Selected Publications
- Cardiomyocyte STIM1 downregulation exacerbates post-Myocardial Infarction remodeling by dysregulating mitochondrial ultrastructure and metabolic signaling.Cacheux M, Velasco J, Wu X, Strauss B, Akar FG. bioRxiv. 2024 Dec 9; 2024 Dec 9. PMID: 39713399.
- Role of AMPK in Atrial Metabolic Homeostasis and Substrate Preference.Toksoy Z, Ma Y, Goedeke L, Li W, Hu X, Wu X, Cacheux M, Liu Y, Akar FG, Shulman GI, Young LH. bioRxiv. 2024 Aug 30; 2024 Aug 30. PMID: 39257756.
- Mitochondrial network remodeling of the diabetic heart: implications to ischemia related cardiac dysfunction.Rudokas MW, McKay M, Toksoy Z, Eisen JN, Bögner M, Young LH, Akar FG. Cardiovasc Diabetol. 2024 Jul 18; 2024 Jul 18. PMID: 39026280.
- A new year's resolution to resolve atrial fibrillation: Resolvin D1 emerges as a powerful target against post-MI atrial remodelling.Velasco JJ, Akar FG. Cardiovasc Res. 2024 Mar 30. PMID: 38387430.
- Top Stories: Mitochondrial origin of inherited cardiac arrhythmias.Akar FG, Maack C. Heart Rhythm. 2024 Feb. PMID: 38296456.
- Quantitative Assessment of Mitochondrial Morphology and Electrophysiological Function in the Diabetic Heart.Cacheux M, Rudokas M, Tieu A, Rizk JA, Hummel ME, Akar FG. Methods Mol Biol. 2024. PMID: 38676886.
- Chronic diastolic stretch unmasks conduction defects in an in vitro model of arrhythmogenic cardiomyopathy.Ng R, Gokhan I, Stankey P, Akar FG, Campbell SG. Am J Physiol Heart Circ Physiol. 2023 Oct 13; 2023 Oct 13. PMID: 37830983.
- A unifying mechanism for the initiation of torsade de pointes: blurring the distinction between trigger and substrate.McKay M, Akar FG. Cardiovasc Res. 2023 Mar 31. PMID: 36869679.
- Gene editing reverses arrhythmia susceptibility in humanized PLN-R14del mice: modelling a European cardiomyopathy with global impact.Dave J, Raad N, Mittal N, Zhang L, Fargnoli A, Oh JG, Savoia ME, Hansen J, Fava M, Yin X, Theofilatos K, Ceholski D, Kohlbrenner E, Jeong D, Wills L, Nonnenmacher M, Haghighi K, Costa KD, Turnbull IC, Mayr M, Cai CL, Kranias EG, Akar FG, Hajjar RJ, Stillitano F. Cardiovasc Res. 2022 Dec 9. PMID: 35191471.
- Humanized Dsp ACM Mouse Model Displays Stress-Induced Cardiac Electrical and Structural Phenotypes.Stevens TL, Manring HR, Wallace MJ, Argall A, Dew T, Papaioannou P, Antwi-Boasiako S, Xu X, Campbell SG, Akar FG, Borzok MA, Hund TJ, Mohler PJ, Koenig SN, El Refaey M. Cells. 2022 Sep 29; 2022 Sep 29. PMID: 36231013.
- Metabolic Regulation of Mitochondrial Dynamics and Cardiac Function.Rudokas MW, Cacheux M, Akar FG. 2022. PMID: 37988544.
- The inspection paradox: An important consideration in the evaluation of rotor lifetimes in cardiac fibrillation.Jenkins EV, Dharmaprani D, Schopp M, Quah JX, Tiver K, Mitchell L, Xiong F, Aguilar M, Pope K, Akar FG, Roney CH, Niederer SA, Nattel S, Nash MP, Clayton RH, Ganesan AN. Front Physiol. 2022; 2022 Sep 6. PMID: 36148313.
- Editorial: The role of genetics and non-coding RNAs in atrial fibrillation.Novelli V, Akar FG. Front Cardiovasc Med. 2022; 2022 Aug 3. PMID: 35990985.
