2024
A qualitative dyad analysis of barriers and facilitators of antiretroviral therapy (ART) adherence among people who inject drugs (PWID) with HIV in Kazakhstan
Neuenschwander P, Altice F, Remien R, Mergenova G, Sarsembayeva L, Rozental E, Gulyayev V, Davis A. A qualitative dyad analysis of barriers and facilitators of antiretroviral therapy (ART) adherence among people who inject drugs (PWID) with HIV in Kazakhstan. AIDS Care 2024, ahead-of-print: 1-10. PMID: 39404196, DOI: 10.1080/09540121.2024.2414078.Peer-Reviewed Original ResearchAntiretroviral therapy adherenceSocial supportART adherenceFacilitators of ART adherenceBarriers to ART adherenceAntiretroviral therapyART adherence interventionsInjection drug useDyad analysisAdherence interventionsAdherence barriersLack of awarenessHIV epidemicAdherencePWIDDrug useHIVInterpersonal levelRelationship contextDyad membersFacilitationIndividual levelPWHDyadsIntimate partners
2022
Implementation of a Dyad-Based Intervention to Improve Antiretroviral Therapy Adherence Among HIV-Positive People Who Inject Drugs in Kazakhstan: A Randomized Trial
Davis A, Mergenova G, Landers S, Sun Y, Rozental E, Gulyaev V, Gulyaev P, Nurkatova M, Terlikbayeva A, Primbetova S, Altice F, Remien R. Implementation of a Dyad-Based Intervention to Improve Antiretroviral Therapy Adherence Among HIV-Positive People Who Inject Drugs in Kazakhstan: A Randomized Trial. Research On Social Work Practice 2022, 33: 313-324. PMID: 37576461, PMCID: PMC10421639, DOI: 10.1177/10497315221117543.Peer-Reviewed Original ResearchHIV-positive PWIDAntiretroviral therapy adherenceHIV-positive peopleTherapy adherenceART adherence interventionsStandard of careSupport partnersART adherenceAdherence interventionsIntervention deliveryPWIDTraining of staffInterventionTrialsAdherenceCouple interventionsSocial supportFamily membersDrugsIntimate partnersRemote deliveryCollection of assessmentsImplementation strategiesDeliveryAdapted versionViral Suppression Levels in Men Who Have Sex With Men and Transgender Women With Newly Diagnosed HIV and Alcohol Use Disorder in Peru: Results From a Randomized, Double-Blind, Placebo-Controlled Trial Using Oral Naltrexone
Gonzales P, Bachireddy C, Grieco A, Ding R, de Leon S, Ulrich A, Lama J, Duerr AC, Altice FL. Viral Suppression Levels in Men Who Have Sex With Men and Transgender Women With Newly Diagnosed HIV and Alcohol Use Disorder in Peru: Results From a Randomized, Double-Blind, Placebo-Controlled Trial Using Oral Naltrexone. JAIDS Journal Of Acquired Immune Deficiency Syndromes 2022, 89: 462-471. PMID: 34897226, PMCID: PMC8881312, DOI: 10.1097/qai.0000000000002889.Peer-Reviewed Original ResearchConceptsMSM/transgender womenAlcohol use disorderOral naltrexoneTransgender womenViral suppressionUse disordersEFV/TDF/FTCTreatment of AUDMaximal viral suppressionSingle treatment regimenPlacebo-controlled trialTDF/FTCAntiretroviral therapy adherenceUse of naltrexoneEvidence-based treatmentsViral suppression levelsMVs levelsSecondary outcomesTherapy adherenceLow adherenceAdherence levelsNaltrexoneAUD treatmentHIVPlacebo
2019
Self-reported antiretroviral therapy adherence and viral load in criminal justice-involved populations
Cunningham WE, Nance RM, Golin CE, Flynn P, Knight K, Beckwith CG, Kuo I, Spaulding A, Taxman FS, Altice F, Delaney JA, Crane HM, Springer SA. Self-reported antiretroviral therapy adherence and viral load in criminal justice-involved populations. BMC Infectious Diseases 2019, 19: 913. PMID: 31664910, PMCID: PMC6819597, DOI: 10.1186/s12879-019-4443-z.Peer-Reviewed Original ResearchConceptsViral loadART adherenceAdherence measuresSelf-reported antiretroviral therapy (ART) adherenceCriminal justice-involved populationsSelf-reported ART adherenceLogistic regressionSelf-reported health statusContinuum of HIVDetectable viral loadPlasma viral loadAIDS Research NetworkAntiretroviral therapy adherenceAssociation of adherenceHealth status levelsVisual analog scaleViral load dataMixed-effects logistic regressionMixed effects linear regressionEffects linear regressionJustice-involved populationsEffects logistic regressionVL outcomesCD4 countART doses
