Publications

2023

Immunocompromised Host Pneumonia: Definitions and Diagnostic Criteria: An Official American Thoracic Society Workshop Report.Cheng GS, Crothers K, Aliberti S, Bergeron A, Boeckh M, Chien JW, Cilloniz C, Cohen K, Dean N, Dela Cruz CS, Dickson RP, Greninger AL, Hage CA, Hohl TM, Holland SM, Jones BE, Keane J, Metersky M, Miller R, Puel A, Ramirez J, Restrepo MI, Sheshadri A, Staitieh B, Tarrand J, Winthrop KL, Wunderink RG, Evans SE. Ann Am Thorac Soc. 2023 Mar. PMID: 36856712.
microRNA-33 deficiency in macrophages enhances autophagy, improves mitochondrial homeostasis, and protects against lung fibrosis.Ahangari F, Price NL, Malik S, Chioccioli M, Bärnthaler T, Adams TS, Kim J, Pradeep SP, Ding S, Cosmos C Jr, Rose KS, McDonough JE, Aurelien NR, Ibarra G, Omote N, Schupp JC, DeIuliis G, Villalba Nunez JA, Sharma L, Ryu C, Dela Cruz CS, Liu X, Prasse A, Rosas I, Bahal R, Fernández-Hernando C, Kaminski N. JCI Insight. 2023 Feb 22; 2023 Feb 22. PMID: 36626225.
Coronaviruses, Lysosomes, and Secondary Bacterial Infections: Coronaviruses Outsmart the Host.Peng X, Dela Cruz CS, Sharma L. DNA Cell Biol. 2023 Feb 10; 2023 Feb 10. PMID: 36763591.
Nonutility of procalcitonin for diagnosing bacterial pneumonia in patients with severe COVID-19.Cohen AJ, Glick LR, Lee S, Kunitomo Y, Tsang DA, Pitafi S, Valda Toro P, Ristic NR, Zhang E, Carey GB, Datta R, Dela Cruz CS, Gautam S. Eur Clin Respir J. 2023; 2023 Feb 8. PMID: 36815942.
Glucocorticoid Therapy in COVID-19.Amati F, Tonutti A, Huston J, Dela Cruz CS. Semin Respir Crit Care Med. 2023 Feb; 2023 Jan 16. PMID: 36646089.
COVID-19.Dela Cruz CS, Feldman C. Semin Respir Crit Care Med. 2023 Feb; 2023 Jan 16. PMID: 36646080.
PD-1(high)CXCR5(-)CD4(+) peripheral helper T cells promote CXCR3(+) plasmablasts in human acute viral infection.Asashima H, Mohanty S, Comi M, Ruff WE, Hoehn KB, Wong P, Klein J, Lucas C, Cohen I, Coffey S, Lele N, Greta L, Raddassi K, Chaudhary O, Unterman A, Emu B, Kleinstein SH, Montgomery RR, Iwasaki A, Dela Cruz CS, Kaminski N, Shaw AC, Hafler DA, Sumida TS. Cell Rep. 2023 Jan 31; 2023 Jan 2. PMID: 36596303.
Identification of two specific transcriptomic clusters of COVID-19 acute respiratory distress syndrome patients with different immune profiles and different outcomes.Shindo Y, Dela Cruz CS, Witzenrath M. Eur Respir J. 2023 Jan; 2023 Jan 27. PMID: 36517181.
Adding Insult to Injury: Does COVID-19 Promote Acute Respiratory Distress Syndrome by Inhibiting Surfactant?Richmond BW, Dela Cruz CS. Am J Respir Crit Care Med. 2023 Jan 1. PMID: 35976979.

2022

Saracatinib, a Selective Src Kinase Inhibitor, Blocks Fibrotic Responses in Preclinical Models of Pulmonary Fibrosis.Ahangari F, Becker C, Foster DG, Chioccioli M, Nelson M, Beke K, Wang X, Justet A, Adams T, Readhead B, Meador C, Correll K, Lili LN, Roybal HM, Rose KA, Ding S, Barnthaler T, Briones N, DeIuliis G, Schupp JC, Li Q, Omote N, Aschner Y, Sharma L, Kopf KW, Magnusson B, Hicks R, Backmark A, Dela Cruz CS, Rosas I, Cousens LP, Dudley JT, Kaminski N, Downey GP. Am J Respir Crit Care Med. 2022 Dec 15. PMID: 35998281.
Coronavirus Lung Infection Impairs Host Immunity against Secondary Bacterial Infection by Promoting Lysosomal Dysfunction.Peng X, Kim J, Gupta G, Agaronyan K, Mankowski MC, Korde A, Takyar SS, Shin HJ, Habet V, Voth S, Audia JP, Chang D, Liu X, Wang L, Cai Y, Tian X, Ishibe S, Kang MJ, Compton S, Wilen CB, Dela Cruz CS, Sharma L. J Immunol. 2022 Oct 1; 2022 Sep 2. PMID: 36165196.
Development of an efficient reproducible cell-cell transmission assay for rapid quantification of SARS-CoV-2 spike interaction with hACE2.Ssenyange G, Kerfoot M, Zhao M, Farhadian S, Chen S, Peng L, Ren P, Dela Cruz CS, Gupta S, Sutton RE. Cell Rep Methods. 2022 Jul 18; 2022 Jun 20. PMID: 35757815.