- Modern Day Wearables to Evade the Widow-Ghost in Brugada Syndrome: From Mythology to Deep-Learning Methodology.Karam CS, Akar FG. JACC Clin Electrophysiol. 2022 Aug. PMID: 35981789.
- A novel exosome-based therapy for post-MI arrhythmias.Cacheux M, Akar FG. Eur Heart J. 2022 Jun 6. PMID: 35325140.
- Atrial AMP-activated protein kinase is critical for prevention of dysregulation of electrical excitability and atrial fibrillation.Su KN, Ma Y, Cacheux M, Ilkan Z, Raad N, Muller GK, Wu X, Guerrera N, Thorn SL, Sinusas AJ, Foretz M, Viollet B, Akar JG, Akar FG, Young LH. JCI Insight. 2022 Apr 22; 2022 Apr 22. PMID: 35451373.
- Right predominant electrical remodeling in a pure model of pulmonary hypertension promotes reentrant arrhythmias.Strauss B, Bisserier M, Obus E, Katz MG, Fargnoli A, Cacheux M, Akar JG, Hummel JP, Hadri L, Sassi Y, Akar FG. Heart Rhythm. 2022 Jan; 2021 Sep 23. PMID: 34563688.
- Arrhythmia Mechanism and Dynamics in a Humanized Mouse Model of Inherited Cardiomyopathy Caused by Phospholamban R14del Mutation.Raad N, Bittihn P, Cacheux M, Jeong D, Ilkan Z, Ceholski D, Kohlbrenner E, Zhang L, Cai CL, Kranias EG, Hajjar RJ, Stillitano F, Akar FG. Circulation. 2021 Aug 10; 2021 May 24. PMID: 34024116.
- Impaired Right Ventricular Calcium Cycling Is an Early Risk Factor in R14del-Phospholamban Arrhythmias.Haghighi K, Gardner G, Vafiadaki E, Kumar M, Green LC, Ma J, Crocker JS, Koch S, Arvanitis DA, Bidwell P, Rubinstein J, van de Leur R, Doevendans PA, Akar FG, Tranter M, Wang HS, Sadayappan S, DeMazumder D, Sanoudou D, Hajjar RJ, Stillitano F, Kranias EG. J Pers Med. 2021 Jun 3; 2021 Jun 3. PMID: 34204946.
- NAD Repletion Therapy: A Silver Bullet for HFpEF?Akar FG, Young LH. Circ Res. 2021 May 28; 2021 May 27. PMID: 34043421.
- 'Social distancing' of the neuronal nitric oxide synthase from its adaptor protein causes arrhythmogenic trigger-substrate interactions in long QT syndrome.Tieu A, Akar FG. Cardiovasc Res. 2021 Jan 21. PMID: 32589704.
- Renewal Theory as a Universal Quantitative Framework to Characterize Phase Singularity Regeneration in Mammalian Cardiac Fibrillation.Dharmaprani D, Schopp M, Kuklik P, Chapman D, Lahiri A, Dykes L, Xiong F, Aguilar M, Strauss B, Mitchell L, Pope K, Meyer C, Willems S, Akar FG, Nattel S, McGavigan AD, Ganesan AN. Circ Arrhythm Electrophysiol. 2019 Dec; 2019 Dec 9. PMID: 31813270.
- Cardiomyocyte-Specific STIM1 (Stromal Interaction Molecule 1) Depletion in the Adult Heart Promotes the Development of Arrhythmogenic Discordant Alternans.Cacheux M, Strauss B, Raad N, Ilkan Z, Hu J, Benard L, Feske S, Hulot JS, Akar FG. Circ Arrhythm Electrophysiol. 2019 Nov; 2019 Nov 15. PMID: 31726860.
- Recurrence quantification analysis of complex-fractionated electrograms differentiates active and passive sites during atrial fibrillation.Baher A, Buck B, Fanarjian M, Paul Mounsey J, Gehi A, Chung E, Akar FG, Webber CL Jr, Akar JG, Hummel JP. J Cardiovasc Electrophysiol. 2019 Nov; 2019 Oct 2. PMID: 31507008.