2018
HIV Sero-Status Non-disclosure Among HIV-Infected Opioid-Dependent Individuals: The Roles of HIV-Related Stigma, Risk Behavior, and Social Support
Shrestha R, Altice FL, Sibilio B, Copenhaver MM. HIV Sero-Status Non-disclosure Among HIV-Infected Opioid-Dependent Individuals: The Roles of HIV-Related Stigma, Risk Behavior, and Social Support. Journal Of Community Health 2018, 44: 112-120. PMID: 30043195, PMCID: PMC6330145, DOI: 10.1007/s10900-018-0560-7.Peer-Reviewed Original ResearchConceptsOpioid-dependent individualsOpioid-dependent patientsHIV statusFamily/friendsSexual partnersHIV disclosureHIV sero-status disclosureRisk behaviorsHIV sero statusAntiretroviral therapy adherenceHigh-risk HIVRole of HIVMultivariable logistic regressionSubstance abuse treatment settingsHIV risk behaviorsInconsistent condom useMultiple sex partnersSocial supportHigh HIVSero statusHIV transmissionTherapy adherenceIndependent correlatesHIV riskHIV stigma
2016
Community-Based Interventions to Improve and Sustain Antiretroviral Therapy Adherence, Retention in HIV Care and Clinical Outcomes in Low- and Middle-Income Countries for Achieving the UNAIDS 90-90-90 Targets
Nachega JB, Adetokunboh O, Uthman OA, Knowlton AW, Altice FL, Schechter M, Galárraga O, Geng E, Peltzer K, Chang LW, Van Cutsem G, Jaffar SS, Ford N, Mellins CA, Remien RH, Mills EJ. Community-Based Interventions to Improve and Sustain Antiretroviral Therapy Adherence, Retention in HIV Care and Clinical Outcomes in Low- and Middle-Income Countries for Achieving the UNAIDS 90-90-90 Targets. Current HIV/AIDS Reports 2016, 13: 241-255. PMID: 27475643, PMCID: PMC5357578, DOI: 10.1007/s11904-016-0325-9.Peer-Reviewed Original ResearchMeSH KeywordsAnti-HIV AgentsCommunity Health CentersCross-Sectional StudiesDeveloping CountriesHealth EducationHealth Services AccessibilityHIV InfectionsHumansMedication AdherenceObservational Studies as TopicPatient DropoutsRandomized Controlled Trials as TopicSustained Virologic ResponseUnited NationsConceptsHealth facility-based interventionsFacility-based interventionsAntiretroviral therapy adherenceCommunity-based interventionsVirologic suppressionCohort studyMiddle-income countriesClinical outcomesTherapy adherenceRelative riskComparable outcomesCommunity-based ART delivery modelTreatment engagementART delivery modelsFacility-based modelsComparative cohort studyRelevant clinical outcomesRandom-effects modelLeast comparable outcomesStable HIVCause mortalityHIV careART adherenceUNAIDS 90ART deliveryAcceptability and feasibility of mHealth and community-based directly observed antiretroviral therapy to prevent mother-to-child HIV transmission in South African pregnant women under Option B+: an exploratory study
Nachega JB, Skinner D, Jennings L, Magidson JF, Altice FL, Burke JG, Lester RT, Uthman OA, Knowlton AR, Cotton MF, Anderson JR, Theron GB. Acceptability and feasibility of mHealth and community-based directly observed antiretroviral therapy to prevent mother-to-child HIV transmission in South African pregnant women under Option B+: an exploratory study. Patient Preference And Adherence 2016, Volume 10: 683-690. PMID: 27175068, PMCID: PMC4854240, DOI: 10.2147/ppa.s100002.Peer-Reviewed Original ResearchFeasibility of mHealthHIV status disclosurePregnant womenAntiretroviral therapyTreatment supportersStatus disclosureChild human immunodeficiency virus (HIV) transmissionCommunity primary care clinicsHuman immunodeficiency virus (HIV) transmissionPregnant South African womenART adherence interventionsAntiretroviral therapy regimenChild HIV transmissionAntiretroviral therapy adherencePrimary care clinicsSouth African pregnant womenMobile phone accessAfrican pregnant womenFocus group discussionsSMS text messagingPMTCT servicesSouth African womenART adherencePhone accessTherapy regimen
2015
Advancing Behavioral HIV Prevention: Adapting an Evidence‐Based Intervention for People Living with HIV and Alcohol Use Disorders