Summary for Clinicians: Clinical Practice Guideline for the Use of Nucleic Acid-based Testing for Noninfluenza Viral Pathogens in Adults with Suspected Community-acquired Pneumonia.Losier A, Harding WC, Dela Cruz CS, Evans S, Ruminjo JK, Thomson C. Ann Am Thorac Soc. 2022 Jul. PMID: 35353672.
Tissue remodeling by an opportunistic pathogen triggers allergic inflammation.Agaronyan K, Sharma L, Vaidyanathan B, Glenn K, Yu S, Annicelli C, Wiggen TD, Penningroth MR, Hunter RC, Dela Cruz CS, Medzhitov R. Immunity. 2022 May 10; 2022 Apr 27. PMID: 35483356.
Multiscale PHATE identifies multimodal signatures of COVID-19.Kuchroo M, Huang J, Wong P, Grenier JC, Shung D, Tong A, Lucas C, Klein J, Burkhardt DB, Gigante S, Godavarthi A, Rieck B, Israelow B, Simonov M, Mao T, Oh JE, Silva J, Takahashi T, Odio CD, Casanovas-Massana A, Fournier J, Farhadian S, Dela Cruz CS, Ko AI, Hirn MJ, Wilson FP, Hussin JG, Wolf G, Iwasaki A, Krishnaswamy S. Nat Biotechnol. 2022 May; 2022 Feb 28. PMID: 35228707.
Nonutility of procalcitonin for diagnosing bacterial pneumonia in COVID-19.Cohen AJ, Glick LR, Lee S, Kunitomo Y, Tsang DA, Pitafi S, Toro PV, Zhang E, Datta R, Dela Cruz CS, Gautam S. medRxiv. 2022 Apr 5; 2022 Apr 5. PMID: 35411344.
New testing guidelines for community-acquired pneumonia.Losier A, Dela Cruz CS. Curr Opin Infect Dis. 2022 Apr 1. PMID: 35245248.
Emerging insights in sarcoidosis: moving forward through reverse translational research.Liu A, Sharma L, Yan X, Dela Cruz CS, Herzog EL, Ryu C. Am J Physiol Lung Cell Mol Physiol. 2022 Apr 1; 2022 Feb 23. PMID: 35196896.
Update on the Features and Measurements of Experimental Acute Lung Injury in Animals: An Official American Thoracic Society Workshop Report.Kulkarni HS, Lee JS, Bastarache JA, Kuebler WM, Downey GP, Albaiceta GM, Altemeier WA, Artigas A, Bates JHT, Calfee CS, Dela Cruz CS, Dickson RP, Englert JA, Everitt JI, Fessler MB, Gelman AE, Gowdy KM, Groshong SD, Herold S, Homer RJ, Horowitz JC, Hsia CCW, Kurahashi K, Laubach VE, Looney MR, Lucas R, Mangalmurti NS, Manicone AM, Martin TR, Matalon S, Matthay MA, McAuley DF, McGrath-Morrow SA, Mizgerd JP, Montgomery SA, Moore BB, Noël A, Perlman CE, Reilly JP, Schmidt EP, Skerrett SJ, Suber TL, Summers C, Suratt BT, Takata M, Tuder R, Uhlig S, Witzenrath M, Zemans RL, Matute-Bello G. Am J Respir Cell Mol Biol. 2022 Feb. PMID: 35103557.
Postnatal Sepsis and Bronchopulmonary Dysplasia in Premature Infants: Mechanistic Insights into "New BPD".Salimi U, Dummula K, Tucker MH, Dela Cruz CS, Sampath V. Am J Respir Cell Mol Biol. 2022 Feb. PMID: 34644520.
Association of circulating cell-free double-stranded DNA and metabolic derangements in idiopathic pulmonary fibrosis.Whalen W, Buyukozkan M, Moore B, Moon JS, Dela Cruz CS, Martinez FJ, Choi AMK, Krumsiek J, Stout-Delgado H, Cho SJ. Thorax. 2022 Feb; 2021 Sep 14. PMID: 34521729.
Distinct Roles of Type I and Type III Interferons during a Native Murine β Coronavirus Lung Infection.Sharma L, Peng X, Qing H, Hilliard BK, Kim J, Swaminathan A, Tian J, Israni-Winger K, Zhang C, Habet V, Wang L, Gupta G, Tian X, Ma Y, Shin HJ, Kim SH, Kang MJ, Ishibe S, Young LH, Kotenko S, Compton S, Wilen CB, Wang A, Dela Cruz CS. J Virol. 2022 Jan 26; 2021 Oct 27. PMID: 34705554.
Single-cell multi-omics reveals dyssynchrony of the innate and adaptive immune system in progressive COVID-19.Unterman A, Sumida TS, Nouri N, Yan X, Zhao AY, Gasque V, Schupp JC, Asashima H, Liu Y, Cosme C Jr, Deng W, Chen M, Raredon MSB, Hoehn KB, Wang G, Wang Z, DeIuliis G, Ravindra NG, Li N, Castaldi C, Wong P, Fournier J, Bermejo S, Sharma L, Casanovas-Massana A, Vogels CBF, Wyllie AL, Grubaugh ND, Melillo A, Meng H, Stein Y, Minasyan M, Mohanty S, Ruff WE, Cohen I, Raddassi K, Niklason LE, Ko AI, Montgomery RR, Farhadian SF, Iwasaki A, Shaw AC, van Dijk D, Zhao H, Kleinstein SH, Hafler DA, Kaminski N, Dela Cruz CS. Nat Commun. 2022 Jan 21; 2022 Jan 21. PMID: 35064122.

