2021
Cooperative function of synaptophysin and synapsin in the generation of synaptic vesicle-like clusters in non-neuronal cells
Park D, Wu Y, Lee SE, Kim G, Jeong S, Milovanovic D, De Camilli P, Chang S. Cooperative function of synaptophysin and synapsin in the generation of synaptic vesicle-like clusters in non-neuronal cells. Nature Communications 2021, 12: 263. PMID: 33431828, PMCID: PMC7801664, DOI: 10.1038/s41467-020-20462-z.Peer-Reviewed Original ResearchConceptsNon-neuronal cellsSV clustersSynaptic vesiclesSmall synaptic-like microvesiclesSV membrane proteinsSynaptic-like microvesiclesSV proteinsDiffuse cytosolic distributionMembrane proteinsReconstitution systemCytosolic distributionCooperative functionSuch vesiclesMechanistic insightsLiquid-like propertiesPowerful modelPhysiological formationProteinSynapsinVesiclesCellsSynaptic transmissionAssembly of structuresDefining featureLiquid condensate
1994
A role for synaptic vesicles in non‐neuronal cells: clues from pancreatic β cells and from chromaffin cells
Thomas‐Reetz A, De Camilli P. A role for synaptic vesicles in non‐neuronal cells: clues from pancreatic β cells and from chromaffin cells. The FASEB Journal 1994, 8: 209-216. PMID: 7907072, DOI: 10.1096/fasebj.8.2.7907072.Peer-Reviewed Original ResearchConceptsSynaptic-like microvesiclesSynaptic vesiclesAbundant synaptic vesicle proteinsVesicular carriersPancreatic beta cellsSynaptic vesicle proteinsVesicular trafficNon-neuronal cellsRecycling compartmentMembrane proteinsRecycling pathwayVesicle proteinsPancreatic β-cellsPeptide-secreting endocrine cellsMolecular mechanismsSpecialized subcompartmentBeta cellsPC12 cellsMembrane compositionVesiclesCell linesΒ-cellsOrganellesNeurotransmitter releaseNeurotransmitter-like substances
1993
Traffic of synaptic vesicle proteins in polarized and nonpolarized cells
Cameron P, Mundigl O, De Camilli P. Traffic of synaptic vesicle proteins in polarized and nonpolarized cells. Journal Of Cell Science. Supplement 1993, 1993: 93-100. PMID: 8144709, DOI: 10.1242/jcs.1993.supplement_17.14.Peer-Reviewed Original ResearchConceptsSV proteinsSynaptic vesiclesSecretory organellesSpecialized secretory organellesSynaptic-like microvesiclesExo-endocytotic recyclingSynaptic vesicle proteinsNon-peptide hormonesEndosomal intermediatesEndocrine cellsNeuronal polarityNonpolarized cellsRecycling pathwayRegulated secretionVesicle proteinsTypical synaptic vesiclesFunctional similarityLarge dense-core vesiclesDense-core vesiclesNeuronal counterpartsVesicular carriersProtein synaptophysinVesicle storesMature neuronsProtein
1990
Glutamic acid decarboxylase (GAD) is colocalized with markers of synaptic-like microvesicles in pancreatic β-cells
Reetz A, Solimena M, Folli F, Takei K, De Camilli P. Glutamic acid decarboxylase (GAD) is colocalized with markers of synaptic-like microvesicles in pancreatic β-cells. Cell Biology International 1990, 14: 52. DOI: 10.1016/0309-1651(90)90314-o.Peer-Reviewed Original Research