2009
SHP-1 Deficient Mast Cells Are Hyperresponsive to Stimulation and Critical in Initiating Allergic Inflammation in the Lung
Zhang L, Oh SY, Wu X, Oh MH, Wu F, Schroeder JT, Takemoto CM, Zheng T, Zhu Z. SHP-1 Deficient Mast Cells Are Hyperresponsive to Stimulation and Critical in Initiating Allergic Inflammation in the Lung. The Journal Of Immunology 2009, 184: 1180-1190. PMID: 20042576, PMCID: PMC4755278, DOI: 10.4049/jimmunol.0901972.Peer-Reviewed Original ResearchConceptsBone marrow-derived mast cellsAllergic asthma phenotypeMarrow-derived mast cellsMast cellsTh2 cytokinesMev miceAsthma phenotypesTh2 cytokines IL-4Allergic inflammatory responseTh2 cytokine productionRelease of mediatorsCytokines IL-4Mast cell productionT cells 2SHP-1 deficiencySrc homology region 2 domain-containing phosphatase-1Amount of mediatorMast cell developmentPulmonary inflammationAllergic inflammationCytokine productionTh2 phenotypeIL-13IL-4Deficient mast cells
2008
Transgenic Expression of Interleukin-13 in the Skin Induces a Pruritic Dermatitis and Skin Remodeling
Zheng T, Oh MH, Oh SY, Schroeder JT, Glick AB, Zhu Z. Transgenic Expression of Interleukin-13 in the Skin Induces a Pruritic Dermatitis and Skin Remodeling. Journal Of Investigative Dermatology 2008, 129: 742-751. PMID: 18830273, PMCID: PMC4356214, DOI: 10.1038/jid.2008.295.Peer-Reviewed Original ResearchConceptsAtopic dermatitisIL-13Transgenic modelElevated serum total IgEPathogenesis of ADPeripheral blood mononuclear cellsPruritic eczematous lesionsSerum total IgEThymic stromal lymphopoietinSystemic immune responsesUpregulation of chemokinesBlood mononuclear cellsKeratin 5 promoterChronic inflammatory phenotypeEczematous lesionsInducible transgenic modelDermal infiltrationTotal IgEAllergic diseasesClinical manifestationsDermal inflammationInflammatory phenotypeMononuclear cellsIL-4Langerhans cells
2007
TH2 and TH1 lung inflammation induced by airway allergen sensitization with low and high doses of double-stranded RNA
Jeon SG, Oh SY, Park HK, Kim YS, Shim EJ, Lee HS, Oh MH, Bang B, Chun EY, Kim SH, Gho YS, Zhu Z, Kim YY, Kim YK. TH2 and TH1 lung inflammation induced by airway allergen sensitization with low and high doses of double-stranded RNA. Journal Of Allergy And Clinical Immunology 2007, 120: 803-812. PMID: 17610940, DOI: 10.1016/j.jaci.2007.05.030.Peer-Reviewed Original ResearchConceptsRespiratory viral infectionsAllergen sensitizationLung inflammationViral infectionAirway sensitizationIL-4Immune responseMouse modelHigh dosesIL-13-deficient miceIFN-gamma-deficient miceT-bet-deficient miceToll-like receptor 3Airway allergen exposureAllergic lung inflammationAdaptive immune responsesToll-like receptorsIL-4 expressionSTAT6-deficient miceNovel mouse modelIFN-gamma expressionAllergen exposurePathophysiologic mechanismsIL-13Deficient mice