2021

Clinical Epidemiology, Risk Factors, and Control Strategies of Klebsiella pneumoniae Infection.Chang D, Sharma L, Dela Cruz CS, Zhang D. Front Microbiol. 2021; 2021 Dec 22. PMID: 34992583.
High-resolution epitope mapping and characterization of SARS-CoV-2 antibodies in large cohorts of subjects with COVID-19.Haynes WA, Kamath K, Bozekowski J, Baum-Jones E, Campbell M, Casanovas-Massana A, Daugherty PS, Dela Cruz CS, Dhal A, Farhadian SF, Fitzgibbons L, Fournier J, Jhatro M, Jordan G, Klein J, Lucas C, Kessler D, Luchsinger LL, Martinez B, Catherine Muenker M, Pischel L, Reifert J, Sawyer JR, Waitz R, Wunder EA Jr, Zhang M, Iwasaki A, Ko A, Shon JC. Commun Biol. 2021 Nov 22; 2021 Nov 22. PMID: 34811480.
SPLUNC1: a novel marker of cystic fibrosis exacerbations.Khanal S, Webster M, Niu N, Zielonka J, Nunez M, Chupp G, Slade MD, Cohn L, Sauler M, Gomez JL, Tarran R, Sharma L, Dela Cruz CS, Egan M, Laguna T, Britto CJ. Eur Respir J. 2021 Nov; 2021 Nov 11. PMID: 33958427.
Design and rationale of the colchicine/statin for the prevention of COVID-19 complications (COLSTAT) trial.Shah T, McCarthy M, Nasir I, Archer H, Ragheb E, Kluger J, Kashyap N, Paredes C, Patel P, Lu J, Kandel P, Song C, Khan M, Ul Haq F, Ahmad R, Howes C, Cambi B, Lancaster G, Cleman M, Dela Cruz CS, Parise H, Lansky A. Contemp Clin Trials. 2021 Nov; 2021 Aug 28. PMID: 34461322.
Community-acquired pneumonia.Aliberti S, Dela Cruz CS, Amati F, Sotgiu G, Restrepo MI. Lancet. 2021 Sep 4. PMID: 34481570.
Repetitive aeroallergen challenges elucidate maladaptive epithelial and inflammatory traits that underpin allergic airway diseases.Smith AM, Harper N, Meunier JA, Branum AP, Jimenez F, Pandranki L, Carrillo A, Dela Cruz CS, Restrepo MI, Maselli DJ, Rather CG, Heisser AH, Ramirez DA, He W, Clark RA, Andrews CP, Evans SE, Pugh JA, Zhang N, Lee GC, Moreira AG, Segal LN, Ramirez RM, Jacobs RL, Manoharan MS, Okulicz JF, Ahuja SK. J Allergy Clin Immunol. 2021 Aug; 2021 Jan 23. PMID: 33493557.
Understanding the Host in the Management of Pneumonia. An Official American Thoracic Society Workshop Report.Dela Cruz CS, Evans SE, Restrepo MI, Dean N, Torres A, Amara-Elori I, Awasthi S, Caler E, Cao B, Chalmers JD, Chastre J, Cohen TS, Cohen AH, Crothers K, Di YP, Egan ME, Feldman C, Gautam S, Halstead ES, Herold S, Jones BE, Luna C, Niederman MS, Mendez R, Menendez R, Mizgerd JP, Nusrat R, Ramirez J, Shindo Y, Waterer G, Yeligar SM, Wunderink RG. Ann Am Thorac Soc. 2021 Jul. PMID: 34242148.
Evidence for SARS-CoV-2 Spike Protein in the Urine of COVID-19 Patients.George S, Pal AC, Gagnon J, Timalsina S, Singh P, Vydyam P, Munshi M, Chiu JE, Renard I, Harden CA, Ott IM, Watkins AE, Vogels CBF, Lu P, Tokuyama M, Venkataraman A, Casanovas-Massana A, Wyllie AL, Rao V, Campbell M, Farhadian SF, Grubaugh ND, Dela Cruz CS, Ko AI, Berna Perez AZ, Akaho EH, Moledina DG, Testani J, John AR, Ledizet M, Mamoun CB. Kidney360. 2021 Jun 24; 2021 Apr 14. PMID: 35373072.
Rapid, reliable, and reproducible cell fusion assay to quantify SARS-Cov-2 spike interaction with hACE2.Zhao M, Su PY, Castro DA, Tripler TN, Hu Y, Cook M, Ko AI, Farhadian SF, Israelow B, Dela Cruz CS, Xiong Y, Sutton RE. PLoS Pathog. 2021 Jun; 2021 Jun 24. PMID: 34166473.
Cutting Edge: Distinct B Cell Repertoires Characterize Patients with Mild and Severe COVID-19.Hoehn KB, Ramanathan P, Unterman A, Sumida TS, Asashima H, Hafler DA, Kaminski N, Dela Cruz CS, Sealfon SC, Bukreyev A, Kleinstein SH. J Immunol. 2021 Jun 15; 2021 May 28. PMID: 34049971.
Elevated IL-15 concentrations in the sarcoidosis lung are independent of granuloma burden and disease phenotypes.Minasyan M, Sharma L, Pivarnik T, Liu W, Adams T, Bermejo S, Peng X, Liu A, Ishikawa G, Perry C, Kaminski N, Gulati M, Herzog EL, Dela Cruz CS, Ryu C. Am J Physiol Lung Cell Mol Physiol. 2021 Jun 1; 2021 Apr 14. PMID: 33851886.
