2012
Epicutaneous Exposure to Staphylococcal Superantigen Enterotoxin B Enhances Allergic Lung Inflammation via an IL-17A Dependent Mechanism
Yu J, Oh MH, Park JU, Myers AC, Dong C, Zhu Z, Zheng T. Epicutaneous Exposure to Staphylococcal Superantigen Enterotoxin B Enhances Allergic Lung Inflammation via an IL-17A Dependent Mechanism. PLOS ONE 2012, 7: e39032. PMID: 22848348, PMCID: PMC3407176, DOI: 10.1371/journal.pone.0039032.Peer-Reviewed Original ResearchConceptsIL-17A-dependent mechanismsAtopic dermatitisAirway hyperresponsivenessAtopic marchLung inflammationDependent mechanismDevelopment of ADSeverity of ADEnterotoxin BSystemic Th2 responseAllergic lung inflammationTh17/ILSkin barrier abnormalitiesIL-6 productionSkin of patientsEpicutaneous exposureAllergic rhinitisIL-17ATh2 responsesEpicutaneous sensitizationLymph nodesImmune environmentLesional skinAllergen ovalbuminStimulating lymphocytes
2011
The Role of TSLP in IL-13-Induced Atopic March
Zhu Z, Oh MH, Yu J, Liu YJ, Zheng T. The Role of TSLP in IL-13-Induced Atopic March. Scientific Reports 2011, 1: 23. PMID: 22355542, PMCID: PMC3251897, DOI: 10.1038/srep00023.Peer-Reviewed Original ResearchConceptsThymic stromal lymphopoietinAtopic dermatitisAtopic marchAirway hyperresponsivenessLevels of TSLPRole of TSLPIL-13 transgenic miceAcute atopic dermatitisAllergic asthma responsesChronic atopic dermatitisHuman atopic dermatitisImmune cell productionSkin of miceSystemic Th2 immunityAD skinAsthma responseLung inflammationMucus hypersecretionTh2 immunitySerum IgE.Th2 cytokinesIL-13AD phenotypeTransgenic miceDependent mechanismThe Atopic March: Progression from Atopic Dermatitis to Allergic Rhinitis and Asthma
Zheng T, Yu J, Oh MH, Zhu Z. The Atopic March: Progression from Atopic Dermatitis to Allergic Rhinitis and Asthma. Allergy Asthma And Immunology Research 2011, 3: 67-73. PMID: 21461244, PMCID: PMC3062798, DOI: 10.4168/aair.2011.3.2.67.Peer-Reviewed Original ResearchPathogenesis of ADAtopic dermatitisAtopic marchAllergic rhinitisMechanisms of ADIgE-mediated sensitizationPruritic skin lesionsT helper 1More effective treatmentsAdaptive immune systemEpidermal barrier functionImmunological sequelaeEnvironmental allergensTh2 paradigmBarrier disruptionInflammatory diseasesSkin lesionsEffective treatmentEpithelial barrierImmune systemDisease initiationBarrier functionPrimary defectLongitudinal studyRhinitis
2010
Thymic Stromal Lymphopoietin (TSLP) Signaling is Required for IL-13-Induced ”Atopic March”: Progression from Atopic Dermatitis (AD) to Asthma
Yu J, Oh M, Oh S, Zhu Z, Zheng T. Thymic Stromal Lymphopoietin (TSLP) Signaling is Required for IL-13-Induced ”Atopic March”: Progression from Atopic Dermatitis (AD) to Asthma. Journal Of Allergy And Clinical Immunology 2010, 125: ab113. DOI: 10.1016/j.jaci.2009.12.446.Peer-Reviewed Original Research