2015
mTORC1 and mTORC2 selectively regulate CD8+ T cell differentiation
Pollizzi K, Patel C, Sun I, Oh M, Waickman A, Wen J, Delgoffe G, Powell J. mTORC1 and mTORC2 selectively regulate CD8+ T cell differentiation. Journal Of Clinical Investigation 2015, 125: 2090-2108. PMID: 25893604, PMCID: PMC4463194, DOI: 10.1172/jci77746.Peer-Reviewed Original ResearchMeSH KeywordsAdoptive TransferAnimalsCarrier ProteinsCD4-CD8 RatioCD8-Positive T-LymphocytesCell Line, TumorDeoxyglucoseFemaleGenes, ReporterGlycolysisImmunologic MemoryInterferon-gammaLymphocyte ActivationLymphopoiesisMaleMechanistic Target of Rapamycin Complex 1Mechanistic Target of Rapamycin Complex 2Melanoma, ExperimentalMiceMice, CongenicMice, Inbred C57BLMonomeric GTP-Binding ProteinsMultiprotein ComplexesNeuropeptidesOvalbuminPeptide FragmentsPhosphorylationProtein Processing, Post-TranslationalProto-Oncogene Proteins c-aktRapamycin-Insensitive Companion of mTOR ProteinRas Homolog Enriched in Brain ProteinRecombinant Fusion ProteinsSirolimusThymomaTOR Serine-Threonine KinasesTransduction, GeneticTumor Necrosis Factor-alphaConceptsGeneration of CD8T cell effectorsT cellsTuberous sclerosis complex 2Cell effectorsT cell effector responsesMemory-like T cellsEffector cell subsetsT cell memoryDifferentiation of CD4T cell-specific deletionT cell differentiationCell-specific deletionSurface marker expressionMTOR-dependent pathwayEvaluation of miceEffector CD8Antitumor immunityEffector phenotypeEffector cellsCell subsetsRecall responsesVaccine efficacyEffector responsesCD8
2013
SHP-1 Regulation of Mast Cell Function in Allergic Inflammation and Anaphylaxis
Zhou L, Oh SY, Zhou Y, Yuan B, Wu F, Oh MH, Wang Y, Takemoto C, Van Rooijen N, Zheng T, Zhu Z. SHP-1 Regulation of Mast Cell Function in Allergic Inflammation and Anaphylaxis. PLOS ONE 2013, 8: e55763. PMID: 23390550, PMCID: PMC3563592, DOI: 10.1371/journal.pone.0055763.Peer-Reviewed Original ResearchMeSH KeywordsAdoptive TransferAllergensAnaphylaxisAnimalsBasophilsCell DifferentiationCells, CulturedCytokinesGene ExpressionInflammationInjections, IntravenousLipopolysaccharidesLungMast CellsMiceMice, KnockoutOvalbuminProtein Tyrosine Phosphatase, Non-Receptor Type 6Respiratory HypersensitivitySignal TransductionTh2 CellsConceptsTh2 immune responseAllergic inflammationAirway inflammationMast cell functionImmune responseMast cellsDeficient bone marrow cellsMast cell-deficient miceCell-deficient miceCell functionSevere allergic reactionsWild-type miceSHP-1Bone marrow cellsAirway stimulationAdoptive transferSystemic anaphylaxisAnaphylactic responseClinical symptomsImmunological homeostasisDeficient miceAllergic reactionsType miceAnaphylaxisInflammation