Psychological Impact During the First Outbreak of COVID-19 on Frontline Health Care Workers in Shanghai.Feng J, Xu J, Xu S, Cao H, Zheng C, Sharma L, Dela Cruz CS, Zhang J, Chu D, Yu L, Tu C, Li F, Ren T, Zhang F, Du C, Gu W, Liu H, Qian Y, Shen C, Tang C, Bi Y, Xiao F, Gu K, Zhang J, Ye Z, Zhao L, Zhai J, Hu X, Qu J, Jie Z. Front Public Health. 2021; 2021 May 17. PMID: 34079783.
Increased complement activation is a distinctive feature of severe SARS-CoV-2 infection.Ma L, Sahu SK, Cano M, Kuppuswamy V, Bajwa J, McPhatter J, Pine A, Meizlish ML, Goshua G, Chang CH, Zhang H, Price C, Bahel P, Rinder H, Lei T, Day A, Reynolds D, Wu X, Schriefer R, Rauseo AM, Goss CW, O’Halloran JA, Presti RM, Kim AH, Gelman AE, Dela Cruz CS, Lee AI, Mudd PA, Chun HJ, Atkinson JP, Kulkarni HS. Sci Immunol. 2021 May 13. PMID: 34446527.
Immune dysregulation and autoreactivity correlate with disease severity in SARS-CoV-2-associated multisystem inflammatory syndrome in children.Ramaswamy A, Brodsky NN, Sumida TS, Comi M, Asashima H, Hoehn KB, Li N, Liu Y, Shah A, Ravindra NG, Bishai J, Khan A, Lau W, Sellers B, Bansal N, Guerrerio P, Unterman A, Habet V, Rice AJ, Catanzaro J, Chandnani H, Lopez M, Kaminski N, Dela Cruz CS, Tsang JS, Wang Z, Yan X, Kleinstein SH, van Dijk D, Pierce RW, Hafler DA, Lucas CL. Immunity. 2021 May 11; 2021 Apr 13. PMID: 33891889.
One Size Does Not Fit All: Moving Towards a Personalized Approach for Steroids in COVID-19.Amati F, Dela Cruz CS. Chest. 2021 May. PMID: 33965120.
Nucleic Acid-based Testing for Noninfluenza Viral Pathogens in Adults with Suspected Community-acquired Pneumonia. An Official American Thoracic Society Clinical Practice Guideline.Evans SE, Jennerich AL, Azar MM, Cao B, Crothers K, Dickson RP, Herold S, Jain S, Madhavan A, Metersky ML, Myers LC, Oren E, Restrepo MI, Semret M, Sheshadri A, Wunderink RG, Dela Cruz CS. Am J Respir Crit Care Med. 2021 May 1. PMID: 33929301.
RIPK3 Activates MLKL-mediated Necroptosis and Inflammasome Signaling during Streptococcus Infection.Huang HR, Cho SJ, Harris RM, Yang J, Bermejo S, Sharma L, Dela Cruz CS, Xu JF, Stout-Delgado HW. Am J Respir Cell Mol Biol. 2021 May. PMID: 33625952.
PINK1 Inhibits Multimeric Aggregation and Signaling of MAVS and MAVS-Dependent Lung Pathology.Kim SH, Shin HJ, Yoon CM, Lee SW, Sharma L, Dela Cruz CS, Kang MJ. Am J Respir Cell Mol Biol. 2021 May. PMID: 33577398.
Mitochondrial antiviral signaling protein is crucial for the development of pulmonary fibrosis.Kim SH, Lee JY, Yoon CM, Shin HJ, Lee SW, Rosas I, Herzog E, Dela Cruz CS, Kaminski N, Kang MJ. Eur Respir J. 2021 Apr; 2021 Apr 15. PMID: 33093124.
Post-infectious inflammatory disease in MIS-C features elevated cytotoxicity signatures and autoreactivity that correlates with severity.Ramaswamy A, Brodsky NN, Sumida TS, Comi M, Asashima H, Hoehn KB, Li N, Liu Y, Shah A, Ravindra NG, Bishai J, Khan A, Lau W, Sellers B, Bansal N, Guerrerio P, Unterman A, Habet V, Rice AJ, Catanzaro J, Chandnani H, Lopez M, Kaminski N, Dela Cruz CS, Tsang JS, Wang Z, Yan X, Kleinstein SH, van Dijk D, Pierce RW, Hafler DA, Lucas CL. medRxiv. 2021 Apr 3; 2021 Apr 3. PMID: 33300011.
Increased SARS-CoV-2 Testing Capacity with Pooled Saliva Samples.Watkins AE, Fenichel EP, Weinberger DM, Vogels CBF, Brackney DE, Casanovas-Massana A, Campbell M, Fournier J, Bermejo S, Datta R, Dela Cruz CS, Farhadian SF, Iwasaki A, Ko AI, Grubaugh ND, Wyllie AL. Emerg Infect Dis. 2021 Apr. PMID: 33755009.