Armstrong ML, LaPlante AM, Altice FL, Copenhaver M, Molina PE. Advancing Behavioral HIV Prevention: Adapting an Evidence‐Based Intervention for People Living with HIV and Alcohol Use Disorders. AIDS Research And Treatment 2015, 2015: 879052. PMID: 26697216, PMCID: PMC4678056, DOI: 10.1155/2015/879052.Peer-Reviewed Original ResearchEvidence-based interventionsAlcohol use disorderDisease progressionHIV preventionUse disordersAlcohol consumptionHIV primary care clinicHolistic Health Recovery ProgramAdapted evidence-based interventionSecondary HIV preventionHIV disease progressionAntiretroviral therapy adherencePrimary care clinicsSuboptimal treatment adherenceHIV risk behaviorsHeavy alcohol consumptionBehavioral HIV preventionHarmful alcohol consumptionHeavy alcohol useHIV/AIDSFocus groupsCare clinicsTherapy adherenceTreatment adherenceOutpatient optionsA non-inferiority trial of an evidence-based secondary HIV prevention behavioral intervention compared to an adapted, abbreviated version: Rationale and intervention description
Shrestha R, Krishnan A, Altice FL, Copenhaver M. A non-inferiority trial of an evidence-based secondary HIV prevention behavioral intervention compared to an adapted, abbreviated version: Rationale and intervention description. Contemporary Clinical Trials 2015, 44: 95-102. PMID: 26253181, PMCID: PMC4744142, DOI: 10.1016/j.cct.2015.08.002.Peer-Reviewed Original ResearchEvidence-based interventionsHIV risk behaviorsHolistic Health Recovery ProgramSex-related HIV risk behaviorsRisk behaviorsClinical settingCurrent HIV prevention effortsReal-world clinical settingHIV prevention behavioral interventionFormal cost-effectiveness analysisAntiretroviral therapy adherenceNon-inferiority trialHIV prevention effortsAddiction treatment settingsCommon clinical settingsCost-effective relativeCost-effectiveness analysisAddiction treatment programsTherapy adherenceTarget HIVTrial designHIVIntervention DescriptionTreatment settingsUnmet needMen Who Have Sex With Men in Peru: Acceptability of Medication-Assisted Therapy for Treating Alcohol Use Disorders
Brown SE, Vagenas P, Konda KA, Clark JL, Lama JR, Gonzales P, Sanchez J, Duerr AC, Altice FL. Men Who Have Sex With Men in Peru: Acceptability of Medication-Assisted Therapy for Treating Alcohol Use Disorders. American Journal Of Men's Health 2015, 11: 1269-1278. PMID: 25787988, PMCID: PMC4573823, DOI: 10.1177/1557988315576775.Peer-Reviewed Original ResearchConceptsMSM/transgender womenAlcohol use disorderMedication-assisted therapyTransgender womenUse disordersManagement of AUDAntiretroviral therapy adherenceAlcohol problemsRisky sexual behaviorPeruvian MSMTherapy adherenceClinical trialsHIV epidemicTreatment programTotal abstinenceLess alcoholTherapyThematic content analysisMultiple studiesMedicationsSexual behaviorHIVDrinking behaviorMenFamily support
2014
Communication technology use and mHealth acceptance among HIV-infected men who have sex with men in Peru: implications for HIV prevention and treatment
Krishnan A, Ferro EG, Weikum D, Vagenas P, Lama JR, Sanchez J, Altice FL. Communication technology use and mHealth acceptance among HIV-infected men who have sex with men in Peru: implications for HIV prevention and treatment. AIDS Care 2014, 27: 273-282. PMID: 25285464, PMCID: PMC4305474, DOI: 10.1080/09540121.2014.963014.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedAlcohol DrinkingAnti-Retroviral AgentsCell PhoneEducationFemaleHealth SurveysHIV InfectionsHomosexuality, MaleHumansMaleMedication AdherenceMiddle AgedPeruPovertyPrevalenceRisk FactorsSexual BehaviorSurveys and QuestionnairesTelemedicineText MessagingTransgender PersonsConceptsAlcohol use disorderTransgender womenMHealth acceptancePoor HIV treatment outcomesHIV treatment outcomesAntiretroviral therapy adherenceSuboptimal ART adherenceHIV risk behaviorsART adherenceRisky sexual behaviorPeruvian MSMTherapy adherenceHIV epidemicHIV preventionTreatment outcomesHIV interventionsUse disordersMedication remindersHealth professionalsHIVMSMConvenience sampleMost participantsIntervention strategiesStandardized assessmentGender disparities in HIV treatment outcomes following release from jail: results from a multicenter study.
