IL-13 Induces Skin Fibrosis in Atopic Dermatitis by Thymic Stromal Lymphopoietin
Oh MH, Oh SY, Yu J, Myers AC, Leonard WJ, Liu YJ, Zhu Z, Zheng T. IL-13 Induces Skin Fibrosis in Atopic Dermatitis by Thymic Stromal Lymphopoietin. The Journal Of Immunology 2011, 186: 7232-7242. PMID: 21576506, PMCID: PMC3399513, DOI: 10.4049/jimmunol.1100504.Peer-Reviewed Original ResearchConceptsThymic stromal lymphopoietinRole of TSLPAtopic dermatitisSkin fibrosisTSLP receptorIL-13Fibrotic remodelingNeutralization of TSLPIL-13 transgenic miceAD skin lesionsElevated IL-13AD-like phenotypeHuman atopic dermatitisReduction of fibrosisNumber of fibrocytesReduced skin inflammationFibrocyte functionTh2 responsesAD lesionsSkin inflammationAD patientsSkin lesionsFurther progressionTissue fibrosisTransgenic miceThe Atopic March: Progression from Atopic Dermatitis to Allergic Rhinitis and Asthma
Zheng T, Yu J, Oh MH, Zhu Z. The Atopic March: Progression from Atopic Dermatitis to Allergic Rhinitis and Asthma. Allergy Asthma And Immunology Research 2011, 3: 67-73. PMID: 21461244, PMCID: PMC3062798, DOI: 10.4168/aair.2011.3.2.67.Peer-Reviewed Original ResearchPathogenesis of ADAtopic dermatitisAtopic marchAllergic rhinitisMechanisms of ADIgE-mediated sensitizationPruritic skin lesionsT helper 1More effective treatmentsAdaptive immune systemEpidermal barrier functionImmunological sequelaeEnvironmental allergensTh2 paradigmBarrier disruptionInflammatory diseasesSkin lesionsEffective treatmentEpithelial barrierImmune systemDisease initiationBarrier functionPrimary defectLongitudinal studyRhinitis