Publications

2025

• Design of precision therapeutics for a CKD risk allele by targeting Shroom3-Rock interaction

  Reghuvaran, A., Kumar, A., Lin, Q. et al. Design of precision therapeutics for a CKD risk allele by targeting Shroom3-Rock interaction. Nat Commun (2025). https://doi.org/10.1038/s41467-025-67854-7

  Peer-Reviewed Original Research

• Mechanisms of Podocyte Injury in Kidney Allografts

  Barsotti, Gabriel C.1; Menon, Madhav C.1; Naik, Abhijit2; Rao, Arundati1,a. Mechanisms of Podocyte Injury in Kidney Allografts. Kidney360 ():10.34067/KID.0000001091, December 05, 2025. | DOI: 10.34067/KID.0000001091

  Peer-Reviewed Original Research

• Divergent GFR Estimates and Clinical Implications.

  Sarav M, Alpern RJ. Divergent GFR Estimates and Clinical Implications. JAMA 2025, 334: 1888-1890. PMID: 41202183, DOI: 10.1001/jama.2025.14043.

  Peer-Reviewed Original Research

• All-optical visualization of specific molecules in the ultrastructural context of brain tissue

  M’Saad O, Cairns A, Gulcicek J, Kasula R, Liao J, Kondratiuk I, Bewersdorf E, Kidd P, Falahati H, Gentile J, Niescier R, Watters K, Sterner R, Lee S, Guo X, Liu X, Desir G, De Camilli P, Rothman J, Koleske A, Biederer T, Kuan A, Bewersdorf J. All-optical visualization of specific molecules in the ultrastructural context of brain tissue. Nature Biotechnology 2025, 1-15. PMID: 41299044, DOI: 10.1038/s41587-025-02905-4.

  Peer-Reviewed Original Research

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• Design and development of a urinary cell pellet mRNA PCR-based assay for progressive kidney disease: Nephro-Dx

  Design and development of a urinary cell pellet mRNA PCR-based assay for progressive kidney disease: Nephro-Dx Ashwani Kumar, Gabriel Caldato Barsotti, Zhengzi Yi, Zeguo Sun, Anand Reghuvaran, EM Tanvir, John Pell, Hongmei Shi, Sudhir Perincheri, Melissa Shaw, Candice Kent, Daris Javed, Petra Leite, Deepa Jayaram, Jeffrey Turner, Kristin Meliambro, Randy Luciano, John He, Dennis Moledina, Francis P Wilson, Weijia Zhang, Madhav C Menon medRxiv 2025.10.31.25338655; doi: https://doi.org/10.1101/2025.10.31.25338655

  Peer-Reviewed Original Research

• Urine Oxalate Excretion and CKD Stage in Patients With Primary Hyperoxaluria Type 1

  Vaughan L, Schulte P, Knauf F, Sas D, Milliner D, Lieske J. Urine Oxalate Excretion and CKD Stage in Patients With Primary Hyperoxaluria Type 1. American Journal Of Kidney Diseases 2025 PMID: 40983145, PMCID: PMC12462907, DOI: 10.1053/j.ajkd.2025.07.013.

  Peer-Reviewed Original Research

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• Vincristine in FSGS: Rediscovering an Old Therapeutic for FSGS

  Kumar A, Prasad P, Menon M. Vincristine in FSGS: Rediscovering an Old Therapeutic for FSGS. Kidney International Reports 2025, 10: 3727-3729. PMID: 41278331, PMCID: PMC12640027, DOI: 10.1016/j.ekir.2025.09.018.

  Peer-Reviewed Original Research

• Qualitative Analysis and Comparison of Externally Led Patient-Focused Drug Development Concepts for Autosomal Recessive Polycystic Kidney Disease Against SONG Initiatives

  Soyfer B, Fedeles S, Ruyle W, Hoover E, Liebau M, Hartung E, Dell K, Guay-Woodford L, Perrone R, Oberdhan D. Qualitative Analysis and Comparison of Externally Led Patient-Focused Drug Development Concepts for Autosomal Recessive Polycystic Kidney Disease Against SONG Initiatives. Kidney Medicine 2025, 7: 101110. PMID: 41209162, PMCID: PMC12595366, DOI: 10.1016/j.xkme.2025.101110.

  Peer-Reviewed Original Research

  Concepts

• Kidney Tubule Secretion Can Discriminate the Cause of Acute Kidney Injury in Cirrhosis.

  Puthumana J, Belcher J, Garcia-Tsao G, Sanyal A, Seegmiller J, Garimella P, Parikh C, Ix J. Kidney Tubule Secretion Can Discriminate the Cause of Acute Kidney Injury in Cirrhosis. Clinical Journal Of The American Society Of Nephrology 2025 PMID: 40956621, DOI: 10.2215/cjn.0000000814.

