The Role of TSLP in IL-13-Induced Atopic March
Zhu Z, Oh MH, Yu J, Liu YJ, Zheng T. The Role of TSLP in IL-13-Induced Atopic March. Scientific Reports 2011, 1: 23. PMID: 22355542, PMCID: PMC3251897, DOI: 10.1038/srep00023.Peer-Reviewed Original ResearchConceptsThymic stromal lymphopoietinAtopic dermatitisAtopic marchAirway hyperresponsivenessLevels of TSLPRole of TSLPIL-13 transgenic miceAcute atopic dermatitisAllergic asthma responsesChronic atopic dermatitisHuman atopic dermatitisImmune cell productionSkin of miceSystemic Th2 immunityAD skinAsthma responseLung inflammationMucus hypersecretionTh2 immunitySerum IgE.Th2 cytokinesIL-13AD phenotypeTransgenic miceDependent mechanismIL-13 Induces Skin Fibrosis in Atopic Dermatitis by Thymic Stromal Lymphopoietin
Oh MH, Oh SY, Yu J, Myers AC, Leonard WJ, Liu YJ, Zhu Z, Zheng T. IL-13 Induces Skin Fibrosis in Atopic Dermatitis by Thymic Stromal Lymphopoietin. The Journal Of Immunology 2011, 186: 7232-7242. PMID: 21576506, PMCID: PMC3399513, DOI: 10.4049/jimmunol.1100504.Peer-Reviewed Original ResearchConceptsThymic stromal lymphopoietinRole of TSLPAtopic dermatitisSkin fibrosisTSLP receptorIL-13Fibrotic remodelingNeutralization of TSLPIL-13 transgenic miceAD skin lesionsElevated IL-13AD-like phenotypeHuman atopic dermatitisReduction of fibrosisNumber of fibrocytesReduced skin inflammationFibrocyte functionTh2 responsesAD lesionsSkin inflammationAD patientsSkin lesionsFurther progressionTissue fibrosisTransgenic mice