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Keeping Yale's COVID-19 Treatment Guidelines Up to Date

For the past year, experts across various disciplines have studied and carefully considered each new piece of evidence about treatment strategies for COVID-19 and translated it into standardized guidelines for Yale School of Medicine and Yale New Haven Health System clinicians

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  • Resist the Script: Antibiotic Overuse in Pneumonia — An Expert Roundtable

    Become educated about the role of climate change. Increases in coccidioidomycosis, avian influenza, Hantavirus, and aspergillosis have all been noted to increase in areas with changes in ambient temperature or rainfall.7 The old and young may be more susceptible to rapid changes in conditions. Climate change has already been found to increase rates of COPD and asthma, which increase the risk for infection.

    Source: PulmonologyAdvisor
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  • Gene Deficiency Linked to Increased Pneumonia Survival

    Klebsiella pneumoniae is a germ that causes pneumonia, with a mortality that can reach up to 70 percent when infection spreads to other organs. Current, antibiotic treatment often fails due to development of antibiotic resistance, so there is an urgent need for new therapies. We have found a deficiency in a gene called Chit1, present in up to 20 percent of humans, gives mice a significant advantage during pneumonia. Absence of this gene helps mice limit bacterial spread to other organs and increase survival with or without antibiotic use. Understanding the mechanisms of the advantage provided by Chit1 deficiency will help to develop new therapies that can boost the host defense against bacterial infection to reduce mortality.

    Source: American Lung Association
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  • Q&A: New CPIRT director on lung infections, antibiotics, and climate change

    This summer, the new Yale Center for Pulmonary Infection Research and Treatment (CPIRT) held its first meeting, with the goal of breathing fresh air into the science of lung infection. Conceived by associate professor Dr. Charles Dela Cruz as a cross-disciplinary hub for investigators, CPIRT brings together innovative minds from basic, translational, and clinical research areas across Yale. The center’s ultimate aim is to develop better treatments for both acute and chronic ailments — from pandemic flu to emphysema — that are affected by lung infections.

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