, Grünmeier R, Seifert M, Michaelides S, Hristov M, König LM, Cadilha BL, Mikhaylov O, Anders HJ, Rothenfusser S, Flavell RA, Cerezo-Wallis D, Tejedo C, Soengas MS, Bald T, Huber S, Endres S, Kobold S. Immunity. 2023 Jan 10. PMID: 36630913.
• Tissue resident iNKT17 cells facilitate cancer cell extravasation in liver metastasis via interleukin-22.Giannou AD, Kempski J, Shiri AM, Lücke J, Zhang T, Zhao L, Zazara DE, Cortesi F, Riecken K, Amezcua Vesely MC, Low JS, Xu H, Kaffe E, Garcia-Perez L, Agalioti T, Yamada Y, Jungraithmayr W, Zigmond E, Karstens KF, Steglich B, Wagner J, Konczalla L, Carambia A, Schulze K, von Felden J, May P, Briukhovetska D, Bedke T, Brockmann L, Starzonek S, Lange T, Koch C, Riethdorf S, Pelczar P, Böttcher M, Sabihi M, Huber FJ, Reeh M, Grass JK, Wahib R, Seese H, Stüben BO, Fard-Aghaie M, Duprée A, Scognamiglio P, Plitzko G, Meiners J, Soukou S, Wittek A, Manthey C, Maroulis IC, Arck PC, Perez D, Gao B, Zarogiannis SG, Strowig T, Pasqualini R, Arap W, Gosálvez JS, Kobold S, Prinz I, Guse AH, Tachezy M, Ghadban T, Heumann A, Li J, Melling N, Mann O, Izbicki JR, Pantel K, Schumacher U, Lohse AW, Flavell RA, Gagliani N, Huber S. Immunity. 2023 Jan 10. PMID: 36630911.
• Platelet-derived TLT-1 promotes tumor progression by suppressing CD8+ T cells.Tyagi T, Jain K, Yarovinsky TO, Chiorazzi M, Du J, Castro C, Griffin J, Korde A, Martin KA, Takyar SS, Flavell RA, Patel AA, Hwa J. J Exp Med. 2023 Jan 2; 2022 Oct 28. PMID: 36305874.
• Epiregulin is a dendritic cell-derived EGFR ligand that maintains skin and lung fibrosis.Odell ID, Steach H, Gauld SB, Reinke-Breen L, Karman J, Carr TL, Wetter JB, Phillips L, Hinchcliff M, Flavell RA. Sci Immunol. 2022 Dec 16; 2022 Dec 9. PMID: 36490328.
• Differential IL18 signaling via IL18 receptor and Na-Cl co-transporter discriminating thermogenesis and glucose metabolism regulation.Zhang X, Luo S, Wang M, Cao Q, Zhang Z, Huang Q, Li J, Deng Z, Liu T, Liu CL, Meppen M, Vromman A, Flavell RA, Hotamışlıgil GS, Liu J, Libby P, Liu Z, Shi GP. Nat Commun. 2022 Dec 8; 2022 Dec 8. PMID: 36482059.
• Cellular Stress-Induced Metabolites in Escherichia coli.Gatsios A, Kim CS, York AG, Flavell RA, Crawford JM. J Nat Prod. 2022 Nov 25; 2022 Nov 8. PMID: 36346625.
• N-Acyl Amides from Neisseria meningitidis and Their Role in Sphingosine Receptor Signaling.Cho W, York AG, Wang R, Wyche TP, Piizzi G, Flavell RA, Crawford JM. Chembiochem. 2022 Nov 18; 2022 Oct 13. PMID: 36112057.
• HIV-1 Vpu restricts Fc-mediated effector functions in vivo.Prévost J, Anand SP, Rajashekar JK, Zhu L, Richard J, Goyette G, Medjahed H, Gendron-Lepage G, Chen HC, Chen Y, Horwitz JA, Grunst MW, Zolla-Pazner S, Haynes BF, Burton DR, Flavell RA, Kirchhoff F, Hahn BH, Smith AB 3rd, Pazgier M, Nussenzweig MC, Kumar P, Finzi A. Cell Rep. 2022 Nov 8. PMID: 36351384.
