2018
Development of biomarker combinations for postoperative acute kidney injury via Bayesian model selection in a multicenter cohort study
Meisner A, Kerr KF, Thiessen-Philbrook H, Wilson FP, Garg AX, Shlipak MG, Kavsak P, Whitlock RP, Coca SG, Parikh CR. Development of biomarker combinations for postoperative acute kidney injury via Bayesian model selection in a multicenter cohort study. Biomarker Research 2018, 6: 3. PMID: 29344362, PMCID: PMC5767010, DOI: 10.1186/s40364-018-0117-z.Peer-Reviewed Original ResearchCardiopulmonary bypass timeMild AKISevere AKICardiac surgeryBiomarker combinationsBypass timeKidney injurySerum creatininePostoperative acute kidney injuryB-type natriuretic peptideAcute kidney injuryBackgroundAcute kidney injuryHeart-type fatty acidMethodsThe primary endpointSerum creatinine increaseMulticenter cohort studyPlasma interleukin-6Optimism-corrected AUCPostoperative biomarkersCreatinine increaseHospital stayPrimary endpointPreoperative levelsCohort studyFrequent complication
2017
Group analysis identifies differentially elevated biomarkers with distinct outcomes for advanced acute kidney injury in cardiac surgery
Lin H, Scherzer R, Philbrook HT, Coca SG, Wilson FP, Garg AX, Shlipak MG, Parikh CR. Group analysis identifies differentially elevated biomarkers with distinct outcomes for advanced acute kidney injury in cardiac surgery. Biomarkers In Medicine 2017, 11: 1091-1102. PMID: 29172665, PMCID: PMC5753615, DOI: 10.2217/bmm-2017-0060.Peer-Reviewed Original ResearchConceptsAdvanced acute kidney injuryAcute kidney injuryKidney injuryCardiac surgeryPatient groupSingle biomarkerIndividual biomarkersPostoperative biomarkersDistinct biomarker patternsNT-proBNPSecondary outcomesIL-10Clinical variablesIL-6Plasma biomarkersCK-MBRisk discriminationAbstractTextH-FABPBiomarkersSignificant differencesSurgeryBiomarker patternsInjuryOutcomes