  Peer-Reviewed Original Research

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  Concepts

• Barriers and Opportunities in Access to Peritoneal Dialysis across Veterans Health Administration.

  Wadhwa A, Reule S, Cavanaugh K, Fischer M, Mackichan K, Sinha A, Palevsky P, Crowley S, Fried L, Shukla A. Barriers and Opportunities in Access to Peritoneal Dialysis across Veterans Health Administration. Clinical Journal Of The American Society Of Nephrology 2025 PMID: 40952802, DOI: 10.2215/cjn.0000000826.

  Peer-Reviewed Original Research

  Concepts

• Loop Diuretic Dose Intensification versus Adjuvant Thiazide for Diuretic Resistance in Acute Heart Failure: Mechanistic Randomized Controlled Trial.

  Rao V, Cox Z, Ivey-Miranda J, Moreno-Villagomez J, Ramos-Mastache D, Maulion C, Bellumkonda L, Turner J, Wilson F, Shilpak M, Estrella M, Welling P, Wilcox C, Ellison D, Forbush B, Testani J. Loop Diuretic Dose Intensification versus Adjuvant Thiazide for Diuretic Resistance in Acute Heart Failure: Mechanistic Randomized Controlled Trial. Journal Of The American Society Of Nephrology 2025 PMID: 40938670, DOI: 10.1681/asn.0000000887.

  Peer-Reviewed Original Research

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  Concepts

• Atypical Hemolytic Uremic Syndrome with Peripheral Gangrene

  Aierken, Ailima; Muhetaer, Gulimire; Zhuang, Jing; Wang, Chun; Tian, Xuefei; Jiang, Hong. Clinical Journal of the American Society of Nephrology 20(9):, September 2025. | DOI: 10.2215/CJN.0000000723

  Peer-Reviewed Case Reports and Technical Notes

• Tailoring of Immunosuppression With Belatacept in De Novo and Conversion Settings and Risk Mitigation Strategies.

  Formica R, Larsen C, Rostaing L. Tailoring of Immunosuppression With Belatacept in De Novo and Conversion Settings and Risk Mitigation Strategies. Transplantation 2025 PMID: 40898400, DOI: 10.1097/tp.0000000000005506.

  Peer-Reviewed Original Research

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  Concepts

• Early Nephropathy Screening as a Health Seeking Behavior Among Type 2 Diabetes Mellitus Patients: A Phenomenological Study in Southwestern Uganda

  Kiconco R, Kalyesubula R, Sanyu N, Agaba B, Ondari E, Tusubira D, Kiwanuka G. Early Nephropathy Screening as a Health Seeking Behavior Among Type 2 Diabetes Mellitus Patients: A Phenomenological Study in Southwestern Uganda. Journal Of Multidisciplinary Healthcare 2025, 18: 5875-5892. PMID: 40978075, PMCID: PMC12450022, DOI: 10.2147/jmdh.s551738.

  Peer-Reviewed Original Research

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  Concepts

• Assessing changes in donor-derived cfDNA in post-kidney transplant patients and its correlation with graft survival

  Sareen N, Miller M, McGowan K, Frankson G, Asch W, formica R, Bow L. Assessing changes in donor-derived cfDNA in post-kidney transplant patients and its correlation with graft survival. Human Immunology 2025, 86: 111466. DOI: 10.1016/j.humimm.2025.111466.

  Peer-Reviewed Original Research

  Concepts

• Characterization of Postural Orthostatic Tachycardia Syndrome in Long COVID Self-reported Data From the LISTEN Study

  AL Mouslmani M, Sawano M, Arun A, Wu Y, Shah R, Kaleem S, Zhou T, Murugiah K, Lu Y, Herrin J, Bishop P, Taub P, Peixoto A, Bhattacharjee B, Iwasaki A, Krumholz H. Characterization of Postural Orthostatic Tachycardia Syndrome in Long COVID Self-reported Data From the LISTEN Study. JACC Advances 2025, 4: 101873. PMID: 40883051, PMCID: PMC12399260, DOI: 10.1016/j.jacadv.2025.101873.

  Peer-Reviewed Original Research

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• Machine learning-based prediction of tubulointerstitial lesions in diabetic kidney disease: a multicenter validation study

  Xu C, Shen Z, Zhong Y, Han S, Liao H, Duan Y, Tian X, Ren X, Lu C, Jiang H. Machine learning-based prediction of tubulointerstitial lesions in diabetic kidney disease: a multicenter validation study. Renal Failure 2025, 47: 2547266. PMID: 40841991, PMCID: PMC12372483, DOI: 10.1080/0886022x.2025.2547266.