- Editorial: Arrhythmogenic Substrates in Diabetes and Obesity.Morrow JP, Akar FG, Aromolaran AS. Front Physiol. 2019; 2019 May 10. PMID: 31133879.
- Intra-tracheal gene delivery of aerosolized SERCA2a to the lung suppresses ventricular arrhythmias in a model of pulmonary arterial hypertension.Strauss B, Sassi Y, Bueno-Beti C, Ilkan Z, Raad N, Cacheux M, Bisserier M, Turnbull IC, Kohlbrenner E, Hajjar RJ, Hadri L, Akar FG. J Mol Cell Cardiol. 2019 Feb; 2018 Nov 28. PMID: 30502350.
- The Mitochondrial Translocator Protein and the Emerging Link Between Oxidative Stress and Arrhythmias in the Diabetic Heart.Ilkan Z, Akar FG. Front Physiol. 2018; 2018 Oct 26. PMID: 30416455.
- Primary Effect of SERCA 2a Gene Transfer on Conduction Reserve in Chronic Myocardial Infarction.Motloch LJ, Cacheux M, Ishikawa K, Xie C, Hu J, Aguero J, Fish KM, Hajjar RJ, Akar FG. J Am Heart Assoc. 2018 Sep 18. PMID: 30371209.
- Acute Left Ventricular Unloading Reduces Atrial Stretch and Inhibits Atrial Arrhythmias.Ishikawa K, Watanabe S, Lee P, Akar FG, Lee A, Bikou O, Fish K, Kho C, Hajjar RJ. J Am Coll Cardiol. 2018 Aug 14. PMID: 30092950.
- Kir2.1 & Na(v)1.5 in Sickness and in Health: Who Needs a Chaperone When They Have an Alpha Partner?Strauss B, Akar FG. Circ Res. 2018 May 25. PMID: 29798894.
- Optical Action Potential Mapping in Acute Models of Ischemia-Reperfusion Injury: Probing the Arrhythmogenic Role of the Mitochondrial Translocator Protein.Ilkan Z, Strauss B, Campana C, Akar FG. Methods Mol Biol. 2018. PMID: 29987816.
- Commentary: Atrial Fibrillation Dynamics and Ionic Block Effects in Six Heterogeneous Human 3D Virtual Atria with Distinct Repolarization Dynamics.Campana C, Akar FG. Front Bioeng Biotechnol. 2017; 2017 Oct 6. PMID: 29057224.
- Protein Phosphatase Inhibitor-1 Gene Therapy in a Swine Model of Nonischemic Heart Failure.Watanabe S, Ishikawa K, Fish K, Oh JG, Motloch LJ, Kohlbrenner E, Lee P, Xie C, Lee A, Liang L, Kho C, Leonardson L, McIntyre M, Wilson S, Samulski RJ, Kranias EG, Weber T, Akar FG, Hajjar RJ. J Am Coll Cardiol. 2017 Oct 3. PMID: 28958332.
- Oxidative stress and inflammation as central mediators of atrial fibrillation in obesity and diabetes.Karam BS, Chavez-Moreno A, Koh W, Akar JG, Akar FG. Cardiovasc Diabetol. 2017 Sep 29; 2017 Sep 29. PMID: 28962617.
- Increased afterload following myocardial infarction promotes conduction-dependent arrhythmias that are unmasked by hypokalemia.Motloch LJ, Ishikawa K, Xie C, Hu J, Aguero J, Fish KM, Hajjar RJ, Akar FG. JACC Basic Transl Sci. 2017 Jun; 2017 Jun 26. PMID: 28798965.
- Reducing mitochondrial bound hexokinase II mediates transition from non-injurious into injurious ischemia/reperfusion of the intact heart.Nederlof R, Gürel-Gurevin E, Eerbeek O, Xie C, Deijs GS, Konkel M, Hu J, Weber NC, Schumacher CA, Baartscheer A, Mik EG, Hollmann MW, Akar FG, Zuurbier CJ. J Physiol Biochem. 2016 Aug; 2017 Mar 3. PMID: 28258543.
- Starve a fever to heal a heart? Interleukin-18 gives new meaning to an old adage.Akar FG. Am J Physiol Heart Circ Physiol. 2016 Aug 1; 2016 Jun 24. PMID: 27342879.
