Lin Shao, PhD
Director, MicroscopyCards
About
Research
Publications
2025
Evolutionarily divergent Mycobacterium tuberculosis CTP synthase filaments are under selective pressure
Lynch E, Lu Y, Park J, Shao L, Kollman J, Rego E. Evolutionarily divergent Mycobacterium tuberculosis CTP synthase filaments are under selective pressure. Nature Communications 2025, 16: 5993. PMID: 40593557, PMCID: PMC12219555, DOI: 10.1038/s41467-025-60847-6.Peer-Reviewed Original ResearchThe bridge-like lipid transport protein VPS13C/PARK23 mediates ER–lysosome contacts following lysosome damage
Wang X, Xu P, Bentley-DeSousa A, Hancock-Cerutti W, Cai S, Johnson B, Tonelli F, Shao L, Talaia G, Alessi D, Ferguson S, De Camilli P. The bridge-like lipid transport protein VPS13C/PARK23 mediates ER–lysosome contacts following lysosome damage. Nature Cell Biology 2025, 27: 776-789. PMID: 40211074, PMCID: PMC12081312, DOI: 10.1038/s41556-025-01653-6.Peer-Reviewed Original ResearchA quantitative ultrastructural timeline of nuclear autophagy reveals a role for dynamin-like protein 1 at the nuclear envelope
Mannino P, Perun A, Surovtsev I, Ader N, Shao L, Rodriguez E, Melia T, King M, Lusk C. A quantitative ultrastructural timeline of nuclear autophagy reveals a role for dynamin-like protein 1 at the nuclear envelope. Nature Cell Biology 2025, 27: 464-476. PMID: 39920277, PMCID: PMC11908896, DOI: 10.1038/s41556-025-01612-1.Peer-Reviewed Original Research
2024
Elucidating subcellular architecture and dynamics at isotropic 100-nm resolution with 4Pi-SIM
Ouyang Z, Wang Q, Li X, Dai Q, Tang M, Shao L, Gou W, Yu Z, Chen Y, Zheng B, Chen L, Ping C, Bi X, Xiao B, Yu X, Liu C, Chen L, Fan J, Huang X, Zhang Y. Elucidating subcellular architecture and dynamics at isotropic 100-nm resolution with 4Pi-SIM. Nature Methods 2024, 22: 335-347. PMID: 39715887, PMCID: PMC11810797, DOI: 10.1038/s41592-024-02515-z.Peer-Reviewed Original ResearchCorrection: Cell cycle controls long-range calcium signaling in the regenerating epidermis
Moore J, Bhaskar D, Gao F, Matte-Martone C, Du S, Lathrop E, Ganesan S, Shao L, Norris R, Sanz N, Annusver K, Kasper M, Cox A, Hendry C, Rieck B, Krishnaswamy S, Greco V. Correction: Cell cycle controls long-range calcium signaling in the regenerating epidermis. Journal Of Cell Biology 2024, 223: e20230209503052024c. PMID: 38477880, PMCID: PMC10938063, DOI: 10.1083/jcb.20230209503052024c.Commentaries, Editorials and Letters
2023
Membrane remodeling properties of the Parkinson’s disease protein LRRK2
Wang X, Espadas J, Wu Y, Cai S, Ge J, Shao L, Roux A, De Camilli P. Membrane remodeling properties of the Parkinson’s disease protein LRRK2. Proceedings Of The National Academy Of Sciences Of The United States Of America 2023, 120: e2309698120. PMID: 37844218, PMCID: PMC10614619, DOI: 10.1073/pnas.2309698120.Peer-Reviewed Original ResearchCell cycle controls long-range calcium signaling in the regenerating epidermis
Moore J, Bhaskar D, Gao F, Matte-Martone C, Du S, Lathrop E, Ganesan S, Shao L, Norris R, Sanz N, Annusver K, Kasper M, Cox A, Hendry C, Rieck B, Krishnaswamy S, Greco V. Cell cycle controls long-range calcium signaling in the regenerating epidermis. Journal Of Cell Biology 2023, 222: e202302095. PMID: 37102999, PMCID: PMC10140546, DOI: 10.1083/jcb.202302095.Peer-Reviewed Original ResearchThree-dimensional structured illumination microscopy with enhanced axial resolution
Li X, Wu Y, Su Y, Rey-Suarez I, Matthaeus C, Updegrove T, Wei Z, Zhang L, Sasaki H, Li Y, Guo M, Giannini J, Vishwasrao H, Chen J, Lee S, Shao L, Liu H, Ramamurthi K, Taraska J, Upadhyaya A, La Riviere P, Shroff H. Three-dimensional structured illumination microscopy with enhanced axial resolution. Nature Biotechnology 2023, 41: 1307-1319. PMID: 36702897, PMCID: PMC10497409, DOI: 10.1038/s41587-022-01651-1.Peer-Reviewed Original Research
2022
Presynaptic autophagy is coupled to the synaptic vesicle cycle via ATG-9
Yang S, Park D, Manning L, Hill SE, Cao M, Xuan Z, Gonzalez I, Dong Y, Clark B, Shao L, Okeke I, Almoril-Porras A, Bai J, De Camilli P, Colón-Ramos DA. Presynaptic autophagy is coupled to the synaptic vesicle cycle via ATG-9. Neuron 2022, 110: 824-840.e10. PMID: 35065714, PMCID: PMC9017068, DOI: 10.1016/j.neuron.2021.12.031.Peer-Reviewed Original Research
2021
Differential adhesion regulates neurite placement via a retrograde zippering mechanism
Sengupta T, Koonce NL, Vázquez-Martínez N, Moyle MW, Duncan LH, Emerson SE, Han X, Shao L, Wu Y, Santella A, Fan L, Bao Z, Mohler W, Shroff H, Colón-Ramos DA. Differential adhesion regulates neurite placement via a retrograde zippering mechanism. ELife 2021, 10: e71171. PMID: 34783657, PMCID: PMC8843091, DOI: 10.7554/elife.71171.Peer-Reviewed Original Research
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