  Peer-Reviewed Original Research

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  MeSH Keywords and Concepts

• In vivo base editing reduces liver cysts in autosomal dominant polycystic kidney disease

  Ibel A, Bhardwaj R, Yilmaz D, Kong S, Wendlinger S, Cordero C, Papaioannou D, Papazian M, Schönauer R, Meng Q, Eckardt K, Hassan F, Volpe I, Klämbt V, Halbritter J, Fedeles S, Krappitz M, Kaminski M. In vivo base editing reduces liver cysts in autosomal dominant polycystic kidney disease. Molecular Therapy 2025, 33: 5373-5382. PMID: 40842155, PMCID: PMC12628146, DOI: 10.1016/j.ymthe.2025.08.026.

  Peer-Reviewed Original Research

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• KidneyGenAfrica, a pan-African partnership to deliver research and training excellence in genomics of kidney disease

  Fatumo S, Ojewunmi O, Camenzuli R, Kintu C, Kamiza A, Brandenburg J, Kalungi A, Kalyesubula R, Salako B, Nash O, Crampin A, Adeyemo A, Nyirenda M, Ramsay M, Fabian J. KidneyGenAfrica, a pan-African partnership to deliver research and training excellence in genomics of kidney disease. Nature Genetics 2025, 57: 2079-2082. PMID: 40835890, DOI: 10.1038/s41588-025-02299-8.

  Peer-Reviewed Original Research

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  Concepts

• The Effect of Ambient Artificial Intelligence Scribes on Trainee Documentation Burden

  Wright D, Kanaparthy N, Melnick E, Levy D, Huot S, Hsiao A, Schwamm L, Ong S. The Effect of Ambient Artificial Intelligence Scribes on Trainee Documentation Burden. Applied Clinical Informatics 2025, 16: 872-878. PMID: 40602775, PMCID: PMC12367366, DOI: 10.1055/a-2647-1142.

  Peer-Reviewed Original Research

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  MeSH Keywords and Concepts

• The kidneys’ effect on the survival of multi-organ transplant recipients

  Formica R. The kidneys’ effect on the survival of multi-organ transplant recipients. The Journal Of Heart And Lung Transplantation 2025 PMID: 40835056, DOI: 10.1016/j.healun.2025.07.031.

  Peer-Reviewed Original Research

• Deep Learning-Based Instance-Level Segmentation of Kidney and Liver Cysts in CT Images of Patients Affected by Polycystic Kidney Disease.

  Gregory A, Khalifa M, Im J, Ramanathan S, Elbarougy D, Cruz C, Yang H, Denic A, Rule A, Chebib F, Dahl N, Hogan M, Harris P, Torres V, Erickson B, Potretzke T, Kline T. Deep Learning-Based Instance-Level Segmentation of Kidney and Liver Cysts in CT Images of Patients Affected by Polycystic Kidney Disease. Kidney360 2025 PMID: 40811034, DOI: 10.34067/kid.0000000924.

  Peer-Reviewed Original Research

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• Urine Proteomic Signatures of Kidney Function Decline after Hospitalization

  Wen Y, Menez S, Philbrook H, Moledina D, Coca S, Xue J, Kaufman J, Chinchillil V, Kimmel P, Ikizler T, Hsu C, Kelly T, Ricardo A, Himmelfarb J, Parikh C. Urine Proteomic Signatures of Kidney Function Decline after Hospitalization. JCI Insight 2025, 10 PMID: 40794429, DOI: 10.1172/jci.insight.195577.

  Peer-Reviewed Original Research

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  MeSH Keywords and Concepts

• An Ethical Analysis of Allocating Organs Out of Sequence

  Kulkarni S, Adebiyi O, Bullock S, Chen G, Dillon J, Jokimaki L, Lee-Riddle G, Madigan-McCown L, Paolillo L, Wilson-Sheehan S, Shepherd L, Stohs E, Truog R, Urbanski M, Wilkinson M, Wells-Williams F, Wu J, Flescher A. An Ethical Analysis of Allocating Organs Out of Sequence. Current Transplantation Reports 2025, 12: 29. DOI: 10.1007/s40472-025-00486-4.

  Peer-Reviewed Original Research

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  Concepts

• Autosomal dominant polycystic kidney disease without apparent family history: A single-center experience.

  Samuels M, Maarouf O, Zeng W, Hamrahian M, Dahl N, Zhang J. Autosomal dominant polycystic kidney disease without apparent family history: A single-center experience. Clinical Nephrology 2025, 104: 144-151. PMID: 40329829, DOI: 10.5414/cn111677.

  Peer-Reviewed Original Research

  Concepts