• Human neutrophil development and functionality are enabled in a humanized mouse model.Zheng Y, Sefik E, Astle J, Karatepe K, Öz HH, Solis AG, Jackson R, Luo HR, Bruscia EM, Halene S, Shan L, Flavell RA. Proc Natl Acad Sci U S A. 2022 Oct 25; 2022 Oct 21. PMID: 36269862.
• tRNA-m(1)A modification promotes T cell expansion via efficient MYC protein synthesis.Liu Y, Zhou J, Li X, Zhang X, Shi J, Wang X, Li H, Miao S, Chen H, He X, Dong L, Lee GR, Zheng J, Liu RJ, Su B, Ye Y, Flavell RA, Yi C, Wu Y, Li HB. Nat Immunol. 2022 Oct; 2022 Sep 22. PMID: 36138184.
• GSK3β mediates the spatiotemporal dynamics of NLRP3 inflammasome activation.Arumugam S, Qin Y, Liang Z, Han SN, Boodapati SLT, Li J, Lu Q, Flavell RA, Mehal WZ, Ouyang X. Cell Death Differ. 2022 Oct; 2022 Apr 27. PMID: 35477991.
• LACC1 bridges NOS2 and polyamine metabolism in inflammatory macrophages.Wei Z, Oh J, Flavell RA, Crawford JM. Nature. 2022 Sep; 2022 Aug 17. PMID: 35978195.
• RNA m(6)A demethylase ALKBH5 regulates the development of γδ T cells.Ding C, Xu H, Yu Z, Roulis M, Qu R, Zhou J, Oh J, Crawford J, Gao Y, Jackson R, Sefik E, Li S, Wei Z, Skadow M, Yin Z, Ouyang X, Wang L, Zou Q, Su B, Hu W, Flavell RA, Li HB. Proc Natl Acad Sci U S A. 2022 Aug 16; 2022 Aug 8. PMID: 35939687.
• Interspecies commensal interactions have nonlinear impacts on host immunity.Rice TA, Bielecka AA, Nguyen MT, Rosen CE, Song D, Sonnert ND, Yang Y, Cao Y, Khetrapal V, Catanzaro JR, Martin AL, Rashed SA, Leopold SR, Hao L, Yu X, van Dijk D, Ring AM, Flavell RA, de Zoete MR, Palm NW. Cell Host Microbe. 2022 Jul 13; 2022 May 30. PMID: 35640610.
• Mouse pulmonary interstitial macrophages mediate the pro-tumorigenic effects of IL-9.Fu Y, Pajulas A, Wang J, Zhou B, Cannon A, Cheung CCL, Zhang J, Zhou H, Fisher AJ, Omstead DT, Khan S, Han L, Renauld JC, Paczesny S, Gao H, Liu Y, Yang L, Tighe RM, Licona-Limón P, Flavell RA, Takatsuka S, Kitamura D, Sun J, Bilgicer B, Sears CR, Yang K, Kaplan MH. Nat Commun. 2022 Jul 1; 2022 Jul 1. PMID: 35778404.
• IL18 signaling causes islet β cell development and insulin secretion via different receptors on acinar and β cells.Zhang X, Luo S, Wang M, Huang Q, Fang W, Li J, Liu T, Zhang Y, Deng Z, Liu CL, Guan S, Ayala JE, Flavell RA, Kulkarni RN, Libby P, Guo J, Liu Z, Shi GP. Dev Cell. 2022 Jun 20; 2022 Jun 7. PMID: 35675813.
• Inhibition of type 1 immunity with tofacitinib is associated with marked improvement in longstanding sarcoidosis.Damsky W, Wang A, Kim DJ, Young BD, Singh K, Murphy MJ, Daccache J, Clark A, Ayasun R, Ryu C, McGeary MK, Odell ID, Fazzone-Chettiar R, Pucar D, Homer R, Gulati M, Miller EJ, Bosenberg M, Flavell RA, King B. Nat Commun. 2022 Jun 6; 2022 Jun 6. PMID: 35668129.