Stability of SARS-CoV-2 RNA in Nonsupplemented Saliva.Ott IM, Strine MS, Watkins AE, Boot M, Kalinich CC, Harden CA, Vogels CBF, Casanovas-Massana A, Moore AJ, Muenker MC, Nakahata M, Tokuyama M, Nelson A, Fournier J, Bermejo S, Campbell M, Datta R, Dela Cruz CS, Farhadian SF, Ko AI, Iwasaki A, Grubaugh ND, Wilen CB, Wyllie AL. Emerg Infect Dis. 2021 Apr. PMID: 33754989.
Added Diagnostic Utility of Clinical Metagenomics for the Diagnosis of Pneumonia in Immunocompromised Adults.Azar MM, Schlaberg R, Malinis MF, Bermejo S, Schwarz T, Xie H, Dela Cruz CS. Chest. 2021 Apr; 2020 Nov 18. PMID: 33217418.
Clinical characteristics and outcomes for 7,995 patients with SARS-CoV-2 infection.McPadden J, Warner F, Young HP, Hurley NC, Pulk RA, Singh A, Durant TJS, Gong G, Desai N, Haimovich A, Taylor RA, Gunel M, Dela Cruz CS, Farhadian SF, Siner J, Villanueva M, Churchwell K, Hsiao A, Torre CJ Jr, Velazquez EJ, Herbst RS, Iwasaki A, Ko AI, Mortazavi BJ, Krumholz HM, Schulz WL. PLoS One. 2021; 2021 Mar 31. PMID: 33788846.
Association of Early Inflammation with Age and Asymptomatic Disease in COVID-19.Xie C, Li Q, Li L, Peng X, Ling Z, Xiao B, Feng J, Chen Z, Chang D, Xie L, Dela Cruz CS, Sharma L. J Inflamm Res. 2021; 2021 Mar 30. PMID: 33833543.
SalivaDirect: A simplified and flexible platform to enhance SARS-CoV-2 testing capacity.Vogels CBF, Watkins AE, Harden CA, Brackney DE, Shafer J, Wang J, Caraballo C, Kalinich CC, Ott IM, Fauver JR, Kudo E, Lu P, Venkataraman A, Tokuyama M, Moore AJ, Muenker MC, Casanovas-Massana A, Fournier J, Bermejo S, Campbell M, Datta R, Nelson A, Dela Cruz CS, Ko AI, Iwasaki A, Krumholz HM, Matheus JD, Hui P, Liu C, Farhadian SF, Sikka R, Wyllie AL, Grubaugh ND. Med. 2021 Mar 12; 2020 Dec 26. PMID: 33521748.
A Clinic Blueprint for Post-Coronavirus Disease 2019 RECOVERY: Learning From the Past, Looking to the Future.Lutchmansingh DD, Knauert MP, Antin-Ozerkis DE, Chupp G, Cohn L, Dela Cruz CS, Ferrante LE, Herzog EL, Koff J, Rochester CL, Ryu C, Singh I, Tickoo M, Winks V, Gulati M, Possick JD. Chest. 2021 Mar; 2020 Nov 4. PMID: 33159907.
What Does Severe Acute Respiratory Syndrome Coronavirus 2 Mean for Global Pneumonia Prevention, Diagnosis, and Treatment?Awasthi S, Campbell H, Dela Cruz CS, Graham HR, Greenslade L, Jehan F, Zar HJ. Chest. 2021 Feb; 2020 Nov 1. PMID: 33144079.
Cutting Edge: Severe SARS-CoV-2 Infection in Humans Is Defined by a Shift in the Serum Lipidome, Resulting in Dysregulation of Eicosanoid Immune Mediators.Schwarz B, Sharma L, Roberts L, Peng X, Bermejo S, Leighton I, Casanovas-Massana A, Minasyan M, Farhadian S, Ko AI, Dela Cruz CS, Bosio CM. J Immunol. 2021 Jan 15; 2020 Dec 4. PMID: 33277388.
JAK-inhibitor and type I interferon ability to produce favorable clinical outcomes in COVID-19 patients: a systematic review and meta-analysis.Walz L, Cohen AJ, Rebaza AP, Vanchieri J, Slade MD, Dela Cruz CS, Sharma L. BMC Infect Dis. 2021 Jan 11; 2021 Jan 11. PMID: 33430799.
Disinfection of Pseudomonas aeruginosa from N95 respirators with ozone: a pilot study.Manning EP, Stephens MD, Dufresne S, Silver B, Gerbarg P, Gerbarg Z, Dela Cruz CS, Sharma L. BMJ Open Respir Res. 2021 Jan. PMID: 33431507.

2020

Editorial: Outsmarting the Host: How Bacterial Pathogens Modulate Immune Responses in the Lung.Borchers MT, Lau GW, Dela Cruz CS. Front Immunol. 2020; 2021 Jan 18. PMID: 33537037.
The kinetics of humoral response and its relationship with the disease severity in COVID-19.Ren L, Zhang L, Chang D, Wang J, Hu Y, Chen H, Guo L, Wu C, Wang C, Wang Y, Wang Y, Wang G, Yang S, Dela Cruz CS, Sharma L, Wang L, Zhang D, Wang J. Commun Biol. 2020 Dec 11; 2020 Dec 11. PMID: 33311543.
Identification of Potent and Safe Antiviral Therapeutic Candidates Against SARS-CoV-2.Xiao X, Wang C, Chang D, Wang Y, Dong X, Jiao T, Zhao Z, Ren L, Dela Cruz CS, Sharma L, Lei X, Wang J. Front Immunol. 2020; 2020 Nov 25. PMID: 33324406.