- LKB1 deletion causes early changes in atrial channel expression and electrophysiology prior to atrial fibrillation.Kim GE, Ross JL, Xie C, Su KN, Zaha VG, Wu X, Palmeri M, Ashraf M, Akar JG, Russell KS, Akar FG, Young LH. Cardiovasc Res. 2015 Oct 1. PMID: 26378152.
- The Classically Cardioprotective Agent Diazoxide Elicits Arrhythmias in Type 2 Diabetes Mellitus.Xie C, Hu J, Motloch LJ, Karam BS, Akar FG. J Am Coll Cardiol. 2015 Sep 8. PMID: 26337994.
- Gene therapy to restore electrophysiological function in heart failure.Motloch LJ, Akar FG. Expert Opin Biol Ther. 2015 Jun; 2015 Apr 12. PMID: 25865107.
- The mitochondrial translocator protein and arrhythmogenesis in ischemic heart disease.Motloch LJ, Hu J, Akar FG. Oxid Med Cell Longev. 2015; 2015 Mar 30. PMID: 25918579.
- Cardiac I-1c overexpression with reengineered AAV improves cardiac function in swine ischemic heart failure.Ishikawa K, Fish KM, Tilemann L, Rapti K, Aguero J, Santos-Gallego CG, Lee A, Karakikes I, Xie C, Akar FG, Shimada YJ, Gwathmey JK, Asokan A, McPhee S, Samulski J, Samulski RJ, Sigg DC, Weber T, Kranias EG, Hajjar RJ. Mol Ther. 2014 Dec; 2014 Jul 15. PMID: 25023328.
- Blue LEDs get the Nobel Prize while Red LEDs are poised to save lives.Karam BS, Akar FG. Front Physiol. 2014; 2014 Nov 14. PMID: 25452731.
- A formidable "TASK": tipping the balance in favor of rhythm control for the management of atrial fibrillation.Akar FG. Heart Rhythm. 2014 Oct; 2014 Jul 17. PMID: 25041966.
- Functional crosstalk between the mitochondrial PTP and KATP channels determine arrhythmic vulnerability to oxidative stress.Xie C, Kauffman J, Akar FG. Front Physiol. 2014; 2014 Jul 16. PMID: 25076913.
- Gene therapies for arrhythmias in heart failure.Akar FG, Hajjar RJ. Pflugers Arch. 2014 Jun; 2014 Feb 26. PMID: 24566976.
- Effect of bortezomib on the efficacy of AAV9.SERCA2a treatment to preserve cardiac function in a rat pressure-overload model of heart failure.Chaanine AH, Nonnenmacher M, Kohlbrenner E, Jin D, Kovacic JC, Akar FG, Hajjar RJ, Weber T. Gene Ther. 2014 Apr; 2014 Feb 27. PMID: 24572786.
- Emergence of atrial repolarization alternans at late stages of remodeling: the "second factor" in atrial fibrillation progression?Akar FG. J Cardiovasc Electrophysiol. 2014 Apr; 2014 Feb 28. PMID: 24479610.
- Advancing functional engineered cardiac tissues toward a preclinical model of human myocardium.Turnbull IC, Karakikes I, Serrao GW, Backeris P, Lee JJ, Xie C, Senyei G, Gordon RE, Li RA, Akar FG, Hajjar RJ, Hulot JS, Costa KD. FASEB J. 2014 Feb; 2013 Oct 30. PMID: 24174427.
- Mitochondrial targets for arrhythmia suppression: is there a role for pharmacological intervention?Akar FG. J Interv Card Electrophysiol. 2013 Sep; 2013 Jul 4. PMID: 23824789.
- Glutathione oxidation unmasks proarrhythmic vulnerability of chronically hyperglycemic guinea pigs.Xie C, Biary N, Tocchetti CG, Aon MA, Paolocci N, Kauffman J, Akar FG. Am J Physiol Heart Circ Physiol. 2013 Apr 1; 2013 Feb 1. PMID: 23376824.
