2021
mTORC1 Signaling Regulates Proinflammatory Macrophage Function and Metabolism.
Collins S, Oh M, Sun I, Chan-Li Y, Zhao L, Powell J, Horton M. mTORC1 Signaling Regulates Proinflammatory Macrophage Function and Metabolism. The Journal Of Immunology 2021, 207: 913-922. PMID: 34290107, DOI: 10.4049/jimmunol.2100230.Peer-Reviewed Original ResearchConceptsKey regulatorImmune cell functionEnhanced histone acetylationCell functionRapid energy sourceClass III histoneDifferentiation of macrophagesHistone acetylationMacrophage functionMTORC1 signalingCellular metabolismOxidative phosphorylationCell metabolismMTOR signalingGlycolytic metabolismAntimicrobial compoundsGenetic deletionM2 macrophagesMouse macrophagesProper wound healingMetabolic programmingSignificant defectsM1 functionImmune cell metabolismSignaling
2014
Regulation of Nasal Airway Homeostasis and Inflammation in Mice by SHP-1 and Th2/Th1 Signaling Pathways
Cho SH, Oh SY, Lane AP, Lee J, Oh MH, Lee S, Zheng T, Zhu Z. Regulation of Nasal Airway Homeostasis and Inflammation in Mice by SHP-1 and Th2/Th1 Signaling Pathways. PLOS ONE 2014, 9: e103685. PMID: 25090641, PMCID: PMC4121172, DOI: 10.1371/journal.pone.0103685.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsChemokinesEosinophiliaGelatinHomeostasisInflammationInterferon-gammaMatrix Metalloproteinase 2Matrix Metalloproteinase 9MetaplasiaMice, Inbred C57BLMice, Mutant StrainsMucusNasal Lavage FluidNasal MucosaProtein Tyrosine Phosphatase, Non-Receptor Type 6RhinitisSignal TransductionTh1 CellsTh2 CellsConceptsMatrix metalloproteinasesNasal inflammationAllergic rhinitisTh1 cytokinesInflammatory cellsTh2 cytokinesNasal airwayChronic inflammatory diseaseExpression of cytokinesTh2-skewed inflammationIFN-γ geneMucus metaplasiaTh1 paradigmAirway homeostasisInflammatory mediatorsTh2 lymphocytesImmune homeostasisInflammatory diseasesViable motheaten miceInflammationTransepithelial migrationCytokinesMev miceClearance mechanismsTh2
2013
SHP-1 Regulation of Mast Cell Function in Allergic Inflammation and Anaphylaxis
Zhou L, Oh SY, Zhou Y, Yuan B, Wu F, Oh MH, Wang Y, Takemoto C, Van Rooijen N, Zheng T, Zhu Z. SHP-1 Regulation of Mast Cell Function in Allergic Inflammation and Anaphylaxis. PLOS ONE 2013, 8: e55763. PMID: 23390550, PMCID: PMC3563592, DOI: 10.1371/journal.pone.0055763.Peer-Reviewed Original ResearchMeSH KeywordsAdoptive TransferAllergensAnaphylaxisAnimalsBasophilsCell DifferentiationCells, CulturedCytokinesGene ExpressionInflammationInjections, IntravenousLipopolysaccharidesLungMast CellsMiceMice, KnockoutOvalbuminProtein Tyrosine Phosphatase, Non-Receptor Type 6Respiratory HypersensitivitySignal TransductionTh2 CellsConceptsTh2 immune responseAllergic inflammationAirway inflammationMast cell functionImmune responseMast cellsDeficient bone marrow cellsMast cell-deficient miceCell-deficient miceCell functionSevere allergic reactionsWild-type miceSHP-1Bone marrow cellsAirway stimulationAdoptive transferSystemic anaphylaxisAnaphylactic responseClinical symptomsImmunological homeostasisDeficient miceAllergic reactionsType miceAnaphylaxisInflammation
2008
Transgenic Expression of Interleukin-13 in the Skin Induces a Pruritic Dermatitis and Skin Remodeling
Zheng T, Oh MH, Oh SY, Schroeder JT, Glick AB, Zhu Z. Transgenic Expression of Interleukin-13 in the Skin Induces a Pruritic Dermatitis and Skin Remodeling. Journal Of Investigative Dermatology 2008, 129: 742-751. PMID: 18830273, PMCID: PMC4356214, DOI: 10.1038/jid.2008.295.Peer-Reviewed Original ResearchConceptsAtopic dermatitisIL-13Transgenic modelElevated serum total IgEPathogenesis of ADPeripheral blood mononuclear cellsPruritic eczematous lesionsSerum total IgEThymic stromal lymphopoietinSystemic immune responsesUpregulation of chemokinesBlood mononuclear cellsKeratin 5 promoterChronic inflammatory phenotypeEczematous lesionsInducible transgenic modelDermal infiltrationTotal IgEAllergic diseasesClinical manifestationsDermal inflammationInflammatory phenotypeMononuclear cellsIL-4Langerhans cells