Circulating markers of angiogenesis and endotheliopathy in COVID-19.Pine AB, Meizlish ML, Goshua G, Chang CH, Zhang H, Bishai J, Bahel P, Patel A, Gbyli R, Kwan JM, Won CH, Price C, Dela Cruz CS, Halene S, van Dijk D, Hwa J, Lee AI, Chun HJ. Pulm Circ. 2020 Oct-Dec; 2020 Nov 25. PMID: 33282193.
Single-Cell Transcriptional Archetypes of Airway Inflammation in Cystic Fibrosis.Schupp JC, Khanal S, Gomez JL, Sauler M, Adams TS, Chupp GL, Yan X, Poli S, Zhao Y, Montgomery RR, Rosas IO, Dela Cruz CS, Bruscia EM, Egan ME, Kaminski N, Britto CJ. Am J Respir Crit Care Med. 2020 Nov 15. PMID: 32603604.
International Perspective on the New 2019 American Thoracic Society/Infectious Diseases Society of America Community-Acquired Pneumonia Guideline: A Critical Appraisal by a Global Expert Panel.Pletz MW, Blasi F, Chalmers JD, Dela Cruz CS, Feldman C, Luna CM, Ramirez JA, Shindo Y, Stolz D, Torres A, Webb B, Welte T, Wunderink R, Aliberti S. Chest. 2020 Nov; 2020 Aug 25. PMID: 32858009.
Severe respiratory viral infection induces procalcitonin in the absence of bacterial pneumonia.Gautam S, Cohen AJ, Stahl Y, Valda Toro P, Young GM, Datta R, Yan X, Ristic NT, Bermejo SD, Sharma L, Restrepo MI, Dela Cruz CS. Thorax. 2020 Nov; 2020 Aug 21. PMID: 32826284.
Does inflammation help during COVID-19?Sharma L, Chang D, Dela Cruz CS. ERJ Open Res. 2020 Oct; 2020 Oct 13. PMID: 33083436.
Detection of SARS-CoV-2 RNA by multiplex RT-qPCR.Kudo E, Israelow B, Vogels CBF, Lu P, Wyllie AL, Tokuyama M, Venkataraman A, Brackney DE, Ott IM, Petrone ME, Earnest R, Lapidus S, Muenker MC, Moore AJ, Casanovas-Massana A, Omer SB, Dela Cruz CS, Farhadian SF, Ko AI, Grubaugh ND, Iwasaki A. PLoS Biol. 2020 Oct; 2020 Oct 7. PMID: 33027248.
Quantification of bronchoalveolar neutrophil extracellular traps and phagocytosis in murine pneumonia.Gautam S, Stahl Y, Young GM, Howell R, Cohen AJ, Tsang DA, Martin T, Sharma L, Dela Cruz CS. Am J Physiol Lung Cell Mol Physiol. 2020 Oct 1; 2020 Aug 12. PMID: 32783617.
Differential effects of the Akt pathway on the internalization of Klebsiella by lung epithelium and macrophages.Chang D, Feng J, Liu H, Liu W, Sharma L, Dela Cruz CS. Innate Immun. 2020 Oct; 2020 Aug 6. PMID: 32762278.
Analytical sensitivity and efficiency comparisons of SARS-CoV-2 RT-qPCR primer-probe sets.Vogels CBF, Brito AF, Wyllie AL, Fauver JR, Ott IM, Kalinich CC, Petrone ME, Casanovas-Massana A, Catherine Muenker M, Moore AJ, Klein J, Lu P, Lu-Culligan A, Jiang X, Kim DJ, Kudo E, Mao T, Moriyama M, Oh JE, Park A, Silva J, Song E, Takahashi T, Taura M, Tokuyama M, Venkataraman A, Weizman OE, Wong P, Yang Y, Cheemarla NR, White EB, Lapidus S, Earnest R, Geng B, Vijayakumar P, Odio C, Fournier J, Bermejo S, Farhadian S, Dela Cruz CS, Iwasaki A, Ko AI, Landry ML, Foxman EF, Grubaugh ND. Nat Microbiol. 2020 Oct; 2020 Jul 10. PMID: 32651556.
Saliva or Nasopharyngeal Swab Specimens for Detection of SARS-CoV-2.Wyllie AL, Fournier J, Casanovas-Massana A, Campbell M, Tokuyama M, Vijayakumar P, Warren JL, Geng B, Muenker MC, Moore AJ, Vogels CBF, Petrone ME, Ott IM, Lu P, Venkataraman A, Lu-Culligan A, Klein J, Earnest R, Simonov M, Datta R, Handoko R, Naushad N, Sewanan LR, Valdez J, White EB, Lapidus S, Kalinich CC, Jiang X, Kim DJ, Kudo E, Linehan M, Mao T, Moriyama M, Oh JE, Park A, Silva J, Song E, Takahashi T, Taura M, Weizman OE, Wong P, Yang Y, Bermejo S, Odio CD, Omer SB, Dela Cruz CS, Farhadian S, Martinello RA, Iwasaki A, Grubaugh ND, Ko AI. N Engl J Med. 2020 Sep 24; 2020 Aug 28. PMID: 32857487.
Pooling saliva to increase SARS-CoV-2 testing capacity.Watkins AE, Fenichel EP, Weinberger DM, Vogels CBF, Brackney DE, Casanovas-Massana A, Campbell M, Fournier J, Bermejo S, Datta R, Dela Cruz CS, Farhadian SF, Iwasaki A, Ko AI, Grubaugh ND, Wyllie AL. medRxiv. 2020 Sep 3; 2020 Sep 3. PMID: 32909003.