Meyer JP, Zelenev A, Wickersham JA, Williams CT, Teixeira PA, Altice FL. Gender disparities in HIV treatment outcomes following release from jail: results from a multicenter study. American Journal Of Public Health 2014, 104: 434-41. PMID: 24432878, PMCID: PMC3953795, DOI: 10.2105/ajph.2013.301553.Peer-Reviewed Original ResearchConceptsHIV treatment outcomesTreatment outcomesViral suppressionJail detaineesMultisite prospective cohort studyOptimal antiretroviral therapy (ART) adherenceOptimal HIV treatment outcomesWorse HIV treatment outcomesMultiple logistic regression modelAntiretroviral therapy prescriptionHIV primary careHIV clinical careProspective cohort studyAntiretroviral therapy adherenceNon-Hispanic whitesLogistic regression modelsGreater comorbidityCohort studyEvaluable participantsMulticenter studyTherapy adherencePrimary careTherapy prescriptionClinical careHeroin use
2013
Design and methods of a double blind randomized placebo-controlled trial of extended-release naltrexone for alcohol dependent and hazardous drinking prisoners with HIV who are transitioning to the community
Springer SA, Altice FL, Herme M, Di Paola A. Design and methods of a double blind randomized placebo-controlled trial of extended-release naltrexone for alcohol dependent and hazardous drinking prisoners with HIV who are transitioning to the community. Contemporary Clinical Trials 2013, 37: 209-218. PMID: 24384538, PMCID: PMC3992862, DOI: 10.1016/j.cct.2013.12.006.Peer-Reviewed Original ResearchConceptsPlacebo-controlled trialHIV treatment outcomesTreatment outcomesCriminal justice system (CJS) populationsPoor antiretroviral therapy (ART) adherenceAlcohol useExtended-release naltrexoneAntiretroviral therapy adherenceMedication-assisted therapyPrevention of relapseAlcohol use disorderSexual risk-taking behaviorsAlcohol-dependent personsXR-NTXHigh morbidityTherapy adherenceAlcohol relapseHigh prevalenceStudy participationEligibility criteriaUse disordersHIVRelapseHazardous drinkingNaltrexone
2012
A Systematic Review of Antiretroviral Adherence Interventions for HIV-Infected People Who Use Drugs
Binford MC, Kahana SY, Altice FL. A Systematic Review of Antiretroviral Adherence Interventions for HIV-Infected People Who Use Drugs. Current HIV/AIDS Reports 2012, 9: 287-312. PMID: 22936463, PMCID: PMC3495269, DOI: 10.1007/s11904-012-0134-8.Peer-Reviewed Original ResearchConceptsMedication-assisted therapyCART adherenceVirologic outcomesSystematic reviewCombination antiretroviral therapy (cART) adherenceAntiretroviral Adherence InterventionPost-intervention adherenceHIV treatment outcomesHIV clinical careAntiretroviral therapy adherenceNurse-delivered interventionShort-term adherenceCognitive behavioral therapyLong-term improvementPeer-driven interventionVirologic benefitAntiretroviral therapyDevelopment of interventionsIntervention cessationAdherence interventionsProspective studyTherapy adherenceEligible studiesTreatment outcomesClinical care