2000
Reversible Block of the Calcium Release Channel/Ryanodine Receptor by Protamine, a Heparin Antidote
Koulen P, Ehrlich B. Reversible Block of the Calcium Release Channel/Ryanodine Receptor by Protamine, a Heparin Antidote. Molecular Biology Of The Cell 2000, 11: 2213-2219. PMID: 10888663, PMCID: PMC14914, DOI: 10.1091/mbc.11.7.2213.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntidotesCalciumCalcium Channel BlockersCell LineChelating AgentsElectrophysiologyHeparin AntagonistsMiceProtaminesRabbitsRyanodine Receptor Calcium Release ChannelConceptsCalcium release channelRyanodine receptorChannel activityIntracellular calcium releaseRelease channelRyanodine receptor activityReceptor type 1Application of protamineMechanism of actionChannel/ryanodine receptorCalcium release channel/ryanodine receptorRelease channel/ryanodine receptorBulk calcium concentrationAddition of heparinRyanodine receptor type 1Single-channel activityReceptor activityCalcium releaseType 1Muscle cellsCalcium concentrationSkeletal muscleHeparin antidoteReversible blockProtamine sulfate
1999
Calcium signaling molecules in human cerebellum at midgestation and in ataxia
Zecevic N, Milosevic A, Ehrlich B. Calcium signaling molecules in human cerebellum at midgestation and in ataxia. Early Human Development 1999, 54: 103-116. PMID: 10213289, DOI: 10.1016/s0378-3782(98)00090-5.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedBlotting, WesternCadaverCalcium ChannelsCalcium-Binding ProteinsCell DifferentiationCerebellar AtaxiaCerebellumEmbryonic and Fetal DevelopmentHumansImmunohistochemistryInositol 1,4,5-Trisphosphate ReceptorsMicroscopy, FluorescencePurkinje CellsReceptors, Cytoplasmic and NuclearRyanodine Receptor Calcium Release ChannelSynapsesConceptsPurkinje cell layerImmune reactionsIntracellular Ca2Precise topographic connectionsInositol trisphosphate receptor type 1Positive immune reactionHuman cerebellumCell layerReceptor type 1Expression of Ca2Channels/receptorsNeuronal typesAdult brainTrisphosphate receptor type 1Cerebellar cortexDiseased brainTopographic connectionsIntrauterine stagesYounger ageType 1Brain developmentInternal storesImmunocytochemical methodsCerebellumAtaxia
1998
Characterization of the ryanodine receptor/channel of invertebrate muscle
Quinn K, Castellani L, Ondrias K, Ehrlich B. Characterization of the ryanodine receptor/channel of invertebrate muscle. American Journal Of Physiology 1998, 274: r494-r502. PMID: 9486309, DOI: 10.1152/ajpregu.1998.274.2.r494.Peer-Reviewed Original ResearchMeSH KeywordsAdenosine TriphosphateAnimalsCaffeineCalciumCalcium ChannelsElectric ConductivityLipid BilayersMicroscopy, ElectronMolluscaMusclesNephropidaeRuthenium RedRyanodineRyanodine Receptor Calcium Release ChannelSarcoplasmic ReticulumConceptsInvertebrate musclesRyanodine receptor/channelVertebrate skeletal muscleDiverse organismsCalcium release channel/ryanodine receptorRelease channel/ryanodine receptorChannel/ryanodine receptorSingle-channel conductanceReceptor/channelElectron microscopic analysisRyanodine receptorSkeletal muscleRelease channelCytoplasmic Ca2Single-channel currentsSpecific ryanodine bindingChannel conductanceSarcoplasmic reticulumRyRsRuthenium redInvertebratesCa2MammalianRyanodine bindingOrganisms
1997
Regulation of Intracellular Calcium Release Channel Function by Arachidonic Acid and Leukotriene B4
Striggow F, Ehrlich B. Regulation of Intracellular Calcium Release Channel Function by Arachidonic Acid and Leukotriene B4. Biochemical And Biophysical Research Communications 1997, 237: 413-418. PMID: 9268725, DOI: 10.1006/bbrc.1997.7152.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsArachidonic AcidCalcium ChannelsCalmodulin-Binding ProteinsCerebellumDogsInositol 1,4,5-TrisphosphateInositol 1,4,5-Trisphosphate ReceptorsLeukotriene B4Muscle ProteinsReceptors, Cytoplasmic and NuclearRyanodine Receptor Calcium Release ChannelConceptsLeukotriene B4Arachidonic acidCalcium release channelNM leukotriene B4Intracellular calcium concentrationRelease channelIntracellular calcium release channelsTrisphosphate-gated channelsRelease channel functionCalcium concentrationRyanodine receptorChannel functionCell typesSpecific mobilizationB4RyRsAgonistsConcerted actionMethanethiosulfonate Derivatives Inhibit Current through the Ryanodine Receptor/Channel
Quinn K, Ehrlich B. Methanethiosulfonate Derivatives Inhibit Current through the Ryanodine Receptor/Channel. The Journal Of General Physiology 1997, 109: 255-264. PMID: 9041453, PMCID: PMC2220055, DOI: 10.1085/jgp.109.2.255.Peer-Reviewed Original Research
1996
Effects of Rapamycin on Ryanodine Receptor/Ca2+-Release Channels From Cardiac Muscle