Host tolerance contributes to persistent viral shedding in COVID-19.Chang D, Chen Z, Wang FS, Xie LX, Dela Cruz CS, Sharma L, Qin EQ. EClinicalMedicine. 2020 Sep; 2020 Sep 15. PMID: 32954242.
Persistent Viral Presence Determines the Clinical Course of the Disease in COVID-19.Chang D, Zhao P, Zhang D, Dong JH, Xu Z, Yang G, Li BY, Liu HX, Li BA, Qin CF, Peng XH, Wang FS, Xie LX, Chen Z, Dela Cruz CS, Sharma L, Qin EQ. J Allergy Clin Immunol Pract. 2020 Sep; 2020 Jun 20. PMID: 32574840.
JAK-Inhibitor and Type I Interferon Ability to Produce Favorable Clinical Outcomes in COVID-19 Patients: A Systematic Review and Meta-Analysis.Walz L, Cohen AJ, Rebaza AP, Vanchieri J, Slade MD, Dela Cruz CS, Sharma L. Res Sq. 2020 Aug 26; 2020 Aug 26. PMID: 32869016.
Rapid decline of seasonal influenza during the outbreak of COVID-19.Young G, Peng X, Rebeza A, Bermejo S, De C, Sharma L, Dela Cruz CS. ERJ Open Res. 2020 Jul; 2020 Aug 17. PMID: 32832527.
SARS-CoV-2 Transmission and the Risk of Aerosol-Generating Procedures.Pasnick S, Carlos WG, Dela Cruz CS, Gross JE, Garrison G, Jamil S. Am J Respir Crit Care Med. 2020 Aug 15. PMID: 32795140.
Janus Kinase-Inhibitor and Type I Interferon Ability to Produce Favorable Clinical Outcomes in COVID-19 Patients: A Systematic Review and Meta-Analysis.Walz L, Cohen AJ, Rebaza AP, Vanchieri J, Slade MD, Dela Cruz CS, Sharma L. medRxiv. 2020 Aug 11; 2020 Aug 11. PMID: 32817985.
Simply saliva: stability of SARS-CoV-2 detection negates the need for expensive collection devices.Ott IM, Strine MS, Watkins AE, Boot M, Kalinich CC, Harden CA, Vogels CBF, Casanovas-Massana A, Moore AJ, Muenker MC, Nakahata M, Tokuyama M, Nelson A, Fournier J, Bermejo S, Campbell M, Datta R, Dela Cruz CS, Farhadian SF, Ko AI, Iwasaki A, Grubaugh ND, Wilen CB, Wyllie AL. medRxiv. 2020 Aug 4; 2020 Aug 4. PMID: 32793924.
Endotheliopathy in COVID-19-associated coagulopathy: evidence from a single-centre, cross-sectional study.Goshua G, Pine AB, Meizlish ML, Chang CH, Zhang H, Bahel P, Baluha A, Bar N, Bona RD, Burns AJ, Dela Cruz CS, Dumont A, Halene S, Hwa J, Koff J, Menninger H, Neparidze N, Price C, Siner JM, Tormey C, Rinder HM, Chun HJ, Lee AI. Lancet Haematol. 2020 Aug; 2020 Jun 30. PMID: 32619411.
Profiling Early Humoral Response to Diagnose Novel Coronavirus Disease (COVID-19).Guo L, Ren L, Yang S, Xiao M, Chang D, Yang F, Dela Cruz CS, Wang Y, Wu C, Xiao Y, Zhang L, Han L, Dang S, Xu Y, Yang QW, Xu SY, Zhu HD, Xu YC, Jin Q, Sharma L, Wang L, Wang J. Clin Infect Dis. 2020 Jul 28. PMID: 32198501.
COVID-19: How Do We Stay Safe?Carlos WG, Dela Cruz CS, Cao B, Gross JE, Pasnick S, Jamil S. Am J Respir Crit Care Med. 2020 Jul 10; 2020 Jul 10. PMID: 32650649.
Reply to Suri et al.: COVID-19 Real-Time RT-PCR: Does Positivity on Follow-up RT-PCR Always Imply Infectivity?Chang D, Mo G, Yuan X, Tao Y, Peng X, Wang F, Xie L, Sharma L, Dela Cruz CS, Qin E. Am J Respir Crit Care Med. 2020 Jul 1. PMID: 32401535.
SARS-CoV-2 Transmission and the Risk of Aerosol Generating Procedures.Pasnick S, Carlos WG, Dela Cruz CS, Gross JE, Garrison G, Jamil S. Am J Respir Crit Care Med. 2020 Jun 30; 2020 Jun 30. PMID: 32603230.
Chitotriosidase: a marker and modulator of lung disease.Chang D, Sharma L, Dela Cruz CS. Eur Respir Rev. 2020 Jun 30; 2020 Apr 29. PMID: 32350087.
COVID-19 vulnerability: the potential impact of genetic susceptibility and airborne transmission.Godri Pollitt KJ, Peccia J, Ko AI, Kaminski N, Dela Cruz CS, Nebert DW, Reichardt JKV, Thompson DC, Vasiliou V. Hum Genomics. 2020 May 12; 2020 May 12. PMID: 32398162.
