Recombinant basic fibroblast growth factor inhibits the airway hyperresponsiveness, mucus production, and lung inflammation induced by an allergen challenge
Jeon SG, Lee CG, Oh MH, Chun EY, Gho YS, Cho SH, Kim JH, Min KU, Kim YY, Kim YK, Elias JA. Recombinant basic fibroblast growth factor inhibits the airway hyperresponsiveness, mucus production, and lung inflammation induced by an allergen challenge. Journal Of Allergy And Clinical Immunology 2007, 119: 831-837. PMID: 17289133, DOI: 10.1016/j.jaci.2006.12.653.Peer-Reviewed Original ResearchConceptsAsthma mouse modelLung inflammationBasic fibroblast growth factorAsthma phenotypesMucus productionFibroblast growth factorAllergen challengeTg miceRecombinant FGF2Therapeutic effectMouse modelWild-type control miceGrowth factorDevelopment of AHRTGF-beta1 miceRegional lymph nodesWhole-body plethysmographyDevelopment of asthmaBronchoalveolar lavage cellularityRecombinant basic fibroblast growth factorFGF2-deficient micePeriodic acid-Schiff stainingFGF2 mRNA expressionRole of FGF2Acid-Schiff staining