IL-13 Induces Skin Fibrosis in Atopic Dermatitis by Thymic Stromal Lymphopoietin
Oh MH, Oh SY, Yu J, Myers AC, Leonard WJ, Liu YJ, Zhu Z, Zheng T. IL-13 Induces Skin Fibrosis in Atopic Dermatitis by Thymic Stromal Lymphopoietin. The Journal Of Immunology 2011, 186: 7232-7242. PMID: 21576506, PMCID: PMC3399513, DOI: 10.4049/jimmunol.1100504.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCytokinesDermatitis, AtopicDisease ProgressionFibrosisHumansInterleukin-13MiceMice, TransgenicThymic Stromal LymphopoietinTransgenesConceptsThymic stromal lymphopoietinRole of TSLPAtopic dermatitisSkin fibrosisTSLP receptorIL-13Fibrotic remodelingNeutralization of TSLPIL-13 transgenic miceAD skin lesionsElevated IL-13AD-like phenotypeHuman atopic dermatitisReduction of fibrosisNumber of fibrocytesReduced skin inflammationFibrocyte functionTh2 responsesAD lesionsSkin inflammationAD patientsSkin lesionsFurther progressionTissue fibrosisTransgenic mice