Antibiotic Stewardship in the Intensive Care Unit. An Official American Thoracic Society Workshop Report in Collaboration with the AACN, CHEST, CDC, and SCCM.Wunderink RG, Srinivasan A, Barie PS, Chastre J, Dela Cruz CS, Douglas IS, Ecklund M, Evans SE, Evans SR, Gerlach AT, Hicks LA, Howell M, Hutchinson ML, Hyzy RC, Kane-Gill SL, Lease ED, Metersky ML, Munro N, Niederman MS, Restrepo MI, Sessler CN, Simpson SQ, Swoboda SM, Guillamet CV, Waterer GW, Weiss CH. Ann Am Thorac Soc. 2020 May. PMID: 32356696.
Time Kinetics of Viral Clearance and Resolution of Symptoms in Novel Coronavirus Infection.Chang D, Mo G, Yuan X, Tao Y, Peng X, Wang FS, Xie L, Sharma L, Dela Cruz CS, Qin E. Am J Respir Crit Care Med. 2020 May 1. PMID: 32200654.
Harnessing Murine Microbiome Models to Study Human Lung Microbiome.Chang D, Sharma L, Dela Cruz CS. Chest. 2020 Apr. PMID: 32252931.
Epidemiologic and Clinical Characteristics of Novel Coronavirus Infections Involving 13 Patients Outside Wuhan, China.Chang D, Lin M, Wei L, Xie L, Zhu G, Dela Cruz CS, Sharma L. JAMA. 2020 Mar 17. PMID: 32031568.
Protecting health-care workers from subclinical coronavirus infection.Chang D, Xu H, Rebaza A, Sharma L, Dela Cruz CS. Lancet Respir Med. 2020 Mar; 2020 Feb 13. PMID: 32061333.
Lung Cancer 2020: Epidemiology, Etiology, and Prevention.Bade BC, Dela Cruz CS. Clin Chest Med. 2020 Mar. PMID: 32008623.
Challenges in understanding lung microbiome: It is NOT like the gut microbiome.Chang D, Dela Cruz CS, Sharma L. Respirology. 2020 Mar; 2019 Dec 23. PMID: 31868282.
Novel Wuhan (2019-nCoV) Coronavirus.Carlos WG, Dela Cruz CS, Cao B, Pasnick S, Jamil S. Am J Respir Crit Care Med. 2020 Feb 15. PMID: 32004066.
Mechanisms of Epithelial Immunity Evasion by Respiratory Bacterial Pathogens.Sharma L, Feng J, Britto CJ, Dela Cruz CS. Front Immunol. 2020; 2020 Feb 11. PMID: 32117248.
Summary for Clinicians: Clinical Practice Guideline for the Diagnosis and Treatment of Community-acquired Pneumonia.Jones BE, Herman DD, Dela Cruz CS, Waterer GW, Metlay JP, Ruminjo JK, Thomson CC. Ann Am Thorac Soc. 2020 Feb. PMID: 31770496.

2019

ATS Health Alert-Vaping-associated Pulmonary Illness (VAPI).Carlos WG, Crotty Alexander LE, Gross JE, Dela Cruz CS, Keller JM, Pasnick S, Jamil S. Am J Respir Crit Care Med. 2019 Oct 1. PMID: 31532698.
Vaping-associated Pulmonary Illness (VAPI).Carlos WG, Crotty Alexander LE, Gross JE, Dela Cruz CS, Keller JM, Pasnick S, Jamil S. Am J Respir Crit Care Med. 2019 Oct 1. PMID: 31532695.
Mechanosensation of cyclical force by PIEZO1 is essential for innate immunity.Solis AG, Bielecki P, Steach HR, Sharma L, Harman CCD, Yun S, de Zoete MR, Warnock JN, To SDF, York AG, Mack M, Schwartz MA, Dela Cruz CS, Palm NW, Jackson R, Flavell RA. Nature. 2019 Sep; 2019 Aug 21. PMID: 31435009.
A potential role of microvesicle-containing miR-223/142 in lung inflammation.Zhang D, Lee H, Wang X, Groot M, Sharma L, Dela Cruz CS, Jin Y. Thorax. 2019 Sep; 2019 Jul 22. PMID: 31331947.
Toll-Like Receptors 2 and 4 Modulate Pulmonary Inflammation and Host Factors Mediated by Outer Membrane Vesicles Derived from Acinetobacter baumannii.Marion CR, Lee J, Sharma L, Park KS, Lee C, Liu W, Liu P, Feng J, Gho YS, Dela Cruz CS. Infect Immun. 2019 Sep; 2019 Aug 21. PMID: 31262980.
Plasma mitochondrial DNA is associated with extrapulmonary sarcoidosis.Ryu C, Brandsdorfer C, Adams T, Hu B, Kelleher DW, Yaggi M, Manning EP, Walia A, Reeves B, Pan H, Winkler J, Minasyan M, Dela Cruz CS, Kaminski N, Gulati M, Herzog EL. Eur Respir J. 2019 Aug; 2019 Aug 29. PMID: 31273041.
Measurement of Chitinase Activity in Biological Samples.Amick AK, Liu Q, Gautam S, Chupp G, Dela Cruz CS, Sharma L. J Vis Exp. 2019 Aug 22; 2019 Aug 22. PMID: 31498326.
When "B" becomes "A": the emerging threat of influenza B virus.Sharma L, Rebaza A, Dela Cruz CS. Eur Respir J. 2019 Aug; 2019 Aug 15. PMID: 31416813.