• Inflammasome activation in infected macrophages drives COVID-19 pathology.Sefik E, Qu R, Junqueira C, Kaffe E, Mirza H, Zhao J, Brewer JR, Han A, Steach HR, Israelow B, Blackburn HN, Velazquez SE, Chen YG, Halene S, Iwasaki A, Meffre E, Nussenzweig M, Lieberman J, Wilen CB, Kluger Y, Flavell RA. Nature. 2022 Jun; 2022 Apr 28. PMID: 35483404.
• A humanized mouse model of chronic COVID-19.Sefik E, Israelow B, Mirza H, Zhao J, Qu R, Kaffe E, Song E, Halene S, Meffre E, Kluger Y, Nussenzweig M, Wilen CB, Iwasaki A, Flavell RA. Nat Biotechnol. 2022 Jun; 2021 Dec 17. PMID: 34921308.
• Transcriptional profiling of macrophages in situ in metastatic melanoma reveals localization-dependent phenotypes and function.Martinek J, Lin J, Kim KI, Wang VG, Wu TC, Chiorazzi M, Boruchov H, Gulati A, Seeniraj S, Sun L, Marches F, Robson P, Rongvaux A, Flavell RA, George J, Chuang JH, Banchereau J, Palucka K. Cell Rep Med. 2022 May 17; 2022 Apr 27. PMID: 35584631.
• In vivo anti-tumor effect of PARP inhibition in IDH1/2 mutant MDS/AML resistant to targeted inhibitors of mutant IDH1/2.Gbyli R, Song Y, Liu W, Gao Y, Biancon G, Chandhok NS, Wang X, Fu X, Patel A, Sundaram R, Tebaldi T, Mamillapalli P, Zeidan AM, Flavell RA, Prebet T, Bindra RS, Halene S. Leukemia. 2022 May; 2022 Mar 10. PMID: 35273342.
• CD4(+) T-cell-derived IL-10 promotes CNS inflammation in mice by sustaining effector T cell survival.Yogev N, Bedke T, Kobayashi Y, Brockmann L, Lukas D, Regen T, Croxford AL, Nikolav A, Hövelmeyer N, von Stebut E, Prinz M, Ubeda C, Maloy KJ, Gagliani N, Flavell RA, Waisman A, Huber S. Cell Rep. 2022 Mar 29. PMID: 35354043.
• m(6)A mRNA modification maintains colonic epithelial cell homeostasis via NF-κB-mediated antiapoptotic pathway.Zhang T, Ding C, Chen H, Zhao J, Chen Z, Chen B, Mao K, Hao Y, Roulis M, Xu H, Kluger Y, Zou Q, Ye Y, Zhan M, Flavell RA, Li HB. Sci Adv. 2022 Mar 25; 2022 Mar 25. PMID: 35333576.
• Allergic airway recall responses require IL-9 from resident memory CD4(+) T cells.Ulrich BJ, Kharwadkar R, Chu M, Pajulas A, Muralidharan C, Koh B, Fu Y, Gao H, Hayes TA, Zhou HM, Goplen NP, Nelson AS, Liu Y, Linnemann AK, Turner MJ, Licona-Limón P, Flavell RA, Sun J, Kaplan MH. Sci Immunol. 2022 Mar 18; 2022 Mar 18. PMID: 35302861.
• An IL-9-pulmonary macrophage axis defines the allergic lung inflammatory environment.Fu Y, Wang J, Zhou B, Pajulas A, Gao H, Ramdas B, Koh B, Ulrich BJ, Yang S, Kapur R, Renauld JC, Paczesny S, Liu Y, Tighe RM, Licona-Limón P, Flavell RA, Takatsuka S, Kitamura D, Tepper RS, Sun J, Kaplan MH. Sci Immunol. 2022 Feb 18; 2022 Feb 18. PMID: 35179949.