- Pathophysiological consequences of TAT-HKII peptide administration are independent of impaired vascular function and ensuing ischemia.Nederlof R, Xie C, Eerbeek O, Koeman A, Milstein DM, Hollmann MW, Mik EG, Warley A, Southworth R, Akar FG, Zuurbier CJ. Circ Res. 2013 Jan 18. PMID: 23329797.
- GSH or palmitate preserves mitochondrial energetic/redox balance, preventing mechanical dysfunction in metabolically challenged myocytes/hearts from type 2 diabetic mice.Tocchetti CG, Caceres V, Stanley BA, Xie C, Shi S, Watson WH, O'Rourke B, Spadari-Bratfisch RC, Cortassa S, Akar FG, Paolocci N, Aon MA. Diabetes. 2012 Dec; 2012 Jul 17. PMID: 22807033.
- Genetic silencing of pacemaker cells: local intervention with global implications.Karam CS, Akar FG. J Am Heart Assoc. 2012 Apr; 2012 Apr 24. PMID: 23130130.
- Biophysical properties and functional consequences of reactive oxygen species (ROS)-induced ROS release in intact myocardium.Biary N, Xie C, Kauffman J, Akar FG. J Physiol. 2011 Nov 1; 2011 Aug 8. PMID: 21825030.
- Mitochondria are sources of metabolic sink and arrhythmias.Akar FG, O'Rourke B. Pharmacol Ther. 2011 Sep; 2011 Apr 14. PMID: 21513732.
- β-Adrenergic receptor activation induces internalization of cardiac Cav1.2 channel complexes through a β-arrestin 1-mediated pathway.Lipsky R, Potts EM, Tarzami ST, Puckerin AA, Stocks J, Schecter AD, Sobie EA, Akar FG, Diversé-Pierluissi MA. J Biol Chem. 2011 Jun 17. PMID: 21812127.
- Disruption of hexokinase II-mitochondrial binding blocks ischemic preconditioning and causes rapid cardiac necrosis.Smeele KM, Southworth R, Wu R, Xie C, Nederlof R, Warley A, Nelson JK, van Horssen P, van den Wijngaard JP, Heikkinen S, Laakso M, Koeman A, Siebes M, Eerbeek O, Akar FG, Ardehali H, Hollmann MW, Zuurbier CJ. Circ Res. 2011 May 13; 2011 Apr 28. PMID: 21527739.
- Deciphering Arrhythmia Mechanisms - Tools of the Trade.Salama G, Akar FG. Card Electrophysiol Clin. 2011 Mar. PMID: 21572551.
- Mitochondrial dysfunction: a new frontier in the search for elusive arrhythmia mechanisms.Xie C, Akar FG. Front Physiol. 2010; 2010 Dec 17. PMID: 21423398.
- Regression of cardiac hypertrophy by cyclic guanosine monophosphate-dependent protein kinase signaling are myocytes active sources or mere beneficiaries?Hajjar RJ, Akar FG. J Am Coll Cardiol. 2010 Dec 7; 2010 Oct 21. PMID: 20970281.
- Optical imaging of mitochondrial function uncovers actively propagating waves of mitochondrial membrane potential collapse across intact heart.Lyon AR, Joudrey PJ, Jin D, Nass RD, Aon MA, O'Rourke B, Akar FG. J Mol Cell Cardiol. 2010 Oct; 2010 Jul 16. PMID: 20624394.
- A brighter side of ROS revealed by selective activation of beta-adrenergic receptor subtypes.Biary N, Akar FG. J Physiol. 2010 Aug 15. PMID: 20710039.
- Use-dependent modulation of myocardial conduction by a new class of HERG agonists: deal breaker or cherry on top?Akar FG. J Cardiovasc Electrophysiol. 2010 Aug 1; 2010 Mar 26. PMID: 20367661.
- Translational potential of human embryonic and induced pluripotent stem cells for myocardial repair: insights from experimental models.Kong CW, Akar FG, Li RA. Thromb Haemost. 2010 Jul; 2010 Jun 10. PMID: 20539906.
- Altered spatiotemporal dynamics of the mitochondrial membrane potential in the hypertrophied heart.Jin H, Nass RD, Joudrey PJ, Lyon AR, Chemaly ER, Rapti K, Akar FG. Biophys J. 2010 May 19. PMID: 20483313.
