2023
Beyond Loss of Kidney Function: Patient Care in Autosomal Dominant Polycystic Kidney Disease
Hogan M, Simmons K, Ullman L, Gondal M, Dahl N. Beyond Loss of Kidney Function: Patient Care in Autosomal Dominant Polycystic Kidney Disease. Kidney360 2023, 4: 1806-1815. PMID: 38010035, PMCID: PMC10758524, DOI: 10.34067/kid.0000000000000296.Peer-Reviewed Original ResearchConceptsAutosomal dominant polycystic kidney diseaseDominant polycystic kidney diseasePolycystic kidney diseaseKidney diseaseKidney Disease Improving Global Outcomes guidelinesGlobal Outcomes (KDIGO) guidelinesInitiation of RRTSuccessful kidney transplantEvidence-based guidelinesCurrent clinical practiceKidney stone managementMajor morbidityCardiac manifestationsKidney transplantOutcomes guidelinesKidney functionDepression screeningDisease benefitPancreatic cystsSpecialized careRoutine managementClinical practicePatient careStone managementDisease aspectsThe Clinical Utility of Genetic Testing in the Diagnosis and Management of Adults with Chronic Kidney Disease
Dahl N, Bloom M, Chebib F, Clark D, Westemeyer M, Jandeska S, Zhang Z, Milo-Rasouly H, Kolupaeva V, Marasa M, Broumand V, Fatica R, Raj D, Demko Z, Marshall K, Punj S, Tabriziani H, Bhorade S, Gharavi A. The Clinical Utility of Genetic Testing in the Diagnosis and Management of Adults with Chronic Kidney Disease. Journal Of The American Society Of Nephrology 2023, 34: 2039-2050. PMID: 37794564, PMCID: PMC10703084, DOI: 10.1681/asn.0000000000000249.Peer-Reviewed Original ResearchConceptsPositive genetic findingsCKD diagnosisGenetic testingGenetic findingsClinical managementCLINICAL TRIAL REGISTRY NAMEUnderlying causeGene panelTRIAL REGISTRY NAMEChronic kidney diseaseManagement of adultsAppropriate treatment strategyClinical care paradigmsPatient's medical historyClinical applicationAcademic medical centerClinical disease categoriesAdult patientsREGISTRY NAMEPrior diagnosisKidney diseaseMulticenter studyMedical historyTreatment strategiesMedical CenterHybrid Revision of Dysfunctional Aneurysmal Arteriovenous Fistulas
Kostiuk V, Chen J, Dahl N, Turner J, Chaar C. Hybrid Revision of Dysfunctional Aneurysmal Arteriovenous Fistulas. Vascular And Endovascular Surgery 2023, 57: 909-913. PMID: 37300698, DOI: 10.1177/15385744231183488.Peer-Reviewed Original ResearchRisk Factors for Common Kidney Stones Are Correlated with Kidney Function Independent of Stone Composition
Simmons K, Nair H, Phadke M, Motamedinia P, Singh D, Montgomery T, Dahl N. Risk Factors for Common Kidney Stones Are Correlated with Kidney Function Independent of Stone Composition. American Journal Of Nephrology 2023, 54: 329-336. PMID: 37253348, DOI: 10.1159/000531046.Peer-Reviewed Original ResearchConceptsEstimate glomerular filtration rateLower estimate glomerular filtration rateRisk factorsUrine chemistryUnivariable analysisMultivariable analysisStone compositionKidney stonesKidney stone risk factorsCommon stone compositionUrine risk factorsRetrospective cohort studyStone analysisStone risk factorsGlomerular filtration rateLow urine pHBody mass indexKidney stone patientsCalcium-containing stonesUric acid stonesStone composition dataUrine oxalateRenal functionCohort studyKidney functionKidney cysts in patients with HOGA1 variants.
