2012
A Systematic Review of Antiretroviral Adherence Interventions for HIV-Infected People Who Use Drugs
Binford MC, Kahana SY, Altice FL. A Systematic Review of Antiretroviral Adherence Interventions for HIV-Infected People Who Use Drugs. Current HIV/AIDS Reports 2012, 9: 287-312. PMID: 22936463, PMCID: PMC3495269, DOI: 10.1007/s11904-012-0134-8.Peer-Reviewed Original ResearchConceptsMedication-assisted therapyCART adherenceVirologic outcomesSystematic reviewCombination antiretroviral therapy (cART) adherenceAntiretroviral Adherence InterventionPost-intervention adherenceHIV treatment outcomesHIV clinical careAntiretroviral therapy adherenceNurse-delivered interventionShort-term adherenceCognitive behavioral therapyLong-term improvementPeer-driven interventionVirologic benefitAntiretroviral therapyDevelopment of interventionsIntervention cessationAdherence interventionsProspective studyTherapy adherenceEligible studiesTreatment outcomesClinical care
2007
Superiority of Directly Administered Antiretroviral Therapy over Self-Administered Therapy among HIV-Infected Drug Users: A Prospective, Randomized, Controlled Trial
Altice FL, Maru DS, Bruce RD, Springer SA, Friedland GH. Superiority of Directly Administered Antiretroviral Therapy over Self-Administered Therapy among HIV-Infected Drug Users: A Prospective, Randomized, Controlled Trial. Clinical Infectious Diseases 2007, 45: 770-778. PMID: 17712763, PMCID: PMC2693907, DOI: 10.1086/521166.Peer-Reviewed Original ResearchConceptsHIV-1 RNA levelsSelf-administered therapyT-lymphocyte countsDrug usersAntiretroviral therapyLymphocyte countRNA levelsPrimary outcomeProportion of patientsGreater mean reductionHIV treatment programsLog10 copies/Human immunodeficiency virusCopies/mLDAART groupVirologic outcomesSecondary outcomesControlled TrialsImmunodeficiency virusPoor adherenceTreatment adherenceEntry criteriaTreat approachCopies/Mean change
2006
Impact of Enhanced Services on Virologic Outcomes in a Directly Administered Antiretroviral Therapy Trial for HIV-Infected Drug Users
Smith-Rohrberg D, Mezger J, Walton M, Bruce RD, Altice FL. Impact of Enhanced Services on Virologic Outcomes in a Directly Administered Antiretroviral Therapy Trial for HIV-Infected Drug Users. JAIDS Journal Of Acquired Immune Deficiency Syndromes 2006, 43: s48-s53. PMID: 17133204, DOI: 10.1097/01.qai.0000248338.74943.85.Peer-Reviewed Original ResearchConceptsHIV-1 RNA levelsVirologic outcomesCase management servicesDrug usersVirologic successService utilizationRNA levelsHigher medical service utilizationHIV-1 RNA reductionLog10 HIV-1 RNAAntiretroviral Therapy (SMART) trialImproved virologic outcomesHealth service utilizationHIV-1 RNASelf-administered therapyCopies/mLMedical service utilizationActive drug usersSubstance abuse servicesAntiretroviral therapyHIV outcomesPrimary outcomeProblematic adherenceTherapy trialsDAART