• CD116+ fetal precursors migrate to the perinatal lung and give rise to human alveolar macrophages.Evren E, Ringqvist E, Doisne JM, Thaller A, Sleiers N, Flavell RA, Di Santo JP, Willinger T. J Exp Med. 2022 Feb 7; 2022 Jan 12. PMID: 35019940.
• m6A modifications regulate intestinal immunity and rotavirus infection.Wang A, Tao W, Tong J, Gao J, Wang J, Hou G, Qian C, Zhang G, Li R, Wang D, Ren X, Zhang K, Ding S, Flavell RA, Li H, Pan W, Zhu S. Elife. 2022 Jan 31; 2022 Jan 31. PMID: 35098923.
• Zero-preserving imputation of single-cell RNA-seq data.Linderman GC, Zhao J, Roulis M, Bielecki P, Flavell RA, Nadler B, Kluger Y. Nat Commun. 2022 Jan 11; 2022 Jan 11. PMID: 35017482.
• Development of Humanized Mouse Models for Studying Human NK Cells in Health and Disease.Shan L, Flavell RA, Herndler-Brandstetter D. Methods Mol Biol. 2022. PMID: 35344167.
• CD4 T cell-intrinsic STING signaling controls the differentiation and effector functions of T(H)1 and T(H)9 cells.Benoit-Lizon I, Jacquin E, Rivera Vargas T, Richard C, Roussey A, Dal Zuffo L, Martin T, Melis A, Vinokurova D, Shahoei SH, Baeza Garcia A, Pignol C, Giorgiutti S, Carapito R, Boidot R, Végran F, Flavell RA, Ryffel B, Nelson ER, Soulas-Sprauel P, Lawrence T, Apetoh L. J Immunother Cancer. 2022 Jan. PMID: 35091453.
• IL-17 Receptor C Signaling Controls CD4(+) T(H)17 Immune Responses and Tissue Injury in Immune-Mediated Kidney Diseases.Schmidt T, Luebbe J, Kilian C, Riedel JH, Hiekmann S, Asada N, Ginsberg P, Robben L, Song N, Kaffke A, Peters A, Borchers A, Flavell RA, Gagliani N, Pelzcar P, Huber S, Huber TB, Turner JE, Paust HJ, Krebs CF, Panzer U. J Am Soc Nephrol. 2021 Dec. PMID: 35167487.
• IL-27 signalling promotes adipocyte thermogenesis and energy expenditure.Wang Q, Li D, Cao G, Shi Q, Zhu J, Zhang M, Cheng H, Wen Q, Xu H, Zhu L, Zhang H, Perry RJ, Spadaro O, Yang Y, He S, Chen Y, Wang B, Li G, Liu Z, Yang C, Wu X, Zhou L, Zhou Q, Ju Z, Lu H, Xin Y, Yang X, Wang C, Liu Y, Shulman GI, Dixit VD, Lu L, Yang H, Flavell RA, Yin Z. Nature. 2021 Dec; 2021 Nov 24. PMID: 34819664.
• Interleukin-10 improves stroke outcome by controlling the detrimental Interleukin-17A response.Piepke M, Clausen BH, Ludewig P, Vienhues JH, Bedke T, Javidi E, Rissiek B, Jank L, Brockmann L, Sandrock I, Degenhardt K, Jander A, Roth V, Schädlich IS, Prinz I, Flavell RA, Kobayashi Y, Renné T, Gerloff C, Huber S, Magnus T, Gelderblom M. J Neuroinflammation. 2021 Nov 13; 2021 Nov 13. PMID: 34772416.
• Phase separation drives RNA virus-induced activation of the NLRP6 inflammasome.Shen C, Li R, Negro R, Cheng J, Vora SM, Fu TM, Wang A, He K, Andreeva L, Gao P, Tian Z, Flavell RA, Zhu S, Wu H. Cell. 2021 Nov 11; 2021 Oct 21. PMID: 34678144.
• m(6)A mRNA methylation-directed myeloid cell activation controls progression of NAFLD and obesity.Qin Y, Li B, Arumugam S, Lu Q, Mankash SM, Li J, Sun B, Li J, Flavell RA, Li HB, Ouyang X. Cell Rep. 2021 Nov 9. PMID: 34758326.