Patel D, Page N, Dahl N. Kidney cysts in patients with HOGA1 variants. Clinical Nephrology 2023, 99: 260-264. PMID: 36928260, DOI: 10.5414/cn110939.Peer-Reviewed Original ResearchPharmacologic Management of Autosomal Dominant Polycystic Kidney Disease
Ackley W, Dahl N, Park M. Pharmacologic Management of Autosomal Dominant Polycystic Kidney Disease. Advances In Kidney Disease And Health 2023, 30: 228-235. PMID: 37088525, DOI: 10.1053/j.akdh.2023.02.002.Peer-Reviewed Original ResearchConceptsAutosomal dominant polycystic kidney diseaseEnd-stage kidney diseaseKidney diseaseDominant polycystic kidney diseasePolycystic kidney diseaseRapid progressionMechanism-specific treatmentsChronic kidney diseaseFourth leading causeTreatment of patientsPharmacologic managementLeading causeKidney disordersFDA approvalDiseaseTolvaptanProgressionTreatmentRiskMorbidityPatientsPathogenesisTherapyHypomorphic PKD1 Alleles Impact Disease Variability in Autosomal Dominant Polycystic Kidney Disease
Gulati A, Dahl N, Hartung E, Clark S, Moudgil A, Goodwin J, Somlo S. Hypomorphic PKD1 Alleles Impact Disease Variability in Autosomal Dominant Polycystic Kidney Disease. Kidney360 2023, 4: 387-392. PMID: 36706243, PMCID: PMC10103195, DOI: 10.34067/kid.0000000000000064.Peer-Reviewed Original Research
2022
Perspectives on Drug Development in Early ADPKD
Mekahli D, Womack H, Dahl NK. Perspectives on Drug Development in Early ADPKD. Clinical Journal Of The American Society Of Nephrology 2022, 17: 1555-1558. PMID: 35998975, PMCID: PMC9528262, DOI: 10.2215/cjn.05190422.Peer-Reviewed Original ResearchA Practical Guide to Genetic Testing for Kidney Disorders of Unknown Etiology
Aron AW, Dahl NK, Besse W. A Practical Guide to Genetic Testing for Kidney Disorders of Unknown Etiology. Kidney360 2022, 3: 1640-1651. PMID: 36245662, PMCID: PMC9528385, DOI: 10.34067/kid.0007552021.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsClinical genetic testingGenetic testingIdentification of pathogenic variantsLimitations of genetic testingKidney-related disordersOut-of-pocket costsRisks of testingVariant nomenclatureProvider educationPathogenic variantsGene panelPatient's desireDiagnosis of kidney diseaseProvidersFollow-up investigationKidney diseaseDiagnostic utilityDiagnostic limitationsKidney disordersValuable diagnostic toolUnknown etiologyGenetic risk allelesUndetermined causeGuide managementDiagnosisDesign and Basic Characteristics of a National Patient-Powered Registry in ADPKD
Hoover E, Perrone RD, Rusconi C, Benson B, Dahl NK, Gitomer B, Manelli A, Mrug M, Park M, Seliger SL, Phadnis MA, Thewarapperuma N, Watnick TJ. Design and Basic Characteristics of a National Patient-Powered Registry in ADPKD. Kidney360 2022, 3: 1350-1358. PMID: 36176661, PMCID: PMC9416821, DOI: 10.34067/kid.0002372022.Peer-Reviewed Original ResearchConceptsAutosomal dominant polycystic kidney diseaseKidney diseaseCore questionnaireManagement of ADPKDPatient-reported diagnosisPost-kidney transplantHealth-related qualityPatient-centered outcomesDominant polycystic kidney diseaseQuality of lifePolycystic kidney diseaseHispanics/LatinosCKD stageKidney transplantMedian ageKidney functionNational PatientBurden scoreDisease stageExtrarenal manifestationsPatient enrollmentADPKD patientsCreatinine valuesClinical trialsClinical studies
2021
An Unusual Cause of AKI in a Kidney Transplant Recipient
Malhotra D, Dahl NK. An Unusual Cause of AKI in a Kidney Transplant Recipient. Kidney360 2021, 2: 1869-1870. PMID: 35373005, PMCID: PMC8785853, DOI: 10.34067/kid.0004332021.Peer-Reviewed Original ResearchAssociation of AKI-D with Urinary Findings and Baseline eGFR in Hospitalized COVID-19 Patients
Patel DM, Phadke M, Dai F, Simonov M, Dahl NK, Kodali R. Association of AKI-D with Urinary Findings and Baseline eGFR in Hospitalized COVID-19 Patients. Kidney360 2021, 2: 1215-1224. PMID: 35369662, PMCID: PMC8676386, DOI: 10.34067/kid.0001612021.Peer-Reviewed Original ResearchConceptsOdds of AKIBaseline eGFRLower oddsHospital AKIInitial urinalysisHospital deathRisk factorsHospitalized COVID-19 patientsActive urine sedimentAssociation of AKIBaseline kidney functionHigher baseline eGFRCongestive heart failureCOVID-19 patientsCoronavirus disease 2019COVID-19Electronic health recordsAKI statusUrinary findingsInflammatory markersUrinalysis findingsHeart failurePatient characteristicsKidney functionDisease 2019Examining the Role of Novel CKD Therapies for the ADPKD Patient
Patel DM, Dahl NK. Examining the Role of Novel CKD Therapies for the ADPKD Patient. Kidney360 2021, 2: 1036-1041. PMID: 35373079, PMCID: PMC8791369, DOI: 10.34067/kid.0007422020.Peer-Reviewed Original ResearchIgA vasculitis complicated by acute kidney failure with thrombotic microangiopathy: successful use of eculizumab
Patel DM, Cantley L, Moeckel G, Dahl NK, Luciano R. IgA vasculitis complicated by acute kidney failure with thrombotic microangiopathy: successful use of eculizumab. Journal Of Nephrology 2021, 34: 2141-2145. PMID: 34019254, DOI: 10.1007/s40620-021-01028-8.Peer-Reviewed Original ResearchMayo Imaging Classification May Be Useful in Determining the Need for Nephrectomy in ADPKD.