- Ultrastructure and regulation of lateralized connexin43 in the failing heart.Hesketh GG, Shah MH, Halperin VL, Cooke CA, Akar FG, Yen TE, Kass DA, Machamer CE, Van Eyk JE, Tomaselli GF. Circ Res. 2010 Apr 2; 2010 Feb 18. PMID: 20167932.
- Mechanoelectrical remodeling and arrhythmias during progression of hypertrophy.Jin H, Chemaly ER, Lee A, Kho C, Hadri L, Hajjar RJ, Akar FG. FASEB J. 2010 Feb; 2009 Oct 13. PMID: 19825979.
- Na+ channel regulation by Ca2+/calmodulin and Ca2+/calmodulin-dependent protein kinase II in guinea-pig ventricular myocytes.Aiba T, Hesketh GG, Liu T, Carlisle R, Villa-Abrille MC, O'Rourke B, Akar FG, Tomaselli GF. Cardiovasc Res. 2010 Feb 1; 2009 Oct 1. PMID: 19797425.
- Arrhythmia models: in vivo, in vitro and in silico.Akar FG, Clancy CE. Drug Discov Today Dis Models. 2009 Fall. PMID: 21072326.
- Electrophysiological consequences of dyssynchronous heart failure and its restoration by resynchronization therapy.Aiba T, Hesketh GG, Barth AS, Liu T, Daya S, Chakir K, Dimaano VL, Abraham TP, O'Rourke B, Akar FG, Kass DA, Tomaselli GF. Circulation. 2009 Mar 10; 2009 Feb 23. PMID: 19237662.
- Key pathways associated with heart failure development revealed by gene networks correlated with cardiac remodeling.Gao Z, Barth AS, DiSilvestre D, Akar FG, Tian Y, Tanskanen A, Kass DA, Winslow RL, Tomaselli GF. Physiol Genomics. 2008 Nov 12; 2008 Sep 9. PMID: 18780759.
- Targeted deletion of kcne2 impairs ventricular repolarization via disruption of I(K,slow1) and I(to,f).Roepke TK, Kontogeorgis A, Ovanez C, Xu X, Young JB, Purtell K, Goldstein PA, Christini DJ, Peters NS, Akar FG, Gutstein DE, Lerner DJ, Abbott GW. FASEB J. 2008 Oct; 2008 Jul 4. PMID: 18603586.
- Arrhythmia mechanisms in the failing heart.Jin H, Lyon AR, Akar FG. Pacing Clin Electrophysiol. 2008 Aug. PMID: 18684263.
- Effects of 4'-chlorodiazepam on cellular excitation-contraction coupling and ischaemia-reperfusion injury in rabbit heart.Brown DA, Aon MA, Akar FG, Liu T, Sorarrain N, O'Rourke B. Cardiovasc Res. 2008 Jul 1; 2008 Feb 26. PMID: 18304929.
- beta-Adrenergic receptor activation induces internalization of cardiac Cav1.2 channel complexes through a beta-arrestin 1-mediated pathway.Lipsky R, Potts EM, Tarzami ST, Puckerin AA, Stocks J, Schecter AD, Sobie EA, Akar FG, Diversé-Pierluissi MA. J Biol Chem. 2008 Jun 20; 2008 May 5. PMID: 18458091.
- Mechanisms of disease: ion channel remodeling in the failing ventricle.Nass RD, Aiba T, Tomaselli GF, Akar FG. Nat Clin Pract Cardiovasc Med. 2008 Apr; 2008 Mar 4. PMID: 18317475.
- The perfect storm: defective calcium cycling in insulated fibers with reduced repolarization reserve.Akar FG. Circ Res. 2007 Nov 9. PMID: 17991890.
- Regulation of ion channels and arrhythmias in the ischemic heart.Akar JG, Akar FG. J Electrocardiol. 2007 Nov-Dec. PMID: 17993326.
- Dynamic changes in conduction velocity and gap junction properties during development of pacing-induced heart failure.Akar FG, Nass RD, Hahn S, Cingolani E, Shah M, Hesketh GG, DiSilvestre D, Tunin RS, Kass DA, Tomaselli GF. Am J Physiol Heart Circ Physiol. 2007 Aug; 2007 Apr 13. PMID: 17434978.