Kaftan E, Marks A, Ehrlich B. Effects of Rapamycin on Ryanodine Receptor/Ca2+-Release Channels From Cardiac Muscle. Circulation Research 1996, 78: 990-997. PMID: 8635249, DOI: 10.1161/01.res.78.6.990.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCalcium ChannelsCarrier ProteinsDNA-Binding ProteinsDogsHeartHeat-Shock ProteinsImmunosuppressive AgentsMuscle ProteinsPolyenesRyanodineRyanodine Receptor Calcium Release ChannelSirolimusTacrolimus Binding ProteinsConceptsRelease channelFK506-binding proteinCardiac muscleLong-term depressionEffect of rapamycinChannel functionProlyl isomerase activityRelease of Ca2Ryanodine receptor/Ca2Immunosuppressant drugsSkeletal muscle isoformCardiac RyRIsomerase activityRyanodine receptorRapamycinRyRsChannel familyImportant regulatory roleCis-trans peptidylOpen probabilitySubmicromolar concentrationsCell typesDrugsMuscleMuscle isoform
1995
Functional properties of intracellular calcium-release channels
Ehrlich B. Functional properties of intracellular calcium-release channels. Current Opinion In Neurobiology 1995, 5: 304-309. PMID: 7580152, DOI: 10.1016/0959-4388(95)80042-5.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCalciumCalcium ChannelsModels, BiologicalMuscle ProteinsRyanodine Receptor Calcium Release ChannelConceptsIntracellular calcium release channelsCalcium release channelLarge ion channelsCellular rolesCytoplasmic proteinsMolecular mechanismsRegulatory sitesTrisphosphate receptorFunctional interactionIon channelsRegulatory processesMajor classesRyanodine receptorProteinRecent studiesFunctional propertiesReceptorsCytoplasmInositol
1994
The pharmacology of intracellular Ca2+-release channels
Ehrlich B, Kaftan E, Bezprozvannaya S, Bezprozvanny I. The pharmacology of intracellular Ca2+-release channels. Trends In Pharmacological Sciences 1994, 15: 145-149. PMID: 7754532, DOI: 10.1016/0165-6147(94)90074-4.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCaffeineCalciumCalcium ChannelsCalmodulin-Binding ProteinsDose-Response Relationship, DrugHeparinInositol 1,4,5-TrisphosphateInositol 1,4,5-Trisphosphate ReceptorsMuscle ProteinsReceptors, Cytoplasmic and NuclearRyanodine Receptor Calcium Release ChannelStabilization of calcium release channel (ryanodine receptor) function by FK506-binding protein
Brillantes A, Ondrias K, Scott A, Kobrinsky E, Ondriašová E, Moschella M, Jayaraman T, Landers M, Ehrlich B, Marks A. Stabilization of calcium release channel (ryanodine receptor) function by FK506-binding protein. Cell 1994, 77: 513-523. PMID: 7514503, DOI: 10.1016/0092-8674(94)90214-3.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCaffeineCalciumCalcium ChannelsCarrier ProteinsCell LineCloning, MolecularGene ExpressionHeat-Shock ProteinsIon Channel GatingIsometric ContractionLipid BilayersMuscle ProteinsPolyenesRabbitsRatsRecombinant ProteinsRNA, MessengerRuthenium RedRyanodineRyanodine Receptor Calcium Release ChannelSarcoplasmic ReticulumSirolimusTacrolimusTacrolimus Binding ProteinsConceptsCellular functionsFK506-binding proteinNatural cellular functionsRelease channel functionInsect cellsProline isomeraseIsomerase activityEndoplasmic reticulumChannel functionFKBP12Channel complexRyanodine receptorCytosolic receptorRelease channel complexRelease channelRapamycinProteinFunctional Ca2Open probabilityCaffeine activationIntracellular Ca2Mean open timeImmunosuppressant drugsCopurifiesReceptors
1991
Bell-shaped calcium-response curves of lns(l,4,5)P3- and calcium-gated channels from endoplasmic reticulum of cerebellum
Bezprozvanny L, Watras J, Ehrlich B. Bell-shaped calcium-response curves of lns(l,4,5)P3- and calcium-gated channels from endoplasmic reticulum of cerebellum. Nature 1991, 351: 751-754. PMID: 1648178, DOI: 10.1038/351751a0.Peer-Reviewed Original ResearchMeSH KeywordsAdenosine TriphosphateAnimalsCalciumCalcium ChannelsCell MembraneCerebellumCytoplasmDogsEndoplasmic ReticulumFeedbackInositol 1,4,5-TrisphosphateInositol 1,4,5-Trisphosphate ReceptorsIon Channel GatingLipid BilayersReceptors, Cell SurfaceReceptors, CholinergicReceptors, Cytoplasmic and NuclearRyanodine Receptor Calcium Release ChannelConceptsCalcium-gated channelsRyanodine receptor/channelEndoplasmic reticulum vesiclesLigand sensitivityEndoplasmic reticulumReceptor/channelCalcium-activated channelChannel typesSame cellsIntracellular calcium regulationCalcium regulationPlanar bilayersCytoplasmic calciumIntracellular storesOpen probabilityCanine cerebellumComplex patternsDifferent responsesAdenine nucleotidesRelease of calciumFunctional propertiesRuthenium redMaximum activityInsP3Cells