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Resist the Script: Antibiotic Overuse in Pneumonia — An Expert Roundtable

Become educated about the role of climate change. Increases in coccidioidomycosis, avian influenza, Hantavirus, and aspergillosis have all been noted to increase in areas with changes in ambient temperature or rainfall.7 The old and young may be more susceptible to rapid changes in conditions. Climate change has already been found to increase rates of COPD and asthma, which increase the risk for infection.

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  • Gene Deficiency Linked to Increased Pneumonia Survival

    Klebsiella pneumoniae is a germ that causes pneumonia, with a mortality that can reach up to 70 percent when infection spreads to other organs. Current, antibiotic treatment often fails due to development of antibiotic resistance, so there is an urgent need for new therapies. We have found a deficiency in a gene called Chit1, present in up to 20 percent of humans, gives mice a significant advantage during pneumonia. Absence of this gene helps mice limit bacterial spread to other organs and increase survival with or without antibiotic use. Understanding the mechanisms of the advantage provided by Chit1 deficiency will help to develop new therapies that can boost the host defense against bacterial infection to reduce mortality.

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  • Q&A: New CPIRT director on lung infections, antibiotics, and climate change

    This summer, the new Yale Center for Pulmonary Infection Research and Treatment (CPIRT) held its first meeting, with the goal of breathing fresh air into the science of lung infection. Conceived by associate professor Dr. Charles Dela Cruz as a cross-disciplinary hub for investigators, CPIRT brings together innovative minds from basic, translational, and clinical research areas across Yale. The center’s ultimate aim is to develop better treatments for both acute and chronic ailments — from pandemic flu to emphysema — that are affected by lung infections.

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  • No Drop in VAP Rates, Study Contends

    Contrary to previously reported numbers from the Centers for Disease Control and Prevention (CDC), ventilator-assisted pneumonia (VAP) rates have not declined, but have remained near 10% since 2005, according to data from the Medicare Patient Safety Monitoring System (MPSMS).

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  • Infections Linked to Hospital Respirators Still Pose Risks to Patients

    A new report out of the University of Connecticut is raising concern about hospital-acquired infections from respirators. The paper looked at VAP or ventilator-associated pneumonia. That's an infection acquired in a hospital after a patient is put on a respirator, which can increase the length of stay, costs, and mortality.

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  • What Pneumonia Experts Say About Clinton’s Case

    If Hillary Clinton brushed aside medical advice to rest after getting a diagnosis of mild pneumonia, she was risking developing a more serious case, medical experts said Monday. Pneumonia — which leads to infiltration of fluid into the lungs, leaving a patient short of breath and often feverish but still able to function — can become serious or even fatal if it is not properly treated, doctors said.

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