- Mapping arrhythmias in the failing heart: from Langendorff to patient.Akar JG, Akar FG. J Electrocardiol. 2006 Oct; 2006 Aug 21. PMID: 16920143.
- Bioartificial sinus node constructed via in vivo gene transfer of an engineered pacemaker HCN Channel reduces the dependence on electronic pacemaker in a sick-sinus syndrome model.Tse HF, Xue T, Lau CP, Siu CW, Wang K, Zhang QY, Tomaselli GF, Akar FG, Li RA. Circulation. 2006 Sep 5; 2006 Aug 21. PMID: 16923751.
- Mitochondrial criticality: a new concept at the turning point of life or death.Aon MA, Cortassa S, Akar FG, O'Rourke B. Biochim Biophys Acta. 2006 Feb; 2005 Sep 27. PMID: 16242921.
- The mitochondrial origin of postischemic arrhythmias.Akar FG, Aon MA, Tomaselli GF, O'Rourke B. J Clin Invest. 2005 Dec; 2005 Nov 10. PMID: 16284648.
- Molecular basis of arrhythmias.Shah M, Akar FG, Tomaselli GF. Circulation. 2005 Oct 18. PMID: 16230503.
- Conduction abnormalities in nonischemic dilated cardiomyopathy: basic mechanisms and arrhythmic consequences.Akar FG, Tomaselli GF. Trends Cardiovasc Med. 2005 Oct. PMID: 16226681.
- Abnormal conduction and repolarization in late-activated myocardium of dyssynchronously contracting hearts.Spragg DD, Akar FG, Helm RH, Tunin RS, Tomaselli GF, Kass DA. Cardiovasc Res. 2005 Jul 1. PMID: 15885674.
- Molecular mechanisms underlying K+ current downregulation in canine tachycardia-induced heart failure.Akar FG, Wu RC, Juang GJ, Tian Y, Burysek M, Disilvestre D, Xiong W, Armoundas AA, Tomaselli GF. Am J Physiol Heart Circ Physiol. 2005 Jun; 2005 Jan 28. PMID: 15681701.
- Functional integration of electrically active cardiac derivatives from genetically engineered human embryonic stem cells with quiescent recipient ventricular cardiomyocytes: insights into the development of cell-based pacemakers.Xue T, Cho HC, Akar FG, Tsang SY, Jones SP, Marbán E, Tomaselli GF, Li RA. Circulation. 2005 Jan 4; 2004 Dec 20. PMID: 15611367.
- Ion channels as novel therapeutic targets in heart failure.Akar FG, Tomaselli GF. Ann Med. 2005. PMID: 15902846.
- Mechanisms underlying conduction slowing and arrhythmogenesis in nonischemic dilated cardiomyopathy.Akar FG, Spragg DD, Tunin RS, Kass DA, Tomaselli GF. Circ Res. 2004 Oct 1; 2004 Sep 2. PMID: 15345654.
- Heterogeneous connexin43 expression produces electrophysiological heterogeneities across ventricular wall.Poelzing S, Akar FG, Baron E, Rosenbaum DS. Am J Physiol Heart Circ Physiol. 2004 May; 2004 Jan 2. PMID: 14704225.
- Phenotypic differences in transient outward K+ current of human and canine ventricular myocytes: insights into molecular composition of ventricular Ito.Akar FG, Wu RC, Deschenes I, Armoundas AA, Piacentino V 3rd, Houser SR, Tomaselli GF. Am J Physiol Heart Circ Physiol. 2004 Feb; 2003 Oct 2. PMID: 14527940.
- Transmural electrophysiological heterogeneities underlying arrhythmogenesis in heart failure.Akar FG, Rosenbaum DS. Circ Res. 2003 Oct 3; 2003 Aug 21. PMID: 12933704.
- Unique topographical distribution of M cells underlies reentrant mechanism of torsade de pointes in the long-QT syndrome.Akar FG, Yan GX, Antzelevitch C, Rosenbaum DS. Circulation. 2002 Mar 12. PMID: 11889021.