• Role of MBD3-SOX2 axis in residual myeloma following pomalidomide.Verma R, Branagan AR, Xu ML, Flavell RA, Dhodapkar KM, Dhodapkar MV. Leukemia. 2021 Nov; 2021 Feb 18. PMID: 33603141.
• METTL3-mediated m(6)A RNA methylation promotes the anti-tumour immunity of natural killer cells.Song H, Song J, Cheng M, Zheng M, Wang T, Tian S, Flavell RA, Zhu S, Li HB, Ding C, Wei H, Sun R, Peng H, Tian Z. Nat Commun. 2021 Sep 17; 2021 Sep 17. PMID: 34535671.
• Reply to: Rectally shed SARS-CoV-2 lacks infectivity: time to rethink faecal-oral transmission?Guo M, Tao W, Flavell RA, Zhu S. Nat Rev Gastroenterol Hepatol. 2021 Sep. PMID: 34312525.
• Vibrational optical coherence tomography detects unique skin fibrotic states: Preliminary results of animal and human studies.Odell ID, Flavell RA, Silver FH. J Am Acad Dermatol. 2021 Sep; 2020 Aug 26. PMID: 32860914.
• CFTR is a negative regulator of γδ T cell IFN-γ production and antitumor immunity.Duan Y, Li G, Xu M, Qi X, Deng M, Lin X, Lei Z, Hu Y, Jia Z, Yang Q, Cao G, Liu Z, Wen Q, Li Z, Tang J, Zhang WK, Huang P, Zheng L, Flavell RA, Hao J, Yin Z. Cell Mol Immunol. 2021 Aug; 2020 Jul 15. PMID: 32669666.
• m(6)A demethylase ALKBH5 controls CD4(+) T cell pathogenicity and promotes autoimmunity.Zhou J, Zhang X, Hu J, Qu R, Yu Z, Xu H, Chen H, Yan L, Ding C, Zou Q, Ye Y, Wang Z, Flavell RA, Li HB. Sci Adv. 2021 Jun; 2021 Jun 16. PMID: 34134995.
• Modulating HIV-1 envelope glycoprotein conformation to decrease the HIV-1 reservoir.Rajashekar JK, Richard J, Beloor J, Prévost J, Anand SP, Beaudoin-Bussières G, Shan L, Herndler-Brandstetter D, Gendron-Lepage G, Medjahed H, Bourassa C, Gaudette F, Ullah I, Symmes K, Peric A, Lindemuth E, Bibollet-Ruche F, Park J, Chen HC, Kaufmann DE, Hahn BH, Sodroski J, Pazgier M, Flavell RA, Smith AB 3rd, Finzi A, Kumar P. Cell Host Microbe. 2021 Jun 9; 2021 May 20. PMID: 34019804.
• Detection of differentially abundant cell subpopulations in scRNA-seq data.Zhao J, Jaffe A, Li H, Lindenbaum O, Sefik E, Jackson R, Cheng X, Flavell RA, Kluger Y. Proc Natl Acad Sci U S A. 2021 Jun 1. PMID: 34001664.
• JUN Amino-Terminal Kinase 1 Signaling in the Proximal Tubule Causes Cell Death and Acute Renal Failure in Rat and Mouse Models of Renal Ischemia/Reperfusion Injury.Grynberg K, Ozols E, Mulley WR, Davis RJ, Flavell RA, Nikolic-Paterson DJ, Ma FY. Am J Pathol. 2021 May; 2021 Feb 16. PMID: 33607044.
• Treatment of granuloma annulare and suppression of proinflammatory cytokine activity with tofacitinib.Wang A, Rahman NT, McGeary MK, Murphy M, McHenry A, Peterson D, Bosenberg M, Flavell RA, King B, Damsky W. J Allergy Clin Immunol. 2021 May; 2020 Dec 11. PMID: 33317858.
