2023
Synaptic vesicle proteins and ATG9A self-organize in distinct vesicle phases within synapsin condensates
Park D, Wu Y, Wang X, Gowrishankar S, Baublis A, De Camilli P. Synaptic vesicle proteins and ATG9A self-organize in distinct vesicle phases within synapsin condensates. Nature Communications 2023, 14: 455. PMID: 36709207, PMCID: PMC9884207, DOI: 10.1038/s41467-023-36081-3.Peer-Reviewed Original ResearchConceptsMembrane proteinsSV membrane proteinsVesicle membrane proteinEctopic expression systemSynaptic vesicle proteinsSynaptic vesicle clustersSV proteinsVesicle proteinsEctopic expressionExpression systemVesicle clustersSynapsinProteinLiquid-like propertiesVesiclesDistinct classesDual roleSynapsin 1FibroblastsATG9ASynapsesExpressionDistinct phasesNerve terminalsClusters
2021
Cooperative function of synaptophysin and synapsin in the generation of synaptic vesicle-like clusters in non-neuronal cells
Park D, Wu Y, Lee SE, Kim G, Jeong S, Milovanovic D, De Camilli P, Chang S. Cooperative function of synaptophysin and synapsin in the generation of synaptic vesicle-like clusters in non-neuronal cells. Nature Communications 2021, 12: 263. PMID: 33431828, PMCID: PMC7801664, DOI: 10.1038/s41467-020-20462-z.Peer-Reviewed Original ResearchConceptsNon-neuronal cellsSV clustersSynaptic vesiclesSmall synaptic-like microvesiclesSV membrane proteinsSynaptic-like microvesiclesSV proteinsDiffuse cytosolic distributionMembrane proteinsReconstitution systemCytosolic distributionCooperative functionSuch vesiclesMechanistic insightsLiquid-like propertiesPowerful modelPhysiological formationProteinSynapsinVesiclesCellsSynaptic transmissionAssembly of structuresDefining featureLiquid condensate
1993
Traffic of synaptic vesicle proteins in polarized and nonpolarized cells
Cameron P, Mundigl O, De Camilli P. Traffic of synaptic vesicle proteins in polarized and nonpolarized cells. Journal Of Cell Science. Supplement 1993, 1993: 93-100. PMID: 8144709, DOI: 10.1242/jcs.1993.supplement_17.14.Peer-Reviewed Original ResearchConceptsSV proteinsSynaptic vesiclesSecretory organellesSpecialized secretory organellesSynaptic-like microvesiclesExo-endocytotic recyclingSynaptic vesicle proteinsNon-peptide hormonesEndosomal intermediatesEndocrine cellsNeuronal polarityNonpolarized cellsRecycling pathwayRegulated secretionVesicle proteinsTypical synaptic vesiclesFunctional similarityLarge dense-core vesiclesDense-core vesiclesNeuronal counterpartsVesicular carriersProtein synaptophysinVesicle storesMature neuronsProtein