Welcome to Belfort De Aguiar Lab!
Our mission: To investigate whether lactation improves insulin sensitivity and increases lipolysis in women.
To achieve our mission, we conduct rigorous high-quality clinic and lab to study the mechanisms of insulin resistance and insulin secretion.
Aim 1: Does lactation improve insulin sensitivity and increase lipolysis in women? In this Aim, we will assess whether lactation amongst women with a history of GDM will improve whole body insulin sensitivity as well as increase whole body lipid turnover by using hyperinsulinemic-euglycemic clamps combined with [6,6-2H]-glucose and [2H5]-glycerol infusions. These stable, non-radiating isotopes have been used extensively and safely to study the mechanisms of insulin resistance amongst non-pregnant as well as pregnant humans; however, these techniques have not previously been applied to the study of insulin sensitivity during lactation.
Our goals will be two-fold:
- to determine whether lactation induces similar changes in insulin sensitivity in humans as in mice and
- to pilot the feasibility of performing larger, more detailed metabolic studies in this population of women post-partum.
Aim 2: Retrospective chart review of women with a history of GDM who had an OGTT 6-8 weeks post-partum as part of standard of care at Yale Medicine’s Maternal-Fetal Medicine Clinic.