2012
Epicutaneous Exposure to Staphylococcal Superantigen Enterotoxin B Enhances Allergic Lung Inflammation via an IL-17A Dependent Mechanism
Yu J, Oh MH, Park JU, Myers AC, Dong C, Zhu Z, Zheng T. Epicutaneous Exposure to Staphylococcal Superantigen Enterotoxin B Enhances Allergic Lung Inflammation via an IL-17A Dependent Mechanism. PLOS ONE 2012, 7: e39032. PMID: 22848348, PMCID: PMC3407176, DOI: 10.1371/journal.pone.0039032.Peer-Reviewed Original ResearchConceptsIL-17A-dependent mechanismsAtopic dermatitisAirway hyperresponsivenessAtopic marchLung inflammationDependent mechanismDevelopment of ADSeverity of ADEnterotoxin BSystemic Th2 responseAllergic lung inflammationTh17/ILSkin barrier abnormalitiesIL-6 productionSkin of patientsEpicutaneous exposureAllergic rhinitisIL-17ATh2 responsesEpicutaneous sensitizationLymph nodesImmune environmentLesional skinAllergen ovalbuminStimulating lymphocytes
2011
IL-13 Induces Skin Fibrosis in Atopic Dermatitis by Thymic Stromal Lymphopoietin
Oh MH, Oh SY, Yu J, Myers AC, Leonard WJ, Liu YJ, Zhu Z, Zheng T. IL-13 Induces Skin Fibrosis in Atopic Dermatitis by Thymic Stromal Lymphopoietin. The Journal Of Immunology 2011, 186: 7232-7242. PMID: 21576506, PMCID: PMC3399513, DOI: 10.4049/jimmunol.1100504.Peer-Reviewed Original ResearchConceptsThymic stromal lymphopoietinRole of TSLPAtopic dermatitisSkin fibrosisTSLP receptorIL-13Fibrotic remodelingNeutralization of TSLPIL-13 transgenic miceAD skin lesionsElevated IL-13AD-like phenotypeHuman atopic dermatitisReduction of fibrosisNumber of fibrocytesReduced skin inflammationFibrocyte functionTh2 responsesAD lesionsSkin inflammationAD patientsSkin lesionsFurther progressionTissue fibrosisTransgenic mice