Rosenberg S, Virmani S, Klarman S, Santovasi S, Dai F, Dahl NK. Mayo Imaging Classification May Be Useful in Determining the Need for Nephrectomy in ADPKD. Kidney360 2021, 2: 325-330. PMID: 35373011, PMCID: PMC8740992, DOI: 10.34067/kid.0003902020.Peer-Reviewed Original Research
2020
Long-Term Safety of Tolvaptan in ADPKD: Where Do We Stand?
Patel DM, Dahl NK. Long-Term Safety of Tolvaptan in ADPKD: Where Do We Stand? Clinical Journal Of The American Society Of Nephrology 2020, 16: 3-5. PMID: 33376103, PMCID: PMC7792649, DOI: 10.2215/cjn.17981120.Peer-Reviewed Original ResearchClinical Applications of Genetic Discoveries in Kidney Transplantation: a Review.
Marin EP, Cohen E, Dahl N. Clinical Applications of Genetic Discoveries in Kidney Transplantation: a Review. Kidney360 2020, 1: 300-305. PMID: 35372915, PMCID: PMC8809267, DOI: 10.34067/kid.0000312019.Peer-Reviewed Original Research
2019
Intraoperative Ultrasound Guidance for Banding of an Arteriovenous Fistula Causing High Cardiac Output Heart Failure
Turner AD, Chen M, Dahl N, Scoutt L, Dardik A, Ochoa Chaar C. Intraoperative Ultrasound Guidance for Banding of an Arteriovenous Fistula Causing High Cardiac Output Heart Failure. Annals Of Vascular Surgery 2019, 66: 665.e5-665.e8. PMID: 31863947, DOI: 10.1016/j.avsg.2019.12.011.Peer-Reviewed Case Reports and Technical NotesConceptsEnd-stage renal diseaseArteriovenous fistulaHigh cardiac output heart failureHigh cardiac output failureHigh-output cardiac failureOutput cardiac failureIntraoperative ultrasound guidanceRare complicationCardiac failureHeart failureRenal diseaseCase reportCardiac functionUltrasound guidanceIntraoperative ultrasoundFlow volumeOutput failureFistulaPatientsGradual declineFailureBandingComplicationsHemodialysisHigh flow volumesRisk factors and safe contrast volume thresholds for postcontrast acute kidney injury after peripheral vascular interventions
Lee SR, Zhuo H, Zhang Y, Dahl N, Dardik A, Ochoa Chaar CI. Risk factors and safe contrast volume thresholds for postcontrast acute kidney injury after peripheral vascular interventions. Journal Of Vascular Surgery 2019, 72: 603-610.e1. PMID: 31843298, DOI: 10.1016/j.jvs.2019.09.059.Peer-Reviewed Original ResearchMeSH KeywordsAcute Kidney InjuryAgedCanadaContrast MediaDatabases, FactualEndovascular ProceduresFemaleHumansIncidenceKidneyMaleMiddle AgedPatient SafetyPeripheral Arterial DiseaseRadiography, InterventionalRenal Insufficiency, ChronicRetrospective StudiesRisk AssessmentRisk FactorsTreatment OutcomeUnited StatesConceptsAdvanced chronic kidney diseaseChronic kidney diseasePeripheral vascular interventionsStages of CKDPostcontrast acute kidney injuryBaseline kidney functionPC-AKIAcute kidney injuryContrast volumeVolume of contrastRisk factorsKidney injuryCumulative incidenceLimb ischemiaKidney functionVascular interventionsMultivariable Cox proportional hazards regressionCox proportional hazards regressionAcute limb ischemiaLong-term mortalityCritical limb ischemiaNormal kidney functionMultivariable logistic regressionProportional hazards regressionLong-term survivalInherited glomerular diseases in the gilded age of genomic advancements
Gulati A, Dahl N, Tufro A. Inherited glomerular diseases in the gilded age of genomic advancements. Pediatric Nephrology 2019, 35: 959-968. PMID: 31049720, PMCID: PMC7184048, DOI: 10.1007/s00467-019-04266-y.Peer-Reviewed Original ResearchConceptsGenomic advancementsHigh-throughput next-generation sequencing technologiesNext-generation sequencing technologiesSingle nucleotide changeSingle nucleotide variationsDisease-causing mutationsDNA variationHuman genomeNext-generation sequencingGenomic informationSequencing technologiesNucleotide variationsAccurate genetic diagnosisNucleotide changesGenetic diagnosisSmall insertionsGenomic knowledgeCytogenetic methodsBiological interpretationMutation spectrumSequencingGenomic medicineGenomeUncertain significanceGlomerular disease