• Pooled CRISPR screening identifies m(6)A as a positive regulator of macrophage activation.Tong J, Wang X, Liu Y, Ren X, Wang A, Chen Z, Yao J, Mao K, Liu T, Meng FL, Pan W, Zou Q, Liu J, Zhou Y, Xia Q, Flavell RA, Zhu S, Li HB. Sci Adv. 2021 Apr; 2021 Apr 28. PMID: 33910903.
• MAP3K2-regulated intestinal stromal cells define a distinct stem cell niche.Wu N, Sun H, Zhao X, Zhang Y, Tan J, Qi Y, Wang Q, Ng M, Liu Z, He L, Niu X, Chen L, Liu Z, Li HB, Zeng YA, Roulis M, Liu D, Cheng J, Zhou B, Ng LG, Zou D, Ye Y, Flavell RA, Ginhoux F, Su B. Nature. 2021 Apr; 2021 Mar 3. PMID: 33658717.
• Potential intestinal infection and faecal-oral transmission of SARS-CoV-2.Guo M, Tao W, Flavell RA, Zhu S. Nat Rev Gastroenterol Hepatol. 2021 Apr; 2021 Feb 15. PMID: 33589829.
• Skin-resident innate lymphoid cells converge on a pathogenic effector state.Bielecki P, Riesenfeld SJ, Hütter JC, Torlai Triglia E, Kowalczyk MS, Ricardo-Gonzalez RR, Lian M, Amezcua Vesely MC, Kroehling L, Xu H, Slyper M, Muus C, Ludwig LS, Christian E, Tao L, Kedaigle AJ, Steach HR, York AG, Skadow MH, Yaghoubi P, Dionne D, Jarret A, McGee HM, Porter CBM, Licona-Limón P, Bailis W, Jackson R, Gagliani N, Gasteiger G, Locksley RM, Regev A, Flavell RA. Nature. 2021 Apr; 2021 Feb 3. PMID: 33536623.
• Cerebellar Kv3.3 potassium channels activate TANK-binding kinase 1 to regulate trafficking of the cell survival protein Hax-1.Zhang Y, Varela L, Szigeti-Buck K, Williams A, Stoiljkovic M, Šestan-Peša M, Henao-Mejia J, D'Acunzo P, Levy E, Flavell RA, Horvath TL, Kaczmarek LK. Nat Commun. 2021 Mar 19; 2021 Mar 19. PMID: 33741962.
• A humanized mouse model of chronic COVID-19 to evaluate disease mechanisms and treatment options.Sefik E, Israelow B, Zhao J, Qu R, Song E, Mirza H, Kaffe E, Halene S, Meffre E, Kluger Y, Nussenzweig M, Wilen CB, Iwasaki A, Flavell RA. Res Sq. 2021 Mar 17; 2021 Mar 17. PMID: 33758831.
• Presynaptic Kv3 channels are required for fast and slow endocytosis of synaptic vesicles.Wu XS, Subramanian S, Zhang Y, Shi B, Xia J, Li T, Guo X, El-Hassar L, Szigeti-Buck K, Henao-Mejia J, Flavell RA, Horvath TL, Jonas EA, Kaczmarek LK, Wu LG. Neuron. 2021 Mar 17; 2021 Jan 27. PMID: 33508244.
• Combined liver-cytokine humanization comes to the rescue of circulating human red blood cells.Song Y, Shan L, Gbyli R, Liu W, Strowig T, Patel A, Fu X, Wang X, Xu ML, Gao Y, Qin A, Bruscia EM, Tebaldi T, Biancon G, Mamillapalli P, Urbonas D, Eynon E, Gonzalez DG, Chen J, Krause DS, Alderman J, Halene S, Flavell RA. Science. 2021 Mar 5. PMID: 33674488.
• The emerging role of Janus kinase inhibitors in the treatment of autoimmune and inflammatory diseases.Damsky W, Peterson D, Ramseier J, Al-Bawardy B, Chun H, Proctor D, Strand V, Flavell RA, King B. J Allergy Clin Immunol. 2021 Mar; 2020 Oct 28. PMID: 33129886.